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Lise  Nigrovic, MD

Lisa Nigrovic
Medicine Research
Emergency Medicine Research
Hospital Title:
Assistant in Medicine
Academic Title:
Associate Professor in Medicine, Harvard Medical School
Research Focus Area:
Infectious DiseasesTrauma
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Research Overview

Dr. Lise Nigrovic’s research focus has been in the study of meningeal infections as well as the radiologic evaluation after blunt trauma for children admitted to the emergency department. Her significant research contributions include the development and multi-center validation of a clinical prediction model to distinguish between bacterial and viral meningitis as well as the impact of observation on the rate of cranial CT for children with minor blunt head trauma. She serves as the site principal investigator for the Pediatric Emergency Medicine Applied Research Network (PECARN) and the vice chair of the Pediatric Emergency Medicine Clinical Research Collaborative (PEM CRC).

About Lise Nigrovic

Lise Nigrovic received her MD in Medicine from Harvard Medical School and her MPH from the Harvard School of Public Health. She completed her residency, chief residency and clinical fellowship in Pediatric Emergency Medicine at Boston Children's Hospital. She now works as an attending in the division of emergency medicine.

Key Publications

  • Nigrovic LE*, Kuppermann N, Malley R. Development and validation of a multivariable predictive model to distinguish bacterial from aseptic meningitis in children in the post-Haemophilus influenzae era. Pediatrics. 2002;110(4):712-9.
  • Nigrovic LE, Kuppermann N, Macias CG, Cannavino CR, Moro-Sutherland DM, Schremmer RD, Schwab SH, Agrawal D, Mansour KM, Bennett JE, Katsogridakis YL, Mohseni MM, Bulloch B, Steele DW, Kaplan RL, Herman MI, Bandyopadhyay S, Dayan P, Truong UT, Wang VJ, Bonsu BK, Chapman JL, Kanegaye JT, Malley R. Clinical prediction rule for identifying children with cerebrospinal fluid pleocytosis at very low risk of bacterial meningitis. JAMA. 2007;297(1):52-60. 
  • Nigrovic LE, Malley R, Kuppermann N. Multi-study validation of the Bacterial Meningitis Score.  Arch Dis Child. 2012;97:799-805.
  • Nigrovic LE, Schunk J, Forester A, Cooper A, Miskin M, Atabaki S, Hoyle J, Dayan P, Holmes J,  Kuppermann N for the Pediatric Emergency Care Applied Research Network (PECARN).  Clinical observation before the decision to obtain a computed tomography (CT) for children with blunt head trauma. Pediatrics. 2011;127 (6):1067-73. 
  • Schonfeld D, Fritz B, Nigrovic LE.  The impact of the duration of observation on cranial computed tomography rate for children with minor blunt head trauma. Ann Emerg Med. 2013;62(6):597-603.


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