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Jay  Wilson, MD

Jay Wilson
Surgery Research
Hospital Title:
Director, Lung Growth Laboratory; Director, Surgical Critical Care; Senior Associate in Surgery
Academic Title:
Associate Professor of Surgery, Harvard Medical School
Research Focus Area:
Fetal and neonatal lung growthCongenital lung growth
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Research Overview

The focus of Jay Wilson's research is to increase lung capacity in children who are born with underdeveloped lungs due to conditions such as congenital diaphragmatic hernia. He pioneered the use of perfluorocarbon--an oxygen-dissolving liquid--to stretch the lungs of premature infants who had difficulty being weaned from ECMO.

Recently, his focus has turned to elucidating the molecular process of fetal and neonatal lung growth, so that these processes might be harnessed to stimulate lung growth in children with congenital disorders.

About Jay Wilson

Jay Wilson received his BS degree from the University of Massachusetts at Amherst, his MS degree from MIT and his MD degree from Albert Einstein College of Medicine. He completed his surgical internship and residency at Brigham and Women's Hospital and his Pediatric Surgical fellowship at Boston Children's Hospital. He is board certified in Surgery, Surgical Critical Care and Pediatric Surgery.


Publications powered by Harvard Catalyst Profiles
  1. High FA, Bhayani P, Wilson JM, Bult CJ, Donahoe PK, Longoni M. De novo frameshift mutation in COUP-TFII (NR2F2) in human congenital diaphragmatic hernia. Am J Med Genet A. 2016 Sep; 170(9):2457-61.
  2. Bairdain S, Betit P, Craig N, Gauvreau K, Rycus P, Wilson JM, Thiagarajan R. Diverse Morbidity and Mortality Among Infants Treated with Venoarterial Extracorporeal Membrane Oxygenation. Cureus. 2015 Apr; 7(4):e263.
  3. Cauley RP, Potanos K, Fullington N, Bairdain S, Sheils CA, Finkelstein JA, Graham DA, Wilson JM. Pulmonary support on day of life 30 is a strong predictor of increased 1 and 5-year morbidity in survivors of congenital diaphragmatic hernia. J Pediatr Surg. 2015 May; 50(5):849-55.
  4. Bairdain S, Khan FA, Fisher J, Zurakowski D, Ariagno K, Cauley RP, Zalieckas J, Wilson JM, Jaksic T, Mehta NM. Nutritional outcomes in survivors of congenital diaphragmatic hernia (CDH)-factors associated with growth at one year. J Pediatr Surg. 2015 Jan; 50(1):74-7.
  5. Longoni M, High FA, Russell MK, Kashani A, Tracy AA, Coletti CM, Hila R, Shamia A, Wells J, Ackerman KG, Wilson JM, Bult CJ, Lee C, Lage K, Pober BR, Donahoe PK. Molecular pathogenesis of congenital diaphragmatic hernia revealed by exome sequencing, developmental data, and bioinformatics. Proc Natl Acad Sci U S A. 2014 Aug 26; 111(34):12450-5.
  6. Dennett KV, Fligor BJ, Tracy S, Wilson JM, Zurakowski D, Chen C. Sensorineural hearing loss in congenital diaphragmatic hernia survivors is associated with postnatal management and not defect size. J Pediatr Surg. 2014 Jun; 49(6):895-9.
  7. Lally KP, Lasky RE, Lally PA, Bagolan P, Davis CF, Frenckner BP, Hirschl RM, Langham MR, Buchmiller TL, Usui N, Tibboel D, Wilson JM. Standardized reporting for congenital diaphragmatic hernia--an international consensus. J Pediatr Surg. 2013 Dec; 48(12):2408-15.
  8. Cauley RP, Stoffan A, Potanos K, Fullington N, Graham DA, Finkelstein JA, Kim HB, Wilson JM. Pulmonary support on day 30 as a predictor of morbidity and mortality in congenital diaphragmatic hernia. J Pediatr Surg. 2013 Jun; 48(6):1183-9.
  9. Kazanci SY, McElhinney DB, Thiagarajan R, Bergersen L, Wilson JM, Marshall AC, Lock JE, Mullen MP. Obstruction of the superior vena cava after neonatal extracorporeal membrane oxygenation: association with chylothorax and outcome of transcatheter treatment. Pediatr Crit Care Med. 2013 Jan; 14(1):37-43.
  10. Ben-Ishay O, Johnson VM, Wilson JM, Buchmiller TL. Congenital diaphragmatic hernia associated with esophageal atresia: incidence, outcomes, and determinants of mortality. J Am Coll Surg. 2013 Jan; 216(1):90-95.e2.
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  12. Ben-Ishay O, Nicksa GA, Wilson JM, Buchmiller TL. Management of giant congenital pulmonary airway malformations requiring pneumonectomy. Ann Thorac Surg. 2012 Oct; 94(4):1073-8.
  13. Stoffan AP, Wilson JM, Jennings RW, Wilkins-Haug LE, Buchmiller TL. Does the ex utero intrapartum treatment to extracorporeal membrane oxygenation procedure change outcomes for high-risk patients with congenital diaphragmatic hernia? J Pediatr Surg. 2012 Jun; 47(6):1053-7.
  14. Yu DC, Pathak B, Vargas SO, Javid PJ, Hisama FM, Wilson JM, Linden BC. Congenital intra-abdominal bilateral juvenile granulosa cell tumors of the testis associated with constitutional loss of material from chromosome 4. Pediatr Dev Pathol. 2011 May-Jun; 14(3):224-7.
  15. Friedman S, Chen C, Chapman JS, Jeruss S, Terrin N, Tighiouart H, Parsons SK, Wilson JM. Neurodevelopmental outcomes of congenital diaphragmatic hernia survivors followed in a multidisciplinary clinic at ages 1 and 3. J Pediatr Surg. 2008 Jun; 43(6):1035-43.
  16. Kunisaki SM, Barnewolt CE, Estroff JA, Nemes LP, Jennings RW, Wilson JM, Fauza DO. Liver position is a prenatal predictive factor of prosthetic repair in congenital diaphragmatic hernia. Fetal Diagn Ther. 2008; 23(4):258-62.
  17. Chen C, Jeruss S, Terrin N, Tighiouart H, Wilson JM, Parsons SK. Impact on family of survivors of congenital diaphragmatic hernia repair: a pilot study. J Pediatr Surg. 2007 Nov; 42(11):1845-52.
  18. Lally KP, Lally PA, Lasky RE, Tibboel D, Jaksic T, Wilson JM, Frenckner B, Van Meurs KP, Bohn DJ, Davis CF, Hirschl RB. Defect size determines survival in infants with congenital diaphragmatic hernia. Pediatrics. 2007 Sep; 120(3):e651-7.
  19. Chen C, Friedman S, Butler S, Jeruss S, Terrin N, Tighiouart H, Ware J, Wilson JM, Parsons SK. Approaches to neurodevelopmental assessment in congenital diaphragmatic hernia survivors. J Pediatr Surg. 2007 Jun; 42(6):1052-6; discussion 1056.
  20. Chen C, Jeruss S, Chapman JS, Terrin N, Tighiouart H, Glassman E, Wilson JM, Parsons SK. Long-term functional impact of congenital diaphragmatic hernia repair on children. J Pediatr Surg. 2007 Apr; 42(4):657-65.
  21. Hayward MJ, Kharasch V, Sheils C, Friedman S, Dunleavy MJ, Utter S, Zurakowski D, Jennings R, Wilson JM. Predicting inadequate long-term lung development in children with congenital diaphragmatic hernia: an analysis of longitudinal changes in ventilation and perfusion. J Pediatr Surg. 2007 Jan; 42(1):112-6.
  22. Kunisaki SM, Barnewolt CE, Estroff JA, Myers LB, Fauza DO, Wilkins-Haug LE, Grable IA, Ringer SA, Benson CB, Nemes LP, Morash D, Buchmiller TL, Wilson JM, Jennings RW. Ex utero intrapartum treatment with extracorporeal membrane oxygenation for severe congenital diaphragmatic hernia. J Pediatr Surg. 2007 Jan; 42(1):98-104; discussion 104-6.
  23. Sakurai MK, Lee S, Arsenault DA, Nose V, Wilson JM, Heymach JV, Puder M. Vascular endothelial growth factor accelerates compensatory lung growth after unilateral pneumonectomy. Am J Physiol Lung Cell Mol Physiol. 2007 Mar; 292(3):L742-7.
  24. Riedlinger WF, Vargas SO, Jennings RW, Estroff JA, Barnewolt CE, Lillehei CW, Wilson JM, Colin AA, Reid LM, Kozakewich HP. Bronchial atresia is common to extralobar sequestration, intralobar sequestration, congenital cystic adenomatoid malformation, and lobar emphysema. Pediatr Dev Pathol. 2006 Sep-Oct; 9(5):361-73.
  25. Kunisaki SM, Fuchs JR, Kaviani A, Oh JT, LaVan DA, Vacanti JP, Wilson JM, Fauza DO. Diaphragmatic repair through fetal tissue engineering: a comparison between mesenchymal amniocyte- and myoblast-based constructs. J Pediatr Surg. 2006 Jan; 41(1):34-9; discussion 34-9.
  26. Pober BR, Lin A, Russell M, Ackerman KG, Chakravorty S, Strauss B, Westgate MN, Wilson J, Donahoe PK, Holmes LB. Infants with Bochdalek diaphragmatic hernia: sibling precurrence and monozygotic twin discordance in a hospital-based malformation surveillance program. Am J Med Genet A. 2005 Oct 1; 138A(2):81-8.
  27. Yang EY, Allmendinger N, Johnson SM, Chen C, Wilson JM, Fishman SJ. Neonatal thoracoscopic repair of congenital diaphragmatic hernia: selection criteria for successful outcome. J Pediatr Surg. 2005 Sep; 40(9):1369-75.
  28. Sakurai MK, Greene AK, Wilson J, Fauza D, Puder M. Pneumonectomy in the mouse: technique and perioperative management. J Invest Surg. 2005 Jul-Aug; 18(4):201-5.
  29. West SD, Wilson JM. Follow up of infants with congenital diaphragmatic hernia. Semin Perinatol. 2005 Apr; 29(2):129-33.
  30. Fuchs JR, Kaviani A, Watson K, Thompson J, Wilson JM, Fauza DO. Intratracheal pulmonary ventilation improves gas exchange during laparoscopy in a pediatric lung injury model. J Pediatr Surg. 2005 Jan; 40(1):22-5.
  31. Chang R, Andreoli S, Ng YS, Truong T, Smith SR, Wilson J, D'Amore PA. VEGF expression is downregulated in nitrofen-induced congenital diaphragmatic hernia. J Pediatr Surg. 2004 Jun; 39(6):825-8; discussion 825-8.
  32. Fuchs JR, Kaviani A, Oh JT, LaVan D, Udagawa T, Jennings RW, Wilson JM, Fauza DO. Diaphragmatic reconstruction with autologous tendon engineered from mesenchymal amniocytes. J Pediatr Surg. 2004 Jun; 39(6):834-8; discussion 834-8.
  33. Chang R, Komura M, Andreoli S, Jennings R, Wilson J, Fauza D. Rapidly polymerizing hydrogel prevents balloon dislodgement in a model of fetal tracheal occlusion. J Pediatr Surg. 2004 Apr; 39(4):557-60.
  34. Chang R, Komura M, Andreoli S, Klingenberg M, Jennings R, Wilson J, Fauza D. Hyperoncotic enhancement of pulmonary growth after fetal tracheal occlusion: a comparison between dextran and albumin. J Pediatr Surg. 2004 Mar; 39(3):324-8; discussion 324-8.
  35. Downard CD, Betit P, Chang RW, Garza JJ, Arnold JH, Wilson JM. Impact of AMICAR on hemorrhagic complications of ECMO: a ten-year review. J Pediatr Surg. 2003 Aug; 38(8):1212-6.
  36. Downard CD, Wilson JM. Current therapy of infants with congenital diaphragmatic hernia. Semin Neonatol. 2003 Jun; 8(3):215-21.
  37. Downard CD, Jaksic T, Garza JJ, Dzakovic A, Nemes L, Jennings RW, Wilson JM. Analysis of an improved survival rate for congenital diaphragmatic hernia. J Pediatr Surg. 2003 May; 38(5):729-32.
  38. Neville HL, Jaksic T, Wilson JM, Lally PA, Hardin WD, Hirschl RB, Lally KP. Bilateral congenital diaphragmatic hernia. J Pediatr Surg. 2003 Mar; 38(3):522-4.
  39. Hirschl RB, Philip WF, Glick L, Greenspan J, Smith K, Thompson A, Wilson J, Adzick NS. A prospective, randomized pilot trial of perfluorocarbon-induced lung growth in newborns with congenital diaphragmatic hernia. J Pediatr Surg. 2003 Mar; 38(3):283-9; discussion 283-9.
  40. Neville HL, Jaksic T, Wilson JM, Lally PA, Hardin WD, Hirschl RB, Langham MR, Lally KP. Fryns syndrome in children with congenital diaphragmatic hernia. J Pediatr Surg. 2002 Dec; 37(12):1685-7.
  41. Dzakovic A, Kaviani A, Jennings RW, Wilson JM, Fauza DO. Positive intrapulmonary oncotic pressure enhances short-term lung growth acceleration after fetal tracheal occlusion. J Pediatr Surg. 2002 Jul; 37(7):1007-10; discussion 1007-10.
  42. Durfee SM, Downard CD, Benson CB, Wilson JM. Postnatal outcome of fetuses with the prenatal diagnosis of gastroschisis. J Ultrasound Med. 2002 Mar; 21(3):269-74.
  43. Islam S, Zaidi AK, Wilson J. Peritoneal infection with multiple species of Candida: a case report. Surg Infect (Larchmt). 2002; 3(1):35-7.
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