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Edda  Fiebiger, PhD

Edda Fiebiger
Fiebiger Laboratory
Medicine Research
Gastroenterology, Hepatology and Nutrition Research
Hospital Title:
Staff Scientist
Academic Title:
Assistant Professor of Pediatrics, Harvard Medical School
Research Focus Area:
Immune Responses in the Gastrointestinal Tract
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Research Overview

Moderate estimates suggest that one out of five individuals in the Western World suffers from some form of allergic condition. In particular, food allergic reactions are of increasing concern in the United States. Approximately one fourth of all American households face restrictions in their diet due to a family member suffering from food allergies. Children appear particularly susceptible when dissecting the age group of peanut butter and cow milk allergic individuals. The Fiebiger Laboratory hopes to define new strategies for diagnosis and treatment of food allergic children.

Dr. Fiebiger and her colleagues are interested in immune responses in the mucosa of the gastrointestinal tract. Their main goal is to better understand basic mechanisms that regulate the pathology of food allergies and are studying general issues of the molecular biology of immune recognition receptors and IgE-mediated activation of the immune system. The gastrointestinal immune system balances the ability to respond to pathogens while remaining unresponsive to food antigens as well as the commensal microflora. In the recent past, the ability of the gastro intestinal immune system to maintain this balance appears to be challenged. Inappropriate immune responses towards food-born antigens result in allergy. A detailed understanding of function, regulation and trafficking of Fc-epsilon-RI will improve understanding of IgE-mediated antigen presentation and hopefully help to establish new treatment strategies for such allergies.

Goals of Dr. Fiebiger's research include:

  • Understanding IgE-mediated immune events in the gastrointestinal tract and gaining new insight into the IgE-allergen induced activation of the immune system.
  • Understanding the principles of IgE-receptor formation, quality control and function.
  • Defining new, non-invasive biomarkers for eosinophilic esophagitis.

About Edda Fiebiger

Edda Fiebiger received a PhD from the University of Vienna, Austria, and completed postgraduate training at Harvard Medical School. Recent awards include: 2008 Gerber Foundation Grant; 2007 CDHNF Young Investigator Development Award; NASPGHAN; 2007 Harvard Digestive Disease Center Pilot Project Grant; and 2006 Junior Faculty Award at Boston Children's Hospital, Eleanor and Miles Shore Foundation.


Publications powered by Harvard Catalyst Profiles
  1. Mudde AC, Lexmond WS, Blumberg RS, Nurko S, Fiebiger E. Eosinophilic esophagitis: published evidences for disease subtypes, indications for patient subpopulations, and how to translate patient observations to murine experimental models. World Allergy Organ J. 2016; 9:23.
  2. Lexmond WS, Rufo PA, Fiebiger E, Lencer WI. Electrophysiological Studies into the Safety of the Anti-diarrheal Drug Clotrimazole during Oral Rehydration Therapy. PLoS Negl Trop Dis. 2015 Sep; 9(9):e0004098.
  3. Lexmond WS, Hu L, Pardo M, Heinz N, Rooney K, LaRosa J, Dehlink E, Fiebiger E, Nurko S. Accuracy of digital mRNA profiling of oesophageal biopsies as a novel diagnostic approach to eosinophilic oesophagitis. Clin Exp Allergy. 2015 Aug; 45(8):1317-27.
  4. Platzer B, Stout M, Fiebiger E. Functions of dendritic-cell-bound IgE in allergy. Mol Immunol. 2015 Dec; 68(2 Pt A):116-9.
  5. Goettel JA, Biswas S, Lexmond WS, Yeste A, Passerini L, Patel B, Yang S, Sun J, Ouahed J, Shouval DS, McCann KJ, Horwitz BH, Mathis D, Milford EL, Notarangelo LD, Roncarolo MG, Fiebiger E, Marasco WA, Bacchetta R, Quintana FJ, Pai SY, Klein C, Muise AM, Snapper SB. Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3. Blood. 2015 Jun 18; 125(25):3886-95.
  6. Shade KT, Platzer B, Washburn N, Mani V, Bartsch YC, Conroy M, Pagan JD, Bosques C, Mempel TR, Fiebiger E, Anthony RM. A single glycan on IgE is indispensable for initiation of anaphylaxis. J Exp Med. 2015 Apr 6; 212(4):457-67.
  7. Platzer B, Baker K, Vera MP, Singer K, Panduro M, Lexmond WS, Turner D, Vargas SO, Kinet JP, Maurer D, Baron RM, Blumberg RS, Fiebiger E. Dendritic cell-bound IgE functions to restrain allergic inflammation at mucosal sites. Mucosal Immunol. 2015 May; 8(3):516-32.
  8. Wurbel MA, Le Bras S, Ibourk M, Pardo M, McIntire MG, Coco D, Geha RS, Fiebiger E, Snapper SB. CCL25/CCR9 interactions are not essential for colitis development but are required for innate immune cell protection from chronic experimental murine colitis. Inflamm Bowel Dis. 2014 Jul; 20(7):1165-76.
  9. Platzer B, Stout M, Fiebiger E. Antigen cross-presentation of immune complexes. Front Immunol. 2014; 5:140.
  10. Lexmond WS, Neves JF, Nurko S, Olszak T, Exley MA, Blumberg RS, Fiebiger E. Involvement of the iNKT cell pathway is associated with early-onset eosinophilic esophagitis and response to allergen avoidance therapy. Am J Gastroenterol. 2014 May; 109(5):646-57.
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  12. Lexmond WS, Pardo M, Rooney K, Goettel JA, Snapper SB, Yen EH, Dehlink E, Nurko S, Fiebiger E. Elevated levels of leukotriene C4 synthase mRNA distinguish a subpopulation of eosinophilic oesophagitis patients. Clin Exp Allergy. 2013 Aug; 43(8):902-13.
  13. Cho JA, Lee AH, Platzer B, Cross BC, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI. The unfolded protein response element IRE1a senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. Cell Host Microbe. 2013 May 15; 13(5):558-69.
  14. D'Angelo JA, Mattox ML, Fiebiger E, Dickinson BL. The cystine/glutamate antiporter regulates the functional expression of indoleamine 2,3-dioxygenase in human dendritic cells. Scand J Immunol. 2012 Oct; 76(4):448-9.
  15. Rath T, Kuo TT, Baker K, Qiao SW, Kobayashi K, Yoshida M, Roopenian D, Fiebiger E, Lencer WI, Blumberg RS. The immunologic functions of the neonatal Fc receptor for IgG. J Clin Immunol. 2013 Jan; 33 Suppl 1:S9-17.
  16. Baker K, Rath T, Lencer WI, Fiebiger E, Blumberg RS. Cross-presentation of IgG-containing immune complexes. Cell Mol Life Sci. 2013 Apr; 70(8):1319-34.
  17. Bannert C, Bidmon-Fliegenschnee B, Stary G, Hotzy F, Stift J, Nurko S, Szépfalusi Z, Fiebiger E, Dehlink E. Fc-epsilon-RI, the high affinity IgE-receptor, is robustly expressed in the upper gastrointestinal tract and modulated by mucosal inflammation. PLoS One. 2012; 7(7):e42066.
  18. Nguyen DD, Wurbel MA, Goettel JA, Eston MA, Ahmed OS, Marin R, Boden EK, Villablanca EJ, Paidassi H, Ahuja V, Reinecker HC, Fiebiger E, Lacy-Hulbert A, Horwitz BH, Mora JR, Snapper SB. Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice. Gastroenterology. 2012 Sep; 143(3):719-29.e1-2.
  19. Platzer B, Dehlink E, Turley SJ, Fiebiger E. How to connect an IgE-driven response with CTL activity? Cancer Immunol Immunother. 2012 Sep; 61(9):1521-5.
  20. Platzer B, Ruiter F, van der Mee J, Fiebiger E. Soluble IgE receptors--elements of the IgE network. Immunol Lett. 2011 Dec 30; 141(1):36-44.
  21. Lexmond W, der Mee Jv, Ruiter F, Platzer B, Stary G, Yen EH, Dehlink E, Nurko S, Fiebiger E. Development and validation of a standardized ELISA for the detection of soluble Fc-epsilon-RI in human serum. J Immunol Methods. 2011 Oct 28; 373(1-2):192-9.
  22. Baker K, Qiao SW, Kuo TT, Aveson VG, Platzer B, Andersen JT, Sandlie I, Chen Z, de Haar C, Lencer WI, Fiebiger E, Blumberg RS. Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells. Proc Natl Acad Sci U S A. 2011 Jun 14; 108(24):9927-32.
  23. Sallmann E, Reininger B, Brandt S, Duschek N, Hoflehner E, Garner-Spitzer E, Platzer B, Dehlink E, Hammer M, Holcmann M, Oettgen HC, Wiedermann U, Sibilia M, Fiebiger E, Rot A, Maurer D. High-affinity IgE receptors on dendritic cells exacerbate Th2-dependent inflammation. J Immunol. 2011 Jul 1; 187(1):164-71.
  24. Dehlink E, Platzer B, Baker AH, Larosa J, Pardo M, Dwyer P, Yen EH, Szépfalusi Z, Nurko S, Fiebiger E. A soluble form of the high affinity IgE receptor, Fc-epsilon-RI, circulates in human serum. PLoS One. 2011; 6(4):e19098.
  25. Wurbel MA, McIntire MG, Dwyer P, Fiebiger E. CCL25/CCR9 interactions regulate large intestinal inflammation in a murine model of acute colitis. PLoS One. 2011; 6(1):e16442.
  26. Yen EH, Hornick JL, Dehlink E, Dokter M, Baker A, Fiebiger E, Nurko S. Comparative analysis of FceRI expression patterns in patients with eosinophilic and reflux esophagitis. J Pediatr Gastroenterol Nutr. 2010 Nov; 51(5):584-92.
  27. D'Angelo JA, Dehlink E, Platzer B, Dwyer P, Circu ML, Garay J, Aw TY, Fiebiger E, Dickinson BL. The cystine/glutamate antiporter regulates dendritic cell differentiation and antigen presentation. J Immunol. 2010 Sep 15; 185(6):3217-26.
  28. Garay J, D'Angelo JA, Park Y, Summa CM, Aiken ML, Morales E, Badizadegan K, Fiebiger E, Dickinson BL. Crosstalk between PKA and Epac regulates the phenotypic maturation and function of human dendritic cells. J Immunol. 2010 Sep 15; 185(6):3227-38.
  29. Dehlink E, Baker AH, Yen E, Nurko S, Fiebiger E. Relationships between levels of serum IgE, cell-bound IgE, and IgE-receptors on peripheral blood cells in a pediatric population. PLoS One. 2010; 5(8):e12204.
  30. Eleonora Dehlink, M.D. Ph.D. and Edda Fiebiger, Ph.D. . In search of a more comprehensive allergy diagnostic: assessment of the total-body IgE pool. 2010.
  31. Platzer B, Fiebiger E. The signal peptide of the IgE receptor alpha-chain prevents surface expression of an immunoreceptor tyrosine-based activation motif-free receptor pool. J Biol Chem. 2010 May 14; 285(20):15314-23.
  32. Paulitschke V, Schicher N, Szekeres T, Jäger W, Elbling L, Riemer AB, Scheiner O, Trimurtulu G, Venkateswarlu S, Mikula M, Swoboda A, Fiebiger E, Gerner C, Pehamberger H, Kunstfeld R. 3,3',4,4',5,5'-hexahydroxystilbene impairs melanoma progression in a metastatic mouse model. J Invest Dermatol. 2010 Jun; 130(6):1668-79.
  33. Singleton TE, Platzer B, Dehlink E, Fiebiger E. The first transmembrane region of the beta-chain stabilizes the tetrameric Fc epsilon RI complex. Mol Immunol. 2009 Jul; 46(11-12):2333-9.
  34. Edelmann MJ, Iphöfer A, Akutsu M, Altun M, di Gleria K, Kramer HB, Fiebiger E, Dhe-Paganon S, Kessler BM. Structural basis and specificity of human otubain 1-mediated deubiquitination. Biochem J. 2009 Mar 1; 418(2):379-90.
  35. Dehlink E, Fiebiger E. The role of the high-affinity IgE receptor, FcepsilonRI, in eosinophilic gastrointestinal diseases. Immunol Allergy Clin North Am. 2009 Feb; 29(1):159-70, xii.
  36. Dehlink E, Yen E, Leichtner AM, Hait EJ, Fiebiger E. First evidence of a possible association between gastric acid suppression during pregnancy and childhood asthma: a population-based register study. Clin Exp Allergy. 2009 Feb; 39(2):246-53.
  37. Catic A, Fiebiger E, Korbel GA, Blom D, Galardy PJ, Ploegh HL. Screen for ISG15-crossreactive deubiquitinases. PLoS One. 2007; 2(7):e679.
  38. Majewski M, Bose TO, Sillé FC, Pollington AM, Fiebiger E, Boes M. Protein kinase C delta stimulates antigen presentation by Class II MHC in murine dendritic cells. Int Immunol. 2007 Jun; 19(6):719-32.
  39. Berkers CR, Verdoes M, Lichtman E, Fiebiger E, Kessler BM, Anderson KC, Ploegh HL, Ovaa H, Galardy PJ. Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib. Nat Methods. 2005 May; 2(5):357-62.
  40. Fiebiger E, Tortorella D, Jouvin MH, Kinet JP, Ploegh HL. Cotranslational endoplasmic reticulum assembly of FcepsilonRI controls the formation of functional IgE-binding receptors. J Exp Med. 2005 Jan 17; 201(2):267-77.
  41. Jaksits S, Bauer W, Kriehuber E, Zeyda M, Stulnig TM, Stingl G, Fiebiger E, Maurer D. Lipid raft-associated GTPase signaling controls morphology and CD8+ T cell stimulatory capacity of human dendritic cells. J Immunol. 2004 Aug 1; 173(3):1628-39.
  42. Kunstfeld R, Hirakawa S, Hong YK, Schacht V, Lange-Asschenfeldt B, Velasco P, Lin C, Fiebiger E, Wei X, Wu Y, Hicklin D, Bohlen P, Detmar M. Induction of cutaneous delayed-type hypersensitivity reactions in VEGF-A transgenic mice results in chronic skin inflammation associated with persistent lymphatic hyperplasia. Blood. 2004 Aug 15; 104(4):1048-57.
  43. Fiebiger E, Hirsch C, Vyas JM, Gordon E, Ploegh HL, Tortorella D. Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin. Mol Biol Cell. 2004 Apr; 15(4):1635-46.
  44. Bertho N, Cerny J, Kim YM, Fiebiger E, Ploegh H, Boes M. Requirements for T cell-polarized tubulation of class II+ compartments in dendritic cells. J Immunol. 2003 Dec 1; 171(11):5689-96.
  45. Winter D, Fiebiger E, Meraner P, Auer H, Brna C, Strohal R, Trautinger F, Knobler R, Fischer GF, Stingl G, Maurer D. Definition of TCR epitopes for CTL-mediated attack of cutaneous T cell lymphoma. J Immunol. 2003 Sep 1; 171(5):2714-24.
  46. Ovaa H, van Swieten PF, Kessler BM, Leeuwenburgh MA, Fiebiger E, van den Nieuwendijk AM, Galardy PJ, van der Marel GA, Ploegh HL, Overkleeft HS. Chemistry in living cells: detection of active proteasomes by a two-step labeling strategy. Angew Chem Int Ed Engl. 2003 Aug 11; 42(31):3626-9.
  47. Fiebiger E, Maehr R, Villadangos J, Weber E, Erickson A, Bikoff E, Ploegh HL, Lennon-Duménil AM. Invariant chain controls the activity of extracellular cathepsin L. J Exp Med. 2002 Nov 4; 196(9):1263-9.
  48. Sabroe RA, Fiebiger E, Francis DM, Maurer D, Seed PT, Grattan CE, Black AK, Stingl G, Greaves MW, Barr RM. Classification of anti-FcepsilonRI and anti-IgE autoantibodies in chronic idiopathic urticaria and correlation with disease severity. J Allergy Clin Immunol. 2002 Sep; 110(3):492-9.
  49. Lennon-Duménil AM, Bakker AH, Maehr R, Fiebiger E, Overkleeft HS, Rosemblatt M, Ploegh HL, Lagaudrière-Gesbert C. Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation. J Exp Med. 2002 Aug 19; 196(4):529-40.
  50. Fiebiger E, Story C, Ploegh HL, Tortorella D. Visualization of the ER-to-cytosol dislocation reaction of a type I membrane protein. EMBO J. 2002 Mar 1; 21(5):1041-53.
  51. Bryant PW, Lennon-Duménil AM, Fiebiger E, Lagaudrière-Gesbert C, Ploegh HL. Proteolysis and antigen presentation by MHC class II molecules. Adv Immunol. 2002; 80:71-114.
  52. Bryant PW, Lennon-Dumenil AM, Fiebiger E, Lagaudriere-Gesbert C, Ploegh HL. Proteolysis and antigen presentation by MHC class II molecules. Adv Immunol. 2002;80:71-114. 2002.
  53. Kessler BM, Tortorella D, Altun M, Kisselev AF, Fiebiger E, Hekking BG, Ploegh HL, Overkleeft HS. Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits. Chem Biol. 2001 Sep; 8(9):913-29.
  54. Fiebiger E, Meraner P, Weber E, Fang IF, Stingl G, Ploegh H, Maurer D. Cytokines regulate proteolysis in major histocompatibility complex class II-dependent antigen presentation by dendritic cells. J Exp Med. 2001 Apr 16; 193(8):881-92.
  55. Elbe-Bürger A, Mommaas AM, Prieschl EE, Fiebiger E, Baumruker T, Stingl G. Major histocompatibility complex class II- fetal skin dendritic cells are potent accessory cells of polyclonal T-cell responses. Immunology. 2000 Oct; 101(2):242-53.
  56. Zuberbier T, Henz BM, Fiebiger E, Maurer D, Stingl G. Anti-FcepsilonRIalpha serum autoantibodies in different subtypes of urticaria. Allergy. 2000 Oct; 55(10):951-4.
  57. Maurer D, Fiebiger E, Reininger B, Ebner C, Petzelbauer P, Shi GP, Chapman HA, Stingl G. Fc epsilon receptor I on dendritic cells delivers IgE-bound multivalent antigens into a cathepsin S-dependent pathway of MHC class II presentation. J Immunol. 1998 Sep 15; 161(6):2731-9.
  58. Fiebiger E, Hammerschmid F, Stingl G, Maurer D. Anti-FcepsilonRIalpha autoantibodies in autoimmune-mediated disorders. Identification of a structure-function relationship. J Clin Invest. 1998 Jan 1; 101(1):243-51.
  59. Fuerst J, Fiebiger E, Jungwirth A, Mack D, Talwar PG, Frick J, Rovan E. Effect of active immunization against luteinizing hormone-releasing hormone on the androgen-sensitive Dunning R3327-PAP and androgen-independent Dunning R3327-AT2.1 prostate cancer sublines. Prostate. 1997 Jul 1; 32(2):77-84.
  60. Maurer D, Ebner C, Reininger B, Petzelbauer P, Fiebiger E, Stingl G. Mechanisms of Fc epsilon RI-IgE-facilitated allergen presentation by dendritic cells. Adv Exp Med Biol. 1997; 417:175-8.
  61. Maurer D, Ebner C, Reininger B, Petzelbauer P, Fiebiger E, Stingl G. . Mechanisms of Fc epsilon RI-IgE-facilitated allergen presentation by dendritic cells. Adv Exp Med Biol. 1997;417:175-8. 1997.
  62. Maurer, D., Ebener C., Reininger B., Petzelbauer P., Fiebiger E., and Stingl G. . Mechanisms of FceRI-IgE-facilitated allergen presentation by dendritic cells. Dendritic Cells in Fundamental and Clinical Immunology, Plenum Press, New York, pp. 175. 1997.
  63. Fiebiger E, Stingl G, Maurer D. Anti-IgE and anti-Fc epsilon RI autoantibodies in clinical allergy. Curr Opin Immunol. 1996 Dec; 8(6):784-9.
  64. Grabbe J, Welker P, Rosenbach T, Nürnberg W, Krüger-Krasagakes S, Artuc M, Fiebiger E, Henz BM. Release of stem cell factor from a human keratinocyte line, HaCaT, is increased in differentiating versus proliferating cells. J Invest Dermatol. 1996 Aug; 107(2):219-24.
  65. Gröger M, Sarmay G, Fiebiger E, Wolff K, Petzelbauer P. Dermal microvascular endothelial cells express CD32 receptors in vivo and in vitro. J Immunol. 1996 Feb 15; 156(4):1549-56.
  66. Fiebiger E, Stingl G, Maurer D. . Anti-IgE and anti-Fc epsilon RI autoantibodies in clinical allergy. Curr Opin Immunol. 1996 Dec;8(6):784-9. 1996.
  67. Fiebiger E, Maurer D, Holub H, Reininger B, Hartmann G, Woisetschläger M, Kinet JP, Stingl G. Serum IgG autoantibodies directed against the alpha chain of Fc epsilon RI: a selective marker and pathogenetic factor for a distinct subset of chronic urticaria patients? J Clin Invest. 1995 Dec; 96(6):2606-12.
  68. Kramer G, Steiner G, Födinger D, Fiebiger E, Rappersberger C, Binder S, Hofbauer J, Marberger M. High expression of a CD38-like molecule in normal prostatic epithelium and its differential loss in benign and malignant disease. J Urol. 1995 Nov; 154(5):1636-41.
  69. Maurer D, Ebner C, Reininger B, Fiebiger E, Kraft D, Kinet JP, Stingl G. The high affinity IgE receptor (Fc epsilon RI) mediates IgE-dependent allergen presentation. J Immunol. 1995 Jun 15; 154(12):6285-90.
  70. Maurer, D., Fiebiger E., Reininger B., Stingl G. 1995. FceRI: Structure, cellular distribution, and function. Symposium in Immunology IV, Springer-Verlag Berlin, Heidelberg, pp 59. 1995.
  71. Maurer D, Fiebiger E, Reininger B, Wolff-Winiski B, Jouvin MH, Kilgus O, Kinet JP, Stingl G. Expression of functional high affinity immunoglobulin E receptors (Fc epsilon RI) on monocytes of atopic individuals. J Exp Med. 1994 Feb 1; 179(2):745-50.
  72. Fürst J, Fiebiger E, Mack D, Frick J, Rovan E. The effect of active immunization against gonadotropin-releasing hormone on the ultrastructure of the rat ventral prostate. Urol Res. 1994; 22(2):107-13.
  73. Stöckl J, Majdic O, Rosenkranz A, Fiebiger E, Kniep B, Stockinger H, Knapp W. Monoclonal antibodies to the carbohydrate structure Lewis(x) stimulate the adhesive activity of leukocyte integrin CD11b/CD18 (CR3, Mac-1, alpha m beta 2) on human granulocytes. J Leukoc Biol. 1993 May; 53(5):541-9.
  74. Kasinrerk W, Fiebiger E, Stefanová I, Baumruker T, Knapp W, Stockinger H. Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule. J Immunol. 1992 Aug 1; 149(3):847-54.
  75. Rovan E, Fiebiger E, Kalla NR, Talwar GP, Aulitzky W, Frick J. Effect of active immunization to luteinizing-hormone-releasing hormone on the fertility and histoarchitecture of the reproductive organs of male rat. Urol Res. 1992; 20(5):323-34.
  76. Heidrich HJ, Fiebiger E. [Research on corynebacterium pyogenes mastitis of cattle with special reference to enzyme therapy. IV. Therapy with antibiotics and varidase cyanamide]. Berl Munch Tierarztl Wochenschr. 1965 Oct 15; 78(20):389-90.
  77. Heidrich HJ, Fiebiger E. [Research on bovine pyogenes mastitis with special reference to enzymatic therapy. 3. Therapy with antibiotics and Fibrolan-Parke Davis]. Berl Munch Tierarztl Wochenschr. 1965 Sep 15; 78(18):341-2.
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