PCMM | 2014

June 13, 2014

Cytotoxic Cells Kill Intracellular Bacteria through Granulysin-Mediated Delivery of Granzymes

Michael Walch, Farokh Dotiwala and Judy Lieberman unveil a new role for killer cells in bacterial defense. In a recent Cell paper they show that granulysin, an antimicrobial protein present in the cytotoxic granules of human killer lymphocytes, delivers death-inducing granzymes into bacteria, where they rapidly kill bacteria and limit the spread of infection.