PCMM | 2015

Molecular mechanism of V(D)J recombination captured by structures of RAG1-RAG2 synaptic complexes.
Ru H, Chambers MG, Fu T, Tong AB, Liao M, Wu H. (2015).  Cell. 163:1138-52 (PDF)

The inflammasome adaptor ASC induces procaspase-8 death effector domain filaments.
Vajjhala P, Lu A, Brown D, Pang S, Sagulenko V, Sester D, Cridland S, Hill J, Schroder K, Stow J, Wu H, Stacey K. (2015). J Biol Chem. 290:29217-30 (PDF)

Cryo-EM structure of the activated NAIP2/NLRC4 Inflammasome reveals nucleated polymerization.
Zhang L, Shuobing C, Jianbin R, Wu J, Tong AB, Yin Q, Li Y, David L, Lu A, Wang WL, Marks C, Ouyang Q, Zhang X, Mao Y, Wu H. (2015). Science. 350:404-9 (PDF)

What’s your favorite crystal structure? Wu H, Yokoyama S, Lugar K, Doudna J, Wilson I, Xu RM.  (2015). Cell. 159:967-968 (PDF)

Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2.
Lu A, Li Y, Qian Y, Ruan J, Yu X, Egelman E, Wu H. (2015). Cell Discovery. published online (PDF)

The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIP3 and protects cells from necroptosis.
Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, Prodhomme T, Duong B, Whang MI, Advincula R, Agelidis A, Barrera J, Wu H, Burlingame A, Malynn BA, Zamvil SS, Ma A. (2015).  Nature Immunology. 16:618-627 (PDF)

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer.
Wei S, Kozono S, Kats L, Nechama M, Li W, Guarnerio J, Luo M, You MH, Yao Y, Kondo A, Hu H, Bozkurt G, Moerke NJ, Cao S, Reschke M, Chen CH, Rego EM, Lo-Coco F, Cantley LC, Lee TH, Wu H, Zhang Y, Pandolfi PP, Zhou XZ, Lu KP. (2015).  Nat Med.21:457-466 (PDF)

The hierarchical structural architecture of inflammasomes, supramolecular inflammatory machines.
Hauenstein A, Zhang L, Wu H. (2015).  Curr Opin Struct Biol. 31:75-83 (PDF)

Structural Biology of Innate Immunity 
Yin Q, Fu TM, Li J, Wu H. 
Annu. Rev. Immunol. (2015). published online. (PDF)