Pathways and Promoter Elements Leading to c-fos Transcription

Recent reviews:

• Ghosh and Greenberg. Calcium signaling in neurons: molecular mechanisms and cellular consequences. Science 1995; 268:239-247.
• Rosen, Ginty, and Greenberg. Calcium regulation of gene expression. Adv Second Messenger Phosphoprotein Res 1995; 30:225-253.

• Miranti, Ginty, Huang, Chatila, and Greenberg. Calcium activates serum response factor-dependent transcription by a Ras- and Elk-1-independent mechanism that involves a Ca2+/calmodulin-dependent kinase. Mol Cell Biol 1995; 15:3672-3684.
• Ginty, Bonni, and Greenberg. Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB. Cell 1994; 77:713-25.
• Rivera, Miranti, Misra, Ginty, Chen, Blenis, and Greenberg. A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity. Mol Cell Biol 1993; 13:6260-73.
• Ginty, Kornhauser, Thompson, Bading, Mayo, Takahashi, and Greenberg. Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock. Science 1993; 260:238-41.
• Bading, Ginty, and Greenberg. Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways. Science 1993; 260:181-6.
• Sheng, Thompson, and Greenberg. CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases. Science 1991; 252:1427-30.