Research

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Nadine Gaab, PhD

Nadine Gaab
Lab:
Gaab Laboratory
Department:
Medicine Research
Division
Developmental Medicine Research
Hospital Title:
Research Associate
Academic Title:
Associate Professor of Pediatrics, Harvard Medical School
Research Focus Area:
Human Auditory SystemReading and Language Impairments
Contact:
857-218-3021
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Learn more about the Gaab Laboratory.

Research Overview

Dr. Gaab is an Associate Professor of Pediatrics at Boston Children’s Hospital and the Harvard Medical School and a member of the faculty at the Harvard Graduate School of Education. She received a PhD in Psychology from the University of Zurich in Switzerland. She did postdoctoral training with John Gabrieli, Gary Glover and Paula Tallal at Stanford University and MIT. Her current research within the Laboratories of Cognitive Neuroscience at Boston Children’s Hospital focuses on auditory and language processing in the human brain and its applications for the development of typical and atypical language and literacy skills. The Gaab Lab utilizes structural and functional magnetic resonance imaging (fMRI) as well as behavioral measurement tools. The Gaab Lab is currently working on various topics such as the identification of possible pre-markers of developmental dyslexia in the pre-reading and infant brain, the identification of the underlying neural mechanism of comorbidity of developmental dyslexia and attention deficit hyperactivity disorder, brain plasticity following sound and music based remediation programs for reading and language impaired children, the influence of musical training on cognitive and academic abilities and the neural correlates of language and reading development across the life-span. The Gaab Lab employs cross-sectional and longitudinal study designs and work closely with over 20 private and public schools within the Greater New England area.

Publications

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  1. Saygin ZM, Osher DE, Norton ES, Youssoufian DA, Beach SD, Feather J, Gaab N, Gabrieli JD, Kanwisher N. Connectivity precedes function in the development of the visual word form area. Nat Neurosci. 2016 Sep; 19(9):1250-5.
  2. Ozernov-Palchik O, Gaab N. Tackling the 'dyslexia paradox': reading brain and behavior for early markers of developmental dyslexiax. Wiley Interdiscip Rev Cogn Sci. 2016 Mar-Apr; 7(2):156-76.
  3. Zuk J, Benjamin C, Kenyon A, Gaab N. Correction: Behavioral and Neural Correlates of Executive Functioning in Musicians and Non-Musicians. PLoS One. 2015; 10(9):e0137930.
  4. Paldino MJ, Hedges K, Gaab N, Galaburda AM, Grant PE. Failure to Identify the Left Arcuate Fasciculus at Diffusion Tractography Is a Specific Marker of Language Dysfunction in Pediatric Patients with Polymicrogyria. Behav Neurol. 2015; 2015:351391.
  5. Im K, Raschle NM, Smith SA, Ellen Grant P, Gaab N. Atypical Sulcal Pattern in Children with Developmental Dyslexia and At-Risk Kindergarteners. Cereb Cortex. 2016 Mar; 26(3):1138-48.
  6. Raschle NM, Smith SA, Zuk J, Dauvermann MR, Figuccio MJ, Gaab N. Investigating the neural correlates of voice versus speech-sound directed information in pre-school children. PLoS One. 2014; 9(12):e115549.
  7. Shetreet E, Chierchia G, Gaab N. Linguistic inability or poor performance: Dissociating scalar implicature generation and mismatch in the developing brain. Dev Psychol. 2014 Sep; 50(9):2264-75.
  8. Zuk J, Benjamin C, Kenyon A, Gaab N. Behavioral and neural correlates of executive functioning in musicians and non-musicians. PLoS One. 2014; 9(6):e99868.
  9. Langer N, Benjamin C, Minas J, Gaab N. The neural correlates of reading fluency deficits in children. Cereb Cortex. 2015 Jun; 25(6):1441-53.
  10. Zuk J, Ozernov-Palchik O, Kim H, Lakshminarayanan K, Gabrieli JD, Tallal P, Gaab N. Enhanced syllable discrimination thresholds in musicians. PLoS One. 2013; 8(12):e80546.
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  12. Shetreet E, Chierchia G, Gaab N. When three is not some: on the pragmatics of numerals. J Cogn Neurosci. 2014 Apr; 26(4):854-63.
  13. Saygin ZM, Norton ES, Osher DE, Beach SD, Cyr AB, Ozernov-Palchik O, Yendiki A, Fischl B, Gaab N, Gabrieli JD. Tracking the roots of reading ability: white matter volume and integrity correlate with phonological awareness in prereading and early-reading kindergarten children. J Neurosci. 2013 Aug 14; 33(33):13251-8.
  14. Zuk J, Andrade PE, Andrade OV, Gardiner M, Gaab N. Musical, language, and reading abilities in early Portuguese readers. Front Psychol. 2013; 4:288.
  15. Raschle NM, Stering PL, Meissner SN, Gaab N. Altered neuronal response during rapid auditory processing and its relation to phonological processing in prereading children at familial risk for dyslexia. Cereb Cortex. 2014 Sep; 24(9):2489-501.
  16. Shetreet E, Chierchia G, Gaab N. When some is not every: dissociating scalar implicature generation and mismatch. Hum Brain Mapp. 2014 Apr; 35(4):1503-14.
  17. Im K, Pienaar R, Paldino MJ, Gaab N, Galaburda AM, Grant PE. Quantification and discrimination of abnormal sulcal patterns in polymicrogyria. Cereb Cortex. 2013 Dec; 23(12):3007-15.
  18. Raschle N, Zuk J, Ortiz-Mantilla S, Sliva DD, Franceschi A, Grant PE, Benasich AA, Gaab N. Pediatric neuroimaging in early childhood and infancy: challenges and practical guidelines. Ann N Y Acad Sci. 2012 Apr; 1252:43-50.
  19. Raschle NM, Zuk J, Gaab N. Functional characteristics of developmental dyslexia in left-hemispheric posterior brain regions predate reading onset. Proc Natl Acad Sci U S A. 2012 Feb 7; 109(6):2156-61.
  20. Benjamin CF, Gaab N. What's the story? The tale of reading fluency told at speed. Hum Brain Mapp. 2012 Nov; 33(11):2572-85.
  21. Kovelman I, Norton ES, Christodoulou JA, Gaab N, Lieberman DA, Triantafyllou C, Wolf M, Whitfield-Gabrieli S, Gabrieli JD. Brain basis of phonological awareness for spoken language in children and its disruption in dyslexia. Cereb Cortex. 2012 Apr; 22(4):754-64.
  22. You H, Gaab N, Wei N, Cheng-Lai A, Wang Z, Jian J, Song M, Meng X, Ding G. Neural deficits in second language reading: fMRI evidence from Chinese children with English reading impairment. Neuroimage. 2011 Aug 1; 57(3):760-70.
  23. Benjamin C, Lieberman DA, Chang M, Ofen N, Whitfield-Gabrieli S, Gabrieli JD, Gaab N. The influence of rest period instructions on the default mode network. Front Hum Neurosci. 2010; 4:218.
  24. Raschle NM, Chang M, Gaab N. Structural brain alterations associated with dyslexia predate reading onset. Neuroimage. 2011 Aug 1; 57(3):742-9.
  25. Ghosh SS, Kakunoori S, Augustinack J, Nieto-Castanon A, Kovelman I, Gaab N, Christodoulou JA, Triantafyllou C, Gabrieli JD, Fischl B. Evaluating the validity of volume-based and surface-based brain image registration for developmental cognitive neuroscience studies in children 4 to 11 years of age. Neuroimage. 2010 Oct 15; 53(1):85-93.
  26. Schulze K, Gaab N, Schlaug G. Perceiving pitch absolutely: comparing absolute and relative pitch possessors in a pitch memory task. BMC Neurosci. 2009; 10:106.
  27. Raschle NM, Lee M, Buechler R, Christodoulou JA, Chang M, Vakil M, Stering PL, Gaab N. Making MR imaging child's play - pediatric neuroimaging protocol, guidelines and procedure. J Vis Exp. 2009; (29).
  28. Gaab N, Gabrieli JD, Glover GH. Resting in peace or noise: scanner background noise suppresses default-mode network. Hum Brain Mapp. 2008 Jul; 29(7):858-67.
  29. Christodoulou JA, Gaab N. Using and misusing neuroscience in education-related research. Cortex. 2009 Apr; 45(4):555-7.
  30. Gaab N, Gabrieli JD, Glover GH. Assessing the influence of scanner background noise on auditory processing. I. An fMRI study comparing three experimental designs with varying degrees of scanner noise. Hum Brain Mapp. 2007 Aug; 28(8):703-20.
  31. Gaab N, Gabrieli JD, Glover GH. Assessing the influence of scanner background noise on auditory processing. II. An fMRI study comparing auditory processing in the absence and presence of recorded scanner noise using a sparse design. Hum Brain Mapp. 2007 Aug; 28(8):721-32.
  32. Gaab N, Gabrieli JD, Deutsch GK, Tallal P, Temple E. Neural correlates of rapid auditory processing are disrupted in children with developmental dyslexia and ameliorated with training: an fMRI study. Restor Neurol Neurosci. 2007; 25(3-4):295-310.
  33. Gaab N, Schulze K, Ozdemir E, Schlaug G. Neural correlates of absolute pitch differ between blind and sighted musicians. Neuroreport. 2006 Dec 18; 17(18):1853-7.
  34. Bermpohl F, Pascual-Leone A, Amedi A, Merabet LB, Fregni F, Gaab N, Alsop D, Schlaug G, Northoff G. Attentional modulation of emotional stimulus processing: an fMRI study using emotional expectancy. Hum Brain Mapp. 2006 Aug; 27(8):662-77.
  35. Tallal P, Gaab N. Dynamic auditory processing, musical experience and language development. Trends Neurosci. 2006 Jul; 29(7):382-90.
  36. Gaab N, Gaser C, Schlaug G. Improvement-related functional plasticity following pitch memory training. Neuroimage. 2006 May 15; 31(1):255-63.
  37. Gaab N, Tallal P, Kim H, Lakshminarayanan K, Archie JJ, Glover GH, Gabrieli JD. Neural correlates of rapid spectrotemporal processing in musicians and nonmusicians. Ann N Y Acad Sci. 2005 Dec; 1060:82-8.
  38. Bermpohl F, Pascual-Leone A, Amedi A, Merabet LB, Fregni F, Gaab N, Alsop D, Schlaug G, Northoff G. Dissociable networks for the expectancy and perception of emotional stimuli in the human brain. Neuroimage. 2006 Apr 1; 30(2):588-600.
  39. Walker MP, Stickgold R, Alsop D, Gaab N, Schlaug G. Sleep-dependent motor memory plasticity in the human brain. Neuroscience. 2005; 133(4):911-7.
  40. Overy K, Norton AC, Cronin KT, Gaab N, Alsop DC, Winner E, Schlaug G. Imaging melody and rhythm processing in young children. Neuroreport. 2004 Aug 6; 15(11):1723-6.
  41. Gaab N, Paetzold M, Becker M, Walker MP, Schlaug G. The influence of sleep on auditory learning: a behavioral study. Neuroreport. 2004 Mar 22; 15(4):731-4.
  42. Gaab N, Schlaug G. The effect of musicianship on pitch memory in performance matched groups. Neuroreport. 2003 Dec 19; 14(18):2291-5.
  43. Gaab N, Schlaug G. Musicians differ from nonmusicians in brain activation despite performance matching. Ann N Y Acad Sci. 2003 Nov; 999:385-8.
  44. Hutchinson S, Lee LH, Gaab N, Schlaug G. Cerebellar volume of musicians. Cereb Cortex. 2003 Sep; 13(9):943-9.
  45. Gaab N, Keenan JP, Schlaug G. The effects of gender on the neural substrates of pitch memory. J Cogn Neurosci. 2003 Aug 15; 15(6):810-20.
  46. Gaab N, Gaser C, Zaehle T, Jancke L, Schlaug G. Functional anatomy of pitch memory--an fMRI study with sparse temporal sampling. Neuroimage. 2003 Aug; 19(4):1417-26.
  47. Jäncke L, Gaab N, Wüstenberg T, Scheich H, Heinze HJ. Short-term functional plasticity in the human auditory cortex: an fMRI study. Brain Res Cogn Brain Res. 2001 Dec; 12(3):479-85.
  48. Ihl R, Grass-Kapanke B, Lahrem P, Brinkmeyer J, Fischer S, Gaab N, Kaupmannsennecke C. [Development and validation of a test for early diagnosis of dementia with differentiation from depression (TFDD)]. Fortschr Neurol Psychiatr. 2000 Sep; 68(9):413-22.
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