DNA's tendency to break in certain spots may help brains evolve, but also can lead to disease, find Boston Children's Hospital researchers.
Burmese pythons can go 4 to 6 weeks between meals. Their unusual metabolism may shed light on the intestines' role in controlling blood sugar in diabetes.
Wet macular degeneration and MacTel are thought to stem from retinal oxygen deprivation. A study in Nature Medicine suggests another cause: fuel starvation.
Combining omalizumab (Xolair) with gradually increasing peanut doses allowed most kids with peanut allergy to eat 8 to 10 peanuts, and later up to 20.
The treatment for kidney stones has remained the same for decades. Lifestyle factors are typically blamed, yet twin studies suggest a genetic component.
Researchers at MIT and Boston Children's want to make beta cell transplants a viable option for diabetes by hiding the cells from the immune system.
Targeting SOCS3 could avoid the side effects of blocking VEGF completely, offering a better way to curb pathologic vessel growth, retinopathy and blindness.
Researchers at Boston Children's Hospital are using models of oral cancers to understand how to stop tumors from spreading.
Researchers have, for the first time, watched a cancer spread from a single cell and found the key step that turns melanoma-prone cell into a malignant one.
A collaborative study in Nature implicates overactive complement C4 genes in schizophrenia, providing new leads for treating the devastating illness.
A team led by Daniel Kohane, MD, PhD, is working on two methods of laser-triggered drug delivery that could give patients durable local pain relief.
Failing to measure drug levels in target tissues is undercutting translational research, says a preclinical research director at Boston Children's Hospital.
Early MRI imaging of children at risk for dyslexia could allow for much earlier, more effective intervention, says neuroscientist Nadine Gaab, PhD.
Deep DNA sequencing in brain tissue finds single-letter and non-inherited mutations in autism spectrum disorder that would not be detected in blood tests.
Vijay Sankaran, MD, received Boston Children's Rising Star Award for his work on red blood cell disorders and is hailed as a leading young scientist.
Medtronic, a leader in diabetes management devices for patients, partners with IBM Watson Health to tap its data aggregation and predictive powers.
Health-care innovators should take a cue from companies like Uber and Kodak, the former U.S. chief technology officer says.
Rothblatt's journey from satellites to organ farms, to founding United Therapeutics to create a cure for her daughter, to the "mindclone" robot BINA 48.
Read about AIR, the low-cost ventilation add-on device that won the Innovation Tank at the Pediatric Innovation Summit.
Author and physician Siddhartha Mukherjee talks about the future of cancer at the 2015 Boston Children's Global Pediatric Innovation Summit.
A partnership between Boston Children's and Fractured FX is creating ultra-realistic mannequins for surgeons to practice on.
An engineering/3D printing service at Boston Children's Hospital takes an 'idea on napkin' to physical prototype within weeks.
In longstanding type 1 diabetes, the hormone IGFBP3 destroys intestinal stem cells, but a preclinical drug could deflect this attack.
2015 MacArthur Fellow Beth Stevens has shown that glial cells are key actors in the brain, changing how disorders like autism and Alzheimer’s are viewed.
Care coordination is a major pain point for kids with complex medical conditions. Boston Children's Ken Mandl and Zak Kohane envisioned a tech solution, and created ACT.md together with Clay Christensen and serial entrepreneur Ted Quinn to help tackle this issue.
Boston Children's Hospital The CLARITY Undiagnosed Challenge is heating up. 22 biomedical teams have until 9/21 to interpret DNA sequences from five undiagnosed families, all of them desperate for answers.
Disease-modifying autism treatments, preventing blinding eye diseases and genetic sickle-cell therapies: Three examples of NIH tax dollars at work.
Boosting migration of donor stem cells could make cord blood transplant more viable for cancer and blood disorders, helping patients find a match.
Magnetized robots, guided by the magnetic field of an MRI scanner, could swim through body fluids to drive needles, puncture tissues or deliver drugs.
Telomeres tip our chromosomes and keep them from degrading. A new study finds shortened telomeres in families with autism--now the question is why.
Deaf mice receiving gene therapy to provide a working TMC1 gene began to hear for the first time.
At the Boston Children’s Hospital Cardiovascular Research Center, researchers were able to effectively reverse the phenotype for cardiomyopathy by intervening early in the genetic coding process for the disease.
Computational epidemiologist John Brownstein talks about how "digital phenotypes" can open new windows into people's health.
Tests for detecting Ebola in the blood can take anywhere from 12 hours to four days to yield results. But a recent study published in The Lancet reveals a new test can accurately determine results in mere minutes.
A mouse study suggests that omega-3 fatty acids, like those found in fish oil, may reduce inflammation in sickle cell disease.
Non-narcotic treatments for chronic pain that work well in people, not just mice, are sorely needed. Drawing from human pain genetics, an international team demonstrates a way to break the cycle of pain hypersensitivity without the development of addiction, tolerance or side effects.
Observing mating behavior in male fruit flies is an easy way to observe motivation. Moreover, the brain circuitry behind fly mating has already been characterized, thanks to the creature’s very small brain.
According to research by Denisa Wagner, PhD, of Boston Children’s Hospital’s Program in Cellular and Molecular Medicine, a poorly understood feature of our immune system’s neutrophils may be one more ingredient in the storm.
While traditional global health programs have focused on curbing infectious disease, low-resource settings like Dhaka are also coming to be seen as “living laboratories” for investigating how adversity affects children’s brain development.
Ten mothers of children with neuromuscular disorders were interviewed about their diagnostic odyssey. The results highlight the distress that can be caused by even minor medical procedures and the benefits to the family of obtaining a diagnosis.
The care and feeding of more than 250,000 zebrafish just got better, thanks to a $4 million grant from the Massachusetts Life Sciences Center to upgrade Boston Children’s Hospital’s Karp Aquatics Facility. Aside from the fish, patients with cancer, blood diseases and more stand to benefit.
Research on cancer immunotherapy—treatments that spur an immune response against cancer cells—has boomed in recent years. And one of the more recent methods—called chimeric antigen receptor (CAR) T-cell therapy—is now in a clinical trial.
Edda Fiebiger, PhD, has been studying IgE and allergies for years, and has noticed a curious association in several epidemiologic studies: people with high levels of IgE in their blood (as in people with allergies) have a lower risk of certain cancers.
Some great inventions were on view at the second annual Boston Children’s Hospital Innovators Showcase. Hosted by the hospital’s Innovation & Digital Health Accelerator and Technology & Innovation Development Office, the event featured everything from virtual reality goggles with gesture control to biomedical technologies.
Can sequencing of newborns’ genomes provide useful medical information beyond what current newborn screening already provides? What results are appropriate to report back to parents? What are the potential risks and harms? How should DNA sequencing information be integrated into patient care?
Children with Rett syndrome display distinctive hand movements or stereotypies, including hand wringing, clasping and other repetitive hand movements. With help from a grant from Boston Children’s Hospital’s Innovation Acceleration Program, researchers are transforming these hand movements into an assessment tool.
Boston Children’s Hospital received nearly $2.2 million from the Massachusetts Life Sciences Center (MLSC) to create a Human Neuron Core. The facility will allow researchers at Boston Children’s and beyond to study neurodevelopmental, psychiatric and neurological disorders directly in living, functioning neurons made from patients with these disorders.
Our genes can mutate at any point in our lives. In rare cases, a mutation randomly occurs in a single cell of an embryo and gets carried forward only in the descendants of that particular cell, leaving its mark in some tissues, but not in others. This pattern of mutation, called somatic mosaicsm, can have complicated consequences down the road.
Life teems with interactions. Proteins bind. Bonds form between atoms, and break. Enzymes cut. Drugs attach to cell receptors. DNA hybridizes. Those interactions make the processes of life work, and capturing them has led to many medical advances.
“This ground-breaking paper shows that with encapsulated, frozen donor stool, fecal transplantation can be used to successfully treat recurring C-diff infection in 90 percent of cases,” says George H. Russell, MD, MS, pediatric gastroenterologist in the Inflammatory Bowel Disease Center at Boston Children’s Hospital and co-author of the Massachusetts General Hospital-sponsored study.
As Epilepsy Awareness month closes out and we embark upon the holiday season, we’re pleased to see an innovation initiated here at Boston Children’s Hospital move toward commercial development.
Evolution is a strange thing: sometimes it favors keeping a mutation in the gene pool, even when a double dose of it is harmful—even fatal. Why? Because a single copy of that mutation is protective in certain situations.
Can rare disease genes be protective?
Jean Connor, PhD, RN, CPNP
Connor, who has her PhD in nursing, directs nursing research at the Boston Children’s Heart Center. Her work translates industry research into actionable lessons and innovations that improve care at the bedside.
Katherine Janeway, MD
“It’s all about the patients,” when asked about the motivations behind her efforts to bring precision medicine to pediatric oncology. But it’s more than that; the drive to combine science and care is in her blood.
Ken Mandl, MD, MPH
Mandl is used to seeing the world through a different lens. In high school, he began clicking photographs and developing them in a darkroom in his basement. Now, he frames subjects through the lens of epidemiology and informatics.
John Brownstein, PhD
Boston Children’s Hospital’s new chief innovation officer is an epidemiologist by training and a founding father of the growing field of digital epidemiology—the use of digital data from a variety of sources to detect and track disease and promote health.
Bruce Zetter, PhD
Though he has had a lifelong passion for science, he once toyed with an acting career. But he stuck with science and pursued a career in academic medicine. Countless patients, students, business partners and mentees have benefitted.
Michael J. Docktor, MD,
Boston Children’s Hospital’s clinical director of Innovation and director of Clinical Mobile Solutions, is also a practicing gastroenterologist, a proud father of two and a passionate mobile-and-digital health trailblazer.
Gena Koufos, RN, MS, MBA, is program manager in Boston Children’s Hospital’s Innovation Acceleration Program. Her role entails designing new programs to support innovation acceleration across the institution
David G. Hunter, MD, PhD, dreamed of a career as a rock star. Instead, he became Boston Children’s Hospital’s ophthalmologist-in-chief and invented the Pediatric Vision Scanner.
Martha Murray, MD has been on a 30-year quest to devise a better way to treat anterior cruciate ligament (ACL) tears.
With all of the recent buzz about precision medicine, it’s no wonder that William Pu, MD is gaining recognition for his innovative application of stem cell science and gene therapy to study Barth syndrome, a type of heart disease that severely weakens heart muscle. Pu’s research was recently recognized by the American Heart Association as one of the top ten cardiovascular disease research advances of 2014.
He’s a big thinker focused on harnessing the hyper-small. Daniel Kohane, MD, PhD, is a leading drug delivery and biomaterials researcher, leveraging nanoparticle technology and other new vehicles to make medications safer and more effective.
Improbable as it sounds, autism researcher Susan Faja, PhD, likens her job to improv. “I really like Tina Fey’s description of her days as an improv comedian,” says Faja, who joined ...
Beggs Laboratory: Current studies are aimed at identification of new nemaline myopathy genes, understanding the basis for the variability observed, and determining how these mutations affect muscle function and lead to weakness.
The Lencer Laboratory is located in the GI Cell and Developmental Biology Laboratories in the GI Division at Boston Children's Hospital.
Sports Medicine Research Laboratory
Led by principal investigator Dr. Martha M. Murray, focuses on sports medicine injuries, including those of the anterior cruciate ligament (ACL), knee meniscus and articular cartilage.
Utilizing rare and common human genetic variation to improve our understanding of red blood cell production and globin gene regulation with application to numerous blood diseases.
The Zon Laboratory focuses on the use of the zebrafish model for research into hematopoiesis and as a screen for oncogenic genes and proteins.
The Boston Globe
National Cancer Institute
Wall Street Journal
The New York Times
Boston Business Journal
Worcester Business Journal
New Boston Post
New York Times
Front Line Genomics Magazine
MIT Technology Review
PBS News Hour
Congratulations @johnbrownstein for being named to @MedTechBoston's 40 Under 40 Healthcare Innovators! https://t.co/VlAsaeqeUU
New #medicalsimulation space brings Hollywood to the #LongwoodMedical area: https://t.co/7IYJTbIEKY https://t.co/ccuyfWCWJb
Medicine meets theater: lifelike 'locations' & special effects enhance practice: https://t.co/HYnZLtzzuK #pediatrics https://t.co/l1aeFwpEcN
RT @ChildrensTIDO: #Pharma & startups weigh in on the potential of #microbiome therapies at @MassBio 2016: https://t.co/Ur7CdDOKIa
New pediatric #simulation center opens for clinicians, families, inventors: https://t.co/qYB2PddUgg #SIMPeds https://t.co/WUIJprRSFM
Poop transplants were the start; microbiome therapeutics is a thriving new space: https://t.co/dDhhnGofw0 https://t.co/PVJndJZeBK
The microbiome as a therapeutic target: #Lifesciences panel discusses the hope and the hype: https://t.co/sTW2cgXBxt https://t.co/xlp9LLoaVM
#Pharma & startups weigh in on the potential of #microbiome therapies at @MassBio 2016: https://t.co/4iwRiPT7ws cc @bernatolle
Microbiome therapeutics: 6 takeaways from @synlogic @VedantaBio @EveloBio & Alan Moss @harvardmed: https://t.co/f6ASB5dbZj
RT @PASMeeting: @BostonChildrens surgeons planned for a craniofacial surgery with 3D printing. Visit booth 621 to see models. https://t.co/…
RT @PASMeeting: @BostonChildrens launches KidsMD skill for Amazon Echo to answer questions about child health. Try it at booth 621. https:/…
RT @PASMeeting: What is a fever? @BostonChildrens will find the answer with Feverprints ResearchKit App. Check it out at booth 621: https:/…