Research in the laboratory relates to the intragraft microvironment, and how it functions to both promote and inhibit the rejection process. Our studies focus on three broad areas including 1) immune-mediated angiogenesis and how angiogenesis factors function in the rejection process 2) how leukocyte-endothelial cell interactions and products of these interactions promote, sustain or inhibit T cell activation and allorecognition, and 3) whether persistent events within the microvasculature are associated with, or mediate chronic allograft rejection. We are currently expanding our research effort into the area of inflammation resolution, and we are specifically interested in endogenous mechanisms and regulatory signaling networks of pro-resolution. Understanding these processes will allow us to develop new paradigms for anti-rejection therapeutics following transplantation.
About David Briscoe
David Briscoe is an Associate Professor at Harvard Medical School and Director of the Transplant Research Program at Boston Children’s Hospital. He is also an elected member of the National Physician-Scientist Honors Society, the American Society of Clinical Investigation (ASCI). David graduated from the Royal College of Surgeons Medical School in Ireland and completed his initial residency training in General Medicine and Pediatrics in Dublin, Ireland. He subsequently trained at the University of Colorado Health Sciences Center in Denver, Colorado, and at Boston Children's Hospital. His initial postdoctoral research was performed in the laboratory of Dr. Jordan Pober, and a second postdoctoral fellowship was performed under the mentorship of Drs. Ramzi Cotran and Andrew Lichtman at the Brigham and Women's Hospital, Harvard Medical School. Dr. Briscoe's first faculty appointment was within the Division of Nephrology at the Boston Children's Hospital, where he established his research effort. In 2013, he was appointed Director of the Transplant Research Program, and in 2015, he became the first incumbent Casey Lee Ball Chair in Transplantation.
View Dr.Briscoe’s publications in PubMed.