PCMM | Stem Cells

A prime example of our research in immune defense is an aggressive study of the role and specificity of a key element in our adaptive immune system: how killer T cells eliminate infectious cells.

Significant progress has occurred in understanding how a vaccine based on a protein derived from a common bacterium may prompt a potent T cell defense against human immunodeficiency virus (HIV). This work will have substantial impact in a more general understanding of how T cells can be marshaled to fight viruses and tumors.

Investigators have identified the following scientific challenges in this area of concentration:

  • Understanding the regulation of T cell response in chronic infections
  • Understanding how to regulate and manipulate killer T cells at the molecular level
  • Discovering the role of programmed cell death (apoptosis) in immune defense
  • Methods for inducing T cells specific for cancer and for viruses

PCMM Scientists studying stem cells


Frederick Alt

Judy Lieberman

Derrick Rossi

Yi Zhang, PhD

Yi Zhang