The Translational Research Program (TRP) is primarily interested in supporting new, innovative cores that promote the mission of building a local or networked infrastructure for conducting preclinical or translational research. Established cores seeking bridge or supplemental funding, or cores that primarily support basic (discovery) research, are not likely to be successful through the TRP mechanism.
The core service plan should include a description of the services to be provided and the background and sig-nificance for the core. The applicant should present a clear description of methods and services to be provided and (if appropriate) discussion of human subjects protection and inclusion, as well as a data safety monitoring plan/board. Cores may contain a non-hypothesis driven research activity, provided that the research is de-signed to improve core services. The applicant should clearly present the facilities, resources, and professional skills that the core will provide to investigators. A plan for funding of the core beyond the two year period sup-ported by the TRP is essential.
The core proposal should also include a discussion of the decision-making processes for core activities includ-ing prioritization of service and allocation of resources, the establishment of any oversight committees, and the planned mechanisms for promoting communication and collaboration among users of the core.
To aid in the review, it is suggested that a table, to show the anticipated use of the core by each investigator, be included in the application. Justify the core by discussing ways in which the centralized services improve quality control, produce an economy of effort, and/or save overall costs for investigators (benefits of core).