Research

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Jing Chen, PhD

Department:
Ophthalmology Research
Hospital Title:
Research Associate
Academic Title:
Assistant Professor of Ophthalmology
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Dr. Jing Chen received her PhD from Boston University and completed her postdoctoral fellowship training in Ophthalmology at Boston Children’s Hospital (BCH) / Harvard Medical School. Since then Dr. Chen was recruited as a faculty member in Ophthalmology Department at BCH and Harvard Medical School, and is also an associate at the BCH Manton Center for Orphan Disease Research.

Dr. Chen’s primary interests are retinal vascular biology and pathologic vascular eye diseases, including retinopathy of prematurity, age-related macular degeneration, diabetic retinopathy, and rare orphan eye diseases: familiar exudative vitreoretinopathy (FEVR) and Norrie disease. Her lab studies animal models of these diseases to investigate disease pathogenesis and develop potential therapeutics. She has published numerous papers and lectured nationally and internationally on vascular eye disorders and angiogenesis research. Her current research projects include: 1) Wnt signaling in controlling vascular growth and permeability in retinopathy; 2) lipid sensing nuclear receptor mediated ocular neovascularization and inflammation; 3) microRNA regulation of pathologic vascular growth in eye diseases.

Selected Publications:

Liu CH, Sun Y, Li J, Gong Y, Tian KT, Evans LP, Morss PC, Fredrick TW, Saba NJ, Chen J. Endothelial microRNA-150 is an intrinsic suppressor of pathologic ocular neovascularization. Proc Natl Acad Sci U S A. 2015 Sep 29;112(39):12163-8. PMID:26374840.

Sun Y, Liu CH, SanGiovanni JP, Evans LP, Tian KT, Zhang B, Stahl A, Pu WT, Kamenecka TM, Solt LA, Chen J. Nuclear receptor ROR? regulates pathologic retinal angiogenesis by modulating Socs3 dependent inflammation. Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10401-6. PMID:26243880.

Li J, Liu CH, Sun Y, Gong Y, Fu Z, Evans LP, Tian KT, Juan AM, Hurst CG, Mammoto A, Chen J. Endothelial TWIST1 promotes pathological ocular angiogenesis. Invest Ophthalmol Vis Sci. 2014 Nov 20;55(12):8267-77.

Chen J, Stahl A, Krah NM, Seaward MR, Dennison RJ, Sapieha P, Hua J, Hatton CJ, Juan AM, Aderman CM, Willett KL, Guerin KI, Mammoto A, Campbell M, Smith LE. Wnt signaling mediates pathologic vascular growth in proliferative retinopathy. Circulation. 2011 Oct 25;124(17):1871-81. PMID: 21969016.

Chen J, Connor KM, Aderman CM, Smith LE. Erythropoietin deficiency decreases vascular stability in mice. J Clin Invest. 2008 Feb 1;118(2):526-533. PMID: 18219289. (cover article).  
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