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Joseph J. Volpe, MD

Joseph Volpe
Neurology Research
Hospital Title:
Neurologist-in-Chief Emeritus
Academic Title:
Bronson Crothers Professor of Neurology, Harvard Medical School
Research Focus Area:
Brain injury in premature infants

Research Overview

Joseph Volpe is generally considered to have founded the field of neonatal neurology. His research focuses on damage to the white matter of the brain in premature infants, a condition called periventricular leukomalacia (PVL). Infants with PVL have an increased risk of developing cerebral palsy and can have intellectual or learning difficulties. Volpe has sought to define the biological mechanisms of PVL and design strategies to prevent it. He has approached this goal through both basic and clinical research.

Through basic research, he has demonstrated that early differentiating oligodendrocytes (cells that compose the white matter of the brain) are exquisitely vulnerable to attack by free radicals. Volpe has discovered that this vulnerability relates to impaired antioxidant defenses, requires iron, leads to apoptotic death, is highly maturation-dependent and can be prevented with mechanism-specific interventions.

Specifically, his work has identified two major upstream mechanisms: hypoxia-ischemia and systemic infection/inflammation with activation of brain microglia. These insults activate two major downstream mechanisms--excitotoxicity and, ultimately, generation of reactive oxygen and nitrogen species. These insights have led to discovery of a variety of interventions that prevent or ameliorate the injury to early differentiating oligodendrocytes.

Volpe's clinical research has demonstrated that PVL in the premature newborn is followed by subsequent impairment of brain development. His work has also contributed to possible strategies for preventing that damage, showing that:

  • Infants with a pressure-passive cerebral circulation can be identified in the first hours of life and are at very high risk for subsequent periventricular white-matter injury.
  • Infants with cerebral hemodynamic disturbance can be identified prior to the occurrence of injury, raising the possibility that correcting the disturbance could prevent white-matter injury.
  • The critical diffuse component of periventricular white-matter injury--invisible to conventional MRI--can be identified by diffusion-based MRI (decreased diffusion) and by proton MR spectroscopy (increased lactate).
  • The disturbances of neuronal/axonal development that result from the white-matter injury involve the cerebral cortex, critical white-matter neurons (subplate neurons, late migrating GABAergic neurons), the thalamus, the basal ganglia and the cerebellum. These gray-matter lesions are likely very critical in the genesis of the cognitive/behavioral/attentional/socialization deficits observed in premature infants.

About Joseph Volpe

Joseph Volpe received his MD from Harvard Medical School. He completed an internship and residency at Massachusetts General Hospital and a fellowship as a research associate at the National Institutes of Health. He is the recipient of numerous honors and prizes. In 1998 he was elected to the Institute of Medicine of the National Academy of Sciences.


Publications powered by Harvard Catalyst Profiles
  1. Volpe JJ. Impaired Neurodevelopmental Outcome After Mild Germinal Matrix-Intraventricular Hemorrhage. Pediatrics. 2015 Dec; 136(6):1185-7.
  2. Hefti MM, Trachtenberg FL, Haynes RL, Hassett C, Volpe JJ, Kinney HC. A Century of Germinal Matrix Intraventricular Hemorrhage in Autopsied Premature Infants: A Historical Account. Pediatr Dev Pathol. 2016 Mar-Apr; 19(2):108-14.
  3. Volpe JJ. Neonatal neurology--my personal journey and some lessons learned. Pediatr Neurol. 2014 Dec; 51(6):753-7.
  4. Volpe JJ. Intracranial hemorrhage in early infancy--renewed importance of vitamin K deficiency. Pediatr Neurol. 2014 Jun; 50(6):545-6.
  5. Volpe JJ. Encephalopathy of congenital heart disease- destructive and developmental effects intertwined. J Pediatr. 2014 May; 164(5):962-5.
  6. de Vries LS, Volpe JJ. Value of sequential MRI in preterm infants. Neurology. 2013 Dec 10; 81(24):2062-3.
  7. Haynes RL, Sleeper LA, Volpe JJ, Kinney HC. Neuropathologic studies of the encephalopathy of prematurity in the late preterm infant. Clin Perinatol. 2013 Dec; 40(4):707-22.
  8. Jantzie LL, Talos DM, Jackson MC, Park HK, Graham DA, Lechpammer M, Folkerth RD, Volpe JJ, Jensen FE. Developmental expression of N-methyl-D-aspartate (NMDA) receptor subunits in human white and gray matter: potential mechanism of increased vulnerability in the immature brain. Cereb Cortex. 2015 Feb; 25(2):482-95.
  9. DeSilva TM, Borenstein NS, Volpe JJ, Kinney HC, Rosenberg PA. Expression of EAAT2 in neurons and protoplasmic astrocytes during human cortical development. J Comp Neurol. 2012 Dec 1; 520(17):3912-32.
  10. Xu G, Takahashi E, Folkerth RD, Haynes RL, Volpe JJ, Grant PE, Kinney HC. Radial coherence of diffusion tractography in the cerebral white matter of the human fetus: neuroanatomic insights. Cereb Cortex. 2014 Mar; 24(3):579-92.
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  12. Volpe JJ. Neonatal encephalopathy: an inadequate term for hypoxic-ischemic encephalopathy. Ann Neurol. 2012 Aug; 72(2):156-66.
  13. Kinney HC, Volpe JJ. Modeling the encephalopathy of prematurity in animals: the important role of translational research. Neurol Res Int. 2012; 2012:295389.
  14. Kinney HC, Haynes RL, Xu G, Andiman SE, Folkerth RD, Sleeper LA, Volpe JJ. Neuron deficit in the white matter and subplate in periventricular leukomalacia. Ann Neurol. 2012 Mar; 71(3):397-406.
  15. Xu G, Broadbelt KG, Haynes RL, Folkerth RD, Borenstein NS, Belliveau RA, Trachtenberg FL, Volpe JJ, Kinney HC. Late development of the GABAergic system in the human cerebral cortex and white matter. J Neuropathol Exp Neurol. 2011 Oct; 70(10):841-58.
  16. Volpe JJ. Systemic inflammation, oligodendroglial maturation, and the encephalopathy of prematurity. Ann Neurol. 2011 Oct; 70(4):525-9.
  17. Dean JM, Moravec MD, Grafe M, Abend N, Ren J, Gong X, Volpe JJ, Jensen FE, Hohimer AR, Back SA. Strain-specific differences in perinatal rodent oligodendrocyte lineage progression and its correlation with human. Dev Neurosci. 2011; 33(3-4):251-60.
  18. Volpe JJ, Kinney HC, Jensen FE, Rosenberg PA. Reprint of "The developing oligodendrocyte: key cellular target in brain injury in the premature infant". Int J Dev Neurosci. 2011 Oct; 29(6):565-82.
  19. Manning SM, Boll G, Fitzgerald E, Selip DB, Volpe JJ, Jensen FE. The clinically available NMDA receptor antagonist, memantine, exhibits relative safety in the developing rat brain. Int J Dev Neurosci. 2011 Nov; 29(7):767-73.
  20. Volpe JJ, Kinney HC, Jensen FE, Rosenberg PA. The developing oligodendrocyte: key cellular target in brain injury in the premature infant. Int J Dev Neurosci. 2011 Jun; 29(4):423-40.
  21. Haynes RL, Xu G, Folkerth RD, Trachtenberg FL, Volpe JJ, Kinney HC. Potential neuronal repair in cerebral white matter injury in the human neonate. Pediatr Res. 2011 Jan; 69(1):62-7.
  22. Andiman SE, Haynes RL, Trachtenberg FL, Billiards SS, Folkerth RD, Volpe JJ, Kinney HC. The cerebral cortex overlying periventricular leukomalacia: analysis of pyramidal neurons. Brain Pathol. 2010 Jul; 20(4):803-14.
  23. De Vivo DC, Fishman MA, Johnsen SD, Prensky AL, Volpe JJ. Honoring a giant in child neurology ... Help find and fund new ones: contributing to the Philip R. Dodge Young Investigator Award endowment fund. J Child Neurol. 2010 Feb; 25(2):250-3.
  24. Volpe JJ. The encephalopathy of prematurity--brain injury and impaired brain development inextricably intertwined. Semin Pediatr Neurol. 2009 Dec; 16(4):167-78.
  25. Volpe JJ. Cerebellum of the premature infant: rapidly developing, vulnerable, clinically important. J Child Neurol. 2009 Sep; 24(9):1085-104.
  26. Volpe JJ. Electroencephalography may provide insight into timing of premature brain injury. Pediatrics. 2009 Sep; 124(3):e542-4.
  27. Gerstner B, Lee J, DeSilva TM, Jensen FE, Volpe JJ, Rosenberg PA. 17beta-estradiol protects against hypoxic/ischemic white matter damage in the neonatal rat brain. J Neurosci Res. 2009 Jul; 87(9):2078-86.
  28. DeSilva TM, Kabakov AY, Goldhoff PE, Volpe JJ, Rosenberg PA. Regulation of glutamate transport in developing rat oligodendrocytes. J Neurosci. 2009 Jun 17; 29(24):7898-908.
  29. Haynes RL, Folkerth RD, Trachtenberg FL, Volpe JJ, Kinney HC. Nitrosative stress and inducible nitric oxide synthase expression in periventricular leukomalacia. Acta Neuropathol. 2009 Sep; 118(3):391-9.
  30. Ligam P, Haynes RL, Folkerth RD, Liu L, Yang M, Volpe JJ, Kinney HC. Thalamic damage in periventricular leukomalacia: novel pathologic observations relevant to cognitive deficits in survivors of prematurity. Pediatr Res. 2009 May; 65(5):524-9.
  31. Volpe JJ. Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Lancet Neurol. 2009 Jan; 8(1):110-24.
  32. Volpe JJ. Neonatal encephalitis and white matter injury: more than just inflammation? Ann Neurol. 2008 Sep; 64(3):232-6.
  33. Volpe JJ. Postnatal sepsis, necrotizing entercolitis, and the critical role of systemic inflammation in white matter injury in premature infants. J Pediatr. 2008 Aug; 153(2):160-3.
  34. Manning SM, Talos DM, Zhou C, Selip DB, Park HK, Park CJ, Volpe JJ, Jensen FE. NMDA receptor blockade with memantine attenuates white matter injury in a rat model of periventricular leukomalacia. J Neurosci. 2008 Jun 25; 28(26):6670-8.
  35. Haynes RL, Billiards SS, Borenstein NS, Volpe JJ, Kinney HC. Diffuse axonal injury in periventricular leukomalacia as determined by apoptotic marker fractin. Pediatr Res. 2008 Jun; 63(6):656-61.
  36. Li J, Ramenaden ER, Peng J, Koito H, Volpe JJ, Rosenberg PA. Tumor necrosis factor alpha mediates lipopolysaccharide-induced microglial toxicity to developing oligodendrocytes when astrocytes are present. J Neurosci. 2008 May 14; 28(20):5321-30.
  37. Desilva TM, Billiards SS, Borenstein NS, Trachtenberg FL, Volpe JJ, Kinney HC, Rosenberg PA. Glutamate transporter EAAT2 expression is up-regulated in reactive astrocytes in human periventricular leukomalacia. J Comp Neurol. 2008 May 10; 508(2):238-48.
  38. Limperopoulos C, Bassan H, Sullivan NR, Soul JS, Robertson RL, Moore M, Ringer SA, Volpe JJ, du Plessis AJ. Positive screening for autism in ex-preterm infants: prevalence and risk factors. Pediatrics. 2008 Apr; 121(4):758-65.
  39. Khwaja O, Volpe JJ. Pathogenesis of cerebral white matter injury of prematurity. Arch Dis Child Fetal Neonatal Ed. 2008 Mar; 93(2):F153-61.
  40. Gerstner B, DeSilva TM, Genz K, Armstrong A, Brehmer F, Neve RL, Felderhoff-Mueser U, Volpe JJ, Rosenberg PA. Hyperoxia causes maturation-dependent cell death in the developing white matter. J Neurosci. 2008 Jan 30; 28(5):1236-45.
  41. Lechpammer M, Manning SM, Samonte F, Nelligan J, Sabo E, Talos DM, Volpe JJ, Jensen FE. Minocycline treatment following hypoxic/ischaemic injury attenuates white matter injury in a rodent model of periventricular leucomalacia. Neuropathol Appl Neurobiol. 2008 Aug; 34(4):379-93.
  42. Billiards SS, Haynes RL, Folkerth RD, Borenstein NS, Trachtenberg FL, Rowitch DH, Ligon KL, Volpe JJ, Kinney HC. Myelin abnormalities without oligodendrocyte loss in periventricular leukomalacia. Brain Pathol. 2008 Apr; 18(2):153-63.
  43. Cameron JS, Alexopoulou L, Sloane JA, DiBernardo AB, Ma Y, Kosaras B, Flavell R, Strittmatter SM, Volpe J, Sidman R, Vartanian T. Toll-like receptor 3 is a potent negative regulator of axonal growth in mammals. J Neurosci. 2007 Nov 21; 27(47):13033-41.
  44. Limperopoulos C, Bassan H, Kalish LA, Ringer SA, Eichenwald EC, Walter G, Moore M, Vanasse M, DiSalvo DN, Soul JS, Volpe JJ, du Plessis AJ. Current definitions of hypotension do not predict abnormal cranial ultrasound findings in preterm infants. Pediatrics. 2007 Nov; 120(5):966-77.
  45. Pierson CR, Folkerth RD, Billiards SS, Trachtenberg FL, Drinkwater ME, Volpe JJ, Kinney HC. Gray matter injury associated with periventricular leukomalacia in the premature infant. Acta Neuropathol. 2007 Dec; 114(6):619-31.
  46. Bassan H, Limperopoulos C, Visconti K, Mayer DL, Feldman HA, Avery L, Benson CB, Stewart J, Ringer SA, Soul JS, Volpe JJ, du Plessis AJ. Neurodevelopmental outcome in survivors of periventricular hemorrhagic infarction. Pediatrics. 2007 Oct; 120(4):785-92.
  47. Limperopoulos C, Bassan H, Gauvreau K, Robertson RL, Sullivan NR, Benson CB, Avery L, Stewart J, Soul JS, Ringer SA, Volpe JJ, duPlessis AJ. Does cerebellar injury in premature infants contribute to the high prevalence of long-term cognitive, learning, and behavioral disability in survivors? Pediatrics. 2007 Sep; 120(3):584-93.
  48. Gerstner B, Sifringer M, Dzietko M, Schüller A, Lee J, Simons S, Obladen M, Volpe JJ, Rosenberg PA, Felderhoff-Mueser U. Estradiol attenuates hyperoxia-induced cell death in the developing white matter. Ann Neurol. 2007 Jun; 61(6):562-73.
  49. Desilva TM, Kinney HC, Borenstein NS, Trachtenberg FL, Irwin N, Volpe JJ, Rosenberg PA. The glutamate transporter EAAT2 is transiently expressed in developing human cerebral white matter. J Comp Neurol. 2007 Apr 20; 501(6):879-90.
  50. Soul JS, Hammer PE, Tsuji M, Saul JP, Bassan H, Limperopoulos C, Disalvo DN, Moore M, Akins P, Ringer S, Volpe JJ, Trachtenberg F, du Plessis AJ. Fluctuating pressure-passivity is common in the cerebral circulation of sick premature infants. Pediatr Res. 2007 Apr; 61(4):467-73.
  51. Ma Y, Li J, Chiu I, Wang Y, Sloane JA, Lü J, Kosaras B, Sidman RL, Volpe JJ, Vartanian T. Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis. J Cell Biol. 2006 Oct 23; 175(2):209-15.
  52. Deng W, Neve RL, Rosenberg PA, Volpe JJ, Jensen FE. Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit composition and cAMP-response element-binding protein regulate oligodendrocyte excitotoxicity. J Biol Chem. 2006 Nov 24; 281(47):36004-11.
  53. Haynes RL, Folkerth RD, Szweda LI, Volpe JJ, Kinney HC. Lipid peroxidation during human cerebral myelination. J Neuropathol Exp Neurol. 2006 Sep; 65(9):894-904.
  54. Bassan H, Feldman HA, Limperopoulos C, Benson CB, Ringer SA, Veracruz E, Soul JS, Volpe JJ, du Plessis AJ. Periventricular hemorrhagic infarction: risk factors and neonatal outcome. Pediatr Neurol. 2006 Aug; 35(2):85-92.
  55. Billiards SS, Haynes RL, Folkerth RD, Trachtenberg FL, Liu LG, Volpe JJ, Kinney HC. Development of microglia in the cerebral white matter of the human fetus and infant. J Comp Neurol. 2006 Jul 10; 497(2):199-208.
  56. Talos DM, Fishman RE, Park H, Folkerth RD, Follett PL, Volpe JJ, Jensen FE. Developmental regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor subunit expression in forebrain and relationship to regional susceptibility to hypoxic/ischemic injury. I. Rodent cerebral white matter and cortex. J Comp Neurol. 2006 Jul 1; 497(1):42-60.
  57. Talos DM, Follett PL, Folkerth RD, Fishman RE, Trachtenberg FL, Volpe JJ, Jensen FE. Developmental regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor subunit expression in forebrain and relationship to regional susceptibility to hypoxic/ischemic injury. II. Human cerebral white matter and cortex. J Comp Neurol. 2006 Jul 1; 497(1):61-77.
  58. Lehnardt S, Henneke P, Lien E, Kasper DL, Volpe JJ, Bechmann I, Nitsch R, Weber JR, Golenbock DT, Vartanian T. A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia. J Immunol. 2006 Jul 1; 177(1):583-92.
  59. Bassan H, Benson CB, Limperopoulos C, Feldman HA, Ringer SA, Veracruz E, Stewart JE, Soul JS, Disalvo DN, Volpe JJ, du Plessis AJ. Ultrasonographic features and severity scoring of periventricular hemorrhagic infarction in relation to risk factors and outcome. Pediatrics. 2006 Jun; 117(6):2111-8.
  60. Deng W, Yue Q, Rosenberg PA, Volpe JJ, Jensen FE. Oligodendrocyte excitotoxicity determined by local glutamate accumulation and mitochondrial function. J Neurochem. 2006 Jul; 98(1):213-22.
  61. Tekgul H, Gauvreau K, Soul J, Murphy L, Robertson R, Stewart J, Volpe J, Bourgeois B, du Plessis AJ. The current etiologic profile and neurodevelopmental outcome of seizures in term newborn infants. Pediatrics. 2006 Apr; 117(4):1270-80.
  62. Zhang Y, Wang H, Li J, Dong L, Xu P, Chen W, Neve RL, Volpe JJ, Rosenberg PA. Intracellular zinc release and ERK phosphorylation are required upstream of 12-lipoxygenase activation in peroxynitrite toxicity to mature rat oligodendrocytes. J Biol Chem. 2006 Apr 7; 281(14):9460-70.
  63. Limperopoulos C, Soul JS, Haidar H, Huppi PS, Bassan H, Warfield SK, Robertson RL, Moore M, Akins P, Volpe JJ, du Plessis AJ. Impaired trophic interactions between the cerebellum and the cerebrum among preterm infants. Pediatrics. 2005 Oct; 116(4):844-50.
  64. Limperopoulos C, Benson CB, Bassan H, Disalvo DN, Kinnamon DD, Moore M, Ringer SA, Volpe JJ, du Plessis AJ. Cerebellar hemorrhage in the preterm infant: ultrasonographic findings and risk factors. Pediatrics. 2005 Sep; 116(3):717-24.
  65. Li J, Baud O, Vartanian T, Volpe JJ, Rosenberg PA. Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes. Proc Natl Acad Sci U S A. 2005 Jul 12; 102(28):9936-41.
  66. Haynes RL, Baud O, Li J, Kinney HC, Volpe JJ, Folkerth DR. Oxidative and nitrative injury in periventricular leukomalacia: a review. Brain Pathol. 2005 Jul; 15(3):225-33.
  67. Volpe JJ. Encephalopathy of prematurity includes neuronal abnormalities. Pediatrics. 2005 Jul; 116(1):221-5.
  68. Haynes RL, Borenstein NS, Desilva TM, Folkerth RD, Liu LG, Volpe JJ, Kinney HC. Axonal development in the cerebral white matter of the human fetus and infant. J Comp Neurol. 2005 Apr 4; 484(2):156-67.
  69. Limperopoulos C, Soul JS, Gauvreau K, Huppi PS, Warfield SK, Bassan H, Robertson RL, Volpe JJ, du Plessis AJ. Late gestation cerebellar growth is rapid and impeded by premature birth. Pediatrics. 2005 Mar; 115(3):688-95.
  70. Yoo SS, Park HJ, Soul JS, Mamata H, Park H, Westin CF, Bassan H, Du Plessis AJ, Robertson RL, Maier SE, Ringer SA, Volpe JJ, Zientara GP. In vivo visualization of white matter fiber tracts of preterm- and term-infant brains with diffusion tensor magnetic resonance imaging. Invest Radiol. 2005 Feb; 40(2):110-5.
  71. Inder TE, Warfield SK, Wang H, Hüppi PS, Volpe JJ. Abnormal cerebral structure is present at term in premature infants. Pediatrics. 2005 Feb; 115(2):286-94.
  72. Shah DK, Daley AJ, Hunt RW, Volpe JJ, Inder TE. Cerebral white matter injury in the newborn following Escherichia coli meningitis. Eur J Paediatr Neurol. 2005; 9(1):13-7.
  73. Ellison VJ, Mocatta TJ, Winterbourn CC, Darlow BA, Volpe JJ, Inder TE. The relationship of CSF and plasma cytokine levels to cerebral white matter injury in the premature newborn. Pediatr Res. 2005 Feb; 57(2):282-6.
  74. Wang H, Li J, Follett PL, Zhang Y, Cotanche DA, Jensen FE, Volpe JJ, Rosenberg PA. 12-Lipoxygenase plays a key role in cell death caused by glutathione depletion and arachidonic acid in rat oligodendrocytes. Eur J Neurosci. 2004 Oct; 20(8):2049-58.
  75. Baud O, Li J, Zhang Y, Neve RL, Volpe JJ, Rosenberg PA. Nitric oxide-induced cell death in developing oligodendrocytes is associated with mitochondrial dysfunction and apoptosis-inducing factor translocation. Eur J Neurosci. 2004 Oct; 20(7):1713-26.
  76. Folkerth RD, Haynes RL, Borenstein NS, Belliveau RA, Trachtenberg F, Rosenberg PA, Volpe JJ, Kinney HC. Developmental lag in superoxide dismutases relative to other antioxidant enzymes in premyelinated human telencephalic white matter. J Neuropathol Exp Neurol. 2004 Sep; 63(9):990-9.
  77. Folkerth RD, Keefe RJ, Haynes RL, Trachtenberg FL, Volpe JJ, Kinney HC. Interferon-gamma expression in periventricular leukomalacia in the human brain. Brain Pathol. 2004 Jul; 14(3):265-74.
  78. Baud O, Haynes RF, Wang H, Folkerth RD, Li J, Volpe JJ, Rosenberg PA. Developmental up-regulation of MnSOD in rat oligodendrocytes confers protection against oxidative injury. Eur J Neurosci. 2004 Jul; 20(1):29-40.
  79. Deng W, Wang H, Rosenberg PA, Volpe JJ, Jensen FE. Role of metabotropic glutamate receptors in oligodendrocyte excitotoxicity and oxidative stress. Proc Natl Acad Sci U S A. 2004 May 18; 101(20):7751-6.
  80. Follett PL, Deng W, Dai W, Talos DM, Massillon LJ, Rosenberg PA, Volpe JJ, Jensen FE. Glutamate receptor-mediated oligodendrocyte toxicity in periventricular leukomalacia: a protective role for topiramate. J Neurosci. 2004 May 5; 24(18):4412-20.
  81. Baud O, Greene AE, Li J, Wang H, Volpe JJ, Rosenberg PA. Glutathione peroxidase-catalase cooperativity is required for resistance to hydrogen peroxide by mature rat oligodendrocytes. J Neurosci. 2004 Feb 18; 24(7):1531-40.
  82. Soul JS, Eichenwald E, Walter G, Volpe JJ, du Plessis AJ. CSF removal in infantile posthemorrhagic hydrocephalus results in significant improvement in cerebral hemodynamics. Pediatr Res. 2004 May; 55(5):872-6.
  83. Seghier ML, Lazeyras F, Zimine S, Maier SE, Hanquinet S, Delavelle J, Volpe JJ, Huppi PS. Combination of event-related fMRI and diffusion tensor imaging in an infant with perinatal stroke. Neuroimage. 2004 Jan; 21(1):463-72.
  84. Anderson NG, Warfield SK, Wells S, Spencer C, Balasingham A, Volpe JJ, Inder TE. A limited range of measures of 2-D ultrasound correlate with 3-D MRI cerebral volumes in the premature infant at term. Ultrasound Med Biol. 2004 Jan; 30(1):11-8.
  85. Inder TE, Wells SJ, Mogridge NB, Spencer C, Volpe JJ. Defining the nature of the cerebral abnormalities in the premature infant: a qualitative magnetic resonance imaging study. J Pediatr. 2003 Aug; 143(2):171-9.
  86. Hennel SJ, Ekert PG, Volpe JJ, Inder TE. Insights into the pathogenesis of cerebral lesions in incontinentia pigmenti. Pediatr Neurol. 2003 Aug; 29(2):148-50.
  87. Li J, Lin JC, Wang H, Peterson JW, Furie BC, Furie B, Booth SL, Volpe JJ, Rosenberg PA. Novel role of vitamin k in preventing oxidative injury to developing oligodendrocytes and neurons. J Neurosci. 2003 Jul 2; 23(13):5816-26.
  88. Volpe JJ. Cerebral white matter injury of the premature infant-more common than you think. Pediatrics. 2003 Jul; 112(1 Pt 1):176-80.
  89. Lehnardt S, Massillon L, Follett P, Jensen FE, Ratan R, Rosenberg PA, Volpe JJ, Vartanian T. Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway. Proc Natl Acad Sci U S A. 2003 Jul 8; 100(14):8514-9.
  90. Deng W, Rosenberg PA, Volpe JJ, Jensen FE. Calcium-permeable AMPA/kainate receptors mediate toxicity and preconditioning by oxygen-glucose deprivation in oligodendrocyte precursors. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6801-6.
  91. Haynes RL, Folkerth RD, Keefe RJ, Sung I, Swzeda LI, Rosenberg PA, Volpe JJ, Kinney HC. Nitrosative and oxidative injury to premyelinating oligodendrocytes in periventricular leukomalacia. J Neuropathol Exp Neurol. 2003 May; 62(5):441-50.
  92. Inder TE, Anderson NJ, Spencer C, Wells S, Volpe JJ. White matter injury in the premature infant: a comparison between serial cranial sonographic and MR findings at term. AJNR Am J Neuroradiol. 2003 May; 24(5):805-9.
  93. Rosenberg PA, Dai W, Gan XD, Ali S, Fu J, Back SA, Sanchez RM, Segal MM, Follett PL, Jensen FE, Volpe JJ. Mature myelin basic protein-expressing oligodendrocytes are insensitive to kainate toxicity. J Neurosci Res. 2003 Jan 15; 71(2):237-45.
  94. Efron D, South M, Volpe JJ, Inder T. Cerebral injury in association with profound iatrogenic hyperglycemia in a neonate. Eur J Paediatr Neurol. 2003; 7(4):167-71.
  95. Inder TE, Buckland L, Williams CE, Spencer C, Gunning MI, Darlow BA, Volpe JJ, Gluckman PD. Lowered electroencephalographic spectral edge frequency predicts the presence of cerebral white matter injury in premature infants. Pediatrics. 2003 Jan; 111(1):27-33.
  96. Inder T, Mocatta T, Darlow B, Spencer C, Volpe JJ, Winterbourn C. Elevated free radical products in the cerebrospinal fluid of VLBW infants with cerebral white matter injury. Pediatr Res. 2002 Aug; 52(2):213-8.
  97. Menache CC, Bourgeois BF, Volpe JJ. Prognostic value of neonatal discontinuous EEG. Pediatr Neurol. 2002 Aug; 27(2):93-101.
  98. Murphy BP, Inder TE, Rooks V, Taylor GA, Anderson NJ, Mogridge N, Horwood LJ, Volpe JJ. Posthaemorrhagic ventricular dilatation in the premature infant: natural history and predictors of outcome. Arch Dis Child Fetal Neonatal Ed. 2002 Jul; 87(1):F37-41.
  99. Volpe JJ. Mental Retardation Research Center at Boston Children's Hospital/Harvard Medical School. Introductory overview. Int J Dev Neurosci. 2002 Jun-Aug; 20(3-5):337-8.
  100. Inder T, Mocatta T, Darlow B, Spencer C, Senthilmohan R, Winterbourn CC, Volpe JJ. Markers of oxidative injury in the cerebrospinal fluid of a premature infant with meningitis and periventricular leukomalacia. J Pediatr. 2002 May; 140(5):617-21.
  101. du Plessis AJ, Volpe JJ. Perinatal brain injury in the preterm and term newborn. Curr Opin Neurol. 2002 Apr; 15(2):151-7.
  102. Lehnardt S, Lachance C, Patrizi S, Lefebvre S, Follett PL, Jensen FE, Rosenberg PA, Volpe JJ, Vartanian T. The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS. J Neurosci. 2002 Apr 1; 22(7):2478-86.
  103. Back SA, Luo NL, Borenstein NS, Volpe JJ, Kinney HC. Arrested oligodendrocyte lineage progression during human cerebral white matter development: dissociation between the timing of progenitor differentiation and myelinogenesis. J Neuropathol Exp Neurol. 2002 Feb; 61(2):197-211.
  104. Hunt RW, Loughnan P, Fink AM, Volpe JJ, Inder TE. Magnetic resonance demonstration in the newborn of generalized cerebral venous dilation with spontaneous resolution. Eur J Paediatr Neurol. 2002; 6(5):289-92.
  105. Soul JS, Robertson RL, Tzika AA, du Plessis AJ, Volpe JJ. Time course of changes in diffusion-weighted magnetic resonance imaging in a case of neonatal encephalopathy with defined onset and duration of hypoxic-ischemic insult. Pediatrics. 2001 Nov; 108(5):1211-4.
  106. Volpe JJ. Neurobiology of periventricular leukomalacia in the premature infant. Pediatr Res. 2001 Nov; 50(5):553-62.
  107. Murphy BP, Zientara GP, Huppi PS, Maier SE, Barnes PD, Jolesz FA, Volpe JJ. Line scan diffusion tensor MRI of the cervical spinal cord in preterm infants. J Magn Reson Imaging. 2001 Jun; 13(6):949-53.
  108. Hüppi PS, Murphy B, Maier SE, Zientara GP, Inder TE, Barnes PD, Kikinis R, Jolesz FA, Volpe JJ. Microstructural brain development after perinatal cerebral white matter injury assessed by diffusion tensor magnetic resonance imaging. Pediatrics. 2001 Mar; 107(3):455-60.
  109. Murphy BP, Inder TE, Huppi PS, Warfield S, Zientara GP, Kikinis R, Jolesz FA, Volpe JJ. Impaired cerebral cortical gray matter growth after treatment with dexamethasone for neonatal chronic lung disease. Pediatrics. 2001 Feb; 107(2):217-21.
  110. Volpe JJ. Perinatal brain injury: from pathogenesis to neuroprotection. Ment Retard Dev Disabil Res Rev. 2001; 7(1):56-64.
  111. Follett PL, Rosenberg PA, Volpe JJ, Jensen FE. NBQX attenuates excitotoxic injury in developing white matter. J Neurosci. 2000 Dec 15; 20(24):9235-41.
  112. Soul JS, Taylor GA, Wypij D, Duplessis AJ, Volpe JJ. Noninvasive detection of changes in cerebral blood flow by near-infrared spectroscopy in a piglet model of hydrocephalus. Pediatr Res. 2000 Oct; 48(4):445-9.
  113. Tsuji M, Saul JP, du Plessis A, Eichenwald E, Sobh J, Crocker R, Volpe JJ. Cerebral intravascular oxygenation correlates with mean arterial pressure in critically ill premature infants. Pediatrics. 2000 Oct; 106(4):625-32.
  114. Volpe JJ. Overview: normal and abnormal human brain development. Ment Retard Dev Disabil Res Rev. 2000; 6(1):1-5.
  115. Inder TE, Huppi PS, Warfield S, Kikinis R, Zientara GP, Barnes PD, Jolesz F, Volpe JJ. Periventricular white matter injury in the premature infant is followed by reduced cerebral cortical gray matter volume at term. Ann Neurol. 1999 Nov; 46(5):755-60.
  116. Back SA, Khan R, Gan X, Rosenberg PA, Volpe JJ. A new Alamar Blue viability assay to rapidly quantify oligodendrocyte death. J Neurosci Methods. 1999 Sep 15; 91(1-2):47-54.
  117. Rosenberg PA, Li Y, Ali S, Altiok N, Back SA, Volpe JJ. Intracellular redox state determines whether nitric oxide is toxic or protective to rat oligodendrocytes in culture. J Neurochem. 1999 Aug; 73(2):476-84.
  118. Inder TE, Huppi PS, Zientara GP, Jolesz FA, Holling EE, Robertson R, Barnes PD, Volpe JJ. The postmigrational development of polymicrogyria documented by magnetic resonance imaging from 31 weeks' postconceptional age. Ann Neurol. 1999 Jun; 45(6):798-801.
  119. Inder T, Huppi PS, Zientara GP, Maier SE, Jolesz FA, di Salvo D, Robertson R, Barnes PD, Volpe JJ. Early detection of periventricular leukomalacia by diffusion-weighted magnetic resonance imaging techniques. J Pediatr. 1999 May; 134(5):631-4.
  120. Hüppi PS, Maier SE, Peled S, Zientara GP, Barnes PD, Jolesz FA, Volpe JJ. Microstructural development of human newborn cerebral white matter assessed in vivo by diffusion tensor magnetic resonance imaging. Pediatr Res. 1998 Oct; 44(4):584-90.
  121. Tsuji M, duPlessis A, Taylor G, Crocker R, Volpe JJ. Near infrared spectroscopy detects cerebral ischemia during hypotension in piglets. Pediatr Res. 1998 Oct; 44(4):591-5.
  122. Volpe JJ. Brain injury in the premature infant: overview of clinical aspects, neuropathology, and pathogenesis. Semin Pediatr Neurol. 1998 Sep; 5(3):135-51.
  123. Inder TE, Volpe JJ. Recovery of congenital isolated pharyngeal dysfunction: implications for early management. Pediatr Neurol. 1998 Sep; 19(3):222-4.
  124. Back SA, Gan X, Li Y, Rosenberg PA, Volpe JJ. Maturation-dependent vulnerability of oligodendrocytes to oxidative stress-induced death caused by glutathione depletion. J Neurosci. 1998 Aug 15; 18(16):6241-53.
  125. Volpe JJ. Neurologic outcome of prematurity. Arch Neurol. 1998 Mar; 55(3):297-300.
  126. Hüppi PS, Warfield S, Kikinis R, Barnes PD, Zientara GP, Jolesz FA, Tsuji MK, Volpe JJ. Quantitative magnetic resonance imaging of brain development in premature and mature newborns. Ann Neurol. 1998 Feb; 43(2):224-35.
  127. Volpe JJ. Neonatal neurologic evaluation by the neurosurgeon. Neurosurg Clin N Am. 1998 Jan; 9(1):1-16.
  128. du Plessis A, Volpe JJ. Prognosis for development in the newborn requiring neurosurgical intervention. Neurosurg Clin N Am. 1998 Jan; 9(1):187-97.
  129. Volpe JJ. Brain injury in the premature infant--from pathogenesis to prevention. Brain Dev. 1997 Dec; 19(8):519-34.
  130. Hansen AR, Volpe JJ, Goumnerova LC, Madsen JR. Intraventricular urokinase for the treatment of posthemorrhagic hydrocephalus. Pediatr Neurol. 1997 Oct; 17(3):213-7.
  131. Volpe JJ. Brain injury in the premature infant. Neuropathology, clinical aspects, pathogenesis, and prevention. Clin Perinatol. 1997 Sep; 24(3):567-87.
  132. Nomura F, Naruse H, duPlessis A, Hiramatsu T, Forbess J, Holtzman D, Volpe JJ, Jonas R, Tsuji M. Cerebral oxygenation measured by near infrared spectroscopy during cardiopulmonary bypass and deep hypothermic circulatory arrest in piglets. Pediatr Res. 1996 Dec; 40(6):790-6.
  133. Yonezawa M, Back SA, Gan X, Rosenberg PA, Volpe JJ. Cystine deprivation induces oligodendroglial death: rescue by free radical scavengers and by a diffusible glial factor. J Neurochem. 1996 Aug; 67(2):566-73.
  134. Rivkin MJ, Volpe JJ. Strokes in children. Pediatr Rev. 1996 Aug; 17(8):265-78.
  135. Tello R, Hartnell GG, Hill T, Volpe J, Finn JP, Cohen M. MR perfusion imaging of the kidney pre- and post-dipyridamole stress. J Magn Reson Imaging. 1996 May-Jun; 6(3):460-4.
  136. Hughes LA, Hartnell GG, Finn JP, Longmaid HE, Volpe J, Wheeler HG, Clouse ME. Time-of-flight MR angiography of the portal venous system: value compared with other imaging procedures. AJR Am J Roentgenol. 1996 Feb; 166(2):375-8.
  137. Volpe JJ. Subplate neurons--missing link in brain injury of the premature infant? Pediatrics. 1996 Jan; 97(1):112-3.
  138. Rivkin MJ, Flax J, Mozell R, Osathanondh R, Volpe JJ, Villa-Komaroff L. Oligodendroglial development in human fetal cerebrum. Ann Neurol. 1995 Jul; 38(1):92-101.
  139. du Plessis AJ, Newburger J, Jonas RA, Hickey P, Naruse H, Tsuji M, Walsh A, Walter G, Wypij D, Volpe JJ. Cerebral oxygen supply and utilization during infant cardiac surgery. Ann Neurol. 1995 Apr; 37(4):488-97.
  140. Tsuji M, Naruse H, Volpe J, Holtzman D. Reduction of cytochrome aa3 measured by near-infrared spectroscopy predicts cerebral energy loss in hypoxic piglets. Pediatr Res. 1995 Mar; 37(3):253-9.
  141. Volpe JJ. Brain injury in the premature infant--current concepts. Prev Med. 1994 Sep; 23(5):638-45.
  142. Volpe JJ. Brain injury caused by intraventricular hemorrhage: is indomethacin the silver bullet for prevention? Pediatrics. 1994 Apr; 93(4):673-7.
  143. Liu GT, Urion DK, Volpe JJ. Cerebral edema in acute hepatic failure: clinicopathologic correlation. Pediatr Neurol. 1993 May-Jun; 9(3):224-6.
  144. Oka A, Belliveau MJ, Rosenberg PA, Volpe JJ. Vulnerability of oligodendroglia to glutamate: pharmacology, mechanisms, and prevention. J Neurosci. 1993 Apr; 13(4):1441-53.
  145. Rivkin MJ, Volpe JJ. Hypoxic-ischemic brain injury in the newborn. Semin Neurol. 1993 Mar; 13(1):30-9.
  146. Volpe JJ. Effect of cocaine use on the fetus. N Engl J Med. 1992 Aug 6; 327(6):399-407.
  147. Feske SK, Carrazana EJ, Kupsky WJ, Volpe JJ. Uncal herniation secondary to bacterial meningitis in a newborn. Pediatr Neurol. 1992 Mar-Apr; 8(2):142-4.
  148. Ishii S, Volpe JJ. Glycoprotein processing is required for completion but not initiation of oligodendroglial differentiation from its bipotential progenitor cell. Dev Neurosci. 1992; 14(3):221-9.
  149. Volpe JJ. Value of MR in definition of the neuropathology of cerebral palsy in vivo. AJNR Am J Neuroradiol. 1992 Jan-Feb; 13(1):79-83.
  150. Ishii S, Volpe JJ. Establishment of a culture system for the study of oligodendroglial development: complementary effects of boiled serum and astrocyte extract. Dev Neurosci. 1992; 14(3):230-7.
  151. Volpe JJ. Brain injury in the premature infant--current concepts of pathogenesis and prevention. Biol Neonate. 1992; 62(4):231-42.
  152. Volpe JJ. Brain development--normal and abnormal. J Perinat Med. 1991; 19 Suppl 1:29-34.
  153. Escobedo M, Barton L, Volpe J. Cerebrospinal fluid studies in an intensive care nursery. J Perinat Med. 1975; 3(3):204-10.
  154. Rich EC, Marshall RE, Volpe JJ. The normal neonatal response to pin-prick. Dev Med Child Neurol. 1974 Aug; 16(4):432-4.
  155. Volpe J. Editorial: Neonatal intracranial hemorrhage--iatrogenic etiology? N Engl J Med. 1974 Jul 4; 291(1):43-5.
  156. Volpe JJ, Vagelos PR. Regulation of mammalian fatty-acid synthetase. The roles of carbohydrate and insulin. Proc Natl Acad Sci U S A. 1974 Mar; 71(3):889-93.
  157. Volpe JJ, Vagelos PR. Fatty acid synthetase of mammalian brain, liver and adipose tissue. Regulation by prosthetic group turnover. Biochim Biophys Acta. 1973 Dec 20; 326(3):293-304.
  158. Rich E, Marshall R, Volpe J. Letter: Plantar reflex flexor in normal neonates. N Engl J Med. 1973 Nov 8; 289(19):1043.
  159. Volpe J. Neonatal Seizures. N Engl J Med. 1973 Aug 23; 289(8):413-6.
  160. Volpe JJ, Lyles TO, Roncari DA, Vagelos PR. Fatty acid synthetase of developing brain and liver. Content, synthesis, and degradation during development. J Biol Chem. 1973 Apr 10; 248(7):2502-13.
  161. Volpe JJ, Vagelos PR. Saturated fatty acid biosynthesis and its regulation. Annu Rev Biochem. 1973; 42:21-60.
  162. Antoon AY, Volpe JJ, Crawford JD. Burn encephalopathy in children. Pediatrics. 1972 Oct; 50(4):609-16.
  163. Volpe JJ, Kishimoto Y. Fatty acid synthetase of brain: development, influence of nutritional and hormonal factors and comparison with liver enzyme. J Neurochem. 1972 Mar; 19(3):737-53.
  164. Volpe JJ, Adams RD. Cerebro-hepato-renal syndrome of Zellweger: an inherited disorder of neuronal migration. Acta Neuropathol. 1972; 20(3):175-98.
  165. Volpe JJ, Laster L. Transsulfuration in fetal and postnatal mammalian liver and brain. Cystathionine synthase, its relation to hormonal influences, and cystathionine. Biol Neonate. 1972; 20(5):385-403.
  166. Volpe JJ, Lee G, Laster L, Robinson JC. Regional distribution of isozymes of D-amino-acid oxidase and acetylesterase in developing primate brain. Exp Neurol. 1970 Jul; 28(1):76-87.
  167. Volpe JJ, Laster L. Trans-sulphuration in primate brain: regional distribution of methionine-activating enzyme in the brain of the rhesus monkey at various stages of development. J Neurochem. 1970 Mar; 17(3):413-24.
  168. Volpe JJ, Laster L. Trans-sulphuration in primate brain: regional distribution of s stages of development. J Neurochem. 1970 Mar; 17(3):425-37.
  169. Chase PH, Volpe JJ, Laster L. Transsulfuration in mammals: fetal and early development of methionine-activating enzyme and its relation to hormonal influences. J Clin Invest. 1968 Sep; 47(9):2099-108.
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