Research

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Paul  Rosenberg, MD, PhD

Paul Rosenberg, MD, PhD
Research Center:
F.M. Kirby Neurobiology Center
Program:
Neurobiology Program
Department:
Neurology Research
Hospital Title:
Senior Associate in Neurology
Academic Title:
Associate Professor of Neurology, Harvard Medical School
Research Focus Area:
Physiology and pathology of glutamate transporters in the central nervous systemmolecular mechanisms of brain injurymechanisms of homeostatic sleep regulation
Contact:
617-919-2634

Research Overview

In our first line of research, we seek to understand the cellular and molecular mechanisms underlying brain injury in order to provide a rational basis for preventing and treating important neurological disorders and diseases. We are investigating how expression and function of the brain's major glutamate transporter, GLT1, is regulated at normal synapses and how GLT1 function is compromised in acute and chronic neurodegenerative diseases. In addition, we are working to characterize pathways of programmed cell death in neurons and oligodendrocytes. In our second line of research, we are investigating the biochemical and molecular basis of behavioral state regulation, with a particular focus on the role of nitric oxide and adenosine in regulating behavioral states (sleeping and waking).

About Paul Rosenberg

Paul Rosenberg received his MD and PhD degrees from Albert Einstein College of Medicine. He completed an internship at University Hospital, Boston, a neurology residency through the Harvard-Longwood Neurological Training Program and a fellowship in cellular neurobiology at Boston Children's Hospital.

Publications

Publications powered by Harvard Catalyst Profiles
  1. Fajardo GC, Rosenberg P, Hayashi K. An Evaluation of Situation Reports and Incident Notices: The DBPR/ESRB Experience. J Public Health Manag Pract. 2016 May-Jun; 22(3):E29-38.
  2. Rimmele TS, Rosenberg PA. GLT-1: The elusive presynaptic glutamate transporter. Neurochem Int. 2016 Sep; 98:19-28.
  3. Brownstein CA, Beggs AH, Rodan L, Shi J, Towne MC, Pelletier R, Cao S, Rosenberg PA, Urion DK, Picker J, Tan WH, Agrawal PB. Clinical heterogeneity associated with KCNA1 mutations include cataplexy and nonataxic presentations. Neurogenetics. 2016 Jan; 17(1):11-6.
  4. Kabakov AY, Rosenberg PA. GLT-1 Transport Stoichiometry Is Constant at Low and High Glutamate Concentrations when Chloride Is Substituted by Gluconate. PLoS One. 2015; 10(8):e0136111.
  5. Malek M, Cortes LM, Sigurdsson A, Rosenberg PA. Differential Diagnosis of a Periapical Radiolucent Lesion. A Case Report and Review of the Literature. N Y State Dent J. 2015 Aug-Sep; 81(5):52-6.
  6. Petr GT, Sun Y, Frederick NM, Zhou Y, Dhamne SC, Hameed MQ, Miranda C, Bedoya EA, Fischer KD, Armsen W, Wang J, Danbolt NC, Rotenberg A, Aoki CJ, Rosenberg PA. Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes. J Neurosci. 2015 Apr 1; 35(13):5187-201.
  7. Saoud TM, Zaazou A, Nabil A, Moussa S, Aly HM, Okazaki K, Rosenberg PA, Lin LM. Histological observations of pulpal replacement tissue in immature dog teeth after revascularization of infected pulps. Dent Traumatol. 2015 Jun; 31(3):243-9.
  8. Saoud TM, Sigurdsson A, Rosenberg PA, Lin LM, Ricucci D. Treatment of a large cystlike inflammatory periapical lesion associated with mature necrotic teeth using regenerative endodontic therapy. J Endod. 2014 Dec; 40(12):2081-6.
  9. Frederick NM, Bertho J, Patel KK, Petr GT, Bakradze E, Smith SB, Rosenberg PA. Dysregulation of system xc(-) expression induced by mutant huntingtin in a striatal neuronal cell line and in R6/2 mice. Neurochem Int. 2014 Oct; 76:59-69.
  10. Drye LT, Spragg D, Devanand DP, Frangakis C, Marano C, Meinert CL, Mintzer JE, Munro CA, Pelton G, Pollock BG, Porsteinsson AP, Rabins PV, Rosenberg PB, Schneider LS, Shade DM, Weintraub D, Yesavage J, Lyketsos CG. Changes in QTc interval in the citalopram for agitation in Alzheimer's disease (CitAD) randomized trial. PLoS One. 2014; 9(6):e98426.
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  12. Elitt CM, Rosenberg PA. The challenge of understanding cerebral white matter injury in the premature infant. Neuroscience. 2014 Sep 12; 276:216-38.
  13. Back SA, Rosenberg PA. Pathophysiology of glia in perinatal white matter injury. Glia. 2014 Nov; 62(11):1790-815.
  14. Skouta R, Dixon SJ, Wang J, Dunn DE, Orman M, Shimada K, Rosenberg PA, Lo DC, Weinberg JM, Linkermann A, Stockwell BR. Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J Am Chem Soc. 2014 Mar 26; 136(12):4551-6.
  15. Goodrich GS, Kabakov AY, Hameed MQ, Dhamne SC, Rosenberg PA, Rotenberg A. Ceftriaxone treatment after traumatic brain injury restores expression of the glutamate transporter, GLT-1, reduces regional gliosis, and reduces post-traumatic seizures in the rat. J Neurotrauma. 2013 Aug 15; 30(16):1434-41.
  16. Jensen MV, Haldeman JM, Zhang H, Lu D, Huising MO, Vale WW, Hohmeier HE, Rosenberg P, Newgard CB. Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion. J Biol Chem. 2013 Aug 9; 288(32):23128-40.
  17. Petr GT, Schultheis LA, Hussey KC, Sun Y, Dubinsky JM, Aoki C, Rosenberg PA. Decreased expression of GLT-1 in the R6/2 model of Huntington's disease does not worsen disease progression. Eur J Neurosci. 2013 Aug; 38(3):2477-90.
  18. Petr GT, Bakradze E, Frederick NM, Wang J, Armsen W, Aizenman E, Rosenberg PA. Glutamate transporter expression and function in a striatal neuronal model of Huntington's disease. Neurochem Int. 2013 Jun; 62(7):973-81.
  19. Rosenberg PB, Wong DF, Edell SL, Ross JS, Joshi AD, Brašic JR, Zhou Y, Raymont V, Kumar A, Ravert HT, Dannals RF, Pontecorvo MJ, Skovronsky DM, Lyketsos CG. Cognition and amyloid load in Alzheimer disease imaged with florbetapir F 18(AV-45) positron emission tomography. Am J Geriatr Psychiatry. 2013 Mar; 21(3):272-8.
  20. DeSilva TM, Borenstein NS, Volpe JJ, Kinney HC, Rosenberg PA. Expression of EAAT2 in neurons and protoplasmic astrocytes during human cortical development. J Comp Neurol. 2012 Dec 1; 520(17):3912-32.
  21. Kairaluoma P, Bachmann M, Kallio H, Rosenberg P, Pere P. Hyperbaric articaine with or without fentanyl in spinal anaesthesia: patient and observer blinded comparison. Acta Anaesthesiol Scand. 2013 Jan; 57(1):118-25.
  22. Shimizu E, Jong G, Partridge N, Rosenberg PA, Lin LM. Histologic observation of a human immature permanent tooth with irreversible pulpitis after revascularization/regeneration procedure. J Endod. 2012 Sep; 38(9):1293-7.
  23. Li T, Finch EA, Graham V, Zhang ZS, Ding JD, Burch J, Oh-hora M, Rosenberg P. STIM1-Ca(2+) signaling is required for the hypertrophic growth of skeletal muscle in mice. Mol Cell Biol. 2012 Aug; 32(15):3009-17.
  24. Chen MY, Chen KL, Chen CA, Tayebaty F, Rosenberg PA, Lin LM. Responses of immature permanent teeth with infected necrotic pulp tissue and apical periodontitis/abscess to revascularization procedures. Int Endod J. 2012 Mar; 45(3):294-305.
  25. Wang C, Hennessey JA, Kirkton RD, Wang C, Graham V, Puranam RS, Rosenberg PB, Bursac N, Pitt GS. Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts. Circ Res. 2011 Sep 16; 109(7):775-82.
  26. Volpe JJ, Kinney HC, Jensen FE, Rosenberg PA. Reprint of "The developing oligodendrocyte: key cellular target in brain injury in the premature infant". Int J Dev Neurosci. 2011 Oct; 29(6):565-82.
  27. Lin LM, Rosenberg PA. Repair and regeneration in endodontics. Int Endod J. 2011 Oct; 44(10):889-906.
  28. Volpe JJ, Kinney HC, Jensen FE, Rosenberg PA. The developing oligodendrocyte: key cellular target in brain injury in the premature infant. Int J Dev Neurosci. 2011 Jun; 29(4):423-40.
  29. DeSilva, T.M. Rosenberg, P.A. Glutamate receptors, transporters, and periventricular leukomalacia. Biology of Oligodendrocytes, Patricia Armati, editor. 2010; In Press.
  30. Kim S, Dayani L, Rosenberg PA, Li J. RIP1 kinase mediates arachidonic acid-induced oxidative death of oligodendrocyte precursors. Int J Physiol Pathophysiol Pharmacol. 2010; 2(2):137-47.
  31. Wong DF, Rosenberg PB, Zhou Y, Kumar A, Raymont V, Ravert HT, Dannals RF, Nandi A, Brasic JR, Ye W, Hilton J, Lyketsos C, Kung HF, Joshi AD, Skovronsky DM, Pontecorvo MJ. In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18). J Nucl Med. 2010 Jun; 51(6):913-20.
  32. Lin L, Chen MY, Ricucci D, Rosenberg PA. Guided tissue regeneration in periapical surgery. J Endod. 2010 Apr; 36(4):618-25.
  33. Rosenberg PA, Frisbie J, Lee J, Lee K, Frommer H, Kottal S, Phelan J, Lin L, Fisch G. Evaluation of pathologists (histopathology) and radiologists (cone beam computed tomography) differentiating radicular cysts from granulomas. J Endod. 2010 Mar; 36(3):423-8.
  34. Kim S, Dayani L, Rosenberg PA and Li J. RIP1 kinase mediates arachidonic acid-induced oxidative death of oligodendrocyte precursors. Int J Physiol Pathophysiol Pharmacol. 2010; 2:137-147.
  35. Rao V, Munro CA, Rosenberg P, Ward J, Bertrand M, Degoankar M, Horská A, Pham D, Yousem DM, Barker PB. Neuroanatomical correlates of depression in post traumatic brain injury: preliminary results of a pilot study. J Neuropsychiatry Clin Neurosci. 2010; 22(2):231-5.
  36. Rosenberg PA, Schindler WG, Krell KV, Hicks ML, Davis SB. Identify the endodontic treatment modalities. J Endod. 2009 Dec; 35(12):1675-94.
  37. Kabakov AY, Rosenberg PA. Evidence for change in current-flux coupling of GLT1 at high glutamate concentrations in rat primary forebrain neurons and GLT1a-expressing COS-7 cells. Eur J Neurosci. 2009 Jul; 30(2):186-95.
  38. Li J, Wang H, Rosenberg PA. Vitamin K prevents oxidative cell death by inhibiting activation of 12-lipoxygenase in developing oligodendrocytes. J Neurosci Res. 2009 Jul; 87(9):1997-2005.
  39. Gerstner B, Lee J, DeSilva TM, Jensen FE, Volpe JJ, Rosenberg PA. 17beta-estradiol protects against hypoxic/ischemic white matter damage in the neonatal rat brain. J Neurosci Res. 2009 Jul; 87(9):2078-86.
  40. DeSilva TM, Kabakov AY, Goldhoff PE, Volpe JJ, Rosenberg PA. Regulation of glutamate transport in developing rat oligodendrocytes. J Neurosci. 2009 Jun 17; 29(24):7898-908.
  41. Lin LM, Ricucci D, Lin J, Rosenberg PA. Nonsurgical root canal therapy of large cyst-like inflammatory periapical lesions and inflammatory apical cysts. J Endod. 2009 May; 35(5):607-15.
  42. Jafarzadeh H, Rosenberg PA. Pulse oximetry: review of a potential aid in endodontic diagnosis. J Endod. 2009 Mar; 35(3):329-33.
  43. DeSilva T.M., Kabakov A.Y., Goldhoff P.A., Volpe J.J., Rosenberg P.A. Regulation of glutamate transport in developing rat oligodendrocytes. Journal of Neuroscience. 2009; 29(24):7898-7908.
  44. Kabakov A.Y., Rosenberg P.A. . Evidence for change in current flux coupling of GLT1 at high glutamate concentrations in primary forebrain neurons and GLT1a expressing COS7 cells. European Journal of Science. 2009; 30(2):186-195.
  45. Li J, Ramenaden ER, Peng J, Koito H, Volpe JJ, Rosenberg PA. Tumor necrosis factor alpha mediates lipopolysaccharide-induced microglial toxicity to developing oligodendrocytes when astrocytes are present. J Neurosci. 2008 May 14; 28(20):5321-30.
  46. Desilva TM, Billiards SS, Borenstein NS, Trachtenberg FL, Volpe JJ, Kinney HC, Rosenberg PA. Glutamate transporter EAAT2 expression is up-regulated in reactive astrocytes in human periventricular leukomalacia. J Comp Neurol. 2008 May 10; 508(2):238-48.
  47. van Leyen K, Arai K, Jin G, Kenyon V, Gerstner B, Rosenberg PA, Holman TR, Lo EH. Novel lipoxygenase inhibitors as neuroprotective reagents. J Neurosci Res. 2008 Mar; 86(4):904-9.
  48. Vorkas CK, Gopinathan MK, Singh A, Devinsky O, Lin LM, Rosenberg PA. Epilepsy and dental procedures. A review. N Y State Dent J. 2008 Mar; 74(2):39-43.
  49. Gerstner B, DeSilva TM, Genz K, Armstrong A, Brehmer F, Neve RL, Felderhoff-Mueser U, Volpe JJ, Rosenberg PA. Hyperoxia causes maturation-dependent cell death in the developing white matter. J Neurosci. 2008 Jan 30; 28(5):1236-45.
  50. Bassan M, Liu H, Madsen KL, Armsen W, Zhou J, Desilva T, Chen W, Paradise A, Brasch MA, Staudinger J, Gether U, Irwin N, Rosenberg PA. Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1. Eur J Neurosci. 2008 Jan; 27(1):66-82.
  51. Lin LM, Lin J, Rosenberg PA. One-appointment endodontic therapy: biological considerations. J Am Dent Assoc. 2007 Nov; 138(11):1456-62.
  52. Zhang Y, Aizenman E, DeFranco DB, Rosenberg PA. Intracellular zinc release, 12-lipoxygenase activation and MAPK dependent neuronal and oligodendroglial death. Mol Med. 2007 Jul-Aug; 13(7-8):350-5.
  53. Gerstner B, Sifringer M, Dzietko M, Schüller A, Lee J, Simons S, Obladen M, Volpe JJ, Rosenberg PA, Felderhoff-Mueser U. Estradiol attenuates hyperoxia-induced cell death in the developing white matter. Ann Neurol. 2007 Jun; 61(6):562-73.
  54. Lu Y, Rosenberg PA. NMDA receptor-mediated extracellular adenosine accumulation is blocked by phosphatase 1/2A inhibitors. Brain Res. 2007 Jun 25; 1155:116-24.
  55. Desilva TM, Kinney HC, Borenstein NS, Trachtenberg FL, Irwin N, Volpe JJ, Rosenberg PA. The glutamate transporter EAAT2 is transiently expressed in developing human cerebral white matter. J Comp Neurol. 2007 Apr 20; 501(6):879-90.
  56. Lin LM, Huang GT, Rosenberg PA. Proliferation of epithelial cell rests, formation of apical cysts, and regression of apical cysts after periapical wound healing. J Endod. 2007 Aug; 33(8):908-16.
  57. Rosenberg PA. Treatment planning: a new paradigm. Eur J Dent. 2007 Apr; 1(2):65.
  58. Redman PT, He K, Hartnett KA, Jefferson BS, Hu L, Rosenberg PA, Levitan ES, Aizenman E. Apoptotic surge of potassium currents is mediated by p38 phosphorylation of Kv2.1. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3568-73.
  59. Rosenberg PA, Amin KG, Zibari Y, Lin LM. Comparison of 4% articaine with 1:100,000 epinephrine and 2% lidocaine with 1:100,000 epinephrine when used as a supplemental anesthetic. J Endod. 2007 Apr; 33(4):403-5.
  60. DeSilva, T.M. Kinney, H.C. Borenstein, N.S. Trachtenberg, F.L. Irwin, N. Volpe, J.J. Rosenberg, P.A. . The glutamate transporter EAAT2 is transiently expressed in developing human cerebral white matter . Journal of Comparative Neurology. 2007; 501:879-890.
  61. Arrigoni E, Rosenberg PA. Nitric oxide-induced adenosine inhibition of hippocampal synaptic transmission depends on adenosine kinase inhibition and is cyclic GMP independent. Eur J Neurosci. 2006 Nov; 24(9):2471-80.
  62. Kalinchuk AV, Lu Y, Stenberg D, Rosenberg PA, Porkka-Heiskanen T. Nitric oxide production in the basal forebrain is required for recovery sleep. J Neurochem. 2006 Oct; 99(2):483-98.
  63. Deng W, Neve RL, Rosenberg PA, Volpe JJ, Jensen FE. Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit composition and cAMP-response element-binding protein regulate oligodendrocyte excitotoxicity. J Biol Chem. 2006 Nov 24; 281(47):36004-11.
  64. Kalinchuk AV, Stenberg D, Rosenberg PA, Porkka-Heiskanen T. Inducible and neuronal nitric oxide synthases (NOS) have complementary roles in recovery sleep induction. Eur J Neurosci. 2006 Sep; 24(5):1443-56.
  65. Deng W, Yue Q, Rosenberg PA, Volpe JJ, Jensen FE. Oligodendrocyte excitotoxicity determined by local glutamate accumulation and mitochondrial function. J Neurochem. 2006 Jul; 98(1):213-22.
  66. Konhilas JP, Watson PA, Maass A, Boucek DM, Horn T, Stauffer BL, Luckey SW, Rosenberg P, Leinwand LA. Exercise can prevent and reverse the severity of hypertrophic cardiomyopathy. Circ Res. 2006 Mar 3; 98(4):540-8.
  67. Zhang Y, Wang H, Li J, Dong L, Xu P, Chen W, Neve RL, Volpe JJ, Rosenberg PA. Intracellular zinc release and ERK phosphorylation are required upstream of 12-lipoxygenase activation in peroxynitrite toxicity to mature rat oligodendrocytes. J Biol Chem. 2006 Apr 7; 281(14):9460-70.
  68. Arrigoni, E. Rosenberg, P.A. Nitric oxide-induced adenosine inhibition of hippocampal synaptic transmission depends on adenosine kinase inhibition and is cGMP independent. European Journal of Neuorscience. 2006; 24:2471-2480.
  69. Kalinchuk, A.V. Lu, Y. Stenberg, D. Rosenberg, P.A. Porkka-Heiskanen, T. Inducible and neuronal nitric oxide have complementary roles in homeostatic sleep regulation. Eur J Neurosci. 2006; 24(5):1443-1456.
  70. Deng, W. Neve, R.L. Rosenberg, P.A. Volpe, J.J. Jensen, F.E. AMPA receptor subunit composition and CREB regulate oligodendrocyte excitotoxicity. J Biol Chem. 2006; 281:36004-36011.
  71. Lin LM, Di Fiore PM, Lin J, Rosenberg PA. Histological study of periradicular tissue responses to uninfected and infected devitalized pulps in dogs. J Endod. 2006 Jan; 32(1):34-8.
  72. Berger UV, DeSilva TM, Chen W, Rosenberg PA. Cellular and subcellular mRNA localization of glutamate transporter isoforms GLT1a and GLT1b in rat brain by in situ hybridization. J Comp Neurol. 2005 Nov 7; 492(1):78-89.
  73. Stiber JA, Tabatabaei N, Hawkins AF, Hawke T, Worley PF, Williams RS, Rosenberg P. Homer modulates NFAT-dependent signaling during muscle differentiation. Dev Biol. 2005 Nov 15; 287(2):213-24.
  74. Li J, Baud O, Vartanian T, Volpe JJ, Rosenberg PA. Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes. Proc Natl Acad Sci U S A. 2005 Jul 12; 102(28):9936-41.
  75. Kalinchuk, A., Stenberg, D., Rosenberg, P.A., and Porkka-Heiskanen, T. On the role of cholinergic neurons of the basal forebrain in regulation of recovery sleep. Abstracts of the Associated Professional Sleep Societies 17th Annual Meeting. June 18-23, 2005. Denver, Colorado, USA. 2005.
  76. Du W, Stiber JA, Rosenberg PB, Meissner G, Eu JP. Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction. J Biol Chem. 2005 Jul 15; 280(28):26287-94.
  77. Akimoto T, Pohnert SC, Li P, Zhang M, Gumbs C, Rosenberg PB, Williams RS, Yan Z. Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway. J Biol Chem. 2005 May 20; 280(20):19587-93.
  78. Kabakov, A.Y. and Rosenberg, P.A. . The major glutamate transporter of the brain, GLT1, changes its stoichiometry. Biophysical Journal. 2005; 88(1, Part 2):25a.
  79. Lin LM, Rosenberg PA, Lin J. Do procedural errors cause endodontic treatment failure? J Am Dent Assoc. 2005 Feb; 136(2):187-93; quiz 231.
  80. Kabakov, A.Y. and Rosenberg, P.A. GLT1 enters a high throughput mode at synaptic concentrations of glutamate. Erice Symposium on Ion Channels and Transporters, Erice, Sicily. 2005.
  81. Zhang Y, Wang H, Li J, Jimenez DA, Levitan ES, Aizenman E, Rosenberg PA. Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation. J Neurosci. 2004 Nov 24; 24(47):10616-27.
  82. Le M, Lu Y, Li Y, Greene RW, Epstein PM, Rosenberg PA. Zaprinast stimulates extracellular adenosine accumulation in rat pontine slices. Neurosci Lett. 2004 Nov 16; 371(1):12-7.
  83. Zhang Y, Rosenberg PA. Caspase-1 and poly (ADP-ribose) polymerase inhibitors may protect against peroxynitrite-induced neurotoxicity independent of their enzyme inhibitor activity. Eur J Neurosci. 2004 Oct; 20(7):1727-36.
  84. Baud O, Li J, Zhang Y, Neve RL, Volpe JJ, Rosenberg PA. Nitric oxide-induced cell death in developing oligodendrocytes is associated with mitochondrial dysfunction and apoptosis-inducing factor translocation. Eur J Neurosci. 2004 Oct; 20(7):1713-26.
  85. Wang H, Li J, Follett PL, Zhang Y, Cotanche DA, Jensen FE, Volpe JJ, Rosenberg PA. 12-Lipoxygenase plays a key role in cell death caused by glutathione depletion and arachidonic acid in rat oligodendrocytes. Eur J Neurosci. 2004 Oct; 20(8):2049-58.
  86. Folkerth RD, Haynes RL, Borenstein NS, Belliveau RA, Trachtenberg F, Rosenberg PA, Volpe JJ, Kinney HC. Developmental lag in superoxide dismutases relative to other antioxidant enzymes in premyelinated human telencephalic white matter. J Neuropathol Exp Neurol. 2004 Sep; 63(9):990-9.
  87. Baud O, Haynes RF, Wang H, Folkerth RD, Li J, Volpe JJ, Rosenberg PA. Developmental up-regulation of MnSOD in rat oligodendrocytes confers protection against oxidative injury. Eur J Neurosci. 2004 Jul; 20(1):29-40.
  88. Rosenberg P, Hawkins A, Stiber J, Shelton JM, Hutcheson K, Bassel-Duby R, Shin DM, Yan Z, Williams RS. TRPC3 channels confer cellular memory of recent neuromuscular activity. Proc Natl Acad Sci U S A. 2004 Jun 22; 101(25):9387-92.
  89. Deng W, Wang H, Rosenberg PA, Volpe JJ, Jensen FE. Role of metabotropic glutamate receptors in oligodendrocyte excitotoxicity and oxidative stress. Proc Natl Acad Sci U S A. 2004 May 18; 101(20):7751-6.
  90. Dietze EC, Troch MM, Bean GR, Heffner JB, Bowie ML, Rosenberg P, Ratliff B, Seewaldt VL. Tamoxifen and tamoxifen ethyl bromide induce apoptosis in acutely damaged mammary epithelial cells through modulation of AKT activity. Oncogene. 2004 May 6; 23(21):3851-62.
  91. Follett PL, Deng W, Dai W, Talos DM, Massillon LJ, Rosenberg PA, Volpe JJ, Jensen FE. Glutamate receptor-mediated oligodendrocyte toxicity in periventricular leukomalacia: a protective role for topiramate. J Neurosci. 2004 May 5; 24(18):4412-20.
  92. Lu Y, Li Y, Herin GA, Aizenman E, Epstein PM, Rosenberg PA. Elevation of intracellular cAMP evokes activity-dependent release of adenosine in cultured rat forebrain neurons. Eur J Neurosci. 2004 May; 19(10):2669-81.
  93. Inoue M, LeGeros RZ, Hoffman C, Diamond K, Rosenberg PA, Craig RG. Effect of enamel matrix proteins on the phenotype expression of periodontal ligament cells cultured on dental materials. J Biomed Mater Res A. 2004 Apr 1; 69(1):172-9.
  94. Craig RG, Kallur SP, Inoue M, Rosenberg PA, LeGeros RZ. Effect of enamel matrix proteins on the periodontal connective tissue-material interface after wound healing. J Biomed Mater Res A. 2004 Apr 1; 69(1):180-7.
  95. McCutcheon JA, Yee H, Hayashi R, Licari B, Lombardo D, Rosenberg PA, Phelan J. Identification of gammadeltaT lymphocytes in human periapical lesions. Oral Microbiol Immunol. 2004 Apr; 19(2):106-10.
  96. Baud O, Greene AE, Li J, Wang H, Volpe JJ, Rosenberg PA. Glutathione peroxidase-catalase cooperativity is required for resistance to hydrogen peroxide by mature rat oligodendrocytes. J Neurosci. 2004 Feb 18; 24(7):1531-40.
  97. Kabakov, A.Y. and Rosenberg, P.A. GLT1 is the major electrogenic glutamate transporter in cultured rat neurons. Biophysical Journal. 2004; v. 86 (1, Part 2):613a.
  98. Chen W, Mahadomrongkul V, Berger UV, Bassan M, DeSilva T, Tanaka K, Irwin N, Aoki C, Rosenberg PA. The glutamate transporter GLT1a is expressed in excitatory axon terminals of mature hippocampal neurons. J Neurosci. 2004 Feb 4; 24(5):1136-48.
  99. DeSilva, T.M., Goldhoff, P.E., Kinney, H.C., Volpe, J.J. and Rosenberg, P.A. Modulation of expression of the glutamate transporter GLT1/EAAT2 may be involved in the pathogenesis of PVL . Program No. 503.20. 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. 2004; Online.
  100. Baud, O., Greene, A.E., Li, J., Wang, H., Volpe, J.J., and Rosenberg, P.A. . Glutathione peroxidase-catalase cooperativity is required for resistance to hydrogen peroxide by mature rat oligodendrocytes. Journal of Neuroscience. 2004; 24:1531-1540.
  101. Bassan, M., Liu, H., Chen, W., Madsen, K.L., Gether, U., Irwin N. and Rosenberg, P.A. Interaction of the glutamate transporter GLT1b with the PDZ protein PICK1 and GLT1a. Program No. 503.16. 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. 2004; Online.
  102. Chen, W., Mahadomrongkul, V., Berger, U.V., Bassan, M., DeSilva, T., Tanaka, K., Irwin, N., Aoki, C., Rosenberg, P.A. The glutamate transporter GLT1a is expressed in excitatory axon terminals of mature hippocampal neurons. Journal of Neuroscience. 2004; 24:1136-1148.
  103. Zhang, Y., Wang, H., Li, J., Jiminez, D.A., Levitan, E.S., Aizenman, E., and Rosenberg, P.A. Peroxynitrite induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation. Journal of Neuroscience. 2004; 24:10616-10627.
  104. Deng, W., Rosenberg, P.A., Volpe, J.J., and Jensen, F.E. . Novel role of MGluRs in oligodendrocyte excitotoxicity and oxidative stress. Proceedings of the National Academy of Science USA. 2004; 101:7751-7756.
  105. Zhang, Y., Wang, H., Li, J., Dong, L., Volpe, J.J. and Rosenberg, P.A. Zinc release and 12-lipoxygenase activation are required for peroxynitrite-induced toxicity to mature oligodendrocytes . Program No. 806.19. 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. 2004; Online.
  106. Zhang, Y. and Rosenberg, P.A. . Caspase-1 and poly (ADP-ribose) polymerase inhibitors protect against peroxynitrite-induced neurotoxicity by a direct scavenging effect. European Journal of Neuroscience. 2004; 20:1727-1736.
  107. Deng, W., Rosenberg, P.A., Volpe, J.J. and Jensen, F.E. Oligodendrocyte excitotoxicity determined by glutamate diffusion and Glur2-free AMPA receptors . Program No. 919.14. 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. 2004; Online.
  108. Follett, P.L., Deng, W., Dai, W., Talos, D., Massillon, L., and Rosenberg, P.A., Volpe, J.J., and Jensen, F.E. Glutamate receptor mediated oligodendrocyte toxicity in periventricular leukomalacia: a protective role for topiramate. Journal of Neuroscience. 2004; 24:4412-4420.
  109. Baud, O., Li, J., Zhang, Y., Neve, R.L., Volpe, J.J., and Rosenberg, P.A. . Nitric oxide induces cell death through mitochondrial dysfunction and Apoptosis-Inducing Factor translocation in developing oligodendrocytes. European Journal of Neuroscience. 2004; 20:1713-1726.
  110. Lu, Y., Li, Y., Herin, G.A., Aizenman, E., Epstein, P.M., Rosenberg, P.A. . Elevation of intracellular cyclic AMP evokes activity dependent release of adenosine in cultured rat forebrain neurons. European Journal of Neuroscience. 2004; 19:2669-2681.
  111. Baud, O., Haynes, R.L., Wang, H., Folkerth, R.D., Li, J., Volpe, J.J., and Rosenberg, P.A. Developmental upregulation of MnSOD in rat oligodendrocytes confers protection against oxidative toxicity. European Journal of Neuroscience. 2004; 20:29-40.
  112. Kalinchuk, A.V., Stenberg, D., Rosenberg, P.A. and Porkka-Heiskanen, T. On the role of neuronal and inducible nitric oxide synthases in regulation of sleep need . Program No. 78.5. 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. 2004; Online.
  113. Li J, Lin JC, Wang H, Peterson JW, Furie BC, Furie B, Booth SL, Volpe JJ, Rosenberg PA. Novel role of vitamin k in preventing oxidative injury to developing oligodendrocytes and neurons. J Neurosci. 2003 Jul 2; 23(13):5816-26.
  114. Lehnardt S, Massillon L, Follett P, Jensen FE, Ratan R, Rosenberg PA, Volpe JJ, Vartanian T. Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway. Proc Natl Acad Sci U S A. 2003 Jul 8; 100(14):8514-9.
  115. Kalinchuk, A.V., Hokkanen, M.-E., Stenberg, D., Rosenberg, P.A., and Porkka-Heiskanen, T. The role of nitric oxide in regulation of sleep need. Abstracts of the Associated Professional Sleep Societies 17th Annual Meeting. June 3-8, 2003. Chicago, Illinois, USA. 2003.
  116. Deng W, Rosenberg PA, Volpe JJ, Jensen FE. Calcium-permeable AMPA/kainate receptors mediate toxicity and preconditioning by oxygen-glucose deprivation in oligodendrocyte precursors. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6801-6.
  117. Haynes RL, Folkerth RD, Keefe RJ, Sung I, Swzeda LI, Rosenberg PA, Volpe JJ, Kinney HC. Nitrosative and oxidative injury to premyelinating oligodendrocytes in periventricular leukomalacia. J Neuropathol Exp Neurol. 2003 May; 62(5):441-50.
  118. Lu Y, Chung HJ, Li Y, Rosenberg PA. NMDA receptor-mediated extracellular adenosine accumulation in rat forebrain neurons in culture is associated with inhibition of adenosine kinase. Eur J Neurosci. 2003 Mar; 17(6):1213-22.
  119. Rosenberg PA, Dai W, Gan XD, Ali S, Fu J, Back SA, Sanchez RM, Segal MM, Follett PL, Jensen FE, Volpe JJ. Mature myelin basic protein-expressing oligodendrocytes are insensitive to kainate toxicity. J Neurosci Res. 2003 Jan 15; 71(2):237-45.
  120. Goldhoff, P.A., DeSilva, T.M. and Rosenberg P.A. Transient expression of the glutamate transporter GLT1a in cerebral white matter of the developing rat brain . Program No. 372.9. 2003 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. 2003; Online.
  121. Deng, W., Rosenberg, P.A., Volpe, J.J., Jensen, F.E. . AMPA/KA receptor mediated excitotoxicity induced by oxygen-glucose deprivation in cultured oligodendrocyte lineage cells. Proceedings of the National Academy of Science USA. 2003; 100:6801-6806.
  122. Bassan, M., Liu, H., Chen, W., Brasch, M., Irwin, N., and Rosenberg, P.A. Interaction of GLT1b with the synaptic protein PICK1. Gordon Conference: Excitatory Amino Acids and Brain Function, Mt. Holyoke, MA. 2003.
  123. Li, J., Lin, J. C., Wang, H., Peterson, J. W., Furie, B. C., Furie, B., Booth, S. L., Volpe, J. J., Rosenberg, P. A. . Novel role of vitamin K in preventing oxidative injury to developing oligodendrocytes and neurons. Journal of Neuroscience. 2003; 23:5816-5826.
  124. Kalinchuk, A.V., Hokkanen, M., Stenberg, D., Rosenberg, P.A. and Porkka-Heiskanen T. Nitric oxide: does it mediate effects of prolonged wakefulness? . Program No. 616.14. 2003 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. 2003; Online.
  125. Haynes, R.L., Rosenberg, P.A., Folkerth, R.D., Volpe, J.J. and Kinney, H.C. Expression of inducible nitric oxide synthase and endothelial nitric oxide synthase in reactive astrocytes in human periventricular leukomalacia. Program No. 352.17. 2003 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. 2003; Online.
  126. Bassan, M., Liu, H., Chen, W., Irwin, N. and Rosenberg, P.A. Functional interaction of GLT1b, a variant form of the glutamate transporter GLT1, with PICK1 . Program No. 372.8. 2003 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. 2003; Online.
  127. Mott JA, Treadwell TA, Hennessy TW, Rosenberg PA, Wolfe MI, Brown CM, Butler JC. Call-tracking data and the public health response to bioterrorism-related anthrax. Emerg Infect Dis. 2002 Oct; 8(10):1088-92.
  128. Zhang Y, Rosenberg PA. The essential nutrient pyrroloquinoline quinone may act as a neuroprotectant by suppressing peroxynitrite formation. Eur J Neurosci. 2002 Sep; 16(6):1015-24.
  129. Lehnardt S, Lachance C, Patrizi S, Lefebvre S, Follett PL, Jensen FE, Rosenberg PA, Volpe JJ, Vartanian T. The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS. J Neurosci. 2002 Apr 1; 22(7):2478-86.
  130. Chen W, Aoki C, Mahadomrongkul V, Gruber CE, Wang GJ, Blitzblau R, Irwin N, Rosenberg PA. Expression of a variant form of the glutamate transporter GLT1 in neuronal cultures and in neurons and astrocytes in the rat brain. J Neurosci. 2002 Mar 15; 22(6):2142-52.
  131. Mahadomrongkul, V., Aoki, C. and Rosenberg, P.A. The glutamate transporter GLT1b & PICK1 both localize to pre- and post-synaptic processes of pyramidal neurons as well as astrocytes of intact adult rat. Program No. 44.7. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. 2002; Online.
  132. Lehnardt, S., Lachance, C., Patrizi, S., Lefebvre, S., Follett, P.L., Jensen, F.E., Rosenberg, P.A., Volpe, J.J., and Vartanian, T. . The toll-like receptor TL4 is necessary for lipopolysaccharide-induced oligodendrocytre injury in the CNS. Journal of Neuroscience. 2002; 22:2478-2486.
  133. Chen, W., Aoki, C., Mahadomrongkul, V., Gruber, C.E., Wang, G.J., Blitzblau, R., Irwin, N., and Rosenberg, P.A. . Expression of a variant form of the glutamate transporter GLT1 in neuronal cultures and in neurons and astrocytes in the rat brain. Journal of Neuroscience. 2002; 22:2142-2152.
  134. Andreeva SG, Dikkes P, Epstein PM, Rosenberg PA. Expression of cGMP-specific phosphodiesterase 9A mRNA in the rat brain. J Neurosci. 2001 Nov 15; 21(22):9068-76.
  135. Wu H, Rothermel B, Kanatous S, Rosenberg P, Naya FJ, Shelton JM, Hutcheson KA, DiMaio JM, Olson EN, Bassel-Duby R, Williams RS. Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway. EMBO J. 2001 Nov 15; 20(22):6414-23.
  136. Nup C, Rosenberg P, Linke H, Tordik P. Quantitation of catecholamines in inflamed human dental pulp by high-performance liquid chromatography. J Endod. 2001 Feb; 27(2):73-5.
  137. Chen, W., Aoki, C., Brasch, M., Irwin, N. and Rosenberg, P.A. A variant form of the glutamate transporter GLT1 interacts with the PDZ protein PICK1 in rat forebrain. Program No. 607.4. 2001 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. 2001; Online.
  138. Andreeva, S.G., Dikkes, P., Epstein, P.M., and Rosenberg, P.A. Expression of cGMP specific phosphodiesterase 9a mRNA in the rat brain. Journal of Neuroscience. 2001; 21:9068-9076.
  139. Follett PL, Rosenberg PA, Volpe JJ, Jensen FE. NBQX attenuates excitotoxic injury in developing white matter. J Neurosci. 2000 Dec 15; 20(24):9235-41.
  140. Sinor JD, Du S, Venneti S, Blitzblau RC, Leszkiewicz DN, Rosenberg PA, Aizenman E. NMDA and glutamate evoke excitotoxicity at distinct cellular locations in rat cortical neurons in vitro. J Neurosci. 2000 Dec 1; 20(23):8831-7.
  141. Panigrahy A, Rosenberg PA, Assmann S, Foley EC, Kinney HC. Differential expression of glutamate receptor subtypes in human brainstem sites involved in perinatal hypoxia-ischemia. J Comp Neurol. 2000 Nov 13; 427(2):196-208.
  142. Rosenberg PA, Li Y, Le M, Zhang Y. Nitric oxide-stimulated increase in extracellular adenosine accumulation in rat forebrain neurons in culture is associated with ATP hydrolysis and inhibition of adenosine kinase activity. J Neurosci. 2000 Aug 15; 20(16):6294-301.
  143. Sanchez RM, Wang C, Gardner G, Orlando L, Tauck DL, Rosenberg PA, Aizenman E, Jensen FE. Novel role for the NMDA receptor redox modulatory site in the pathophysiology of seizures. J Neurosci. 2000 Mar 15; 20(6):2409-17.
  144. Rosenberg, P.A., Le, M., and Li Y. Nitric oxide stimulated increase in extracellular adenosine accumulation in rat forebrain neurons in culture is associated with ATP hydrolysis and inhibition of adenosine kinase activity. Journal of Neuroscience. 2000; 20:6294-6301.
  145. Sanchez, R.M., Wang, C., Gardner, G., Orlando, L., Tauck, D.L., Rosenberg, P.A., Aizenman, E., and Jensen, F.J. Novel role for the NMDA receptor redox modulatory site in the pathophysiology of seizures. Journal of Neuroscience. 2000; 20:2409-2417.
  146. Sinor, J.D., Du, S., Venneti, S., Blitzblau, R.C., Leszkiewicz, D.N., Rosenberg, P.A., and Aizenman, E. . NMDA and glutamate evoke excitotoxicity at distinct cellular locations in rat cortical neurons in vitro. Journal of Neuroscience. 2000; 20:8831-8837.
  147. Follett, P.L., Rosenberg, P.A., Volpe, J.J., and Jensen, F.E. . NBQX attenuates excitotoxicity in developing oligodendrocytes in vivo. Journal of Neuroscience. 2000; 20:9235-9241.
  148. Nup C, Boylan R, Bhagat R, Ippolito G, Ahn SH, Erakin C, Rosenberg PA. An evaluation of resin-ionomers to prevent coronal microleakage in endodontically treated teeth. J Clin Dent. 2000; 11(1):16-9.
  149. Back SA, Khan R, Gan X, Rosenberg PA, Volpe JJ. A new Alamar Blue viability assay to rapidly quantify oligodendrocyte death. J Neurosci Methods. 1999 Sep 15; 91(1-2):47-54.
  150. Rosenberg PA, Li Y, Ali S, Altiok N, Back SA, Volpe JJ. Intracellular redox state determines whether nitric oxide is toxic or protective to rat oligodendrocytes in culture. J Neurochem. 1999 Aug; 73(2):476-84.
  151. Benowitz LI, Jing Y, Tabibiazar R, Jo SA, Petrausch B, Stuermer CA, Rosenberg PA, Irwin N. Axon outgrowth is regulated by an intracellular purine-sensitive mechanism in retinal ganglion cells. J Biol Chem. 1998 Nov 6; 273(45):29626-34.
  152. Back SA, Gan X, Li Y, Rosenberg PA, Volpe JJ. Maturation-dependent vulnerability of oligodendrocytes to oxidative stress-induced death caused by glutathione depletion. J Neurosci. 1998 Aug 15; 18(16):6241-53.
  153. Wang GJ, Chung HJ, Schnuer J, Lea E, Robinson MB, Potthoff WK, Aizenman E, Rosenberg PA. Dihydrokainate-sensitive neuronal glutamate transport is required for protection of rat cortical neurons in culture against synaptically released glutamate. Eur J Neurosci. 1998 Aug; 10(8):2523-31.
  154. Rosenberg PA, Babick PJ, Schertzer L, Leung A. The effect of occlusal reduction on pain after endodontic instrumentation. J Endod. 1998 Jul; 24(7):492-6.
  155. Aizenman E, Brimecombe JC, Potthoff WK, Rosenberg PA. Why is the role of nitric oxide in NMDA receptor function and dysfunction so controversial? Prog Brain Res. 1998; 118:53-71.
  156. Wang GJ, Chung HJ, Schnuer J, Pratt K, Zable AC, Kavanaugh MP, Rosenberg PA. High affinity glutamate transport in rat cortical neurons in culture. Mol Pharmacol. 1998 Jan; 53(1):88-96.
  157. Aizenman, E., Brimecombe, J.C., Potthoff, W.K., and Rosenberg, P.A. . Why is the role of nitric oxide in NMDA receptor function and dysfunction so controversial?. Progress in Neurobiology. 1998; 18:53-71.
  158. Back, S.A., Gan, D., Li, Y., Rosenberg, P.A., and Volpe, J.J. . Maturation-dependent vulnerability of oligodendrocytes to oxidative stress-induced death caused by glutathione depletion. Journal of Neuroscience. 1998; 18:6241-6253.
  159. Craig RG, Zuroff M, Rosenberg PA. The effect of endodontic materials on periodontal ligament cell proliferation, alkaline phosphatase activity, and extracellular matrix protein synthesis in vitro. J Endod. 1997 Aug; 23(8):494-8.
  160. Wang TF, Rosenberg PA, Guidotti G. Characterization of brain ecto-apyrase: evidence for only one ecto-apyrase (CD39) gene. Brain Res Mol Brain Res. 1997 Jul; 47(1-2):295-302.
  161. Hartnett KA, Stout AK, Rajdev S, Rosenberg PA, Reynolds IJ, Aizenman E. NMDA receptor-mediated neurotoxicity: a paradoxical requirement for extracellular Mg2+ in Na+/Ca2+-free solutions in rat cortical neurons in vitro. J Neurochem. 1997 May; 68(5):1836-45.
  162. Kahn FH, Rosenberg PA, Schertzer L, Korthals G, Nguyen PN. An in-vitro evaluation of sealer placement methods. Int Endod J. 1997 May; 30(3):181-6.
  163. Rosenberg, P.A. Potential therapeutic intervention following hypoxic/ischemic insult. Mental Retardation and Developmental Disabilities Reviews. 1997; 3:76-84.
  164. Churchwell KB, Wright SH, Emma F, Rosenberg PA, Strange K. NMDA receptor activation inhibits neuronal volume regulation after swelling induced by veratridine-stimulated Na+ influx in rat cortical cultures. J Neurosci. 1996 Dec 1; 16(23):7447-57.
  165. Blitzblau R, Gupta S, Djali S, Robinson MB, Rosenberg PA. The glutamate transport inhibitor L-trans-pyrrolidine-2,4-dicarboxylate indirectly evokes NMDA receptor mediated neurotoxicity in rat cortical cultures. Eur J Neurosci. 1996 Sep; 8(9):1840-52.
  166. Pawlikowska L, Cottrell SE, Harms MB, Li Y, Rosenberg PA. Extracellular synthesis of cADP-ribose from nicotinamide-adenine dinucleotide by rat cortical astrocytes in culture. J Neurosci. 1996 Sep 1; 16(17):5372-81.
  167. Yonezawa M, Back SA, Gan X, Rosenberg PA, Volpe JJ. Cystine deprivation induces oligodendroglial death: rescue by free radical scavengers and by a diffusible glial factor. J Neurochem. 1996 Aug; 67(2):566-73.
  168. Rosenberg PA, Li Y. Forskolin evokes extracellular adenosine accumulation in rat cortical cultures. Neurosci Lett. 1996 Jun 14; 211(1):49-52.
  169. Kahn FH, Rosenberg PA, Schulman A, Pines M. Comparison of fatigue for three prefabricated threaded post systems. J Prosthet Dent. 1996 Feb; 75(2):148-53.
  170. Pawlikowska, L., Cottrell, S.E., Harms, M.B., and Rosenberg, P.A. . Extracellular synthesis of cyclic adenosine diphospho-ribose from NAD by rat cortical astrocytes in culture. Journal of Neuroscience. 1996; 16:5372-5381.
  171. Churchwell, K.B., Emma, F., Rosenberg, P.A., and Strange, K. . NMDA receptor activation inhibits neuronal volume regulation following swelling induced by veratridine-stimulated sodium influx in rat cortical cultures. Journal of Neuroscience. 1996; 16:7447-7457.
  172. Blitzblau, R., Gupta, S., Djali, S., Robinson, M.B., and Rosenberg, P.A. The glutamate transport inhibitor l-trans-pyrrolidine-2,4-dicarboxylate evokes NMDA receptor mediated neurotoxicity in rat cortical cultures. European Journal of Neuroscience. 1996; 8:1840-1852.
  173. Paavola A, Yliruusi J, Kajimoto Y, Kalso E, Wahlström T, Rosenberg P. Controlled release of lidocaine from injectable gels and efficacy in rat sciatic nerve block. Pharm Res. 1995 Dec; 12(12):1997-2002.
  174. Rosenberg PA, Li Y. Vasoactive intestinal peptide regulates extracellular adenosine levels in rat cortical cultures. Neurosci Lett. 1995 Nov 17; 200(2):93-6.
  175. Rosenberg PA, Li Y. Adenylyl cyclase activation underlies intracellular cyclic AMP accumulation, cyclic AMP transport, and extracellular adenosine accumulation evoked by beta-adrenergic receptor stimulation in mixed cultures of neurons and astrocytes derived from rat cerebral cortex. Brain Res. 1995 Sep 18; 692(1-2):227-32.
  176. Schachman MA, Rosenberg PA, Linke HA. Quantitation of catecholamines in uninflamed human dental pulp tissues by high-performance liquid chromatography. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Jul; 80(1):83-6.
  177. Ueno E, Rosenberg P. beta-Bungarotoxin blocks phorbol ester-stimulated phosphorylation of MARCKS, GAP-43 and synapsin I in rat brain synaptosomes. Toxicon. 1995 Jun; 33(6):747-62.
  178. Kahn FH, Rosenberg PA, Gliksberg J. An in vitro evaluation of the irrigating characteristics of ultrasonic and subsonic handpieces and irrigating needles and probes. J Endod. 1995 May; 21(5):277-80.
  179. Newcomer TA, Rosenberg PA, Aizenman E. Iron-mediated oxidation of 3,4-dihydroxyphenylalanine to an excitotoxin. J Neurochem. 1995 Apr; 64(4):1742-8.
  180. Newcomer TA, Rosenberg PA, Aizenman E. TOPA quinone, a kainate-like agonist and excitotoxin is generated by a catecholaminergic cell line. J Neurosci. 1995 Apr; 15(4):3172-7.
  181. Newcomer, T.A., Rosenberg, P.A., and Aizenman, E. . Topa quinone, a kainate-like agonist and excitotoxin, is generated by a catecholaminergic cell line. Journal of Neuroscience. 1995; 15:3172-3177.
  182. Wong WS, Rosenberg PA, Boylan RJ, Schulman A. A comparison of the apical seals achieved using retrograde amalgam fillings and the Nd:YAG laser. J Endod. 1994 Dec; 20(12):595-7.
  183. Speliotes EK, Hartnett KA, Blitzblau RC, Aizenman E, Rosenberg PA. Comparison of the potency of competitive NMDA antagonists against the neurotoxicity of glutamate and NMDA. J Neurochem. 1994 Sep; 63(3):879-85.
  184. Jensen FE, Gardner GJ, Williams AP, Gallop PM, Aizenman E, Rosenberg PA. The putative essential nutrient pyrroloquinoline quinone is neuroprotective in a rodent model of hypoxic/ischemic brain injury. Neuroscience. 1994 Sep; 62(2):399-406.
  185. Rosenberg PA, Knowles R, Knowles KP, Li Y. Beta-adrenergic receptor-mediated regulation of extracellular adenosine in cerebral cortex in culture. J Neurosci. 1994 May; 14(5 Pt 2):2953-65.
  186. Lipton SA, Rosenberg PA. Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med. 1994 Mar 3; 330(9):613-22.
  187. Aizenman E, Jensen FE, Gallop PM, Rosenberg PA, Tang LH. Further evidence that pyrroloquinoline quinone interacts with the N-methyl-D-aspartate receptor redox site in rat cortical neurons in vitro. Neurosci Lett. 1994 Feb 28; 168(1-2):189-92.
  188. Kimbro KS, Rosenberg PA, Saavedra RA. Box I and II motif from myelin basic protein gene promoter binds to nuclear proteins from rodent brain. J Mol Neurosci. 1994; 5(1):27-37.
  189. Aizenman, E., Jensen, F.E., Gallop, P.M., Rosenberg, P.A., and Tang, L.H. Further evidence that pyrroloquinoline quinone interacts with the NMDA receptor redox modulatory site. Neuroscience Letters. 1994; 168:189-192.
  190. Rosenberg, P.A., Knowles, R., Knowles, K.P., and Li Y. . Beta-adrenergic receptor mediated regulation of extracellular adenosine in cerebral cortex in culture. Journal of Neuroscience. 1994; 14:2953-2965.
  191. Kimbro, K.S., Rosenberg, P.A., and Saavedra, R.A. . Box I and II motif from myelin basic protein gene promoter binds specifically to nuclear proteins from rodent brain. Journal of Molecular Neuroscience. 1994; 5:27-37.
  192. Jensen, F.E., Gardner, G.J., Williams, A., Gallop, P.M., Aizenman, E., and Rosenberg, P.A. . The putative essential nutrient pyrroloquinoline quinone is a neuroprotectant in a rodent stroke model. Neuroscience. 1994; 62:339-406.
  193. Jacobs GD, Rosenberg PA, Friedman R, Matheson J, Peavy GM, Domar AD, Benson H. Multifactor behavioral treatment of chronic sleep-onset insomnia using stimulus control and the relaxation response. A preliminary study. Behav Modif. 1993 Oct; 17(4):498-509.
  194. Newcomer TA, Palmer AM, Rosenberg PA, Aizenman E. Nonenzymatic conversion of 3,4-dihydroxyphenylalanine to 2,4,5-trihydroxyphenylalanine and 2,4,5-trihydroxyphenylalanine quinone in physiological solutions. J Neurochem. 1993 Sep; 61(3):911-20.
  195. Oka A, Belliveau MJ, Rosenberg PA, Volpe JJ. Vulnerability of oligodendroglia to glutamate: pharmacology, mechanisms, and prevention. J Neurosci. 1993 Apr; 13(4):1441-53.
  196. Harris KM, Rosenberg PA. Localization of synapses in rat cortical cultures. Neuroscience. 1993 Mar; 53(2):495-508.
  197. Shina R, Crain RC, Rosenberg P, Condrea E. The asymmetric distribution of phosphatidylcholine in rat brain synaptic plasma membranes. Neurochem Int. 1993 Feb; 22(2):189-95.
  198. Harris, K.M. and Rosenberg, P.A. . Localization of synapses in rat cerebral cortex in dissociated cell culture. Neuroscience. 1993; 53:495-508.
  199. Oka, A., Belliveau, M.J., Rosenberg, P.A., and Volpe, J.J. . Vulnerability of oligodendroglia to glutamate: pharmacology, mechanisms, and prevention. Journal of Neuroscience. 1993; 13:1441-1453.
  200. Newcomer, T.A., Palmer, A.M., Rosenberg, P.A., and Aizenman, E. . Non-enzymatic conversion of 3,4-dihydroxyphenylalanine (DOPA) to 2,4,5-trihydroxyphenylalanine (TOPA) and TOPA quinone in physiological solutions. Journal of Neurochemistry. 1993; 61:911-920.
  201. Ramnath RR, Strange K, Rosenberg PA. Neuronal injury evoked by depolarizing agents in rat cortical cultures. Neuroscience. 1992 Dec; 51(4):931-9.
  202. Ueno E, Rosenberg P. Inhibition of phosphorylation of synapsin I and other synaptosomal proteins by beta-bungarotoxin, a phospholipase A2 neurotoxin. J Neurochem. 1992 Dec; 59(6):2030-9.
  203. Paul A. Rosenberg. Controlling glutamine/glutamate related neuronal injury. 1992.
  204. Ghassemi A, Rosenberg P. Effects of snake venom phospholipase A2 toxins (beta-bungarotoxin, notexin) and enzymes (Naja naja atra, Naja nigricollis) on aminophospholipid asymmetry in rat cerebrocortical synaptosomes. Biochem Pharmacol. 1992 Sep 25; 44(6):1073-83.
  205. Aizenman E, Boeckman FA, Rosenberg PA. Glutathione prevents 2,4,5-trihydroxyphenylalanine excitotoxicity by maintaining it in a reduced, non-active form. Neurosci Lett. 1992 Sep 14; 144(1-2):233-6.
  206. Elias Aizenman, Paul M. Gallop, and Paul A. Rosenberg. Method of resisting neurodegenerative disorders. 1992.
  207. Elias Aizenman, Paul M. Gallop, and Paul A. Rosenberg. Method of resisting neurodegenerative disorders. 1992.
  208. Rosenberg PA. Functional significance of cyclic AMP secretion in cerebral cortex. Brain Res Bull. 1992 Sep-Oct; 29(3-4):315-8.
  209. Aizenman E, Hartnett KA, Zhong C, Gallop PM, Rosenberg PA. Interaction of the putative essential nutrient pyrroloquinoline quinone with the N-methyl-D-aspartate receptor redox modulatory site. J Neurosci. 1992 Jun; 12(6):2362-9.
  210. Rosenberg PA, Amin S, Leitner M. Glutamate uptake disguises neurotoxic potency of glutamate agonists in cerebral cortex in dissociated cell culture. J Neurosci. 1992 Jan; 12(1):56-61.
  211. Rosenberg, P.A., Amin, S., and Leitner, M. . Glutamate uptake disguises neurotoxic potency of glutamate agonists in cerebral cortex in dissociated cell culture. Journal of Neuroscience. 1992; 12:56-61.
  212. Aizenman, E.A., Hartnett, K.A., Zhong, C., Gallop, P.M., and Rosenberg, P.A. . Interaction of the putative essential nutrient pyrroloquinoline quinone with the N-methyl-D-aspartate receptor redox modulatory site. Journal of Neuroscience. 1992; 12:2362-2369.
  213. Rosenberg PA, Loring R, Xie Y, Zaleskas V, Aizenman E. 2,4,5-trihydroxyphenylalanine in solution forms a non-N-methyl-D-aspartate glutamatergic agonist and neurotoxin. Proc Natl Acad Sci U S A. 1991 Jun 1; 88(11):4865-9.
  214. Rosenberg PA. Accumulation of extracellular glutamate and neuronal death in astrocyte-poor cortical cultures exposed to glutamine. Glia. 1991; 4(1):91-100.
  215. Rosenberg, P.A., Loring, R., Xie Y., Zaleskas, V., and Aizenman, E. . 2,4,5-Trihydroxyphenylalanine in solution forms a non-NMDA glutamatergic agonist and neurotoxin. Proceedings of the National Academy of Science U.S.A. 1991; 88:4865-4869.
  216. Shina R, Yates SL, Ghassemi A, Rosenberg P, Condrea E. Inhibitory effect of EDTA.Ca2+ on the hydrolysis of synaptosomal phospholipids by phospholipase A2 toxins and enzymes. Biochem Pharmacol. 1990 Nov 15; 40(10):2233-9.
  217. Aizenman E, White WF, Loring RH, Rosenberg PA. A 3,4-dihydroxyphenylalanine oxidation product is a non-N-methyl-D-aspartate glutamatergic agonist in rat cortical neurons. Neurosci Lett. 1990 Aug 14; 116(1-2):168-71.
  218. Aizenman, E., White, W.F., Loring, R.H., and Rosenberg, P.A. . A dopa oxidation product is a non-NMDA glutamatergic agonist. Neuroscience Letters. 1990; 116:168-171.
  219. Rosenberg PA, Aizenman E. Hundred-fold increase in neuronal vulnerability to glutamate toxicity in astrocyte-poor cultures of rat cerebral cortex. Neurosci Lett. 1989 Aug 28; 103(2):162-8.
  220. Rosenberg PA, Dichter MA. Extracellular cAMP accumulation and degradation in rat cerebral cortex in dissociated cell culture. J Neurosci. 1989 Aug; 9(8):2654-63.
  221. Rosenberg, P.A. and Dichter, M.A. . Extracellular cAMP accumulation and degradation in rat cerebral cortex in dissociated cell culture. Journal of Neuroscience. 1989; 9:2654-2663.
  222. Rosenberg PA. Catecholamine toxicity in cerebral cortex in dissociated cell culture. J Neurosci. 1988 Aug; 8(8):2887-94.
  223. Hoffman EP, Hudecki MS, Rosenberg PA, Pollina CM, Kunkel LM. Cell and fiber-type distribution of dystrophin. Neuron. 1988 Jul; 1(5):411-20.
  224. Rosenberg, P.A. . Catecholamine toxicity in cerebral cortex. Journal of Neuroscience. 1988; 8:2887-2894.
  225. Rosenberg PA, Dichter MA. A small subset of cortical astrocytes in culture accumulates glycogen. Int J Dev Neurosci. 1987; 5(3):227-35.
  226. Rosenberg, P.A. and Dichter, M.A. . A small subset of cortical astrocytes in culture accumulates glycogen. International Journal of Developmental Neuroscience. 1987; 5:227-235.
  227. Rosenberg PA, Schweitzer JS, Dichter MA. Effects of norepinephrine on rat neocortical neurons in dissociated cell culture. Brain Res. 1985 Oct 7; 344(2):369-72.
  228. Rosenberg PA, Dichter MA. Glycogen accumulation in rat cerebral cortex in dissociated cell culture. J Neurosci Methods. 1985 Oct-Nov; 15(2):101-12.
  229. Rosenberg PA. Local anesthetic complications: a review and case report. N Y J Dent. 1985 Feb; 55(2):55-8.
  230. Rosenberg, P.A. and Dichter, M.A. . Glycogen cytochemistry in cerebral cortex in dissociated cell culture. Journal of Neuroscience Methods. 1985; 15:101-112.
  231. Deacon TW, Eichenbaum H, Rosenberg P, Eckmann KW. Afferent connections of the perirhinal cortex in the rat. J Comp Neurol. 1983 Oct 20; 220(2):168-90.
  232. Rosenberg PA. Occlusion, the dental pulp, and endodontic treatment. Dent Clin North Am. 1981 Jul; 25(3):423-37.
  233. Benkel HD, Frommer HH, Rosenberg PA, Stieglitz HT. Comparison of endodontic measurement controls using a paralleling technique with a grid and a conventional measurement. Oral Surg Oral Med Oral Pathol. 1980 Feb; 49(2):157-61.
  234. Fishman MJ, Just GM, Lentini S, Rosenberg PA, Principato M. A quantitative examination of immunoglobulins in bovine gingiva and dental pulp. J Endod. 1979 Jun; 5(6):176-80.
  235. Lipke E, Mautner R, Browdy D, Rosenberg PA. The effects of etching enamel with acid on human dental pulp. A preliminary study. Oral Surg Oral Med Oral Pathol. 1979 Apr; 47(4):359-63.
  236. Finkelstein, A. and Rosenberg, P.A. . Single file transport: Implications for ion and water movement through gramicidin A channels. Membrane Transport Processes. C.F. Stevens and R.W. Tsien, editors. 1979; 3:73-88.
  237. Paul A. Rosenberg. The gramicidin channel: water permeability and ion-water coupling. 1979.
  238. Miller GS, Sternberg RN, Piliero SJ, Rosenberg PA. Histologic identification of mast cells in human dental pulp. Oral Surg Oral Med Oral Pathol. 1978 Oct; 46(4):559-66.
  239. Rosenberg PA, Finkelstein A. Water permeability of gramicidin A-treated lipid bilayer membranes. J Gen Physiol. 1978 Sep; 72(3):341-50.
  240. Rosenberg PA, Finkelstein A. Interaction of ions and water in gramicidin A channels: streaming potentials across lipid bilayer membranes. J Gen Physiol. 1978 Sep; 72(3):327-40.
  241. Rosenberg, P.A. and Finkelstein, A. . Interaction of ions and water in gramicidin A channels. Streaming potentials across lipid bilayer membranes. Journal of General Physiology. 1978; 72:327-340.
  242. Busch LR, Chiat LR, Goldstein LG, Held SA, Rosenberg PA. Determination of the accuracy of the Sono-Explorer for establishing endodontic measurement control. J Endod. 1976 Oct; 2(10):295-7.
  243. Giambalvo CT, Rosenberg P. The effect of phospholipases and proteases on the binding of gamma-aminobutyric acid to junctional complexes of rat cerebellum. Biochim Biophys Acta. 1976 Jul 15; 436(4):741-56.
  244. Birchfield J, Rosenberg PA. Role of the anesthetic solution in intrapulpal anesthesia. J Endod. 1975 Jan; 1(1):26-7.
  245. Rosenberg PA, Wendt RG. Periapical repair: apparent or real? N Y State Dent J. 1974 May; 40(5):283-5.
  246. Rosenberg PA, Ziffer JA. The endodontic aspect of complete root amputation. N Y State Dent J. 1973 Nov; 39(9):537-9.
  247. Rosenberg PA, Feldman A. Periapical surgery on a two-rooted maxillary central incisor. N Y State Dent J. 1973 Apr; 39(4):218-9.
  248. Herrenkohl LR, Rosenberg PA. Exteroceptive stimulation of maternal behavior in the naive rat. Physiol Behav. 1972 Apr; 8(4):595-8.
  249. Rosenberg PA, Antonoff SJ. Gold posts. Common problems in preparation and technique for fabrication. N Y State Dent J. 1971 Dec; 37(10):601-6.
  250. Morazain R, Rosenberg P. Lipid changes in tri-o-cresylphosphate-induced neuropathy. Toxicol Appl Pharmacol. 1970 Mar; 16(2):461-74.
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