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Clifford  Woolf, MB, BCh, PhD

Clifford Woolf
Woolf Laboratory
Research Center:
F.M. Kirby Neurobiology Center
Neurobiology Program
Neurology Research
Hospital Title:
Director, F.M. Kirby Neurobiology Center and Neurobiology Program
Academic Title:
Professor of Neurology and Neurobiology, Harvard Medical School
Research Focus Area:
PainFormation of neural circuitsRegeneration
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Research Overview

Neuronal plasticity, its mechanistic basis, how it contributes to the normal and abnormal functions of the nervous system, and how it can be a target for therapy comprise the major focus of Dr. Woolf’s investigations. Specifically, he studies neural plasticity in relation to pain, regeneration, neurodegenerative disorders and developmental neurobiology.

Dr. Woolf has spearheaded discoveries on how functional synaptic plasticity, structural reorganization of synaptic architecture, injury-induced transcriptional changes, neuro-immune interactions and activity-dependent loss of interneurons all contribute to the pathogenesis and maintenance of pain. He has linked polymorphisms in human genes with the risk of developing pain and has pioneered new ways of phenotyping pain in patients. His work has led to the identification of novel targets for analgesics, and, with Bruce Bean at HMS, he has discovered a way of producing a long-lasting local analgesia. With Lee Rubin at HU, he has converted human embryonic stem cells into pain neurons for disease modeling and testing analgesics and with Josef Penninger used genome-wide screens in Drosophila to identify novel pain genes.

Additionally, Dr. Woolf has explored how axonal injury activates a survival and regeneration program in sensory and motor neurons, and he has identified the transcription factors that act as master regulators of these. This has led to novel genetic approaches to increase regeneration and ameliorate motor neuron disease.

Currently devoted to investigating how the functional, chemical and structural plasticity of neurons contributes to adaptive and maladaptive functions of the mammalian nervous system, the Woolf lab’s major efforts are dedicated to the study of pain, the formation of neural circuits during development, and the failure of regeneration in the adult CNS. Most of this work is focused on primary sensory and spinal cord neurons, which are studied using a multidisciplinary approach that spans mouse and human genetics, molecular and cell biology, bioinformatics, synaptic electrophysiology, neuroanatomy, integrative systems biology and behavior. The lab represents a complex mixture of basic and translational neuroscience and works closely with a wide number of academic groups and the pharmaceutical and biotechnology industry to identify and validate molecular targets for novel analgesics and axonal growth determinants. 

Some of the Group’s major current interests include: 

  • Neuro-immune interactions
  • Post-translational processing and transcriptional control of membrane receptors and ion channels mediating pain hypersensitivity
  • Intracellular signal transduction cascade in neurons
  • Role of transcription factors as master regulators of neuronal function
  • Exploiting stem cell technology to model human neurological disease
  • Mechanisms responsible for cell survival in injured sensory and motor neurons
  • Contributions of intrinsic growth determinants in establishing regenerative capacity
  • Central sensitization, its mechanism and contribution to pain
  • Bioinformatic analyses of  the transcriptome in neurons
  • Role of tetrahydrobiopterin in pain
  • Genotype – phenotype associations in pain
  • Targeting drugs selectively into neurons via large pore channels

About Clifford Woolf

Clifford Woolf, MB, BCh, PhD was appointed Director of the F.M. Kirby Neurobiology Center and the Neurobiology Program at Boston Children's Hospital in February 2010. After training for his MD and PhD at the University of the Witwatersrand in Johannesburg South Africa, Dr. Woolf moved to England in 1978. He worked at University College London for close on 20 years, towards the latter part as a Professor of Neurobiology. In 1997, Dr. Woolf moved to Boston as the first incumbent of the Richard J Kitz Chair of Anesthesia Research at Harvard Medical School and established the Neural Plasticity Research Group, based in the Department of Anesthesia and Critical Care at the Massachusetts General Hospital. Dr Woolf is a faculty member of the Harvard Stem Cell Institute and the Department of Neurobiology at Harvard Medical School.

Honors: 1973   William Cullen Medal, University of the Witwatersrand, Johannesburg, South Africa, for most distinguished B.Sc. graduate in the Faculty of Science; 1977 South African Medical Association Medal for most distinguished Medical graduate; 1987 Distinguished Young Investigator Award, International Association for the Study of Pain; 1991 Bristol-Myers Squibb Pain Research Award; 2001 Spine Society of Europe Medal; 2002 Bonica Medal; 2004 American Society of Anesthesia Award for Excellence in Research; 2009 Wall Medal, Royal College of Anaesthetists. 2010 Bonica Lecture, International Association for the Study of Pain.


Publications powered by Harvard Catalyst Profiles
  1. Vardeh D, Mannion RJ, Woolf CJ. Toward a Mechanism-Based Approach to Pain Diagnosis. J Pain. 2016 Sep; 17(9 Suppl):T50-69.
  2. Perry RB, Rishal I, Doron-Mandel E, Kalinski AL, Medzihradszky KF, Terenzio M, Alber S, Koley S, Lin A, Rozenbaum M, Yudin D, Sahoo PK, Gomes C, Shinder V, Geraisy W, Huebner EA, Woolf CJ, Yaron A, Burlingame AL, Twiss JL, Fainzilber M. Nucleolin-Mediated RNA Localization Regulates Neuron Growth and Cycling Cell Size. Cell Rep. 2016 Aug 9; 16(6):1664-76.
  3. Chiu IM, Pinho-Ribeiro FA, Woolf CJ. Pain and infection: pathogen detection by nociceptors. Pain. 2016 Jun; 157(6):1192-3.
  4. Andrews NA, Latrémolière A, Basbaum AI, Mogil JS, Porreca F, Rice AS, Woolf CJ, Currie GL, Dworkin RH, Eisenach JC, Evans S, Gewandter JS, Gover TD, Handwerker H, Huang W, Iyengar S, Jensen MP, Kennedy JD, Lee N, Levine J, Lidster K, Machin I, McDermott MP, McMahon SB, Price TJ, Ross SE, Scherrer G, Seal RP, Sena ES, Silva E, Stone L, Svensson CI, Turk DC, Whiteside G. Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations. Pain. 2016 Apr; 157(4):901-9.
  5. Kahle KT, Schmouth JF, Lavastre V, Latremoliere A, Zhang J, Andrews N, Omura T, Laganière J, Rochefort D, Hince P, Castonguay G, Gaudet R, Mapplebeck JC, Sotocinal SG, Duan J, Ward C, Khanna AR, Mogil JS, Dion PA, Woolf CJ, Inquimbert P, Rouleau GA. Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition. Sci Signal. 2016 Mar 29; 9(421):ra32.
  6. Neogi T, Guermazi A, Roemer F, Nevitt MC, Scholz J, Arendt-Nielsen L, Woolf C, Niu J, Bradley LA, Quinn E, Law LF. Association of Joint Inflammation With Pain Sensitization in Knee Osteoarthritis: The Multicenter Osteoarthritis Study. Arthritis Rheumatol. 2016 Mar; 68(3):654-61.
  7. Talbot S, Foster SL, Woolf CJ. Neuroimmunity: Physiology and Pathology. Annu Rev Immunol. 2016 May 20; 34:421-47.
  8. Chandran V, Coppola G, Nawabi H, Omura T, Versano R, Huebner EA, Zhang A, Costigan M, Yekkirala A, Barrett L, Blesch A, Michaelevski I, Davis-Turak J, Gao F, Langfelder P, Horvath S, He Z, Benowitz L, Fainzilber M, Tuszynski M, Woolf CJ, Geschwind DH. A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program. Neuron. 2016 Mar 2; 89(5):956-70.
  9. Ghasemlou N, Chiu IM, Julien JP, Woolf CJ. CD11b+Ly6G- myeloid cells mediate mechanical inflammatory pain hypersensitivity. Proc Natl Acad Sci U S A. 2015 Dec 8; 112(49):E6808-17.
  10. Nawabi H, Belin S, Cartoni R, Williams PR, Wang C, Latremolière A, Wang X, Zhu J, Taub DG, Fu X, Yu B, Gu X, Woolf CJ, Liu JS, Gabel CV, Steen JA, He Z. Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms. Neuron. 2015 Nov 18; 88(4):704-19.
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  12. Sakuma M, Gorski G, Sheu SH, Lee S, Barrett LB, Singh B, Omura T, Latremoliere A, Woolf CJ. Lack of motor recovery after prolonged denervation of the neuromuscular junction is not due to regenerative failure. Eur J Neurosci. 2016 Feb; 43(3):451-62.
  13. Nie D, Chen Z, Ebrahimi-Fakhari D, Di Nardo A, Julich K, Robson VK, Cheng YC, Woolf CJ, Heiman M, Sahin M. The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex. J Neurosci. 2015 Jul 29; 35(30):10762-72.
  14. McNeish J, Gardner JP, Wainger BJ, Woolf CJ, Eggan K. From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial. Cell Stem Cell. 2015 Jul 2; 17(1):8-10.
  15. Gewandter JS, Dworkin RH, Turk DC, Farrar JT, Fillingim RB, Gilron I, Markman JD, Oaklander AL, Polydefkis MJ, Raja SN, Robinson JP, Woolf CJ, Ziegler D, Ashburn MA, Burke LB, Cowan P, George SZ, Goli V, Graff OX, Iyengar S, Jay GW, Katz J, Kehlet H, Kitt RA, Kopecky EA, Malamut R, McDermott MP, Palmer P, Rappaport BA, Rauschkolb C, Steigerwald I, Tobias J, Walco GA. Research design considerations for chronic pain prevention clinical trials: IMMPACT recommendations. Pain. 2015 Jul; 156(7):1184-97.
  16. Talbot S, Abdulnour RE, Burkett PR, Lee S, Cronin SJ, Pascal MA, Laedermann C, Foster SL, Tran JV, Lai N, Chiu IM, Ghasemlou N, DiBiase M, Roberson D, Von Hehn C, Agac B, Haworth O, Seki H, Penninger JM, Kuchroo VK, Bean BP, Levy BD, Woolf CJ. Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation. Neuron. 2015 Jul 15; 87(2):341-54.
  17. Latremoliere A, Latini A, Andrews N, Cronin SJ, Fujita M, Gorska K, Hovius R, Romero C, Chuaiphichai S, Painter M, Miracca G, Babaniyi O, Remor AP, Duong K, Riva P, Barrett LB, Ferreirós N, Naylor A, Penninger JM, Tegeder I, Zhong J, Blagg J, Channon KM, Johnsson K, Costigan M, Woolf CJ. Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway. Neuron. 2015 Jun 17; 86(6):1393-406.
  18. Omura T, Omura K, Tedeschi A, Riva P, Painter MW, Rojas L, Martin J, Lisi V, Huebner EA, Latremoliere A, Yin Y, Barrett LB, Singh B, Lee S, Crisman T, Gao F, Li S, Kapur K, Geschwind DH, Kosik KS, Coppola G, He Z, Carmichael ST, Benowitz LI, Costigan M, Woolf CJ. Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS. Neuron. 2015 Jun 3; 86(5):1215-27.
  19. Belin S, Nawabi H, Wang C, Tang S, Latremoliere A, Warren P, Schorle H, Uncu C, Woolf CJ, He Z, Steen JA. Injury-induced decline of intrinsic regenerative ability revealed by quantitative proteomics. Neuron. 2015 May 20; 86(4):1000-14.
  20. Vicuña L, Strochlic DE, Latremoliere A, Bali KK, Simonetti M, Husainie D, Prokosch S, Riva P, Griffin RS, Njoo C, Gehrig S, Mall MA, Arnold B, Devor M, Woolf CJ, Liberles SD, Costigan M, Kuner R. The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase. Nat Med. 2015 May; 21(5):518-23.
  21. Foster SL, Talbot S, Woolf CJ. CNS injury: IL-33 sounds the alarm. Immunity. 2015 Mar 17; 42(3):403-5.
  22. Chiu IM, Barrett LB, Williams EK, Strochlic DE, Lee S, Weyer AD, Lou S, Bryman G, Roberson DP, Ghasemlou N, Piccoli C, Ahat E, Wang V, Cobos EJ, Stucky CL, Ma Q, Liberles SD, Woolf C. Correction: Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity. Elife. 2015; 4:e06720.
  23. Muscara F, McCarthy MC, Woolf C, Hearps SJ, Burke K, Anderson VA. Early psychological reactions in parents of children with a life threatening illness within a pediatric hospital setting. Eur Psychiatry. 2015 Jul; 30(5):555-61.
  24. Chiu IM, Barrett LB, Williams EK, Strochlic DE, Lee S, Weyer AD, Lou S, Bryman GS, Roberson DP, Ghasemlou N, Piccoli C, Ahat E, Wang V, Cobos EJ, Stucky CL, Ma Q, Liberles SD, Woolf CJ. Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity. Elife. 2014; 3.
  25. Wainger BJ, Buttermore ED, Oliveira JT, Mellin C, Lee S, Saber WA, Wang AJ, Ichida JK, Chiu IM, Barrett L, Huebner EA, Bilgin C, Tsujimoto N, Brenneis C, Kapur K, Rubin LL, Eggan K, Woolf CJ. Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts. Nat Neurosci. 2015 Jan; 18(1):17-24.
  26. Choi SH, Kim YH, Hebisch M, Sliwinski C, Lee S, D'Avanzo C, Chen H, Hooli B, Asselin C, Muffat J, Klee JB, Zhang C, Wainger BJ, Peitz M, Kovacs DM, Woolf CJ, Wagner SL, Tanzi RE, Kim DY. A three-dimensional human neural cell culture model of Alzheimer's disease. Nature. 2014 Nov 13; 515(7526):274-8.
  27. Kahle KT, Gao G, Zhang J, Latremoliere A, Andrews N, Shang Y, Alessi D, Woolf C, Elledge S, Clapham D. Ronald R. Tasker Young Investigator Award 165 Promoting Endogenous GABAergic Analgesia via Kinase Modulation of Neuronal Ion Plasticity. Neurosurgery. 2014 Aug; 61 Suppl 1:214.
  28. Woolf CJ. What to call the amplification of nociceptive signals in the central nervous system that contribute to widespread pain? Pain. 2014 Oct; 155(10):1911-2.
  29. Painter MW, Brosius Lutz A, Cheng YC, Latremoliere A, Duong K, Miller CM, Posada S, Cobos EJ, Zhang AX, Wagers AJ, Havton LA, Barres B, Omura T, Woolf CJ. Diminished Schwann cell repair responses underlie age-associated impaired axonal regeneration. Neuron. 2014 Jul 16; 83(2):331-43.
  30. Fell GL, Robinson KC, Mao J, Woolf CJ, Fisher DE. Skin ß-endorphin mediates addiction to UV light. Cell. 2014 Jun 19; 157(7):1527-34.
  31. Kahle KT, Khanna A, Clapham DE, Woolf CJ. Therapeutic restoration of spinal inhibition via druggable enhancement of potassium-chloride cotransporter KCC2-mediated chloride extrusion in peripheral neuropathic pain. JAMA Neurol. 2014 May; 71(5):640-5.
  32. Wainger BJ, Kiskinis E, Mellin C, Wiskow O, Han SS, Sandoe J, Perez NP, Williams LA, Lee S, Boulting G, Berry JD, Brown RH, Cudkowicz ME, Bean BP, Eggan K, Woolf CJ. Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons. Cell Rep. 2014 Apr 10; 7(1):1-11.
  33. Kiskinis E, Sandoe J, Williams LA, Boulting GL, Moccia R, Wainger BJ, Han S, Peng T, Thams S, Mikkilineni S, Mellin C, Merkle FT, Davis-Dusenbery BN, Ziller M, Oakley D, Ichida J, Di Costanzo S, Atwater N, Maeder ML, Goodwin MJ, Nemesh J, Handsaker RE, Paull D, Noggle S, McCarroll SA, Joung JK, Woolf CJ, Brown RH, Eggan K. Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1. Cell Stem Cell. 2014 Jun 5; 14(6):781-95.
  34. Browne LE, Woolf CJ. Casting light on pain. Nat Biotechnol. 2014 Mar; 32(3):240-1.
  35. Seijffers R, Zhang J, Matthews JC, Chen A, Tamrazian E, Babaniyi O, Selig M, Hynynen M, Woolf CJ, Brown RH. ATF3 expression improves motor function in the ALS mouse model by promoting motor neuron survival and retaining muscle innervation. Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4):1622-7.
  36. Brenneis C, Kistner K, Puopolo M, Jo S, Roberson D, Sisignano M, Segal D, Cobos EJ, Wainger BJ, Labocha S, Ferreirós N, von Hehn C, Tran J, Geisslinger G, Reeh PW, Bean BP, Woolf CJ. Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block. Br J Pharmacol. 2014 Jan; 171(2):438-51.
  37. Neogi T, Frey-Law L, Scholz J, Niu J, Arendt-Nielsen L, Woolf C, Nevitt M, Bradley L, Felson DT. Sensitivity and sensitisation in relation to pain severity in knee osteoarthritis: trait or state? Ann Rheum Dis. 2015 Apr; 74(4):682-8.
  38. Chiu IM, Heesters BA, Ghasemlou N, Von Hehn CA, Zhao F, Tran J, Wainger B, Strominger A, Muralidharan S, Horswill AR, Bubeck Wardenburg J, Hwang SW, Carroll MC, Woolf CJ. Bacteria activate sensory neurons that modulate pain and inflammation. Nature. 2013 Sep 5; 501(7465):52-7.
  39. Roberson DP, Gudes S, Sprague JM, Patoski HA, Robson VK, Blasl F, Duan B, Oh SB, Bean BP, Ma Q, Binshtok AM, Woolf CJ. Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons. Nat Neurosci. 2013 Jul; 16(7):910-8.
  40. Yang YM, Gupta SK, Kim KJ, Powers BE, Cerqueira A, Wainger BJ, Ngo HD, Rosowski KA, Schein PA, Ackeifi CA, Arvanites AC, Davidow LS, Woolf CJ, Rubin LL. A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS. Cell Stem Cell. 2013 Jun 6; 12(6):713-26.
  41. Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger BJ, Ichida J, Hanada R, Orthofer M, Cronin SJ, Komnenovic V, Minis A, Sato F, Mimata H, Yoshimura A, Tamir I, Rainer J, Kofler R, Yaron A, Eggan KC, Woolf CJ, Glatzel M, Herbst R, Martinez J, Penninger JM. CLP1 links tRNA metabolism to progressive motor-neuron loss. Nature. 2013 Mar 28; 495(7442):474-80.
  42. Kokel D, Cheung CY, Mills R, Coutinho-Budd J, Huang L, Setola V, Sprague J, Jin S, Jin YN, Huang XP, Bruni G, Woolf CJ, Roth BL, Hamblin MR, Zylka MJ, Milan DJ, Peterson RT. Photochemical activation of TRPA1 channels in neurons and animals. Nat Chem Biol. 2013 Apr; 9(4):257-63.
  43. Bruehl S, Apkarian AV, Ballantyne JC, Berger A, Borsook D, Chen WG, Farrar JT, Haythornthwaite JA, Horn SD, Iadarola MJ, Inturrisi CE, Lao L, Mackey S, Mao J, Sawczuk A, Uhl GR, Witter J, Woolf CJ, Zubieta JK, Lin Y. Personalized medicine and opioid analgesic prescribing for chronic pain: opportunities and challenges. J Pain. 2013 Feb; 14(2):103-13.
  44. Puopolo M, Binshtok AM, Yao GL, Oh SB, Woolf CJ, Bean BP. Permeation and block of TRPV1 channels by the cationic lidocaine derivative QX-314. J Neurophysiol. 2013 Apr; 109(7):1704-12.
  45. Brenneis C, Kistner K, Puopolo M, Segal D, Roberson D, Sisignano M, Labocha S, Ferreirós N, Strominger A, Cobos EJ, Ghasemlou N, Geisslinger G, Reeh PW, Bean BP, Woolf CJ. Phenotyping the function of TRPV1-expressing sensory neurons by targeted axonal silencing. J Neurosci. 2013 Jan 2; 33(1):315-26.
  46. Woolf CJ. Pain: morphine, metabolites, mambas, and mutations. Lancet Neurol. 2013 Jan; 12(1):18-20.
  47. Neely GG, Rao S, Costigan M, Mair N, Racz I, Milinkeviciute G, Meixner A, Nayanala S, Griffin RS, Belfer I, Dai F, Smith S, Diatchenko L, Marengo S, Haubner BJ, Novatchkova M, Gibson D, Maixner W, Pospisilik JA, Hirsch E, Whishaw IQ, Zimmer A, Gupta V, Sasaki J, Kanaho Y, Sasaki T, Kress M, Woolf CJ, Penninger JM. Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception. PLoS Genet. 2012; 8(12):e1003071.
  48. Chiu IM, von Hehn CA, Woolf CJ. Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology. Nat Neurosci. 2012 Aug; 15(8):1063-7.
  49. Korngut L, Ma CH, Martinez JA, Toth CC, Guo GF, Singh V, Woolf CJ, Zochodne DW. Overexpression of human HSP27 protects sensory neurons from diabetes. Neurobiol Dis. 2012 Sep; 47(3):436-43.
  50. Sisignano M, Park CK, Angioni C, Zhang DD, von Hehn C, Cobos EJ, Ghasemlou N, Xu ZZ, Kumaran V, Lu R, Grant A, Fischer MJ, Schmidtko A, Reeh P, Ji RR, Woolf CJ, Geisslinger G, Scholich K, Brenneis C. 5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals. J Neurosci. 2012 May 2; 32(18):6364-72.
  51. Hughes JP, Chessell I, Malamut R, Perkins M, Backonja M, Baron R, Farrar JT, Field MJ, Gereau RW, Gilron I, McMahon SB, Porreca F, Rappaport BA, Rice F, Richman LK, Segerdahl M, Seminowicz DA, Watkins LR, Waxman SG, Wiech K, Woolf C. Understanding chronic inflammatory and neuropathic pain. Ann N Y Acad Sci. 2012 May; 1255:30-44.
  52. Sorge RE, Trang T, Dorfman R, Smith SB, Beggs S, Ritchie J, Austin JS, Zaykin DV, Vander Meulen H, Costigan M, Herbert TA, Yarkoni-Abitbul M, Tichauer D, Livneh J, Gershon E, Zheng M, Tan K, John SL, Slade GD, Jordan J, Woolf CJ, Peltz G, Maixner W, Diatchenko L, Seltzer Z, Salter MW, Mogil JS. Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. Nat Med. 2012 Apr; 18(4):595-9.
  53. von Hehn CA, Baron R, Woolf CJ. Deconstructing the neuropathic pain phenotype to reveal neural mechanisms. Neuron. 2012 Feb 23; 73(4):638-52.
  54. Cobos EJ, Ghasemlou N, Araldi D, Segal D, Duong K, Woolf CJ. Inflammation-induced decrease in voluntary wheel running in mice: a nonreflexive test for evaluating inflammatory pain and analgesia. Pain. 2012 Apr; 153(4):876-84.
  55. Costigan M, Latremoliere A, Woolf CJ. Analgesia by inhibiting tetrahydrobiopterin synthesis. Curr Opin Pharmacol. 2012 Feb; 12(1):92-9.
  56. Ma CH, Brenner GJ, Omura T, Samad OA, Costigan M, Inquimbert P, Niederkofler V, Salie R, Sun CC, Lin HY, Arber S, Coppola G, Woolf CJ, Samad TA. The BMP coreceptor RGMb promotes while the endogenous BMP antagonist noggin reduces neurite outgrowth and peripheral nerve regeneration by modulating BMP signaling. J Neurosci. 2011 Dec 14; 31(50):18391-400.
  57. Brenneis C, Sisignano M, Coste O, Altenrath K, Fischer MJ, Angioni C, Fleming I, Brandes RP, Reeh PW, Woolf CJ, Geisslinger G, Scholich K. Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation. Mol Pain. 2011; 7:78.
  58. Ma CH, Omura T, Cobos EJ, Latrémolière A, Ghasemlou N, Brenner GJ, van Veen E, Barrett L, Sawada T, Gao F, Coppola G, Gertler F, Costigan M, Geschwind D, Woolf CJ. Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice. J Clin Invest. 2011 Nov; 121(11):4332-47.
  59. Son EY, Ichida JK, Wainger BJ, Toma JS, Rafuse VF, Woolf CJ, Eggan K. Conversion of mouse and human fibroblasts into functional spinal motor neurons. Cell Stem Cell. 2011 Sep 2; 9(3):205-18.
  60. Roberson DP, Binshtok AM, Blasl F, Bean BP, Woolf CJ. Targeting of sodium channel blockers into nociceptors to produce long-duration analgesia: a systematic study and review. Br J Pharmacol. 2011 Sep; 164(1):48-58.
  61. Neely GG, Keene AC, Duchek P, Chang EC, Wang QP, Aksoy YA, Rosenzweig M, Costigan M, Woolf CJ, Garrity PA, Penninger JM. TrpA1 regulates thermal nociception in Drosophila. PLoS One. 2011; 6(8):e24343.
  62. Dworkin RH, Turk DC, Basch E, Berger A, Cleeland C, Farrar JT, Haythornthwaite JA, Jensen MP, Kerns RD, Markman J, Porter L, Raja SN, Ross E, Todd K, Wallace M, Woolf CJ. Considerations for extrapolating evidence of acute and chronic pain analgesic efficacy. Pain. 2011 Aug; 152(8):1705-8.
  63. Boulting GL, Kiskinis E, Croft GF, Amoroso MW, Oakley DH, Wainger BJ, Williams DJ, Kahler DJ, Yamaki M, Davidow L, Rodolfa CT, Dimos JT, Mikkilineni S, MacDermott AB, Woolf CJ, Henderson CE, Wichterle H, Eggan K. A functionally characterized test set of human induced pluripotent stem cells. Nat Biotechnol. 2011 Mar; 29(3):279-86.
  64. Neely GG, Hess A, Costigan M, Keene AC, Goulas S, Langeslag M, Griffin RS, Belfer I, Dai F, Smith SB, Diatchenko L, Gupta V, Xia CP, Amann S, Kreitz S, Heindl-Erdmann C, Wolz S, Ly CV, Arora S, Sarangi R, Dan D, Novatchkova M, Rosenzweig M, Gibson DG, Truong D, Schramek D, Zoranovic T, Cronin SJ, Angjeli B, Brune K, Dietzl G, Maixner W, Meixner A, Thomas W, Pospisilik JA, Alenius M, Kress M, Subramaniam S, Garrity PA, Bellen HJ, Woolf CJ, Penninger JM. A genome-wide Drosophila screen for heat nociception identifies a2d3 as an evolutionarily conserved pain gene. Cell. 2010 Nov 12; 143(4):628-38.
  65. del Camino D, Murphy S, Heiry M, Barrett LB, Earley TJ, Cook CA, Petrus MJ, Zhao M, D'Amours M, Deering N, Brenner GJ, Costigan M, Hayward NJ, Chong JA, Fanger CM, Woolf CJ, Patapoutian A, Moran MM. TRPA1 contributes to cold hypersensitivity. J Neurosci. 2010 Nov 10; 30(45):15165-74.
  66. Woolf CJ. What is this thing called pain? J Clin Invest. 2010 Nov; 120(11):3742-4.
  67. Woolf CJ. Central sensitization: implications for the diagnosis and treatment of pain. Pain. 2011 Mar; 152(3 Suppl):S2-15.
  68. Woolf CJ. Overcoming obstacles to developing new analgesics. Nat Med. 2010 Nov; 16(11):1241-7.
  69. Costigan M, Belfer I, Griffin RS, Dai F, Barrett LB, Coppola G, Wu T, Kiselycznyk C, Poddar M, Lu Y, Diatchenko L, Smith S, Cobos EJ, Zaykin D, Allchorne A, Gershon E, Livneh J, Shen PH, Nikolajsen L, Karppinen J, Männikkö M, Kelempisioti A, Goldman D, Maixner W, Geschwind DH, Max MB, Seltzer Z, Woolf CJ. Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1. Brain. 2010 Sep; 133(9):2519-27.
  70. Latremoliere A, Woolf CJ. Synaptic plasticity and central sensitization: author reply. J Pain. 2010 Aug; 11(8):801-3.
  71. Ross SE, Mardinly AR, McCord AE, Zurawski J, Cohen S, Jung C, Hu L, Mok SI, Shah A, Savner EM, Tolias C, Corfas R, Chen S, Inquimbert P, Xu Y, McInnes RR, Rice FL, Corfas G, Ma Q, Woolf CJ, Greenberg ME. Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice. Neuron. 2010 Mar 25; 65(6):886-98.
  72. Kim HY, Kim K, Li HY, Chung G, Park CK, Kim JS, Jung SJ, Lee MK, Ahn DK, Hwang SJ, Kang Y, Binshtok AM, Bean BP, Woolf CJ, Oh SB. Selectively targeting pain in the trigeminal system. Pain. 2010 Jul; 150(1):29-40.
  73. Backonja M, Woolf CJ. Future directions in neuropathic pain therapy: closing the translational loop. Oncologist. 2010; 15 Suppl 2:24-9.
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  332. Woolf CJ, Fitzgerald M. Lamina-specific alteration of C-fibre evoked activity by morphine in the dorsal horn of the rat spinal cord. Neurosci Lett. 1981 Aug 7; 25(1):37-41.
  333. Dickenson AH, Hellon RF, Woolf CJ. Tooth pulp input to the spinal trigeminal nucleus: a comparison of inhibitions following segmental and raphe magnus stimulation. Brain Res. 1981 Jun 9; 214(1):73-87.
  334. Dawson NJ, Dickenson AH, Hellon RF, Woolf CJ. Inhibitory controls on thermal neurones in the spinal trigeminal nucleus of cats and rats. Brain Res. 1981 Mar 30; 209(2):440-5.
  335. Woolf CJ. Intrathecal high dose morphine produces hyperalgesia in the rat. Brain Res. 1981 Mar 30; 209(2):491-5.
  336. Aziz LA, Forsling ML, Woolf CJ. The effect of intracerebroventricular injections of morphine on vasopressin release in the rat. J Physiol. 1981 Feb; 311:401-9.
  337. Fitzgerald M, Woolf CJ. The stereospecific effect of naloxone on rat dorsal horn neurones; inhibition in superficial laminae and excitation in deeper laminae. Pain. 1980 Dec; 9(3):293-306.
  338. Wall PD, Woolf CJ. What we don't know about pain. Nature. 1980 Sep 18; 287(5779):185-6.
  339. Woolf CJ. Intracerebral naloxone and the reaction to thermal noxious stimulation in the rat. Brain Res. 1980 May 26; 190(2):578-83.
  340. Woolf CJ. Analgesia and hyperalgesia produced in the rat by intrathecal naloxone. Brain Res. 1980 May 12; 189(2):593-7.
  341. Woolf CJ, Mitchell D, Barrett GD. Antinociceptive effect of peripheral segmental electrical stimulation in the rat. Pain. 1980 Apr; 8(2):237-52.
  342. Willies GH, Woolf CJ. The site of action of corticosteroid antipyresis in the rabbit. J Physiol. 1980 Mar; 300:1-6.
  343. Woolf CJ. Transcutaneous electrical nerve stimulation and the reaction to experimental pain in human subjects. Pain. 1979 Oct; 7(2):115-27.
  344. Mitchell D, Woolf CJ. Descending tryptaminergic pathways and the antinociceptive effect produced by peripheral electrical stimulation in the rat [proceedings]. J Physiol. 1979 Aug; 293:59P-60P.
  345. Chandler HD, Woolf CJ, Hepburn HR. Gliding edge dislocations in proteins as a mechanism for active ion transport. Biochem J. 1978 Mar 1; 169(3):559-65.
  346. Woolf CJ, Mitchell D, Myers RA, Barrett GD. Failure of naloxone to reverse peripheral transcutaneous electro-analgesia in patients suffering from acute trauma. S Afr Med J. 1978 Feb 4; 53(5):179-80.
  347. Woolf CJ, Barrett GD, Mitchell D, Myers RA. Naloxone-reversible peripheral electroanalgesia in intact and spinal rats. Eur J Pharmacol. 1977 Oct 1; 45(3):311-4.
  348. Myers RA, Woolf CJ, Mitchell D. Management of acute traumatic pain by peripheral transcutaneous electrical stimulation. S Afr Med J. 1977 Aug 13; 52(8):309-12.
  349. Borsook D, Laburn HP, Rosendorff C, Willies GH, Woolf CJ. A dissociation between temperature regulation and fever in the rabbit. J Physiol. 1977 Apr; 266(2):423-33.
  350. Willies GH, Woolf CJ, Rosendorff C. The effect of an inhibitor of adenylate cyclase on the development of pyrogen, prostaglandin and cyclic AMP fevers in the rabbit. Pflugers Arch. 1976 Dec 28; 367(2):177-81.
  351. Woolf CJ, Willies GH, Rosendorff C. Does cyclic AMP have a role in the pathogenesis of fever in the rabbit? Naturwissenschaften. 1976 Feb; 63(2):94-5.
  352. Willies GH, Woolf CJ, Rosendorff C. The effect of sodium salicylate on dibutyryl cyclic AMP fever in the conscious rabbit. Neuropharmacology. 1976 Jan; 15(1):9-10.
  353. Laburn H, Woolf CJ, Willies GH, Rosendorff C. Pyrogen and prostaglandin fever in the rabbit-II: Effects of noradrenaline depletion and adrenergic receptor blockade. Neuropharmacology. 1975 May-Jun; 14(5-6):405-11.
  354. Woolf CJ, Willies GH, Laburn H, Rosendorff C. Pyrogen and prostaglandin fever in the rabbit-I: Effects of salicylate and the role of cyclic AMP. Neuropharmacology. 1975 May-Jun; 14(5-6):397-403.
  355. Woolf CJ, Laburn HP, Willies GH, Rosendorff C. Hypothalamic heating and cooling in monoamine-depleted rabbits. Am J Physiol. 1975 Feb; 228(2):569-74.
  356. Woolf CJ, Willies GH, Hepburn HR, Rosendorff C. Time dependence of a neurochemical correlate of a learning task: a non-disruptive approach to memory consolidation. Experientia. 1974 Jul 15; 30(7):760-2.
  357. Laburn HP, Rosendorff C, Willies G, Woolf C. Proceedings: A role for noradrenaline and cyclic AMP in prostaglandin E1 Fever. J Physiol. 1974 Jul; 240(2):49P-50P.
  358. Suero JT, Woolf CR. Alterations in the mechanical properties of the lung during dyspnea in chronic obstructive pulmonary disease. J Clin Invest. 1970 Apr; 49(4):747-51.
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F.M. Kirby Neurobiology Center

The F.M. Kirby Neurobiology Center, together with the Neurobiology Program at Boston Children’s Hospital, is the largest basic neuroscience research enterprise at a U.S. hospital. It incorporates basic and translational neuroscience research, focusing primarily on developmental neurobiology.

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