LIke ThisLIke ThisLIke This

Lise E. Nigrovic, MD, MPH

Lisa Nigrovic
Medicine Research
Emergency Medicine Research
Hospital Title:
Director of Education, Clinical Research Center ; Senior Associate Physician in Medicine
Academic Title:
Associate Professor of Pediatrics and Emergency Medicine, Harvard Medical School
Research Focus Area:
Diagnostic TestsLyme DiseaseMeningitis
Contact Via Email
Send an email to SendYour Name*Your Email Address*Subject*Comments*

Research Overview

Dr. Lise Nigrovic’s research focus has been in the approach to diagnosis and management of children with infectious and traumatic emergencies. Her significant research contributions include the development and multi-center validation of a clinical prediction model to distinguish between bacterial and viral meningitis. She serves as the site principal investigator for the Pediatric Emergency Medicine Applied Research Network (PECARN) and current chair of the Pediatric Emergency Medicine Clinical Research Collaborative (PEM CRC). Her current research focuses on the diagnosis of Lyme disease in children with the establishment of a multi-center pediatric Lyme disease biorepository with ongoing specimen collection.

About Lise Nigrovic

Lise Nigrovic received her MD in Medicine from Harvard Medical School and her MPH in clinical effectiveness from the Harvard School of Public Health. She completed her residency, chief residency and clinical fellowship in Pediatric Emergency Medicine at Boston Children's Hospital. She joined the faculty in the Division of Emergency Medicine at Boston Children’s Hospital in 2006. She now serves as the director of education for the Clinical Research Center.

Key Publications

  • Nigrovic LE, Kuppermann N, Malley R. Development and validation of a multivariable predictive model to distinguish bacterial from aseptic meningitis in children in the post-Haemophilus influenzae era. Pediatrics. 2002;110(4):712-9.

  • Nigrovic LE, Kuppermann N, Macias CG, Cannavino CR, Moro-Sutherland DM, Schremmer RD, Schwab SH, Agrawal D, Mansour KM, Bennett JE, Katsogridakis YL, Mohseni MM, Bulloch B, Steele DW, Kaplan RL, Herman MI, Bandyopadhyay S, Dayan P, Truong UT, Wang VJ, Bonsu BK, Chapman JL, Kanegaye JT, Malley R. Clinical prediction rule for identifying children with cerebrospinal fluid pleocytosis at very low risk of bacterial meningitis. JAMA. 2007;297(1):52-60.

  • Nigrovic LE, Malley R, Kuppermann N. Multi-study validation of the Bacterial Meningitis Score. Arch Dis Child. 2012;97:799-805.

  • Nigrovic LE, Schunk J, Forester A, Cooper A, Miskin M, Atabaki S, Hoyle J, Dayan P, Holmes J, Kuppermann N for the Pediatric Emergency Care Applied Research Network (PECARN). Clinical observation before the decision to obtain a computed tomography (CT) for children with blunt head trauma. Pediatrics. 2011;127 (6):1067-73.

  • Schonfeld D, Fritz B, Nigrovic LE. The impact of the duration of observation on cranial computed tomography rate for children with minor blunt head trauma. Ann Emerg Med. 2013;62(6):597-603.
LIke ThisLIke ThisLIke This