ICCTR | About Us | Biostatistics & Research Design (BARD)

 

Mission

The mission of the BARD Center is to promote excellence in the design and analysis of research studies at Boston Children’s Hospital. The ICCTR BARD Center provides biostatistical and methodological expertise, as well as scientific leadership through collaborative relationships with Boston Children’s investigators. The Center also provides educational offerings in a variety of areas.

Our group includes PhD and masters-level staff with experience in the design and analysis of a wide range of research studies, including pre-clinical experiments, observational and randomized studies, health econometrics and survey research, qualitative evaluations, and high dimensional functional neuroimaging studies. Learn more about the BARD team.

BARD services include:

  • Full biostatistical project support, tailored to your study and resources
  • Long-term collaborations with our faculty researchers
  • Study design and grant preparation
  • Short term consultations with our staff

For further information, please contact:

Dr. Edie Weller, Center Director
Dr. Michael Monuteaux, Center Assistant Director

BARD services

Biostatistics and Research Design faculty and staff can collaborate with investigator on: 

check markProtocol development/Grant preparation

We can ensure that the study objectives, specific aims, and endpoints are well defined, measurable and feasible and advise on appropriate design and methods.  Members can write sections related to research aims, data collection and data management methods, registration and randomization, sample size and power, statistical analysis methods and interim monitoring.

check markStudy design and planning

We provide advice on the most efficient, valid, and feasible study design (cohort, case control, prospective, retrospective, cross sectional, randomized clinical trial, etc.) as well as advice on:

  • appropriate selection of the sample from the target population
  • choice of control group(s)
  • strategies for recruitment and retention
  • data collection methods
  • database design   

In addition, we provide guidance on design issues that are unique to the following methodologies:

  • qualitative studies (use of focus groups, semi-structured or cognitive interviews)
  • survey research, including instrument creation/validation and sampling and data collection methods (e.g., in-person or telephone interviews, mail surveys, web surveys)
  • health econometrics (e.g., cost impact, cost-effectiveness, cost-benefit evaluations)  

check markRandomization

We generate randomization schemes and assignments for single- and double-blind studies. Members work in conjunction with the Research Pharmacy for the implementation of investigator-initiated randomized trials.

check markData analysis

We analyze study data, provide interpretation of statistical analysis results, including interpretation of previously published results as well as results of ongoing analyses. This includes guidance on and development of:

  • statistical graphics and tabular displays of data
  • interim or final data analyses
  • data and safety monitoring board reports

In addition, we provide support for analysis issues that are unique to:

  • qualitative studies (advice on how to analyze qualitative data including transcribing and coding of focus groups and interviews)
  • survey research (data analysis from complex survey design, including the use of post-survey adjustments and post-stratification weights)
  • econometrics research (advice on cost impact, cost-effectiveness, cost-benefit analysis and other types of economic evaluations) 

check markManuscript preparation

We can contribute to the writing of manuscripts for submission to peer-reviewed scientific journals and prepare abstracts and presentations for scientific meetings.

Education

The Biostatistics and Research Design (BARD) Center offers educational opportunities for Boston Children's researchers on statistical design and analysis considerations for research studies. We also offer workshops on the use of statistical packages for data management and reporting. The objective of the BARD Educational Program is to impart a practical, conceptual understanding of the content we teach. Specifically, in each course we strive to achieve the following learning objectives:

  • an understanding of the purpose/intent of the method
  • an understanding of when/under what circumstances the method is applicable
  • an ability to interpret the method’s results, in context
  • an ability to critically evaluate the scientific literature where the method is used
  • an ability to use the method with guidance from a biostatistician, when appropriate

The following table provides a description of the BARD Educational Offerings. We encourage researchers to also explore the Harvard Catalyst educational opportunities. Please contact icctr-education@childrens.harvard.edu for the biostatistics educational course listing.

Educational program offerings

Course Title Scheduling Frequency
How to Work with a Biostatistician Annual

Design Series:

  • Design Matters: Choosing the Right Design for Your Research Question
  • Case Series and Case-Control Studies
  • Cross-Sectional and Cohort Studies
  • Clinical Trials
  • Power and How to Get It:; Sample Size and Detectable Effects
  • Survey Questionnaire Design & Implementation
Annual

Analysis Series

  • Data Visualization and Basic Statistical Testing (A)
  • Linear Regression (A)
  • Logistic Regression (B)
  • Longitudinal Analysis (B)
  • Survival Analysis (B)
Annual (A) or Biennial (B)

Special Topics

  • Economic Evaluation Methods (B)
  • Inter-rater Reliability Studies (B)
  • Qualitative Methods (A)
  • Survey Validation Methodology (A)
  • Introduction to STATA (A)
  • Data management and reporting in SPSS (A)
Annual (A) or Biennial (B)

Careers

Interested in joining our team? Check back often to learn more about our latest job openings.

Frequently asked questions

Who can request help?

Any faculty or trainee at BCH is eligible to request our help.  Clinical, preclinical, or translation research studies are all eligible.

When should I consult with a biostatistician?

As early in the planning stages of your study as possible!

How can I access services?

Use the following flow chart to determine how to access services or fill out an online support request.

Illustration demonstrating how to access BARD services

How does 'funded support' work?

  • "Funded support" is required if the investigator needs more help than a one-hour consult can provide.
  • A BARD Center team member and Investigator determine the number of hours/effort over fixed time.
  • Budget and scope of work are created and approved by ICCTR and Investigator.

Please note:

  • Rates vary according to expertise and experience.
  • Funding is not required if the work is for an extramural grant application that budgets support for the BARD staff member (as co-investigator, or key personnel).
  • Trainees (e.g. residents and fellows) with research scholarship requirements can receive 20 hours of support for a discounted rate if BARD Center Members have availability.

How to do I prepare for a consult with a BARD Center member?

  • Have your study aims/hypotheses finalized.
  • If possible, explore funding resources in case you require additional support beyond the consult.
  • Consider whether the degree of collaboration you require with the BARD Center member may entail authorship on the resulting academic product.

How soon after I submit a request can I expect a response?

Someone from the BARD Center will contact you within 10 business days to discuss your request.

Team

Leadership

Edie Weller, PhD

Edie Weller, PhD

Director of ICCTR Biostatistics and Research Design Center Associate Professor of Pediatrics, Harvard Medical School
Michael Monuteaux, ScD

Michael Monuteaux, ScD

Associate Director of ICCTR Biostatistics and Research Design Center, Senior Epidemiologist and Biostatistician Associate Professor of Pediatrics, Harvard Medical School

Faculty

Henry Feldman, PhD

Henry Feldman, PhD

Principal Biostatistician, Institutional Centers for Clinical and Translational Research (ICCTR) Associate Professor of Pediatrics, Harvard Medical School
Kosuke Kawai, ScD

Kosuke Kawai, ScD

Senior Biostatistician and Epidemiologist, Biostatistics and Research Design (BARD) Assistant Professor of Otolaryngology, Harvard Medical School
Enju Liu, PhD

Enju Liu

Senior Biostatistician Assistant Professor, Harvard Medical School
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Mihail Samnaliev, PhD

Health Economist Assistant Professor, Harvard Medical School
 Georgios Sideridis, PhD

Georgios Sideridis, PhD

Senior Survey Methodologist Assistant Professor of Pediatrics, Harvard Medical School
Caterina Stamoulis, PhD

Caterina Stamoulis, PhD

Principal Investigator, Stamoulis Laboratory; Senior Biostatistician, Institutional Centers for Clinical and Translational Research (ICCTR) Assistant Professor of Pediatrics, Harvard Medical School
David N. Williams, PhD

David N. Williams, PhD

Senior Biostatistician, Orthopedic Surgery Instructor of Pediatrics, Harvard Medical School

Masters

Laura Berbert, MS

Laura Berbert, MS

Biostatitician II, Institutional Centers for Clinical and Translational Research (ICCTR)
Peter Forbes, RT

Peter Forbes, MA, RT

Senior Biostatistician, Institutional Centers for Clinical and Translational Research (ICCTR)
Kimberly Greco, MPH

Kimberly Greco, MPH

Biostatitician I, Institutional Centers for Clinical and Translational Research (ICCTR)
Paul Lakin, MS

Paul Lakin, MS

Biostatistician I
Shanshan Liu

Shanshan Liu, MS, MPH

Biostatistician II, Institutional Centers for Clinical and Translational Research (ICCTR)
Paul Mitchell, MS

Paul Mitchell, MS

Senior Biostatistician, Biostatistics and Research Design (BARD)
Carter Petty, MA

Carter Petty, MA

Senior Biostatistician, Biostatistics and Research Design (BARD)
Kathryn Williams, MS

Kathryn Williams, MS

Biostatistician IV, Institutional Centers for Clinical and Translational Research (ICCTR)