PCMM | 2015

β-subunit Binding is Sufficient for Ligands to open the Integrin αIIbβ3 Headpiece.
Lin FY, Zhu J, Eng ET, Hudson NE, Springer TA.
J Biol Chem. 2015 Dec 2. (PDF)

Cytoskeletal perturbation leads to platelet dysfunction and thrombocytopenia in variant forms of Glanzmann thrombasthenia.
Bury L, Falcinelli E, Chiasserini D, Springer TA, Italiano JE Jr, Gresele P. 
Haematologica. 2016 Jan;101(1):46-56. 

Linker regions and flexibility around the metalloprotease domain account for conformational activation of ADAMTS-13.
Deforche L, Roose E, Vandenbulcke A, Vandeputte N, Feys HB, Springer TA, Mi LZ, Muia J, Sadler JE, Soejima K, Rottensteiner H, Deckmyn H, De Meyer SF, Vanhoorelbeke K. 
J Thromb Haemost. 2015 Nov;13(11):2063-75. 

Structural basis for quinine-dependent antibody binding to platelet integrin αIIbβ3.
Zhu J, Zhu J, Bougie DW, Aster RH, Springer TA.
Blood. 2015 Oct 29;126(18):2138-45. (PDF)

Force-induced on-rate switching and modulation by mutations in gain-of-function von Willebrand diseases.
Kim J, Hudson NE, Springer TA.
Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4648-53. (PDF)

Carbon nanotube-assisted optical activation of TGF-β signalling by near-infrared light.
Lin L, Liu L, Zhao B, Xie R, Lin W, Li H, Li Y, Shi M, Chen YG, Springer TA, Chen X.
Nat Nanotechnol. 2015 May;10(5):465-71. 

Structure of bone morphogenetic protein 9 procomplex.
Mi LZ, Brown CT, Gao Y, Tian Y, Le VQ, Walz T, Springer TA.
Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3710-5. (PDF)