Dr. Warman and his colleagues study matrix biology and aim to understand the role of the extracellular matrix in determining the structure and function of tissues and organs. They approach this by focusing upon human diseases primarily affecting the skeletal and vascular systems. Their research employs several strategies. In order to determine the roles of structural extracellular matrix proteins in cartilage and bone, they have used the candidate gene approach to identify mutations within these proteins as the cause of specific forms of skeletal dysplasia and osteoarthritis. With both the clinical phenotypes and gene mutations in hand, they are now performing focused biochemical, protein, histologic, and electron microscopic analyses upon the affected tissues in order to gain novel insights into each protein's precise role.
Another aspect of Dr. Warman's work involves the study of extracellular matrices as mediators of differentiation and development, through their ability to sequester and present regulatory molecules, provide sites for cell anchorage, and signals for determination of cell polarity. He and his colleagues are exploring this aspect of matrix biology through the study of specific human disorders in which the regulated growth and maintenance of matrix appears disturbed. Using positional and functional cloning strategies, they intend to identify and characterize the responsible genes. They expect this will yield significant insights into common problems of matrix homeostasis such as osteoporosis and tissue vascularization.
About Matthew Warman
Dr. Warman studied material science at Brown University and medicine at Cornell University Medical College. He completed an internship and residency in pediatrics at the Children's Hospital in Washington D.C., and a fellowship in medical genetics at the Children's Hospital in Boston. Following completion of his fellowship in 1989, he remained on staff as a clinical geneticist and also joined the laboratory of Dr. Bjorn Olsen at Harvard Medical School as a postdoctoral fellow. He subsequently joined the faculty at Case Western Reserve University School of Medicine. Dr. Warman is board certified in Pediatrics as well as in Clinical, Biochemical, and Molecular Genetics and maintains a strong clinical interest in these disciplines. He in 1994.
Articles on PubMed.org authored or co-authored by Dr. Warman.
Center for the Study of Genetic Skeletal Disorders