Stem cell transplantation and tissue engineering hold great promise in regenerative medicine. However, generating tissues with stable functional vascular beds remains a major challenge. Our laboratory is interested in understanding mechanisms of vascular network formation using human stem and progenitor cells. We specialize in the biology and therapeutic potential of human circulating Endothelial Colony-Forming Cells. Current projects in the lab are focused on:
- Endothelial colony-forming cells (ECFCs) biology
- Bioengineering vascular networks
- Genetically-engineered vasculature for protein drug delivery
About Juan Melero-Martin
Dr. Melero-Martin graduated in Chemical Engineering from University of Seville, Spain, in 1998. After working three years in industry, he went on to earn a PhD in biochemical engineering from the University of Birmingham, UK in 2005. Dr. Melero-Martin's doctoral research focused on tissue engineering and was sponsored by Smith & Nephew. From 2005 to 2008, he trained as a post-doctoral fellow in the Vascular Biology Program at Boston Children's Hospital. He joined the Department of Cardiac Surgery at Children's Hospital in 2008. In 2009, he received a K99/R00 Pathway to Independence Award from the NIH.
Human endothelial colony-forming cells serve as trophic mediators for mesenchymal stem cell engraftment via paracrine signaling. Lin RZ, Moreno-Luna R, Li D, Jaminet SCS, Greene AK, Melero-Martin JM. Proc Natl Acad Sci USA 2014; in press.
Transdermal regulation of vascular network bioengineering using a photopolymerizable methacrylated gelatin hydrogel. Lin RZ, Chen YC, Moreno-Luna R, Khademhosseini A, Melero-Martin JM. Biomaterials 2013; 34(28):6785-96.
Induction of erythropoiesis using human vascular networks genetically-engineered for controlled erythropoietin release. Lin RZ, Dreyzin A, Aamodt K, Li D, Jaminet SCS, Dudley AC, Melero-Martin JM. Blood 2011; 118(20):5420-8.
Engineering robust and functional vascular networks in vivo with human adult and cord blood-derived progenitor cells. Melero-Martin JM, De Obaldia ME, Kang S-Y, Khan ZA, Yuan L, Oettgen P, Bischoff J. Circ Res 2008; 103:194-202.
In vivo vasculogenic potential of human blood-derived endothelial progenitor cells. Melero-Martin JM, Khan ZA, Picard A, Wu X, Paruchuri S, Bischoff J. Blood 2007; 109:4761-4768.
See all publications in PubMed