Dave Goldberg (david.goldberg@childrens.harvard.edu)

Education
2002 M.S., University of Medicine and Dentistry of New Jersey, Newark, NJ
1996 B.A., Brandeis University, Waltham, MA

Publications

Thesis
Goldberg D. (2001) Inosine enhances central nervous system plasticity following injury.

Research papers and reviews

• Chen P*, Goldberg DE*, Kolb B, Lanser M, Benowitz LI. Inosine induces axonal rewiring and improves behavioral outcome after stroke. Proceedings of the National Academy of Sciences of the U.S.A. 99: 9031-9036 (* indicates equal contribution to this work).
• Benowitz LI, Goldberg DE, Irwin N. Inosine stimulates axon growth in vitro and in the adult CNS. In: L. McKerracher, G. Doucet, S. Rossignol, eds. Spinal Cord Trauma: Regeneration Neural Repair and Functional Recovery. Prog. Brain Res. 137: Ch. 28.
• Benowitz LI, Goldberg DE, Irwin N. A purine sensitive mechanism regulates the molecular program for axon growth. Restorative Neurology and Neuroscience 19: 1-9.
• Benowitz LI, Goldberg DE, Madsen JR, Soni D, Irwin N. Inosine stimulates extensive axon collateral growth in the rat corticospinal tract after injury. Proceedings of the National Academy of Sciences of the U.S.A. 96: 13486-13490.
• Madsen JR, MacDonald P, Irwin N, Goldberg DE, Rimm IJ, Stieg PE, Benowitz LI. Tacrolimus (FK-506) improves functional recovery after spinal cord injury in rats. Experimental Neurology 154: 673-683.

Abstracts and Presentations

• Goldberg DE, Chen P, Baker K, Lanser M, Benowitz LI. Rewiring the brain after stroke: Optimizing inosine treatment to maximize functional outcome. Keystone Symposium, Axonal Connections: Molecular Cues for Development and Regeneration, Platform and Poster Presentations, Keystone, CO, 2003.
• Benowitz LI, Goldberg DE, Chen P. Inosine induces axonal rewiring and improves functional outcome after CNS injury. 3rd Asia Pacific Symposium on Neural Regeneration. Perth, Australia, 2002.
• Goldberg DE, Chen P, Kolb B, Lanser B, Benowitz LI. Behavioral recovery after stroke mediated by adaptive rewiring of the adult mammalian CNS following treatment with inosine. Society for Neuroscience, Poster Presentation, Orlando, FL, 2002.
• Shah PJ, Goldberg DE, Aoki C, Benowitz LI. Inosine-enhanced sprouting of intact corticospinal tract (CST) axons into the denervated CST leads to enhanced synapse formation in the adjacent denervated neuropil. Society for Neuroscience, Poster Presentation, San Diego, CA, 2001.
• Chen P, Goldberg DE, Benowitz LI. Inosine promotes synaptic reorganization and functional recovery after cerebral infarction. Congress of Neurological Surgeons, Oral Presentation, San Diego, CA, 2000.
• Madsen JR, Goldberg DE. Characterization of ICP spikes associated with seizures. American Association of Neurological Surgeons, Oral Presentation, San Francisco, CA, 2000.
• Madsen JR, Goldberg DE, Irwin N, Benowitz LI. Stimulation of extensive axon growth in the injured rat corticospinal tract with inosine. Congress of Neurological Surgeons, Oral Presentation, Boston, MA, 1999.
• Madsen JR, Goldberg DE, Riviello J, Magge S. Intracranial pressure measurements during seizures in children. Congress of Neurological Surgeons, Oral Poster, Boston, MA, 1999.
• Madsen JR, Irwin N, Goldberg DE, Benowitz LI. Neuroimmunophilin ligands increase neuronal expression of GAP-43 and improve functional recovery after spinal cord injury in rats. Congress of Neurological Surgeons, Slide Presentation, Seattle, WA, 1998.