Research

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Recent Hur Lab Publications

2016

Filament assemblies in foreign nucleic acid sensors.
Sohn J., and Hur S. 
Curr Opin Struct Biol. 2016 Apr;37:134-44. 

Endogenous Retroelements and the Host Innate Immune Sensors.
Mu X., Ahmad S., and Hur S. Adv Immunol. 2016;132:47-69.


2015

Identification of a Natural Viral RNA Motif That Optimizes Sensing of Viral RNA by RIG-I
Xu J, Mercado-Lopez X, Grier JT, Kim WK, Chun LF, Irvine EB, Del Toro Duany Y, Kell A, Hur S, Gale M Jr, Raj A, Lopez CB.
MBio.(2015) 6:e01265-15.  (PDF)


Unusual cutaneous features associated with a heterozygous gain-of-function mutation in IFIH1: Aicardi-Goutires-Singleton-Merten overlapping syndrome.

Bursztejn AC, Briggs TA, Del Toro Duany Y, Anderson BH, O'Sullivan J, Williams SG, Bodemer C, Fraitag S, Gebhard F, Leheup B, Lemelle I, Oojageer A, Raffo E, Schmitt E, Rice GI, Hur S, Crow YJ.,  Br J Dermatol. Epub ahead of print.

Helicases in antiviral immunity: dual properties as sensors and effectors
Ahmad S and Hur S, .
Trends in Biochemical Sciences (2015) 40:576-85. (Review) (PDF)

Measuring Monomer-to-Filament Transition of MAVS as an In Vitro Activity Assay for RIG-I-Like Receptors
Wu B, Houh Y & Hur S, ,
Methods Molecular Biology, Vol 1390, In Press, (Book Chapter)

How RIG-I like receptors activate MAVS
Wu B & Hur S.
Curr. Opin. Virol. (2015) 12:91-8 (PDF)

ATP-Dependent Effector-like Functions of RIG-I-like Receptors.
Yao H, Dittmann M, Peisley A, Hoffmann HH, Gilmore RH, Schmidt T, Schmid-Burgk JL, Hornung V, Rice CM, Hur S.
Mol Cell. 2015 Apr 16. pii: S1097-2765(15)00179-3. (PDF)

MDA5-filament, dynamics and disease.
Del Toro Duany Y, Wu B, Hur S. Curr Opin Virol. 2015 Feb 9;12C:20-25. (PDF)

2014

Molecular imprinting as a signal-activation mechanism of the viral RNA sensor RIG-I.
Wu B, Peisley A, Tetrault D, Li Z, Egelman EH, Magor KE, Walz T, Penczek PA, Hur S.
Mol Cell. 2014 Aug 21;55(4):511-23 --Highlighted in Molecular Cell (2014), 55:505-7

Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I.
Peisley A, Wu B, Xu H, Chen ZJ, Hur S.
Nature. 2014 May 1;509(7498):110-4.

Gain of function mutations in IFIH1 (MDA5) cause a spectrum of human disease phenotypes associated with an upregulation of type I interferon signaling. 
Rice GI*, del Toro Duany Y*, Jenkinson EM, Forte GMA, Anderson BH, Ariaudo G, Bader-Meunier B, Baildam EM, Battini R, Beresford MW, Casarano M, Chouchane M, Cimaz R, Collins AE, Cordeiro NJV, Dale RC, Davidson JE, De Waele L, Desguerre I, Faivre L, Fazzi E, Isidor B, Lagae L, Latchman AR, Lebon P, Li C, Livingston JH, Lourenco CM, Mancardi MM, Masurel-Paulet A, McInnes IB, Menezes MP, Mignot C, O’Sullivan J, Orcesi S, Picco PP, Riva E, Robinson RA, Rodrigues D, Salvatici E, Scott C, Szybowska M, Tolmie JL, Vanderver A, Vanhulle C, Vieira JP, Webb K, Whitney RN, Williams SG, Wolfe LA, Zuberi SM,  Hur S**, Crow YJ**. 
Nature Genetics, (2014), 46:503-9, (* co-first authors, ** co-corresponding authors). --Highlighted in Nature Genetics (2014), 84:1551-61


2013

RIG-I forms signaling-competent filaments in an ATP-dependent, ubiquitin-independent manner.
Peisley A, Wu B, Yao H, Walz T, Hur S.
Mol Cell. 2013 Sep 12;51(5):573-83. -- Highlighted in Faculty1000Prime

Multi-level regulation of cellular recognition of viral dsRNA. 
Alys Peisley & Sun Hur
Cell Mol Life Sci. (2013), Volume: 70, Pages: 1949-63. 

Structural Basis for dsRNA recognition, filament formation and antiviral signaling by MDA5.
Bin Wu, Alys Peisley, Claire Richards, Hui Yao, Xiaohui Zeng, Cecilie Lin, Feixia Chu, Thomas Walz and Sun Hur 
Cell (2013), Volume: 152, Pages: 276-89. -- Highlighted in Nat. Rev. Immunol. (2013), 13:153

Viral counterattack against the host innate immune system
Bin Wu and Sun Hur
Cell Research (2013), Volume: 23, Pages: 735-6

2012

Kinetic Mechanism for Viral dsRNA Length Discrimination by MDA5 Filament.
Alys Peisley*, MyungHyun Jo*, Cecilie Lin, Bin Wu, McGhee Orme-Johnson, Thomas Walz, Sungchul Hohng & Sun Hur. 
Proc.Natl. Acad. Sci. U.S.A. (2012), Volume: 109, Pages: E3340-9. 

MDA5 detects the double-stranded RNA replicative form in picornavirus-infected cells
Qian Feng, Stanleyson V. Hato, Martijn A. Langereis, Jan Zoll, Richard Virgen-Slane, Alys Peisley, Sun Hur, Bert L. Semler, Ronald van Rij, Frank J.M van Kuppeveld. 
Cell Reports (2012), Volume: 2, Pages: 1187-96

2011

Cooperative Assembly and Dynamic Disassembly of MDA5 Filaments for Viral dsRNA Recognition. 
Alys Peisley, Cecilie Lin, Bin Wu, McGhee Orme-Johnson, Marion Liu, Thomas Walz & Sun Hur.
Proc. Natl. Acad. Sci. U.S.A. (2011), 108: 21010-5. 



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