Research

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Jonathan Mansbach, MD, MPH

Jonathan Mansbach
Department:
Medicine Research
Division
General Pediatrics Research
Academic Title:
Assistant Professor of Pediatrics, Harvard Medical School
Research Focus Area:
Bronchiolitis care

Research Overview

Dr. Mansbach has been performing multicenter bronchiolitis and respiratory virus research with the Emergency Medicine Network (www.emnet-usa.org) over the past decade.  He has been Principal Investigator, Co-Investigator, or site Principal Investigator of multiple industry, foundation, and NIH grants. Currently, Dr. Mansbach is Co-Investigator and on the Steering Committee for a NIH-funded multicenter study following 1,000 children hospitalized with bronchiolitis for the development of recurrent wheezing and eventual asthma. He is also actively investigating the influence of the nasopharyngeal microbiome and 25-hydroxyvitamin D levels on the severity of a child’s bronchiolitis illness.

About Jonathan Mansbach, MD, MPH

Dr. Mansbach graduated from Haverford College and Duke University School of Medicine before coming to Boston Children’s Hospital as an intern. He has been at Boston Children’s Hospital ever since. He completed a hospitalist and adolescent medicine fellowship, and now spends the majority of his time investigating bronchiolitis and respiratory viruses. He obtained a Masters of Public Health from the Harvard School of Public Health.

Key publications

  • Mansbach JM, Clark S, Christopher NC, LoVecchio F, Kunz S, Acholonu U, Camargo CA Jr. Prospective multicenter study of bronchiolitis: Predicting safe discharges from the Emergency Department. Pediatrics. 2008;121(4):680-688.
  • Mansbach JM, Espinola JA, Macias CG, Ruhlen ME, Sullivan AF, Camargo CA Jr. Variability in the diagnostic labeling of non-bacterial lower respiratory tract infections: A multicenter study of children presenting to the Emergency Department. Pediatrics. 2009;123(4):e573-e581.
  • Mansbach JM, Ginde AA, Camargo CA Jr. Serum 25-hydroxyvitamin D levels among U.S. children ages 1-11 years: Do children need more vitamin D? Pediatrics. 2009;124:1404-1410. PMCID: PMC3765249.
  • Jartti T, Ruuskanen O, Mansbach JM, Vuorinen T, and Camargo CA. Low serum  25-hydroxyvitamin D levels are associated with increased risk of viral co-infections in wheezing children. J Allergy Clin Immunol. 2010;126(5):1074-1076. PMCID: PMC3772528.
  • Mansbach JM, Piedra PA, Teach SJ, Sullivan AF, Forgey T, Clark S, Espinola JA, Camargo CA Jr. Prospective, multicenter study of viral etiology and hospital length-of-stay in children with severe bronchiolitis. Arch Pediatr Adolesc Med. 2012;166(8):700-706. PMCID: PMC3394902.
  • Mansbach JM, Piedra PA, Stevenson MD, Sullivan AF, Forgey TF, Clark S, Espinola JA, Camargo CA Jr. Prospective multicenter study of children with bronchiolitis requiring mechanical ventilation. Pediatrics. 2012;130:e492-e500. PMCID: PMC3428760.
  • Mansbach JM, Piedra PA, Borregaard N, Martineau AR, Neuman MI, Espinola JA, Camargo CA Jr. Serum cathelicidin level is associated with viral etiology and severity of bronchiolitis. J Allergy Clin Immunol. 2012;130(4):1007-1008. PMCID: PMC3462235.
  • Mansbach JM, Piedra PA, Laham FR, McAdam AJ, Clark S, Sullivan AF, Camargo CA. Nasopharyngeal LDH concentrations predict bronchiolitis severity in a prospective multicenter emergency department study. Pediatr Infect Dis J. 2012;31(7):767-769. PMCID: PMC3375381.
  • Schroeder A, Mansbach JM, Stevens M, Macias CG, Fisher ES, Barcega B, Sullivan AF, Espinola JA, Camargo CA Jr. Apnea in children hospitalized with bronchiolitis. Pediatrics. 2013;132(5):e1194-1201. PMCID: PMC3813402.
  • Hyde ER, Petrosino JF, Piedra PA, Camargo CA, Espinola JA, Mansbach JM. Nasopharyngeal Proteobacteria are associated with viral etiology and acute wheezing in children with severe bronchiolitis. J Allergy Clin Immunol. 2014;133(4):1220-1222. PMCID: PMC3972371.

Active Projects

2009-2014 Vitamin D deficiency and the severity of bronchiolitis

K23 AI077801
Principal Investigator

This study examines the vitamin D level of the children enrolled for the U01 study at Boston Children’s Hospital.

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