Research

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Michela Fagiolini, PhD

Michela Fagiolini
Research Center:
F.M. Kirby Neurobiology Center
Program:
Neurobiology Program
Department:
Neurology Research
Hospital Title:
Associate in Neurology
Academic Title:
Assistant Professor of Neurology, Harvard Medical School
Research Focus Area:
Experience-dependent Visual PlasticityNeurodevelopmental DisordersRett syndrome
Contact:
617-919-2419
Contact Via Email
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Research Overview

Neurons acquire multiple functional properties through experience-dependent development during specific times in early postnatal life called “critical periods”. In recent years we have achieved the first direct control over critical period timing by manipulating a specific subset of local inhibitory circuits in the visual cortex. Our research focuses on the mechanisms underlying these fundamental processes and how they may be altered in neurodevelopmental disorders. To this end, we combine molecular techniques with electrophysiological and behavioral analysis of systems level phenomena in vivo.

Currently we are studying experience-dependent brain development in mouse models of autism spectrum disorders (ASDs). We are particularly focused on Rett Syndromea leading cause of intellectual disability with autistic features. We are developing new strategies to restore cortical function and critical period timing by targeting Excitatory/Inhibitory circuits as a possible therapeutic intervention. 

About Michela Fagiolini

Dr. Fagiolini received her M.S. in Biological Sciences from University of Pisa, Italy and her Ph.D. in Neurobiology from Scuola Normale Superiore, Italy. After completing a postdoctoral fellowship in Physiology at the University of California, San Francisco under the mentorship of Dr. Michael P. Stryker, she joined the Laboratory for Neuronal Circuit Development at the Brain Science Institute in Japan. There she began a productive collaboration with Dr. Takao K. Hensch.

Publications

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  1. Thompson AD, Picard N, Min L, Fagiolini M, Chen C. Cortical Feedback Regulates Feedforward Retinogeniculate Refinement. Neuron. 2016 Sep 7; 91(5):1021-33.
  2. Mardinly AR, Spiegel I, Patrizi A, Centofante E, Bazinet JE, Tzeng CP, Mandel-Brehm C, Harmin DA, Adesnik H, Fagiolini M, Greenberg ME. Sensory experience regulates cortical inhibition by inducing IGF1 in VIP neurons. Nature. 2016 Mar 17; 531(7594):371-5.
  3. Volkmann RA, Fanger CM, Anderson DR, Sirivolu VR, Paschetto K, Gordon E, Virginio C, Gleyzes M, Buisson B, Steidl E, Mierau SB, Fagiolini M, Menniti FS. MPX-004 and MPX-007: New Pharmacological Tools to Study the Physiology of NMDA Receptors Containing the GluN2A Subunit. PLoS One. 2016; 11(2):e0148129.
  4. Bei F, Lee HH, Liu X, Gunner G, Jin H, Ma L, Wang C, Hou L, Hensch TK, Frank E, Sanes JR, Chen C, Fagiolini M, He Z. Restoration of Visual Function by Enhancing Conduction in Regenerated Axons. Cell. 2016 Jan 14; 164(1-2):219-32.
  5. Lennartsson A, Arner E, Fagiolini M, Saxena A, Andersson R, Takahashi H, Noro Y, Sng J, Sandelin A, Hensch TK, Carninci P. Remodeling of retrotransposon elements during epigenetic induction of adult visual cortical plasticity by HDAC inhibitors. Epigenetics Chromatin. 2015; 8:55.
  6. LeBlanc JJ, DeGregorio G, Centofante E, Vogel-Farley VK, Barnes K, Kaufmann WE, Fagiolini M, Nelson CA. Visual evoked potentials detect cortical processing deficits in Rett syndrome. Ann Neurol. 2015 Nov; 78(5):775-86.
  7. Patrizi A, Picard N, Simon AJ, Gunner G, Centofante E, Andrews NA, Fagiolini M. Chronic Administration of the N-Methyl-D-Aspartate Receptor Antagonist Ketamine Improves Rett Syndrome Phenotype. Biol Psychiatry. 2016 May 1; 79(9):755-64.
  8. Mierau SB, Patrizi A, Hensch TK, Fagiolini M. Cell-Specific Regulation of N-Methyl-D-Aspartate Receptor Maturation by Mecp2 in Cortical Circuits. Biol Psychiatry. 2016 May 1; 79(9):746-54.
  9. Arner E, Daub CO, Vitting-Seerup K, Andersson R, Lilje B, Drabløs F, Lennartsson A, Rönnerblad M, Hrydziuszko O, Vitezic M, Freeman TC, Alhendi AM, Arner P, Axton R, Baillie JK, Beckhouse A, Bodega B, Briggs J, Brombacher F, Davis M, Detmar M, Ehrlund A, Endoh M, Eslami A, Fagiolini M, Fairbairn L, Faulkner GJ, Ferrai C, Fisher ME, Forrester L, Goldowitz D, Guler R, Ha T, Hara M, Herlyn M, Ikawa T, Kai C, Kawamoto H, Khachigian LM, Klinken SP, Kojima S, Koseki H, Klein S, Mejhert N, Miyaguchi K, Mizuno Y, Morimoto M, Morris KJ, Mummery C, Nakachi Y, Ogishima S, Okada-Hatakeyama M, Okazaki Y, Orlando V, Ovchinnikov D, Passier R, Patrikakis M, Pombo A, Qin XY, Roy S, Sato H, Savvi S, Saxena A, Schwegmann A, Sugiyama D, Swoboda R, Tanaka H, Tomoiu A, Winteringham LN, Wolvetang E, Yanagi-Mizuochi C, Yoneda M, Zabierowski S, Zhang P, Abugessaisa I, Bertin N, Diehl AD, Fukuda S, Furuno M, Harshbarger J, Hasegawa A, Hori F, Ishikawa-Kato S, Ishizu Y, Itoh M, Kawashima T, Kojima M, Kondo N, Lizio M, Meehan TF, Mungall CJ, Murata M, Nishiyori-Sueki H, Sahin S, Nagao-Sato S, Severin J, de Hoon MJ, Kawai J, Kasukawa T, Lassmann T, Suzuki H, Kawaji H, Summers KM, Wells C, Hume DA, Forrest AR, Sandelin A, Carninci P, Hayashizaki Y. Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science. 2015 Feb 27; 347(6225):1010-4.
  10. Vitezic M, Bertin N, Andersson R, Lipovich L, Kawaji H, Lassmann T, Sandelin A, Heutink P, Goldowitz D, Ha T, Zhang P, Patrizi A, Fagiolini M, Forrest AR, Carninci P, Saxena A. CAGE-defined promoter regions of the genes implicated in Rett Syndrome. BMC Genomics. 2014; 15:1177.
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  12. Gogolla N, Takesian AE, Feng G, Fagiolini M, Hensch TK. Sensory integration in mouse insular cortex reflects GABA circuit maturation. Neuron. 2014 Aug 20; 83(4):894-905.
  13. Andersson R, Gebhard C, Miguel-Escalada I, Hoof I, Bornholdt J, Boyd M, Chen Y, Zhao X, Schmidl C, Suzuki T, Ntini E, Arner E, Valen E, Li K, Schwarzfischer L, Glatz D, Raithel J, Lilje B, Rapin N, Bagger FO, Jørgensen M, Andersen PR, Bertin N, Rackham O, Burroughs AM, Baillie JK, Ishizu Y, Shimizu Y, Furuhata E, Maeda S, Negishi Y, Mungall CJ, Meehan TF, Lassmann T, Itoh M, Kawaji H, Kondo N, Kawai J, Lennartsson A, Daub CO, Heutink P, Hume DA, Jensen TH, Suzuki H, Hayashizaki Y, Müller F, Forrest AR, Carninci P, Rehli M, Sandelin A. An atlas of active enhancers across human cell types and tissues. Nature. 2014 Mar 27; 507(7493):455-61.
  14. Forrest AR, Kawaji H, Rehli M, Baillie JK, de Hoon MJ, Haberle V, Lassmann T, Kulakovskiy IV, Lizio M, Itoh M, Andersson R, Mungall CJ, Meehan TF, Schmeier S, Bertin N, Jørgensen M, Dimont E, Arner E, Schmidl C, Schaefer U, Medvedeva YA, Plessy C, Vitezic M, Severin J, Semple C, Ishizu Y, Young RS, Francescatto M, Alam I, Albanese D, Altschuler GM, Arakawa T, Archer JA, Arner P, Babina M, Rennie S, Balwierz PJ, Beckhouse AG, Pradhan-Bhatt S, Blake JA, Blumenthal A, Bodega B, Bonetti A, Briggs J, Brombacher F, Burroughs AM, Califano A, Cannistraci CV, Carbajo D, Chen Y, Chierici M, Ciani Y, Clevers HC, Dalla E, Davis CA, Detmar M, Diehl AD, Dohi T, Drabløs F, Edge AS, Edinger M, Ekwall K, Endoh M, Enomoto H, Fagiolini M, Fairbairn L, Fang H, Farach-Carson MC, Faulkner GJ, Favorov AV, Fisher ME, Frith MC, Fujita R, Fukuda S, Furlanello C, Furino M, Furusawa J, Geijtenbeek TB, Gibson AP, Gingeras T, Goldowitz D, Gough J, Guhl S, Guler R, Gustincich S, Ha TJ, Hamaguchi M, Hara M, Harbers M, Harshbarger J, Hasegawa A, Hasegawa Y, Hashimoto T, Herlyn M, Hitchens KJ, Ho Sui SJ, Hofmann OM, Hoof I, Hori F, Huminiecki L, Iida K, Ikawa T, Jankovic BR, Jia H, Joshi A, Jurman G, Kaczkowski B, Kai C, Kaida K, Kaiho A, Kajiyama K, Kanamori-Katayama M, Kasianov AS, Kasukawa T, Katayama S, Kato S, Kawaguchi S, Kawamoto H, Kawamura YI, Kawashima T, Kempfle JS, Kenna TJ, Kere J, Khachigian LM, Kitamura T, Klinken SP, Knox AJ, Kojima M, Kojima S, Kondo N, Koseki H, Koyasu S, Krampitz S, Kubosaki A, Kwon AT, Laros JF, Lee W, Lennartsson A, Li K, Lilje B, Lipovich L, Mackay-Sim A, Manabe R, Mar JC, Marchand B, Mathelier A, Mejhert N, Meynert A, Mizuno Y, de Lima Morais DA, Morikawa H, Morimoto M, Moro K, Motakis E, Motohashi H, Mummery CL, Murata M, Nagao-Sato S, Nakachi Y, Nakahara F, Nakamura T, Nakamura Y, Nakazato K, van Nimwegen E, Ninomiya N, Nishiyori H, Noma S, Noma S, Noazaki T, Ogishima S, Ohkura N, Ohimiya H, Ohno H, Ohshima M, Okada-Hatakeyama M, Okazaki Y, Orlando V, Ovchinnikov DA, Pain A, Passier R, Patrikakis M, Persson H, Piazza S, Prendergast JG, Rackham OJ, Ramilowski JA, Rashid M, Ravasi T, Rizzu P, Roncador M, Roy S, Rye MB, Saijyo E, Sajantila A, Saka A, Sakaguchi S, Sakai M, Sato H, Savvi S, Saxena A, Schneider C, Schultes EA, Schulze-Tanzil GG, Schwegmann A, Sengstag T, Sheng G, Shimoji H, Shimoni Y, Shin JW, Simon C, Sugiyama D, Sugiyama T, Suzuki M, Suzuki N, Swoboda RK, 't Hoen PA, Tagami M, Takahashi N, Takai J, Tanaka H, Tatsukawa H, Tatum Z, Thompson M, Toyodo H, Toyoda T, Valen E, van de Wetering M, van den Berg LM, Verado R, Vijayan D, Vorontsov IE, Wasserman WW, Watanabe S, Wells CA, Winteringham LN, Wolvetang E, Wood EJ, Yamaguchi Y, Yamamoto M, Yoneda M, Yonekura Y, Yoshida S, Zabierowski SE, Zhang PG, Zhao X, Zucchelli S, Summers KM, Suzuki H, Daub CO, Kawai J, Heutink P, Hide W, Freeman TC, Lenhard B, Bajic VB, Taylor MS, Makeev VJ, Sandelin A, Hume DA, Carninci P, Hayashizaki Y. A promoter-level mammalian expression atlas. Nature. 2014 Mar 27; 507(7493):462-70.
  15. Picard N, Leslie JH, Trowbridge SK, Subramanian J, Nedivi E, Fagiolini M. Aberrant development and plasticity of excitatory visual cortical networks in the absence of cpg15. J Neurosci. 2014 Mar 5; 34(10):3517-22.
  16. Kang E, Durand S, LeBlanc JJ, Hensch TK, Chen C, Fagiolini M. Visual acuity development and plasticity in the absence of sensory experience. J Neurosci. 2013 Nov 6; 33(45):17789-96.
  17. Durand S, Patrizi A, Quast KB, Hachigian L, Pavlyuk R, Saxena A, Carninci P, Hensch TK, Fagiolini M. NMDA receptor regulation prevents regression of visual cortical function in the absence of Mecp2. Neuron. 2012 Dec 20; 76(6):1078-90.
  18. Saxena A, Wagatsuma A, Noro Y, Kuji T, Asaka-Oba A, Watahiki A, Gurnot C, Fagiolini M, Hensch TK, Carninci P. Trehalose-enhanced isolation of neuronal sub-types from adult mouse brain. Biotechniques. 2012 Jun; 52(6):381-5.
  19. de Lima S, Koriyama Y, Kurimoto T, Oliveira JT, Yin Y, Li Y, Gilbert HY, Fagiolini M, Martinez AM, Benowitz L. Full-length axon regeneration in the adult mouse optic nerve and partial recovery of simple visual behaviors. Proc Natl Acad Sci U S A. 2012 Jun 5; 109(23):9149-54.
  20. LeBlanc JJ, Fagiolini M. Autism: a "critical period" disorder? Neural Plast. 2011; 2011:921680.
  21. Gogolla N, Leblanc JJ, Quast KB, Südhof TC, Fagiolini M, Hensch TK. Common circuit defect of excitatory-inhibitory balance in mouse models of autism. J Neurodev Disord. 2009 Jun; 1(2):172-81.
  22. Fagiolini M, Jensen CL, Champagne FA. Epigenetic influences on brain development and plasticity. Curr Opin Neurobiol. 2009 Apr; 19(2):207-12.
  23. Aliu E, Anderhub H, Antonelli LA, Antoranz P, Backes M, Baixeras C, Barrio JA, Bartko H, Bastieri D, Becker JK, Bednarek W, Berger K, Bernardini E, Bigongiari C, Biland A, Bock RK, Bonnoli G, Bordas P, Bosch-Ramon V, Bretz T, Britvitch I, Camara M, Carmona E, Chilingarian A, Commichau S, Contreras JL, Cortina J, Costado MT, Covino S, Curtef V, Dazzi F, De Angelis A, De Cea Del Pozo E, de Los Reyes R, De Lotto B, De Maria M, De Sabata F, Delgado Mendez C, Dominguez A, Dorner D, Doro M, Elsässer D, Errando M, Fagiolini M, Ferenc D, Fernandez E, Firpo R, Fonseca MV, Font L, Galante N, Garcia Lopez RJ, Garczarczyk M, Gaug M, Goebel F, Hadasch D, Hayashida M, Herrero A, Höhne D, Hose J, Hsu CC, Huber S, Jogler T, Kranich D, La Barbera A, Laille A, Leonardo E, Lindfors E, Lombardi S, Longo F, Lopez M, Lorenz E, Majumdar P, Maneva G, Mankuzhiyil N, Mannheim K, Maraschi L, Mariotti M, Martinez M, Mazin D, Meucci M, Meyer M, Miranda JM, Mirzoyan R, Moles M, Moralejo A, Nieto D, Nilsson K, Ninkovic J, Otte N, Oya I, Paoletti R, Paredes JM, Pasanen M, Pascoli D, Pauss F, Pegna RG, Perez-Torres MA, Persic M, Peruzzo L, Piccioli A, Prada F, Prandini E, Puchades N, Raymers A, Rhode W, Ribó M, Rico J, Rissi M, Robert A, Rügamer S, Saggion A, Saito TY, Salvati M, Sanchez-Conde M, Sartori P, Satalecka K, Scalzotto V, Scapin V, Schweizer T, Shayduk M, Shinozaki K, Shore SN, Sidro N, Sierpowska-Bartosik A, Sillanpää A, Sobczynska D, Spanier F, Stamerra A, Stark LS, Takalo L, Tavecchio F, Temnikov P, Tescaro D, Teshima M, Tluczykont M, Torres DF, Turini N, Vankov H, Venturini A, Vitale V, Wagner RM, Wittek W, Zabalza V, Zandanel F, Zanin R, Zapatero J, de Jager OC, de Ona Wilhelmi E. Observation of pulsed gamma-rays above 25 GeV from the Crab pulsar with MAGIC. Science. 2008 Nov 21; 322(5905):1221-4.
  24. Plessy C, Fagiolini M, Wagatsuma A, Harasawa N, Kuji T, Asaka-Oba A, Kanzaki Y, Fujishima S, Waki K, Nakahara H, Hensch TK, Carninci P. A resource for transcriptomic analysis in the mouse brain. PLoS One. 2008; 3(8):e3012.
  25. Albert J, Aliu E, Anderhub H, Antonelli LA, Antoranz P, Backes M, Baixeras C, Barrio JA, Bartko H, Bastieri D, Becker JK, Bednarek W, Berger K, Bernardini E, Bigongiari C, Biland A, Bock RK, Bonnoli G, Bordas P, Bosch-Ramon V, Bretz T, Britvitch I, Camara M, Carmona E, Chilingarian A, Commichau S, Contreras JL, Cortina J, Costado MT, Covino S, Curtef V, Dazzi F, De Angelis A, De Cea Del Pozo E, de Los Reyes R, De Lotto B, De Maria M, De Sabata F, Mendez CD, Dominguez A, Dorner D, Doro M, Errando M, Fagiolini M, Ferenc D, Fernández E, Firpo R, Fonseca MV, Font L, Galante N, López RJ, Garczarczyk M, Gaug M, Goebel F, Hayashida M, Herrero A, Höhne D, Hose J, Hsu CC, Huber S, Jogler T, Kneiske TM, Kranich D, La Barbera A, Laille A, Leonardo E, Lindfors E, Lombardi S, Longo F, López M, Lorenz E, Majumdar P, Maneva G, Mankuzhiyil N, Mannheim K, Maraschi L, Mariotti M, Martínez M, Mazin D, Meucci M, Meyer M, Miranda JM, Mirzoyan R, Mizobuchi S, Moles M, Moralejo A, Nieto D, Nilsson K, Ninkovic J, Otte N, Oya I, Panniello M, Paoletti R, Paredes JM, Pasanen M, Pascoli D, Pauss F, Pegna RG, Perez-Torres MA, Persic M, Peruzzo L, Piccioli A, Prada F, Prandini E, Puchades N, Raymers A, Rhode W, Ribó M, Rico J, Rissi M, Robert A, Rügamer S, Saggion A, Saito TY, Salvati M, Sanchez-Conde M, Sartori P, Satalecka K, Scalzotto V, Scapin V, Schmitt R, Schweizer T, Shayduk M, Shinozaki K, Shore SN, Sidro N, Sierpowska-Bartosik A, Sillanpää A, Sobczynska D, Spanier F, Stamerra A, Stark LS, Takalo L, Tavecchio F, Temnikov P, Tescaro D, Teshima M, Tluczykont M, Torres DF, Turini N, Vankov H, Venturini A, Vitale V, Wagner RM, Wittek W, Zabalza V, Zandanel F, Zanin R, Zapatero J. Very-high-energy gamma rays from a distant quasar: how transparent is the universe? Science. 2008 Jun 27; 320(5884):1752-4.
  26. Katagiri H, Fagiolini M, Hensch TK. Optimization of somatic inhibition at critical period onset in mouse visual cortex. Neuron. 2007 Mar 15; 53(6):805-12.
  27. Pallas SL, Wenner P, Gonzalez-Islas C, Fagiolini M, Razak KA, Kim G, Sanes D, Roerig B. Developmental plasticity of inhibitory circuitry. J Neurosci. 2006 Oct 11; 26(41):10358-61.
  28. Albert J, Aliu E, Anderhub H, Antoranz P, Armada A, Asensio M, Baixeras C, Barrio JA, Bartelt M, Bartko H, Bastieri D, Bavikadi SR, Bednarek W, Berger K, Bigongiari C, Biland A, Bisesi E, Bock RK, Bordas P, Bosch-Ramon V, Bretz T, Britvitch I, Camara M, Carmona E, Chilingarian A, Ciprini S, Coarasa JA, Commichau S, Contreras JL, Cortina J, Curtef V, Danielyan V, Dazzi F, De Angelis A, de Los Reyes R, De Lotto B, Domingo-Santamaría E, Dorner D, Doro M, Errando M, Fagiolini M, Ferenc D, Fernández E, Firpo R, Flix J, Fonseca MV, Font L, Fuchs M, Galante N, Garczarczyk M, Gaug M, Giller M, Goebel F, Hakobyan D, Hayashida M, Hengstebeck T, Höhne D, Hose J, Hsu CC, Isar PG, Jacon P, Kalekin O, Kosyra R, Kranich D, Laatiaoui M, Laille A, Lenisa T, Liebing P, Lindfors E, Lombardi S, Longo F, López J, López M, Lorenz E, Lucarelli F, Majumdar P, Maneva G, Mannheim K, Mansutti O, Mariotti M, Martínez M, Mase K, Mazin D, Merck C, Meucci M, Meyer M, Miranda JM, Mirzoyan R, Mizobuchi S, Moralejo A, Nilsson K, Oña-Wilhelmi E, Orduña R, Otte N, Oya I, Paneque D, Paoletti R, Paredes JM, Pasanen M, Pascoli D, Pauss F, Pavel N, Pegna R, Persic M, Peruzzo L, Piccioli A, Poller M, Pooley G, Prandini E, Raymers A, Rhode W, Ribó M, Rico J, Riegel B, Rissi M, Robert A, Romero GE, Rügamer S, Saggion A, Sánchez A, Sartori P, Scalzotto V, Scapin V, Schmitt R, Schweizer T, Shayduk M, Shinozaki K, Shore SN, Sidro N, Sillanpää A, Sobczynska D, Stamerra A, Stark LS, Takalo L, Temnikov P, Tescaro D, Teshima M, Tonello N, Torres A, Torres DF, Turini N, Vankov H, Vitale V, Wagner RM, Wibig T, Wittek W, Zanin R, Zapatero J. Variable very-high-energy gamma-ray emission from the microquasar LS I +61 303. Science. 2006 Jun 23; 312(5781):1771-3.
  29. Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y. The transcriptional landscape of the mammalian genome. Science. 2005 Sep 2; 309(5740):1559-63.
  30. Hensch TK, Fagiolini M. Excitatory-inhibitory balance and critical period plasticity in developing visual cortex. Prog Brain Res. 2005; 147:115-24.
  31. Fagiolini M, Fritschy JM, Löw K, Möhler H, Rudolph U, Hensch TK. Specific GABAA circuits for visual cortical plasticity. Science. 2004 Mar 12; 303(5664):1681-3.
  32. Hirozane-Kishikawa T, Shiraki T, Waki K, Nakamura M, Arakawa T, Kawai J, Fagiolini M, Hensch TK, Hayashizaki Y, Carninci P. Subtraction of cap-trapped full-length cDNA libraries to select rare transcripts. Biotechniques. 2003 Sep; 35(3):510-6, 518.
  33. Iwai Y, Fagiolini M, Obata K, Hensch TK. Rapid critical period induction by tonic inhibition in visual cortex. J Neurosci. 2003 Jul 30; 23(17):6695-702.
  34. Carninci P, Waki K, Shiraki T, Konno H, Shibata K, Itoh M, Aizawa K, Arakawa T, Ishii Y, Sasaki D, Bono H, Kondo S, Sugahara Y, Saito R, Osato N, Fukuda S, Sato K, Watahiki A, Hirozane-Kishikawa T, Nakamura M, Shibata Y, Yasunishi A, Kikuchi N, Yoshiki A, Kusakabe M, Gustincich S, Beisel K, Pavan W, Aidinis V, Nakagawara A, Held WA, Iwata H, Kono T, Nakauchi H, Lyons P, Wells C, Hume DA, Fagiolini M, Hensch TK, Brinkmeier M, Camper S, Hirota J, Mombaerts P, Muramatsu M, Okazaki Y, Kawai J, Hayashizaki Y. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Genome Res. 2003 Jun; 13(6B):1273-89.
  35. Fagiolini M, Katagiri H, Miyamoto H, Mori H, Grant SG, Mishina M, Hensch TK. Separable features of visual cortical plasticity revealed by N-methyl-D-aspartate receptor 2A signaling. Proc Natl Acad Sci U S A. 2003 Mar 4; 100(5):2854-9.
  36. Silver MA, Fagiolini M, Gillespie DC, Howe CL, Frank MG, Issa NP, Antonini A, Stryker MP. Infusion of nerve growth factor (NGF) into kitten visual cortex increases immunoreactivity for NGF, NGF receptors, and choline acetyltransferase in basal forebrain without affecting ocular dominance plasticity or column development. Neuroscience. 2001; 108(4):569-85.
  37. Fagiolini M, Hensch TK. Inhibitory threshold for critical-period activation in primary visual cortex. Nature. 2000 Mar 9; 404(6774):183-6.
  38. Pizzorusso T, Fagiolini M, Gianfranceschi L, Porciatti V, Maffei L. Role of neurotrophins in the development and plasticity of the visual system: experiments on dark rearing. Int J Psychophysiol. 2000 Mar; 35(2-3):189-96.
  39. Antonini A, Fagiolini M, Stryker MP. Anatomical correlates of functional plasticity in mouse visual cortex. J Neurosci. 1999 Jun 1; 19(11):4388-406.
  40. Hensch TK, Fagiolini M, Mataga N, Stryker MP, Baekkeskov S, Kash SF. Local GABA circuit control of experience-dependent plasticity in developing visual cortex. Science. 1998 Nov 20; 282(5393):1504-8.
  41. Fagiolini M, Caleo M, Strettoi E, Maffei L. Axonal transport blockade in the neonatal rat optic nerve induces limited retinal ganglion cell death. J Neurosci. 1997 Sep 15; 17(18):7045-52.
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The F.M. Kirby Neurobiology Center, together with the Neurobiology Program at Boston Children’s Hospital, is the largest basic neuroscience research enterprise at a U.S. hospital. It incorporates basic and translational neuroscience research, focusing primarily on developmental neurobiology.

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