Research

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2014

Molecular imprinting as a signal-activation mechanism of the viral RNA sensor RIG-I.
Wu B, Peisley A, Tetrault D, Li Z, Egelman EH, Magor KE, Walz T, Penczek PA, Hur S.
Mol Cell. 2014 Aug 21;55(4):511-23 --Highlighted in Molecular Cell (2014), 55:505-7

Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I.
Peisley A, Wu B, Xu H, Chen ZJ, Hur S.
Nature. 2014 May 1;509(7498):110-4.

Gain of function mutations in IFIH1 (MDA5) cause a spectrum of human disease phenotypes associated with an upregulation of type I interferon signaling. 
Rice GI*, del Toro Duany Y*, Jenkinson EM, Forte GMA, Anderson BH, Ariaudo G, Bader-Meunier B, Baildam EM, Battini R, Beresford MW, Casarano M, Chouchane M, Cimaz R, Collins AE, Cordeiro NJV, Dale RC, Davidson JE, De Waele L, Desguerre I, Faivre L, Fazzi E, Isidor B, Lagae L, Latchman AR, Lebon P, Li C, Livingston JH, Lourenco CM, Mancardi MM, Masurel-Paulet A, McInnes IB, Menezes MP, Mignot C, O’Sullivan J, Orcesi S, Picco PP, Riva E, Robinson RA, Rodrigues D, Salvatici E, Scott C, Szybowska M, Tolmie JL, Vanderver A, Vanhulle C, Vieira JP, Webb K, Whitney RN, Williams SG, Wolfe LA, Zuberi SM,  Hur S**, Crow YJ**. 
Nature Genetics, (2014), 46:503-9, (* co-first authors, ** co-corresponding authors). --Highlighted in Nature Genetics (2014), 84:1551-61

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