Translational Neuroscience Center (TNC)

The Translational Neuroscience Center (TNC) was launched by Boston Children’s pioneering physicians and biomedical scientists in Developmental MedicineGenetics and GenomicsNeurobiologyNeurologyNeurosurgery and Psychiatry. The TNC has established new ties between laboratory researchers and clinicians who care for children at the hospital; developed new shared resources for efficient translation of discoveries from bench to bedside; and promoted cross-fertilization of ideas to maximize research value.

The TNC is led by neurologist Mustafa Sahin, MD, PhD, and includes clinical director, Lisa Prock, MD, MPH (Developmental Medicine) and co-directors of the clinical research and regulatory affairs service, Kira Dies, ScM, CGC and Stephanie Brewster, MS, CGC working together with the distinguished TNC Executive Committee.

The Translational Neurosience Center strives to improve the lives of children and adolescents with nervous system disorders through

  • innovative clinical programs
  • outstanding basic science
  • efficient translation of novel ideas into practical tools for diagnosis, treatment and prevention of childhood diseases

Our approach

The goal of the TNC is to improve the lives of children with brain disorders via timely and efficient translation of scientific research through collaboration among Boston Children's Hospital's exceptional investigators and in partnership with the external research community.

Advances in our understanding of the nervous system have created unprecedented opportunities to tackle pediatric diseases that once seemed completely resistant to therapy. Clinical trials for genetic diseases associated with autism spectrum disorder, for muscular dystrophy and for childhood brain tumors are pushing the boundaries of pediatric medicine.

Strengthening the hospital’s existing relationships with academic, government, and corporate collaborators, as well as disease-based foundations, are the TNC's initiatives. By clarifying and enriching Boston Children’s resources available to pursue translational research in the faculty’s core areas of expertise, which include autism spectrum disorders, musculoskeletal disorders, pain/regeneration and neuro-oncology; the TNC can facilitate the development of new interdisciplinary collaborations to improve early diagnosis, accelerate drug discovery and generate additional novel strategies for reducing the burden of pediatric nervous system disorders for patients and families in Boston, as well as across the U.S. and the globe.

Our Mission

  • Accelerate the translation of research discoveries into new cures for pediatric nervous system disorders.
  • Develop effective new strategies for disease prevention and treatment through collaborations among Children's Hospital's world-renowned basic scientists in partnership with the external drug discovery community.
  • Train future leaders about critical components of pediatric translational neuroscience.
  • Share new models of interdisciplinary translational medicine in pediatric neuroscience with local, national and international collaborators.