Using recent advances in culture technology, scientists aim to engineer cell lines for multiple rare cancers and interrogate them for therapeutic targets.
A study in Nature finds that the microRNA let-7 is key in curbing neuroblastoma, and could provide a targeted, nontoxic alternative to chemotherapy.
A look behind the World Health Organization's updated brain tumor classification scheme, which includes, for the first time, molecular and genetic features.
Reporting in Nature, scientists detail the final cellular events necessary for both sepsis and stemming the bacterial attack that may provoke it.
The Precision Vaccines Program seeks to tailor vaccines to the populations that need to be protected: newborns, the elderly, pregnant women and others.
The chromosome tips known as telomeres can be compromised by many different mutations. Dyskeratosis congenita is just one of the diseases that result.
DNA's tendency to break in certain spots may help brains evolve, but also can lead to disease, find Boston Children's Hospital researchers.
Burmese pythons can go 4 to 6 weeks between meals. Their unusual metabolism may shed light on the intestines' role in controlling blood sugar in diabetes.
Wet macular degeneration and MacTel are thought to stem from retinal oxygen deprivation. A study in Nature Medicine suggests another cause: fuel starvation.
The treatment for kidney stones has remained the same for decades. Lifestyle factors are typically blamed, yet twin studies suggest a genetic component.
Researchers at MIT and Boston Children's want to make beta cell transplants a viable option for diabetes by hiding the cells from the immune system.
A collaborative study in Nature implicates overactive complement C4 genes in schizophrenia, providing new leads for treating the devastating illness.
Jean Connor, PhD, RN, CPNP
Connor, who has her PhD in nursing, directs nursing research at the Boston Children’s Heart Center. Her work translates industry research into actionable lessons and innovations that improve care at the bedside.
Katherine Janeway, MD
“It’s all about the patients,” when asked about the motivations behind her efforts to bring precision medicine to pediatric oncology. But it’s more than that; the drive to combine science and care is in her blood.
Ken Mandl, MD, MPH
Mandl is used to seeing the world through a different lens. In high school, he began clicking photographs and developing them in a darkroom in his basement. Now, he frames subjects through the lens of epidemiology and informatics.
John Brownstein, PhD
Boston Children’s Hospital’s new chief innovation officer is an epidemiologist by training and a founding father of the growing field of digital epidemiology—the use of digital data from a variety of sources to detect and track disease and promote health.
Bruce Zetter, PhD
Though he has had a lifelong passion for science, he once toyed with an acting career. But he stuck with science and pursued a career in academic medicine. Countless patients, students, business partners and mentees have benefitted.
Michael J. Docktor, MD,
Boston Children’s Hospital’s clinical director of Innovation and director of Clinical Mobile Solutions, is also a practicing gastroenterologist, a proud father of two and a passionate mobile-and-digital health trailblazer.
Gena Koufos, RN, MS, MBA, is program manager in Boston Children’s Hospital’s Innovation Acceleration Program. Her role entails designing new programs to support innovation acceleration across the institution
David G. Hunter, MD, PhD, dreamed of a career as a rock star. Instead, he became Boston Children’s Hospital’s ophthalmologist-in-chief and invented the Pediatric Vision Scanner.
Martha Murray, MD has been on a 30-year quest to devise a better way to treat anterior cruciate ligament (ACL) tears.
With all of the recent buzz about precision medicine, it’s no wonder that William Pu, MD is gaining recognition for his innovative application of stem cell science and gene therapy to study Barth syndrome, a type of heart disease that severely weakens heart muscle. Pu’s research was recently recognized by the American Heart Association as one of the top ten cardiovascular disease research advances of 2014.
He’s a big thinker focused on harnessing the hyper-small. Daniel Kohane, MD, PhD, is a leading drug delivery and biomaterials researcher, leveraging nanoparticle technology and other new vehicles to make medications safer and more effective.
Improbable as it sounds, autism researcher Susan Faja, PhD, likens her job to improv. “I really like Tina Fey’s description of her days as an improv comedian,” says Faja, who joined ...
Beggs Laboratory: Current studies are aimed at identification of new nemaline myopathy genes, understanding the basis for the variability observed, and determining how these mutations affect muscle function and lead to weakness.
The Lencer Laboratory is located in the GI Cell and Developmental Biology Laboratories in the GI Division at Boston Children's Hospital.
Sports Medicine Research Laboratory
Led by principal investigator Dr. Martha M. Murray, focuses on sports medicine injuries, including those of the anterior cruciate ligament (ACL), knee meniscus and articular cartilage.
Utilizing rare and common human genetic variation to improve our understanding of red blood cell production and globin gene regulation with application to numerous blood diseases.
The Zon Laboratory focuses on the use of the zebrafish model for research into hematopoiesis and as a screen for oncogenic genes and proteins.
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Largest study to date finds promise in genetic sequencing of pediatric #braintumor: https://t.co/TDpKa57IfR via @harvardgazette
Pediatric brain tumor genomics arrives, as the need for new therapies grows: https://t.co/jCf5Y4vA5l… https://t.co/fPycvWjWh6
Majority of #braintumor have genetic abnormalities that could aid diagnosis/treatment: https://t.co/eIrxMCPh2e via @Forbes
.@ChildCancerCare reports on the largest # of child #braintumors to be genetically profiled in clinical practice: https://t.co/LLsqCbYq1d
Genetic analysis of #braintumor: 56% with abnormalities to help guide diagnosis/treatment: https://t.co/HgOZ4yl5Ab via @Forbes #childcancer
Mobile phone microscopy for #DNA #sequencing at the point of care – via @NatureBiotech: https://t.co/yfcbnpHXSA #telemedine
#Zebrafish break out of biomedical labs to inspire K-12 #STEM students: https://t.co/QbckJskmQg via @eschoolnews
The beat goes on: A wearable soft robot for failing hearts: https://t.co/6JUBi37xtR #biomed #medicaldevice… https://t.co/2Ru6cJzcnG
Soft robot could aid failing hearts by mimicking healthy #cardiacmuscle: https://t.co/9Yh8DQpkz9 https://t.co/bnpFbXumpI
New insights, possible targets for #preventivecardiology: changes in #DNAmethylation: https://t.co/MvYMNyUzfN https://t.co/SmLTFew9uh
A new global #vaccines initiative, to prep for epidemics – via @washingtonpost: https://t.co/xdpZfiPeI2
On Vector: This soft robot hugs hearts to help them beat: https://t.co/JVNeSiG2lx #heart #tech #robots https://t.co/t3P8baDfbm