Past Studies

Past studies within the CTRP: 

SynapDx Autism Spectrum Disorder Gene Expression Analysis Study

PI: Bill Barbaresi, MD and Liz Harstad, MD
Participants: Children 18 months - 5 years of age with any diagnosis

Show_more_start

The primary objectives of this study are: 1) To develop an algorithm to classify blood RNA gene expression patterns to maximize agreement between classification and a clinical assessment of presence or absence of ASD, and 2) To prospectively assess the clinical sensitivity and specificity of the blood RNA gene expression classification algorithm in a separate population of children referred to a developmental evaluation clinic for possible developmental disorder.

show_more_end


Parent-Child Cognitive Behavioral Therapy for Anxiety in Young Children with Autism Spectrum Disorders
PI: Katherine Driscoll, PhD and Dina Hirsfeld-Becker, PhD
Participants: 3-12 yr olds with a clinical diagnosis of ASD and their parents

Patient somatic cell donation for reprogramming experiments in neurological disease

PI: Mira Irons, MD and Lisa Prock, MD, MPH
Participants: Children and adults of any age, preference given to children under 10 and participants with ASD, 15q11 dup, 16p11 del, Shank3, TSC2, UBE3A

show_more_start

This study uses stem cells created from patient skin or blood cells to characterize the patient's neurogenetic disease and try to develop new treatments. 

show_more_end


Open Label Extension Arbaclofen in ASD (STX209) Study

PI: Bill Barbaresi, MD
Participants: Children or adults ages 3-18+ yrs with a confirmed ASD diagnosis

show_more_start

Will provide data on the long-term safety and tolerability of STX209 among subjects with ASD who receive treatment under conditions reflective of their typical medical care rather than more restricted conditions in pivotal efficacy trials.

show_more_end


Neural markers of the transition from risk for attention-deficit/hyperactivity disorder (ADHD) to stable ADHD diagnosis
PI: Margaret Sheridan, PhD
Participants: Children ages 3-7 yrs with a clinical diagnosis of ADHD


A randomized, double-blind, placebo-controlled, parallel group study to evaluate AFQ056 in adult patients with Fragile X Syndrome
PI: Lisa Prock, MD, MPHJonathan Picker, MBChB, PhDLiz Harstad, MDKaizad Munshi, MD, MPH
Participants: Adolescents ages 12-18yrs with a clinical diagnosis of Fragile X Syndrome and adults with a clinical diagnosis of Fragile X Syndrome


A randomized, double-blind, placebo-controlled, parallel group study to evaluate the effects of AFQ056 combined with a reading intervention the reading abilities of male patients with Fragile X Syndrome
PI: Lisa Prock, MD, MPH, Jonathan Picker, MBChB, PhD, Liz Harstad, MD, Kaizad Munshi, MD, MPH
Participants: Adolescents ages 12-18 yrs with a clinical diagnosis of Fragile X Syndrome