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Adrienne G. Randolph, MD, MSc

Adrienne Randolph
Department of Anesthesiology, Perioperative and Pain Medicine Research
Critical Care Medicine Research
Hospital Title:
Senior Associate in Critical Care Medicine
Academic Title:
Associate Professor of Anaesthesia, Harvard Medical School
Research Focus Area:
Sepsis, Acute Lung Injury, Influenza, Staphylococcus aureus, Immunobiology, Antimicrobial proteins and peptides, Influenza Vaccination, Pediatric Critical Care health services research
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Research Overview

Dr. Randolph currently leads a 27 center NIH funded study evaluating the immune response to life-threatening and fatal influenza in children. In this study we are investigating the mechanisms underlying disease susceptibility and severity including interferon regulatory pathways, bacterial coinfection with a focus on Staphlococcus aureus, and host genetic susceptibility. The ultimate goal of this research is to identify new therapeutic targets to decrease morbidity and mortality from severe influenza infection. Dr. Randolph also leads studies of influenza vaccine effectiveness in preventing influenza-related critical illness, funded by the CDC Influenza Division and other sources. Dr. Randolph follows a large cohort of children hospitalized for bronchiolitis in infancy caused by respiratory syncytial virus (RSV) with the goal of identifying immunoregulatory genes underlying disease susceptibility.

About Adrienne Randolph

Dr. Randolph is the founder and first Chair of the Pediatric Acute Lung Injury and Sepsis Investigator’s (PALISI) Network, a clinical research consortium of over 80 pediatric ICUs in the U.S. and Canada.  Dr. Randolph is a Council member of the International Sepsis Forum and is also active in many other professional societies including the Society for Critical Care Medicine and the American Thoracic Society.  She has published numerous multicenter trials, cohort studies and clinical practice guidelines in the area of sepsis and acute lung failure in children.  She has received multiple grants to study life-threatening and fatal influenza infection and leads a 40-center Pediatric Critical Care Influenza (PICFlu) Study Group.  

Key Publications

  • Randolph AG, Wypij D, Venkataraman ST, Hanson JH, Gedeit RG, Meert K, Luckett PM, Forbes P, Lilley M, Thompson J, Cheifetz IM, Hibberd P, Wetzel R, Cox PN, Arnold JH. Effect of mechanical ventilator weaning protocols on respiratory outcomes in infants and children - A randomized controlled trial. Journal of the American Medical Association 2002; 288: 2561-88.
  • Randolph AG, Gonzales CA, Cortellini L, Yeh TS. Growth of pediatric intensive care units in the United States from 1995 to 2001. Journal of Pediatrics 2004; 144: 792-98.
  • Guidelines for the prevention of intravascular catheter-related infections - art. no. e51. Pediatrics 2002; 110: E51.
  • Randolph AG, Lange C, Silverman EK, Lazarus R, Silverman ES, Raby B, Brown A, Ozonoff A, Richter B, Weiss ST. IL12B gene is associated with asthma. Am J Hum Genet 2004:75;709-715.
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