Infectious Diseases Research

Research in the Division of Infectious Diseases includes both basic investigation and clinical research. The bench research in the division has the broad objective of elucidating basic mechanisms of microbial pathogenesis and the related host responses that mediate susceptibility to infection, host injury, and protective immunity. Investigation targets viral, bacterial, fungal, and parasitic pathogens of major significance in community acquired infections in the United States, in infections of immunocompromised hosts, and in global public health. Current projects include:

  • Pathogen-host signaling in streptococcal infection
  • Novel strategies for pneumococcal vaccines
  • Enhancing innate and adaptive immunity in neonates
  • Regulation of bacterial virulence gene expression
  • Modeling cholera infection and host responses in Drosophila
  • HIV pathogenesis, immune response, and vaccine development
  • Regulation of morphogenesis in Candida albicans
  • Molecular approaches to malaria pathogenesis

Clinical research is focused in two broad areas: clinical trials in pediatric HIV and clinical epidemiology/clinical decision-making.

Researchers in the Division of Infectious Diseases hold faculty appointments at Harvard Medical School.

Latest Research in Infectious Diseases:

Asim A. Ahmed, MD
Molecular mechanisms of viral entry, Host determinants of viral entry, Mosquito-borne viruses, Encephalitis, Emerging viruses
Anna Aldovini, MD HIV biology
Dingding An, PhD  Host-microbe interactions 
Sandra Burchett, MD, MS Viral infections
Simon Dove, PhD Transcription regulation
Jeffrey Dvorin, MD, PhD Malaria, Parasitology, Tropical Medicine
 Lakshmi Ganapathi, MBBS Clinical Research in Immunocompromised/Transplant Infectious diseases, HIV/Hepatitis C harm reduction in adolescents
Courtney Gidengil, MD, MPH Pediatric Health Services Research
Donald Goldmann, MD Bacterial Infection
Robert N. Husson, MD Molecular pathogenesis of mycobacterial infection
Julia R. Koehler, MD Fungus; Candida albicans
Grace M. Lee, MD, MPH Vaccine and Drug Safety, Healthcare-Associated Infections, Antimicrobial Stewardship
Katherine P. Lemon, MD, PhD Human Upper Respiratory Tract, Human Microbiome (nose, throat, and skin microbiomes), Bacterial Interspecies Interactions
Ofer Levy, MD, PhD Innate immunity of the human newborn
Yingjie Lu, PhD vaccine development for infectious disease
Richard Malley, MD Pneumococcal pathogenesis and immunity, vaccine development
Kenneth McIntosh, MD HIV and viral infections
Kristin Moffitt, MD Host bacterial pathogen interactions, Bacterial vaccine development
Mari Nakamura, MD, MPH Vaccine health services research, Health information technology
Gregory Priebe, MD
Gregory Priebe, MD
Gregory Priebe, MD 
Pseudomonas aeruginosa infections
Thomas J. Sandora, MD, MPH
Hospital epidemiology, Hand hygiene, Healthcare-Associated Infections, Infection Prevention & Hospital Epidemiology
Tanvi Sharma, MD, MPH Pediatric HIV, Immunocompromised infectious diseases
Rinn Song, MD, MPH Global Health; Pediatric TB 
Neeraj Surana, MD, PhD  Immunology and the microbiota
Jorge Velarde, MD, PhD
Group A Streptococcus Pathogenesis
Paula I. Watnick, MD, PhD

Impact of diarrheal pathogens on host metabolism and development; Vaccines and therapeutics for bacterial infection

Michael R. Wessels, MD Streptococcus infection
Fan Zhang, PhD
 Vaccine Development; Immune Mechanism of Protection Against Human Pathogens