CLARITY Undiagnosed is an international challenge in which scientific teams can compete to provide answers for five families with undiagnosed conditions.
Thermia is an online fever calculator developed by the HealthMap team at Boston Children’s Hospital to help concerned parents interpret a child’s temperature and understand which steps they should consider taking.
Research on cancer immunotherapy—treatments that spur an immune response against cancer cells—has boomed in recent years. And one of the more recent methods—called chimeric antigen receptor (CAR) T-cell therapy—is now in a clinical trial.
A recent study conducted by Boston Children’s Hospital urologist Carlos Estrada, MD and bioengineer Joshua Mauney, PhD, shows two-layer, biodegradable silk scaffolds to be a promising cell-free, “off-the-shelf” alternative to traditional implants for the reconstruction.
Researchers at Boston Children's have found a noninvasive alternative method to measure children’s intracranial pressure in the ear.
Edda Fiebiger, PhD, has been studying IgE and allergies for years, and has noticed a curious association in several epidemiologic studies: people with high levels of IgE in their blood (as in people with allergies) have a lower risk of certain cancers.
After 14 months of global consultation and four international meetings, The Lancet Commission on Global Surgery published a 32,000- word report today in that provides a strategy for governments, policy makers, non-profits, funding agencies, academic institutions, professional associations, health care providers and local communities to engage in concrete action in low- and middle-income countries.
Preterm infants in neonatal intensive care units, particularly those with catheters and intravenous lines, are at high risk for bloodstream infections that can cause lasting brain injury. A new study may change how people think about these infections, suggesting that inflammation is as important to address as the infection itself.
Some great inventions were on view at the second annual Boston Children’s Hospital Innovators Showcase. Hosted by the hospital’s Innovation Acceleration Program and Technology & Innovation Development Office, the event featured everything from virtual reality goggles with gesture control to biomedical technologies.
It’s long been known that a master clock in the hypothalamus, deep in the center of our brain, governs our bodily functions on a 24-hour cycle.
David Hunter, MD, PhD, chief of Ophthalmology at Boston Children’s Hospital, gets a lot of questions from parents, but the number one question is: “What can my baby see?”
Can sequencing of newborns’ genomes provide useful medical information beyond what current newborn screening already provides? What results are appropriate to report back to parents? What are the potential risks and harms? How should DNA sequencing information be integrated into patient care?
Children with Rett syndrome display distinctive hand movements or stereotypies, including hand wringing, clasping and other repetitive hand movements. With help from a grant from Boston Children’s Hospital’s Innovation Acceleration Program, researchers are transforming these hand movements into an assessment tool.
Much has been written about the successes that result from medical hackathons, in which people from across the health care ecosystem converge to solve challenges. For example, PillPack, which formed out of MIT Hacking Medicine, recently closed an $8.75 million funding round. But is this a realistic snapshot of what happens after a hackathon?
SXSW Interactive has grown to include almost 50 events related to health and medical technologies. This year featured the Impact Pediatric Health pitch competition. More than 150 startup companies applied for the opportunity to pitch to a slate of venture capitalists, executives from four major children’s hospitals and ABC “Shark Tank” investor and entrepreneur Mark Cuban.
Boston Children’s Hospital received nearly $2.2 million from the Massachusetts Life Sciences Center (MLSC) to create a Human Neuron Core. The facility will allow researchers at Boston Children’s and beyond to study neurodevelopmental, psychiatric and neurological disorders directly in living, functioning neurons made from patients with these disorders.
Our genes can mutate at any point in our lives. In rare cases, a mutation randomly occurs in a single cell of an embryo and gets carried forward only in the descendants of that particular cell, leaving its mark in some tissues, but not in others. This pattern of mutation, called somatic mosaicsm, can have complicated consequences down the road.
Life teems with interactions. Proteins bind. Bonds form between atoms, and break. Enzymes cut. Drugs attach to cell receptors. DNA hybridizes. Those interactions make the processes of life work, and capturing them has led to many medical advances.
“This ground-breaking paper shows that with encapsulated, frozen donor stool, fecal transplantation can be used to successfully treat recurring C-diff infection in 90 percent of cases,” says George H. Russell, MD, MS, pediatric gastroenterologist in the Inflammatory Bowel Disease Center at Boston Children’s Hospital and co-author of the Massachusetts General Hospital-sponsored study.
As Epilepsy Awareness month closes out and we embark upon the holiday season, we’re pleased to see an innovation initiated here at Boston Children’s Hospital move toward commercial development.
Evolution is a strange thing: sometimes it favors keeping a mutation in the gene pool, even when a double dose of it is harmful—even fatal. Why? Because a single copy of that mutation is protective in certain situations.
A major theme at Taking on Tomorrow 2014 was the difficulty in making the business case for innovation in pediatrics, since the market size is small relative to the adult market. Muna AbdulRaqqaq Tahlak, MD, CEO of Latifa Hospital in Dubai, was among many who urged innovators to collaborate and aggregate their data to make the most impact.
Helping concerned parents interpret a child’s temperature
An alternative method to measure intracranial pressure
Is inflammation as important to address as the infection itself?
BabySee: Mobile app lets you see through an infant’s eyes
SXSW Interactive 2015
Can rare disease genes be protective?
Gena Koufos, RN, MS, MBA, is program manager in Boston Children’s Hospital’s Innovation Acceleration Program. Her role entails designing new programs to support innovation acceleration across the institution
David G. Hunter, MD, PhD, dreamed of a career as a rock star. Instead, he became Boston Children’s Hospital’s ophthalmologist-in-chief and invented the Pediatric Vision Scanner.
Martha Murray, MD has been on a 30-year quest to devise a better way to treat anterior cruciate ligament (ACL) tears.
With all of the recent buzz about precision medicine, it’s no wonder that William Pu, MD is gaining recognition for his innovative application of stem cell science and gene therapy to study Barth syndrome, a type of heart disease that severely weakens heart muscle. Pu’s research was recently recognized by the American Heart Association as one of the top ten cardiovascular disease research advances of 2014.
He’s a big thinker focused on harnessing the hyper-small. Daniel Kohane, MD, PhD, is a leading drug delivery and biomaterials researcher, leveraging nanoparticle technology and other new vehicles to make medications safer and more effective.
Improbable as it sounds, autism researcher Susan Faja, PhD, likens her job to improv. “I really like Tina Fey’s description of her days as an improv comedian,” says Faja, who joined ...
Beggs Laboratory: Current studies are aimed at identification of new nemaline myopathy genes, understanding the basis for the variability observed, and determining how these mutations affect muscle function and lead to weakness.
The Lencer Laboratory is located in the GI Cell and Developmental Biology Laboratories in the GI Division at Boston Children's Hospital.
Sports Medicine Research Laboratory
Led by principal investigator Dr. Martha M. Murray, focuses on sports medicine injuries, including those of the anterior cruciate ligament (ACL), knee meniscus and articular cartilage.
Utilizing rare and common human genetic variation to improve our understanding of red blood cell production and globin gene regulation with application to numerous blood diseases.
The Zon Laboratory focuses on the use of the zebrafish model for research into hematopoiesis and as a screen for oncogenic genes and proteins.
The Boston Globe
Boston Business Journal
Vector - Boston Children's Hospital's science and clinical innovation blog
International health initiative combines clinical expertise with cloud-based social networking technologies to build pediatric medical skills
U.S.News & World Report
By Naomi Fried, PhD
Next-generation bionic limbs will have camera 'vision' to guide their movements: http://t.co/LIofuJDDgv via @ZDnet @gcnichs
A drug that helps protect & regenerate heart muscle cells may help treat congenital heart defects: http://t.co/c374HTzYRF #CHD
Baby genes to be mapped at birth in medical first: http://t.co/CzKLwki2E0 via @newscientist @hvthomson
Study finds first six months of life are best for stimulating child heart growth: http://t.co/8GohLJc0y3 http://t.co/tWZVzJUT7G
Patients have 'paints' injected into their blood to illuminate brain tumors: http://t.co/hAt1KkkiKD via @OPBnews http://t.co/aEWjC4PJkx
DNA testing offers insight into newborn health & survival: http://t.co/qmBb259j7b via @usnews @leonardkl http://t.co/lcjbuRxtMF
Bacteria or virus? Quick blood test can spare unnecessary antibiotic use: http://t.co/uIJfPGPi9n via @novapbs
FDA maps out its stance on #wearables: http://t.co/ygnGqrUChl via @business @satariano #AppleWatch
Don't miss if you're in Boston: Second annual Innovators' Showcase Apr 15, 2-4: http://t.co/24HAeAeUns
On April 15 from 2-4, sample inventions and technologies from around Boston Children's Hospital: http://t.co/TiT3VQjXUo
Seeking a better future for postdocs: http://t.co/SzREi5KRf7 via @NatureNews @KendallSciWrite
A preview of Boston Children's Innovators' Showcase April 15: http://t.co/6P5wCeIsW9