Research

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Matthew  Harris, PhD

Matthew Harris
Lab:
Harris Laboratory
Department:
Orthopedic Surgery Research
Hospital Title:
Assistant Professor of Genetics
Academic Title:
Assistant Professor of Genetics
Research Focus Area:
Orthopedics: skeletal development
Contact:
617-919-2032
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Research Overview

The Harris laboratory studies fish as a model to understand the development of the skeleton and the inherent capacity for growth and repair in vertebrates. We use the power of forward genetics in the zebrafish as a means to identify genetic variants that regulate growth and form of the adult fish skeleton. These findings are then analyzed in the mouse and other vertebrates to understand the conservation of these mechanisms and the growth potential within the developing skeleton. In parallel to work in the zebrafish, comparative studies in other fish species are being conducted to take advantage of the genetic diversity among fish and the varied means by which they regulate development. The work in the lab has uncovered novel mechanisms by which size control is developmentally regulated that involve cell-extracellular matrix interactions as well as control of electrochemical signaling in tissues. Additionally, through the analysis of late development, we have identified genes that regulate the maintenance of tissues and the onset of pathologies associated with aging. We are currently investigating these genes and their role in vertebrate aging.

Articles on PubMed.org authored or co-authored by Dr. Harris.

Publications

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  1. Harris MP, Hawkins MB. Out of the Mouth of Minnows. Dev Cell. 2015 Nov 9; 35(3):263-4.
  2. Daane JM, Rohner N, Konstantinidis P, Djuranovic S, Harris MP. Parallelism and Epistasis in Skeletal Evolution Identified through Use of Phylogenomic Mapping Strategies. Mol Biol Evol. 2016 Jan; 33(1):162-73.
  3. Hu WF, Pomp O, Ben-Omran T, Kodani A, Henke K, Mochida GH, Yu TW, Woodworth MB, Bonnard C, Raj GS, Tan TT, Hamamy H, Masri A, Shboul M, Al Saffar M, Partlow JN, Al-Dosari M, Alazami A, Alowain M, Alkuraya FS, Reiter JF, Harris MP, Reversade B, Walsh CA. Katanin p80 regulates human cortical development by limiting centriole and cilia number. Neuron. 2014 Dec 17; 84(6):1240-57.
  4. Harris MP, Purcell P. The Society of Craniofacial Genetics and Developmental Biology 36th annual meeting. Am J Med Genet A. 2014 Aug; 164A(8):1873-90.
  5. Perathoner S, Daane JM, Henrion U, Seebohm G, Higdon CW, Johnson SL, Nüsslein-Volhard C, Harris MP. Bioelectric signaling regulates size in zebrafish fins. PLoS Genet. 2014 Jan; 10(1):e1004080.
  6. Henke K, Bowen ME, Harris MP. Identification of mutations in zebrafish using next-generation sequencing. Curr Protoc Mol Biol. 2013; 104:Unit 7.13.
  7. Henke K, Bowen ME, Harris MP. Perspectives for identification of mutations in the zebrafish: making use of next-generation sequencing technologies for forward genetic approaches. Methods. 2013 Aug 15; 62(3):185-96.
  8. Levesque MP, Krauss J, Koehler C, Boden C, Harris MP. New tools for the identification of developmentally regulated enhancer regions in embryonic and adult zebrafish. Zebrafish. 2013 Mar; 10(1):21-9.
  9. Dauber A, Lafranchi SH, Maliga Z, Lui JC, Moon JE, McDeed C, Henke K, Zonana J, Kingman GA, Pers TH, Baron J, Rosenfeld RG, Hirschhorn JN, Harris MP, Hwa V. Novel microcephalic primordial dwarfism disorder associated with variants in the centrosomal protein ninein. J Clin Endocrinol Metab. 2012 Nov; 97(11):E2140-51.
  10. Chen YY, Harris MP, Levesque MP, Nüsslein-Volhard C, Sonawane M. Heterogeneity across the dorso-ventral axis in zebrafish EVL is regulated by a novel module consisting of sox, snail1a and max genes. Mech Dev. 2012 Mar-Jun; 129(1-4):13-23.
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  12. Bowen ME, Henke K, Siegfried KR, Warman ML, Harris MP. Efficient mapping and cloning of mutations in zebrafish by low-coverage whole-genome sequencing. Genetics. 2012 Mar; 190(3):1017-24.
  13. Norton WH, Stumpenhorst K, Faus-Kessler T, Folchert A, Rohner N, Harris MP, Callebert J, Bally-Cuif L. Modulation of Fgfr1a signaling in zebrafish reveals a genetic basis for the aggression-boldness syndrome. J Neurosci. 2011 Sep 28; 31(39):13796-807.
  14. Rohner N, Perathoner S, Frohnhöfer HG, Harris MP. Enhancing the efficiency of N-ethyl-N-nitrosourea-induced mutagenesis in the zebrafish. Zebrafish. 2011 Sep; 8(3):119-23.
  15. Konstantinidis P, Harris MP. Same but different: ontogeny and evolution of the Musculus adductor mandibulae in the Tetraodontiformes. J Exp Zool B Mol Dev Evol. 2011 Jan 15; 316(1):10-20.
  16. Volkmann K, Chen YY, Harris MP, Wullimann MF, Köster RW. The zebrafish cerebellar upper rhombic lip generates tegmental hindbrain nuclei by long-distance migration in an evolutionary conserved manner. J Comp Neurol. 2010 Jul 15; 518(14):2794-817.
  17. Rohner N, Bercsényi M, Orbán L, Kolanczyk ME, Linke D, Brand M, Nüsslein-Volhard C, Harris MP. Duplication of fgfr1 permits Fgf signaling to serve as a target for selection during domestication. Curr Biol. 2009 Oct 13; 19(19):1642-7.
  18. Harris MP, Rohner N, Schwarz H, Perathoner S, Konstantinidis P, Nüsslein-Volhard C. Zebrafish eda and edar mutants reveal conserved and ancestral roles of ectodysplasin signaling in vertebrates. PLoS Genet. 2008; 4(10):e1000206.
  19. Harris MP, Hasso SM, Ferguson MW, Fallon JF. The development of archosaurian first-generation teeth in a chicken mutant. Curr Biol. 2006 Feb 21; 16(4):371-7.
  20. Harris MP, Williamson S, Fallon JF, Meinhardt H, Prum RO. Molecular evidence for an activator-inhibitor mechanism in development of embryonic feather branching. Proc Natl Acad Sci U S A. 2005 Aug 16; 102(33):11734-9.
  21. Harris MP, Linkhart BL, Fallon JF. Bmp7 mediates early signaling events during induction of chick epidermal organs. Dev Dyn. 2004 Sep; 231(1):22-32.
  22. Harris MJ, Arias IM. FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body. Biochim Biophys Acta. 2003 Jul 21; 1633(2):127-31.
  23. Harris MP, Fallon JF, Prum RO. Shh-Bmp2 signaling module and the evolutionary origin and diversification of feathers. J Exp Zool. 2002 Aug 15; 294(2):160-76.
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