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Adrienne Randolph, MD, MSc

Adrienne Randolph
Department:
Department of Anesthesiology, Perioperative and Pain Medicine Research
Division
Critical Care Medicine Research
Hospital Title:
Senior Associate in Critical Care
Academic Title:
Associate Professor of Anaesthesia, Harvard Medical School
Research Focus Area:
Sepsis, Acute Lung Injury, Influenza, Staphylococcus aureus, Immunobiology, Antimicrobial proteins and peptides, Influenza Vaccination, Pediatric Critical Care health services research
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Research Overview

Dr. Randolph currently leads a 27 center NIH funded study evaluating the immune response to life-threatening and fatal influenza in children. In this study we are investigating the mechanisms underlying disease susceptibility and severity including interferon regulatory pathways, bacterial coinfection with a focus on Staphlococcus aureus, and host genetic susceptibility. The ultimate goal of this research is to identify new therapeutic targets to decrease morbidity and mortality from severe influenza infection. Dr. Randolph also leads studies of influenza vaccine effectiveness in preventing influenza-related critical illness, funded by the CDC Influenza Division and other sources. Dr. Randolph follows a large cohort of children hospitalized for bronchiolitis in infancy caused by respiratory syncytial virus (RSV) with the goal of identifying immunoregulatory genes underlying disease susceptibility.

About Adrienne Randolph

Adrienne Randolph received an MD from Stanford University School of Medicine and an MSc in medical informatics from the University of Utah. She completed an internship at Children's Hospital of Philadelphia and pediatric residency and pediatric critical care fellowship at the University of California School of Medicine in San Francisco.

Dr Randolph is the founder and chair of the Pediatric Acute Lung Injury and Sepsis Investigator's (PALISI) Network. She is also the Director of the RSV and Asthma Research Study Center at Boston Children's Hospital.

Key Publications

  • Randolph AG, Wypij D, Venkataraman ST, Hanson JH, Gedeit RG, Meert K, Luckett PM, Forbes P, Lilley M, Thompson J, Cheifetz IM, Hibberd P, Wetzel R, Cox PN, Arnold JH. Effect of mechanical ventilator weaning protocols on respiratory outcomes in infants and children - A randomized controlled trial. Journal of the American Medical Association 2002; 288: 2561-88.
     
  • Randolph AG, Gonzales CA, Cortellini L, Yeh TS. Growth of pediatric intensive care units in the United States from 1995 to 2001. Journal of Pediatrics 2004; 144: 792-98.
     
  • Guidelines for the prevention of intravascular catheter-related infections - art. no. e51. Pediatrics 2002; 110: E51.
     
  • Randolph AG, Lange C, Silverman EK, Lazarus R, Silverman ES, Raby B, Brown A, Ozonoff A, Richter B, Weiss ST. IL12B gene is associated with asthma. Am J Hum Genet 2004:75;709-715.
 
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