Toru Nakazawa (toru.nakazawa@childrens.harvard.edu)

Education
1995 M.D., Tohoku University, School of Medicine, Sendai, Japan
2002 Ph.D., Tohoku University, School of Medicine, Sendai, Japan

Professional Experience
1995-1996 Clinical Resident, Tohoku University Hospital, Sendai, Japan
1996-1998 Clinical Fellow, Yamagata City Hospital, Yamagata, Japan
1998-2000 Research Fellow, Department of Molecular Genetics, National Institute of Longevity and Science (NILS), Aichi, Japan
2001-2002 Visiting Research Investigator: Department of Molecular Genetics, NILS, Aichi, Japan
2001- Diplomate of Ophthalmology: The Japanese Ophthalmological Society
2003- Post-doctoral Research Fellow, Massachuesetts Eye and Ear Infirmary, Harvard Medical School.
2005- Post-doctoral Research Fellow, Children's Hospital, Harvard Medical School.

Professional Organizations
1995- The Japanese Ophthalmological Society
1999- Association for Research in Vision and Ophthalmology
2001- The Japanese Ophthalmologists Association
2001- Japanese Neuroscience Society

Publications (clinical reports)

• Nakazawa T, Sato Y, Omura M and Yuda F. Primary malignant lymphoma in the central nerve system associated with ocular symptom. Yamagata Saiseikan Medical Journal, 22(1), 81-85, 1997
• Nakazawa T, Abe T, Hasegawa T and Tamai M. Optic disc edema associated with spinocerebellar degeneration. Ophthalmologica, 212, 281-283, 1998.
• Nakazawa T, Sato Y, Omura M, Ishizawa K and Yuda F. Primary malignant lymphoma in nasal cavity associated with ocular symptoms. Yamagata Saiseikan Medical Journal, 23(1), 53-60, 1998.
• Nakazawa T, Omura M and Sugita R. A case of herpes zoster ophthalmicus with total ophthalmoplegia. Jpn J Clin Ophthalmol, 52(13), 1933-1937, 1998.
• Nakazawa T, Abe T, Omura M. Varicella zoster-associated optic neuropathy with choroidal involvement. Neuro-Ophthalmology, 21(1), 39-45, 1999.
• Nakazawa T, Abe T, Sato Y, Yuda, Omura M and Tamai M. Magnetic Resonance Imaging of a non-pigmented adenoma of the ciliary epithelium. Acta Ophthalmologica Scandinavia, 78(4), 470-473, 2000.
• Nakazawa T, Yamaguchi K, Shimura M, Yoshida M, Yoshioka Y and Tamai M. Clinical feature of unilateral acute idiopathic maculopathy. Jpn J Ophthalmol, 47(4), 385-391, 2003.
• Shimura M, Yasuda K, Nakazawa T, Kano T, Ohta S, Tamai M. Quantifying alterations of macular thickness before and after panretinal photocoagulation in patients with severe diabetic retinopathy and good vision. Ophthalmology, 110(12), 2386-2394, 2003.
• Nakazawa T, Yamaguchi K, Nakagawa Y, Suzuki K, Takahashi H, Tamai M. Two cases of orbital myositis with monoclonal gammopathy of undetermined significance. Nippon Ganka Gakkai Zasshi. 108(2):110-7, 2004.
• Shimura M, Yasuda K, Nakazawa T, Ota S, Tamai M. Effective treatment of diffuse diabetic macular edema by temporal grid pattern photocoagulation. Ophthalmic Surg Lasers Imaging. 2004 Jul-Aug;35(4):270-80.
• Shimura M, Yasuda K, Nakazawa T, Tamai M. Visual Dysfunction after Panretinal Photocoagulation in Patients with Severe Diabetic Retinopathy and Good Vision. Am J Ophthalmol, in press

Publications (research reports)

• Nakazawa T, Nakano I, Furuyama T, Morii H, Tamai M and Mori N. The SCG10-related gene family in the developing rat retina: Persistent expression of SCLIP and stathmin in mature ganglion cell layer. Brain Res, 14,861(2), 399-407, 2000.
• Furuyama T, Nakazawa T, Nakano I and Mori N. Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse daf-16 homologues. Biochem J, 349(2), 629-634, 2000.
• Nakazawa T, Nakano I, Sato M, Nakamura T, Tamai M and Mori N. Comparative expression profiles of Trk receptors and Shc-related phosphotyrosine adapters during retinal development: Potential roles of N-Shc/ShcC in BDNF signal transduction and modulation. J Neurosci. Res. 68(6), 668-680, 2002.
• Nakazawa T, Tomita H, Yamaguchi K, Sato Y, Shimura M, Kuwahara S and Tamai M. Neuroprotective effect of nipradilol on axotomized rat retinal ganglion cells. Curr Eye Res. 2002; 24:114-122.
• Nakazawa T, Tamai M, Mori N. Brain-derived neurotrophic factor prevents axotomized retinal ganglion cell death through MAPK and PI3K signaling pathways. Invest Ophthalmol Vis Sci. 2002; 43: 3319-3326.
• Akiyama H, Nakazawa T, Shimura M, Tomita H and Tamai M. Presence of Mitogen-Activated Protein Kinase in Retinal Muller Cells and its Neuroprotective Effect against Ischemia-reperfusion Injury Neuroreport. 2002; 13: 2103-7.
• Tomita H, Nakazawa T, Sugano E and Tamai M. Nipradilol inhibits apoptosis by preventing the activation of caspase-3 via S-nitrosylation and the cGMP-dependent pathway. Eur J Pharmacol. 2002 452(3):263.
• Yamaguchi K, Tomita H, Sugano E, Nakazawa T, Tamai M. Mitogen-activated protein kinase inhibitor, PD98059, inhibits rat retinal pigment epithelial cell replication by cell cycle arrest.
  Jpn J Ophthalmol. 2002;46(6):634-9.
• Yasuda K, Shimura M, Nakazawa T, Sato H, Tomita H, Sugano E, Tamai M. Expression and functional properties of unique inward rectifier K+ channel Kir7.1 in the porcine iris and retinal pigment epithelium. Curr Eye Res. 2003 Nov;27(5):279-87.
• Nakazawa T, Shimura M, Tomita H, Akiyama H, Yuki Y, Hideyo K and Tamai M. Intrinsic Activation of PI3K/ Akt Signaling pathway and its Neuroprotective Effect against Retinal Injury. Curr Eye Res. 2003 Jan;26(1):55-63.
• Fuse N, Takahashi K, Akiyama H, Nakazawa T, Seimiya M, Kuwahara S, Tamai M. Molecular genetic analysis of optineurin gene for primary open-angle and normal tension glaucoma in the Japanese population. J Glaucoma. 2004 Aug;13(4):299-303.
• Sato H, Tomita H, Nakazawa T, Wakana S, Tamai M. Deleted in Polyposis 1-like 1 Gene (Dp1l1): A Novel Gene Richly Expressed in Retinal Ganglion Cells. Invest Ophthalmol Vis Sci. 2005 Mar;46(3):791-6.
• Nakazawa T, Endo S, Shimura M, Kondo M, Ueno S, Tamai M. Retinal G-substrate, Potential Downstream Component of NO/cGMP/PKG Pathway, is Located in Subtype of Amacrine Cells with Protein Phosphatases. Mol Brain Res, 2005, 135(1-2), 58-68.