Ricardo Dolmetsch
Brief Personal Statement:
Born in Cali, Colombia. Diehard fan of El Deportivo Cali and the Colombian national soccer team. Son of the director of the Orquesta Sinfonica del Valle; and Angela Cuevas (Mujeres por la Democracia, eighty votes out of eight million in the last election) . Lover of arepas, pandebono and salsa music. Adopted fan of the Stanford Football team. Graduate of Colegio Bolivar, Brown University, and Stanford University. Runner, soccer player, omnivorous reader, itinerant traveler, serial entrepreneur, bad musician. Check out my papers:
Differential activation of transcription factors by calcium response amplitude and duration. R.E. Dolmetsch, R.S. Lewis, C.C. Goodnow, and J.I. Healy. Nature 386:855-858
Signaling between intracellular calcium stores and depletion-activated calcium channels generates calcium oscillations in T lymphocytes. R.E. Dolmetsch and R.S. Lewis. J. Gen. Physiol. 103:365-388
Different Nuclear Signals Are Activated by the B Cell Receptor during Positive Versus Negative Signaling. J.I. Healy, R.E. Dolmetsch, L.A. Timmerman, J.G. Cyster, M.L. Thomas, G.R. Crabtree, R.S. Lewis, and C.C. Goodnow. Immunity 6:419-428
Positive and negative regulation of depletion-activated calcium channels by calcium. R.S. Lewis, R.E. Dolmetsch, and A. Zweifach. In Organellar Ion channels and Transporters 242-253
Research:
For my Ph.D. I worked on the mechanism and the function of calcium oscillations in T lymphocytes. I found that oscillations are probably generated by the feedback between unusual calcium channels that are activated by depletion of the internal stores and the internal stores themselves. I also found that different calcium patterns can activate different transcriptional pathways, showing for the first time that the pattern of calcium fluxes actually contains information that can be decoded by the nucleus of a cell. I spent most of my time in graduate school building The Beast which was a machine to generate calcium oscillations of arbitrary frequencies and amplitudes in the cytoplasm of single cells. I am an expert miniature plumber.
Favorite Web Links:
News about the mother country
Makers of Igor
How to contact:
email: Ricardo Dolmetsch <dolmetsch@hub.tch.harvard.edu>
Phone/Fax/Postal Address
Greenberg Lab World Wide Web Pages