PCMM | 2012

Neutrophil extracellular traps promote deep vein thrombosis in mice
Brill A, Fuchs TA, Savchenko AS, Thomas GM, Martinod K, De Meyer SF, Bhandari AA, Wagner DD. 
J Thromb Haemost. 2012;10(1):136-144. PMCID: 3319651.

Extrahepatic high-density lipoprotein receptor SR-BI and apoA-I protect against deep vein thrombosis in mice 
Brill A, Yesilaltay A, De Meyer SF, Kisucka J, Fuchs TA, Kocher O, Krieger M, Wagner DD.
Arterioscler Thromb Vasc Biol. 2012;32(8):1841-1847. PMCID: 3495568.

Endocytosis of soluble immune complexes leads to their clearance by FcgammaRIIIB but induces neutrophil extracellular traps via FcgammaRIIA in vivo.
Chen K, Nishi H, Travers R, Tsuboi N, Martinod K, Wagner DD, Stan R, Croce K, Mayadas TN. 
Blood. 2012;120(22):4421-4431. PMCID: 3507149.

ADAMTS13 exerts a thrombolytic effect in microcirculation.
Crescente M, Thomas GM, Demers M, Voorhees JR, Wong SL, Ho-Tin-Noe B, Wagner DD.
Thromb Haemost. 2012;108(3):527-532.

Protective anti-inflammatory effect of ADAMTS13 on myocardial ischemia/reperfusion injury in mice.
De Meyer SF, Savchenko AS, Haas MS, Schatzberg D, Carroll MC, Schiviz A, Dietrich B, Rottensteiner H, Scheiflinger F, Wagner DD. 
Blood. 2012;120(26):5217-5223. PMCID: 3537313.

von Willebrand factor: an emerging target in stroke therapy 
De Meyer SF, Stoll G, Wagner DD, Kleinschnitz C.
Stroke. 2012;43(2):599-606.

Extracellular chromatin is an important mediator of ischemic stroke in mice.
De Meyer SF, Suidan GL, Fuchs TA, Monestier M, Wagner DD. 
Arterioscler Thromb Vasc Biol. 2012;32(8):1884-1891. PMCID: 3494463.

Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis.
Demers M, Krause DS, Schatzberg D, Martinod K, Voorhees JR, Fuchs TA, Scadden DT, Wagner DD. 
Proc Natl Acad Sci U S A. 2012;109(32):13076-13081. PMCID: 3420209.

Targeting platelet function to improve drug delivery.
Demers M, Wagner DD. 
Oncoimmunology. 2012;1(1):100-102. PMCID: 3376975.

Neutrophil extracellular trap (NET) impact on deep vein thrombosis. 
Fuchs TA, Brill A, Wagner DD. 
Arterioscler Thromb Vasc Biol. 2012;32(8):1777-1783. PMCID: 3495595.

Circulating DNA and myeloperoxidase indicate disease activity in patients with thrombotic microangiopathies 
Fuchs TA, Kremer Hovinga JA, Schatzberg D, Wagner DD, Lammle B. 
Blood. 2012;120(6):1157-1164. PMCID: 3418712.

Desialylation accelerates platelet clearance after refrigeration and initiates GPIbalpha metalloproteinase-mediated cleavage in mice.
Jansen AJ, Josefsson EC, Rumjantseva V, Liu QP, Falet H, Bergmeier W, Cifuni SM, Sackstein R, von Andrian UH, Wagner DD, Hartwig JH, Hoffmeister KM. 
Blood. 2012;119(5):1263-1273. PMCID: 3277358.

Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels.
Korin N, Kanapathipillai M, Matthews BD, Crescente M, Brill A, Mammoto T, Ghosh K, Jurek S, Bencherif SA, Bhatta D, Coskun AU, Feldman CL, Wagner DD, Ingber DE. 
Science. 2012;337(6095):738-742.

ARC15105 is a potent antagonist of von Willebrand factor mediated platelet activation and adhesion. 
Siller-Matula JM, Merhi Y, Tanguay JF, Duerschmied D, Wagner DD, McGinness KE, Pendergrast PS, Chung JK, Tian X, Schaub RG, Jilma B. 
Arterioscler Thromb Vasc Biol. 2012;32(4):902-909.

Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice.
Thomas GM, Carbo C, Curtis BR, Martinod K, Mazo IB, Schatzberg D, Cifuni SM, Fuchs TA, von Andrian UH, Hartwig JH, Aster RH, Wagner DD. 
Blood. 2012;119(26):6335-6343. PMCID: 3383196.

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo.
von Bruhl ML, Stark K, Steinhart A, Chandraratne S, Konrad I, Lorenz M, Khandoga A, Tirniceriu A, Coletti R, Kollnberger M, Byrne RA, Laitinen I, Walch A, Brill A, Pfeiler S, Manukyan D, Braun S, Lange P, Riegger J, Ware J, Eckart A, Haidari S, Rudelius M, Schulz C, Echtler K, Brinkmann V, Schwaiger M, Preissner KT, Wagner DD, Mackman N, Engelmann B, Massberg S.
J Exp Med. 2012;209(4):819-835. PMCID: 3328366.