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Recent Kirchhausen Lab Publications


Identification and characterization of a novel broad spectrum virus entry inhibitor. 
Chou YY, Cuevas C, Carocci M, Stubbs SH, Ma M, Cureton DK, Chao L, Evesson F, He K, Yang PL, Whelan SP, Ross SR, Kirchhausen T, Gaudin R. J Virol. 2016 Feb 24. pii: JVI.00103-16. 

Membrane fission by dynamin: what we know and what we need to know
Antonny, B. Burd, C. De Camilli, P. Chen, E. Daumke, O. Faelber, K. Ford, M. Frolov, V. A. Frost, A. Hinshaw, J. E. Kirchhausen, T. Kozlov, M. M. Lenz, M. Low, H. H. McMahon, H. Merrifield, C. Pollard, T. D. Robinson, P. J. Roux, A. Schmid, S.
The EMBO journal (2016)

Data publication with the structural biology data grid supports live analysis
Meyer, P. A. Socias, S. Key, J. Ransey, E. Tjon, E. C. Buschiazzo, A. Lei, M. Botka, C. Withrow, J. Neau, D. Rajashankar, K. Anderson, K. S. Baxter, R. H. Blacklow, S. C. Boggon, T. J. Bonvin, A. M. Borek, D. Brett, T. J. Caflisch, A. Chang, C. I. Chazin, W. J. Corbett, K. D. Cosgrove, M. S. Crosson, S. Dhe-Paganon, S. Di Cera, E. Drennan, C. L. Eck, M. J. Eichman, B. F. Fan, Q. R. Ferre-D'Amare, A. R. Christopher Fromme, J. Garcia, K. C. Gaudet, R. Gong, P. Harrison, S. C. Heldwein, E. E. Jia, Z. Keenan, R. J. Kruse, A. C. Kvansakul, M. McLellan, J. S. Modis, Y. Nam, Y. Otwinowski, Z. Pai, E. F. Pereira, P. J. Petosa, C. Raman, C. S. Rapoport, T. A. Roll-Mecak, A. Rosen, M. K. Rudenko, G. Schlessinger, J. Schwartz, T. U. Shamoo, Y. Sondermann, H. Tao, Y. J. Tolia, N. H. Tsodikov, O. V. Westover, K. D. Wu, H. Foster, I. Fraser, J. S. Maia, F. R. Gonen, T. Kirchhausen, T. Diederichs, K. Crosas, M. Sliz, P.
Nature communications (2016), Volume: 7, Pages: 10882

Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy
Aguet, F. Upadhyayula, S. Gaudin, R. Chou, Y. Y. Cocucci, E. He, K. Chen, B. C. Mosaliganti, K. Pasham, M. Skillern, W. Legant, W. R. Liu, T. L. Findlay, G. Marino, E. Danuser, G. Megason, S. Betzig, E. Kirchhausen, T.
Molecular biology of the cell (2016)

Seipin is required for converting nascent to mature lipid droplets
Wang, H. Becuwe, M. Housden, B. E. Chitraju, C. Porras, A. J. Graham, M. M. Liu, X. N. Thiam, A. R. Savage, D. B. Agarwal, A. K. Garg, A. Olarte, M. J. Lin, Q. Frohlich, F. Hannibal-Bach, H. K. Upadhyayula, S. Perrimon, N. Kirchhausen, T. Ejsing, C. S. Walther, T. C. Farese, R. V.
eLife (2016), Volume: 5

Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion
191. Hu Y, Kim JH, He K, Wan Q, Kim J, Flach M, Kirchhausen T.
The Journal of experimental medicine (2016)

Inhibition of JCPyV infection mediated by targeted viral genome editing using CRISPR/Cas9
Yi-Ying Chou, Annabel Krupp, Campbell Kaynor, Raphaël Gaudin, Minghe Ma, Ellen Cahir-McFarland, Tom Kirchhausen
Sci Rep (2016)


Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown
Wittrup, A., Ai, A., Liu, X., Hamar, P., Trifonova, R., Charisse, K., Manoharan, M., Kirchhausen, T. and Lieberman, J. Nature biotechnology. 2015, 33. 8. 870-876. (PDF)

Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics
Li, D., Shao, L., Chen, B. C., Zhang, X., Zhang, M., Moses, B., Milkie, D. E., Beach, J. R., Hammer, J. A., 3rd, Pasham, M., Kirchhausen, T., Baird, M. A., Davidson, M. W., Xu, P. and Betzig, E. Science. 2015, 349. 6251. aab3500. (PDF)

Endocytosis of ligand activated sphingosine 1-phosphate receptor 1 mediated by the clathrin-pathway. 
Reeves, P. M., Kang, Y. L. and Kirchhausen, T. Traffic. 2015 PMID: 26481905  (PDF)

Superinfection exclusion is absent during acute Junin virus infection of Vero and A549 cells.
Gaudin, R. and Kirchhausen, T. 2015.  Scientific reports. 2015,  5. 15990. (PDF)

Asymmetric formation of coated pits on dorsal and ventral surfaces at the leading edge of motile cells and on protrusions of immobile cells.
Kural C, Akatay AA, Gaudin R, Chen BC, Legant WR, Betzig E, Kirchhausen T. Mol Biol Cell. 2015 Apr 7. 




Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology.
Ishikawa Y, Maeda M, Pasham M, Aguet F, Tacheva-Grigorova SK, Masuda T, Yi H, Lee SU, Xu J, Teruya-Feldstein J, Ericsson M, Mullally A, Heuser J, Kirchhausen T, Maeda T. Haematologica. 2015 Apr;100(4):439-51. (PDF)


Key Interactions for Clathrin Coat Stability
Bocking, T. Aguet, F. Rapoport, I. Banzhaf, M. Yu, A. Zeeh, J. C. Kirchhausen, T.
Structure (2014) (PDF)

Walch, M. Dotiwala, F. Mulik, S. Thiery, J. Kirchhausen, T. Clayberger, C. Krensky, A. M. Martinvalet, D. Lieberman, J.
Cell (2014), Volume: 157, Issue: 6, Pages: 1309-1323 (PDF)

Carmo-Fonseca, M. Kirchhausen, T.
Nucleus (2014), Volume: 5, Issue: 1 (PDF)

Kirchhausen, T. Owen, D. Harrison, S. C.
Cold Spring Harbor perspectives in biology (2014), Volume: 6, Issue: 5 (PDF)

Hagemann, A. I. Kurz, J. Kauffeld, S. Chen, Q. Reeves, P. M. Weber, S. Schindler, S. Davidson, G. Kirchhausen, T. Scholpp, S.
Journal of cell science (2014) (PDF)

Abdelhakim, A. H. Salgado, E. N. Fu, X. Pasham, M. Nicastro, D. Kirchhausen, T. Harrison, S. C.
PLoS pathogens (2014), Volume: 10, Issue: 9, Pages: e1004355 (PDF)

Cocucci, E. Gaudin, R. Kirchhausen, T.
Molecular biology of the cell (2014) (PDF)

Ishikawa, Y. Maeda, M. Pasham, M. Aguet, F. Tacheva-Grigorova, S. K. Masuda, T. Yi, H. Lee, S. Xu, J. Teruya-Feldstein, J. Ericsson, M. Mullally, A. Heuser, J. Kirchhausen, T. Maeda, T.
Haematologica (2014) (PDF)


Release of cellular tension signals self-restorative ventral lamellipodia to heal barrier micro-wounds
Martinelli, R. Kamei, M. Sage, P. T. Massol, R. Varghese, L. Sciuto, T. Toporsian, M. Dvorak, A. M. Kirchhausen, T. Springer, T. A. Carman, C. V.
The Journal of cell biology (2013), Volume: 201, Issue: 3, Pages: 449-65 (PDF)

Similar uptake but different trafficking and escape routes of reovirus virions and ISVPs imaged in polarized MDCK cells
Boulant, S. Stanifer, M. Kural, C. Cureton, D. K. Massol, R. Nibert, M. L. Kirchhausen, T.
Molecular biology of the cell (2013) (PDF)

The small molecule dispergo tubulates the endoplasmic reticulum and inhibits export
Lu, L. Hannoush, R. N. Goess, B. C. Varadarajan, S. Shair, M. D. Kirchhausen, T.
Molecular biology of the cell (2013) (PDF)

Endocytosis and recycling of immune complexes by follicular dendritic cells enhances B cell antigen binding and activation
Heesters, B. A. Chatterjee, P. Kim, Y. A. Gonzalez, S. F. Kuligowski, M. P. Kirchhausen, T. Carroll, M. C.
Immunity (2013), Volume: 38, Issue: 6, Pages: 1164-75 (PDF)

Uptake of rabies virus into epithelial cells by clathrin-mediated endocytosis depends upon actin
Piccinotti, S. Kirchhausen, T. Whelan, S. P.
Journal of Virology (2013) (PDF)

Live-Cell Visualization of Pre-mRNA Splicing with Single-Molecule Sensitivity
Martin, R. M. Rino, J. Carvalho, C. Kirchhausen, T. Carmo-Fonseca, M.
Cell Reports (2013) 

Clathrin-Mediated Endocytosis Persists during Unperturbed Mitosis
Tacheva-Grigorova, S. K. Santos, A. J. Boucrot, E. Kirchhausen, T.
Cell Reports (2013), Volume: 4, Issue: 4, Pages: 659-68

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