Research

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Paul  Rosenberg, MD, PhD

Paul Rosenberg, MD, PhD
Research Center:
F.M. Kirby Neurobiology Center
Program:
Neurobiology Program
Department:
Neurology Research
Hospital Title:
Senior Associate in Neurology
Academic Title:
Associate Professor of Neurology, Harvard Medical School
Research Focus Area:
Physiology and pathology of glutamate transporters in the central nervous systemmolecular mechanisms of brain injurymechanisms of homeostatic sleep regulation
Contact:
617-919-2634

Research Overview

In our first line of research, we seek to understand the cellular and molecular mechanisms underlying brain injury in order to provide a rational basis for preventing and treating important neurological disorders and diseases. We are investigating how expression and function of the brain's major glutamate transporter, GLT1, is regulated at normal synapses and how GLT1 function is compromised in acute and chronic neurodegenerative diseases. In addition, we are working to characterize pathways of programmed cell death in neurons and oligodendrocytes. In our second line of research, we are investigating the biochemical and molecular basis of behavioral state regulation, with a particular focus on the role of nitric oxide and adenosine in regulating behavioral states (sleeping and waking).

About Paul Rosenberg

Paul Rosenberg received his MD and PhD degrees from Albert Einstein College of Medicine. He completed an internship at University Hospital, Boston, a neurology residency through the Harvard-Longwood Neurological Training Program and a fellowship in cellular neurobiology at Children's Hospital Boston.

Key Publications

  • Kim S, et al. RIP1 kinase mediates arachidonic acid-induced oxidative death of oligodendrocyte precursors. Int J Physiol Pathophysiol Pharmacol 2010; 2(2):137-47.
     
  • Kabakov AY, Rosenberg PA. Evidence for change in current-flux coupling of GLT1 at high glutamate concentrations in rat primary forebrain neurons and GLT1a-expressing COS-7 cells. Eur J Neurosci 2009 Jul; 30(2):186-95.
     
  • DeSilva TM, Kabakov AY, Goldhoff PE, Volpe JJ, Rosenberg PA. Regulation of glutamate transport in developing rat oligodendrocytes. J Neurosci 2009 Jun 17; 29(24):7898-908.
     
  • Li J, Ramenaden ER, Peng J, Koito H, Volpe JJ, Rosenberg PA. Tumor necrosis factor alpha mediates lipopolysaccharide-induced microglial toxicity to developing oligodendrocytes when astrocytes are present. J Neurosci 2008 May 14; 28(20):5321-30.
     
  • Bassan M, Liu H, Madsen KL, Armsen W, Zhou J, Desilva T, Chen W, Paradise A, Brasch MA, Staudinger J, Gether U, Irwin N, Rosenberg PA. Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1. Eur J Neurosci 2008 Jan; 27(1):66-82.
     
  • Zhang Y, Aizenman E, DeFranco DB, Rosenberg PA. Intracellular zinc release, 12-lipoxygenase activation and MAPK dependent neuronal and oligodendroglial death. Mol Med 2007 Jul-Aug; 13(7-8):350-5.
 

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RELATED RESEARCH CENTER

F.M. Kirby Neurobiology Center

The Program in Neurobiology at Boston Children's Hospital, including the F.M. Kirby Neurobiology Center, is the largest basic neuroscience research enterprise at a U.S. hospital. It incorporates basic and translational neuroscience research, focusing primarily on developmental neurobiology.

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