Post Doc Positions

Post-doctoral Training Fellowship in Bioinformatics

The Laboratories of Dr. Judith Steen, Associate Professor of Neurology, and Dr. Hanno Steen, Associate Professor of Pathology, are joint multidisciplinary laboratories working to understand neuroregeneration and neurodegenerative disease using systems biology approaches. The laboratory develops novel qualitative and quantitative methodologies in mass spectrometry and at the interface of proteomics and transcriptomics with emphasis on computational proteomics approaches.

These novel qualitative and quantitative methods and bioinformatics tools developed in our group are being applied to understand the biology of regeneration and neurodegeneration in mouse models, stem cells and human tissues. The research is aimed to identify biomarkers of the neurodegenerative process and to find molecular targets for therapeutics. Further functional studies using biochemical, molecular and cell biology approaches are used to verify and understand the role of biomarkers and targets in the context of injury and disease. The goal of our research is to use molecular information provided by our quantitative proteomics measurements and transcriptomics information to ameliorate neurodegeneration and promote regeneration.

We are looking for highly motivated individuals with experience in bioinformatics/computational biology and quantitative proteomics to fill a bioinformatics fellow position. Our group is integrated in the vibrant, stimulating and multidisciplinary research environment of the F.M. Kirby Neurobiology Center at Boston Children’s Hospital and Harvard Medical School with affiliation with Harvard University. The post-doctoral fellow will be involved in method development in transcriptomics and proteomics and the integration of both and work closely with lab-based post-doctoral fellows in the group.

If you are interested in joining our multidisciplinary, stimulating and engaging lab please send an e-mail with your CV and 3 references to Dr. Judith Steen (Judith.steen@childrens.harvard.edu) and/or Dr. Hanno Steen (Hanno.steen@childrens.harvard.edu).

 

Post-doctoral Training Fellowship in Neurobiology or Quantitative Mass Spectrometry

The Laboratories of Dr. Judith Steen, Associate Professor of Neurology, and Dr. Hanno Steen, Associate Professor of Pathology, are joint multidisciplinary laboratories working to understand neuroregeneration and neurodegenerative disease using systems biology approaches. The laboratory develops novel qualitative and quantitative methodologies in mass spectrometry and at the interface of proteomics and transcriptomics.

These novel qualitative and quantitative methods and bioinformatics tools developed in our group are being applied to understand the biology of regeneration and neurodegeneration in mouse models, stem cells and human tissues. The research is aimed to identify biomarkers of the neurodegenerative process and to find molecular targets for therapeutics. Further functional studies using biochemical, molecular and cell biology approaches are used to verify and understand the role of biomarkers and targets in the context of injury and disease. The goal of our research is to use molecular information provided by our quantitative proteomics measurements and transcriptomics information to ameliorate neurodegeneration and promote regeneration.

We are looking for highly motivated individuals with a Ph.D. in biochemistry or neurobiology with a strong background in quantitative mass spectrometry, molecular biology, or developmental biology. A strong interest in neurobiology and neurodegenerative disease is desired. Our group is integrated in the vibrant, stimulating and multidisciplinary research environment of the F.M. Kirby Neurobiology Center at Boston Children’s Hospital and Harvard Medical School with affiliation with Harvard University. The post-doctoral fellow will be involved in method development in transcriptomics and proteomics and the integration of both and work closely with other lab-based post-doctoral fellows and bioinformatics fellows in the group.

If you are interested in joining our multidisciplinary, stimulating and engaging lab please send an e-mail with your CV and 3 references to Dr. Judith Steen (Judith.steen@childrens.harvard.edu) and/or Dr. Hanno Steen (Hanno.steen@childrens.harvard.edu).

 

Postdoctoral Fellow Position (Stem Cells, Neuropsychiatric Disorders, Imaging, Phenotypic Screening)

A unique postdoctoral position is available for joint mentorship by Dr. Mustafa Sahin and Dr. Joseph Gonzalez-Heydrich, to work at Boston Children's Hospital as part of the Harvard Medical School community. We are seeking a highly motivated, independent, and well-organized scientist who has experience with iPSC-derived neurons to drive an innovative research project focused on modeling neuropsychiatric disorders in culture.

This position is unique because it offers the opportunity to be mentored by two leading neurologists in the field. Dr. Sahin's lab is a leader in the study of neurodevelopmental disorders, especially TSC, and has grown to include expertise in iPSC-modeling of early onset epilepsy and intellectual disability while Dr. Gonzalez-Heydrich is a leading psychiatrist who sees patients with early onset psychosis and has identified novel potentially disease-causing mutations. The selected candidate will drive an innovative and promising project using patient-specific iPSC-derived neurons. The lab uses state-of-the-art high content imaging, multi-electrode array platforms, and targeted RNA sequencing, along with traditional biochemistry and molecular biology techniques to answer important questions relevant to the causes of neurodevelopmental disorders. Training on these state-of-the-art platforms will be provided, as needed. Strong oral and written communication skills will be essential for success in this position.

Postdoctoral fellow. PhD in Neuroscience, Cell Biology, or related field with experience in iPSC cell culture and neuronal differentiation. Experience with neuropsychiatric disorders or high content imaging is a plus. Candidates must be self-motivated, capable of working independently, and be scientifically curious.

To apply, please submit CV and 3 references to Elizabeth.Buttermore@childrens.harvard.edu