Research

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2015

Harnessing RNAi-based nanomedicines for therapeutic gene silencing in B-cell malignancies
Weinstein S, Toker IA, Emmanuel R, Ramishetti S, Hazan-Halevy I, Rosenblum D, Goldsmith M, Abraham A, Benjamini O, Bairey O, Raanani P, Nagler A, Lieberman J, Peer D.
Proc Natl Acad Sci 2015 Dec (PDF)

Gene knockdown by EpCAM aptamer-siRNA chimeras suppresses epithelial breast cancers and their tumor-initiating cells
Gilboa-Geffen A, Hamar P, Le MT, Wheeler LA, Trifonova R, Petrocca F, Wittrup A, Lieberman J.
Mol Cancer Ther 2015 Sep (PDF)

Knocking down disease: a progress report on siRNA therapeutics.
Wittrup A, Lieberman J.
Nat Rev Genet 2015 Sep;16:543-52(PDF)

Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown. 
Wittrup A, Ai A, Liu X, Hamar P, Trifonova R, Charisse K, Manoharan M, Kirchhausen T, Lieberman J.
Nat Biotechnol 2015 (PDF)

miR-34 and p53: new insights into a complex functional relationship.
Navarro F, Lieberman J.
PLoS One 2015 Jul 15;10(7):e0132767. (PDF)

Manipulating the in vivo immune response by targeted gene knockdown.
Lieberman J.
Curr Opin Immunol 2015 Jul 3;35:63-72. (PDF)

A high yield and cost-efficient expression system of human granzymes in mammalian cells. 
Dotiwala F, Fellay I, Filgueira L, Martinvalet D, Lieberman J, Walch M.
J Vis Exp 2015 Jun 10;100:e52911(PDF) 

An RNA-binding protein, Lin28, recognizes and remodels G-quartets in the miRNAs and mRNAs it regulates
O'Day E, Lee MT, Imai S, Tan SM, Kirchner R, Arthanari H, Hofmann O, Wagner G, Lieberman J.
J Biol Chem 2015 Jun 17;290(29):17909-22. (PDF)

Apoptosis triggers specific, rapid, and global mRNA decay with 3'uridylated intermediates degraded by DIS3L2
Thomas MP, LiuX, Whangbo J, McCrossan G, Sanborn KB, Basar E, Walch M, Lieberman J.
Cell Rep 2015 May 19;11(7):1079-89. (PDF) 

Ex Vivo cytosolic delivery of functional macromolecules to immune cells.
Sharei A, Trifonova R, Jhunjhunwala S, Hartoularos GC, Eyerman AT, Lytton-Jean A, Angin M, Sharma S, Poceviciute R, Mao S, Heimann M, Liu S, Talkar T, Khan O, Addo M, von Andrian UH, Anderson DG, Langer R, Lieberman J, Jensen K.
PLoS One 2015 Apr 13;10(4):e0118803. (PDF)

The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation
Luo ML, Chang G, Chen CH,  Hu H, Huang P, Zheng M, Yao Y, Wei S, Wulf G, Lieberman J, Zhen Zhou X, Song E, Lu KP.
Cell Rep 2015 Apr 7;11(1):111-24. (PDF)

Harnessing RNA interference for therapy: the silent treatment. 
Lieberman J, Sharp P.
JAMA 2015 Mar 24;313(12):1207-8. (PDF) 

miR-200 promotes the mesenchymal to epithelial transition by suppressing multiple members of the Zeb2 and Snail1 transcriptional repressor complexes.
Perdigao-Henriques R, Petrocca F, Altschuler G, Thomas MP, Le MT, Tan SM, Hide W, Lieberman J.
Oncogene 2015 Mar 23 (PDF)

Granzyme B-induced mitochondrial ROS are required for apoptosis
Jacquemin G, Margiotta D, Kasahara A, Bassoy EY, Walch M, Thiery J, Lieberman J, Martinvalet D.
Cell Death Differ 2015 May;22(5):862-74. (PDF)

Dysregulation of microRNA biogenesis and gene silencing in cancer.
Akiko Hata, Judy Lieberman.
Science Signaling (2015), Volume: 8, Issue: 368. (PDF)
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