The Manton Center has a strong commitment to train a new generation of investigators. The Manton Center continues to build on the reputable training programs which have been established at Boston Children's Hospital through Harvard Medical School for over a century and offers an unparalleled education to our nation's most promising medical students, residents and postdoctoral fellows who want to deepen their knowledge of rare diseases. Having these bright young scientists involved, in turn, brings original insights to orphan disease research, benefiting children and advancing the goals of The Manton Center.

The purpose of The Manton Center's Fellowship Program is to identify, and support the training of, the very best clinical and research Fellows to prepare them for a career treating and researching orphan diseases and their underlying biology. It is anticipated that the successful Fellows will graduate to independent junior faculty positions at Children's and other top medical centers in the United States and around the world, and that these graduates will form a cadre of highly trained and productive scientists and physician-scientists focused on research, treatment and care of children with orphan diseases.

All proposed training programs and projects must be related to the mission and goals of The Manton Center. In brief, The Manton Center has been established to encourage the development of new and innovative research on rare "orphan" conditions that have hitherto been understudied due to a lack of resources and interest on the part of the scientific and medical community. The Fellowship program will support the salary, and minimal expenses, of doctoral-level Fellows proposing research projects and training programs of relevance to The Manton Center's mission.

Orphan disease research is defined as any basic science, translational, or clinical studies of direct relevance to a disease, syndrome or disorder that affects fewer than 200,000 people in the United States. A fellowship proposal will qualify as relevant to orphan disease research if the training program:

  • Proposes laboratory studies on new approaches or discoveries to study basic science of relevance to an orphan disease or group of orphan diseases
  • Proposes laboratory or clinical studies on new approaches or discoveries to address clinical problems related to an orphan disease or group of orphan diseases
  • Proposes laboratory or clinical studies on new experimental or diagnostic reagents and procedures to diagnose or treat an orphan disease
  • Proposes laboratory studies to develop new biochemical, cellular, or animal models of human orphan disease(s)
  • Proposes laboratory or clinical studies to adapt approaches already in place in other disciplines to address orphan disease(s)