Research

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Recent Lieberman Lab Publications

2015

Harnessing RNAi-based nanomedicines for therapeutic gene silencing in B-cell malignancies

Weinstein S, Toker IA, Emmanuel R, Ramishetti S, Hazan-Halevy I, Rosenblum D, Goldsmith M, Abraham A, Benjamini O, Bairey O, Raanani P, Nagler A, Lieberman J, Peer D. Proc Natl Acad Sci 2015 Dec (PDF)

 

Gene knockdown by EpCAM aptamer-siRNA chimeras suppresses epithelial breast cancers and their tumor-initiating cells

Gilboa-Geffen A, Hamar P, Le MT, Wheeler LA, Trifonova R, Petrocca F, Wittrup A, Lieberman J. Mol Cancer Ther 2015 Sep (PDF)

 

Knocking down disease: a progress report on siRNA therapeutics.

Wittrup A, Lieberman J. Nat Rev Genet 2015 Sep;16:543-52(PDF)

 

Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown. 

Wittrup A, Ai A, Liu X, Hamar P, Trifonova R, Charisse K, Manoharan M, Kirchhausen T, Lieberman J. Nat Biotechnol 2015 (PDF)


miR-34 and p53: new insights into a complex functional relationship.

Navarro F, Lieberman J. PLoS One 2015 Jul 15;10(7):e0132767. (PDF)

 

Manipulating the in vivo immune response by targeted gene knockdown.

Lieberman J. Curr Opin Immunol 2015 Jul 3;35:63-72. (PDF)

 

A high yield and cost-efficient expression system of human granzymes in mammalian cells. 

Dotiwala F, Fellay I, Filgueira L, Martinvalet D, Lieberman J, Walch M. J Vis Exp 2015 Jun 10;100:e52911(PDF)

 

An RNA-binding protein, Lin28, recognizes and remodels G-quartets in the miRNAs and mRNAs it regulates

O'Day E, Lee MT, Imai S, Tan SM, Kirchner R, Arthanari H, Hofmann O, Wagner G, Lieberman J. J Biol Chem 2015 Jun 17;290(29):17909-22. (PDF)

 

Apoptosis triggers specific, rapid, and global mRNA decay with 3'uridylated intermediates degraded by DIS3L2

Thomas MP, LiuX, Whangbo J, McCrossan G, Sanborn KB, Basar E, Walch M, Lieberman J. Cell Rep 2015 May 19;11(7):1079-89. (PDF)

 

Ex Vivo cytosolic delivery of functional macromolecules to immune cells.

Sharei A, Trifonova R, Jhunjhunwala S, Hartoularos GC, Eyerman AT, Lytton-Jean A, Angin M, Sharma S, Poceviciute R, Mao S, Heimann M, Liu S, Talkar T, Khan O, Addo M, von Andrian UH, Anderson DG, Langer R, Lieberman J, Jensen K. PLoS One 2015 Apr 13;10(4):e0118803. (PDF)

 

The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation

Luo ML, Chang G, Chen CH,  Hu H, Huang P, Zheng M, Yao Y, Wei S, Wulf G, Lieberman J, Zhen Zhou X, Song E, Lu KP. Cell Rep 2015 Apr 7;11(1):111-24. (PDF)

 

Harnessing RNA interference for therapy: the silent treatment. 

Lieberman J, Sharp P. JAMA 2015 Mar 24;313(12):1207-8. (PDF)

 

miR-200 promotes the mesenchymal to epithelial transition by suppressing multiple members of the Zeb2 and Snail1 transcriptional repressor complexes.

Perdigao-Henriques R, Petrocca F, Altschuler G, Thomas MP, Le MT, Tan SM, Hide W, Lieberman J. Oncogene 2015 Mar 23 (PDF)

  

Granzyme B-induced mitochondrial ROS are required for apoptosis

Jacquemin G, Margiotta D, Kasahara A, Bassoy EY, Walch M, Thiery J, Lieberman J, Martinvalet D. Cell Death Differ 2015 May;22(5):862-74. (PDF)


Dysregulation of microRNA biogenesis and gene silencing in cancer.
Akiko Hata, Judy Lieberman.
Science Signaling (2015), Volume: 8, Issue: 368. (PDF)



2014

Distribution of immune cells in the human cervix and implications for HIV transmission.
Trifonova RT, Lieberman J, van Baarle D.
Am J Reprod Immunol. (2014), Volume: 71, Issue: 3, Pages: 252-64. (PDF)

Leukocyte protease binding to nucleic acids promotes nuclear localization and cleavage of nucleic acid binding proteins.
Thomas MP, Whangbo J, McCrossan G, Deutsch AJ, Martinod K, Walch M, Lieberman J.
J Immunol. (2014), Volume: 192, Issue: 11, Pages: 5390-7. (PDF)

Prolyl Isomerase Pin1 Acts Downstream of miR200c to Promote Cancer Stem-like Cell Traits in Breast Cancer.
Luo ML, Gong C, Chen CH, Lee DY, Hu H, Huang P, Yao Y, Guo W, Reinhardt F, Wulf G, Lieberman J, Zhou XZ, Song E, Lu KP.
Cancer Res. (2014), Volume: 74, Issue: 13, Pages: 1-14. (PDF)

Perforin: a key pore-forming protein for immune control of viruses and cancer.
Thiery J, Lieberman J.
Subcell Biochem (2014), Issue: 80, Pages: 197-220.

Cytotoxic Cells Kill Intracellular Bacteria through Granulysin-Mediated Delivery of Granzymes.
Walch M, Dotiwala F, Mulik S, Thiery J, Kirchhausen T, Clayberger C, Krensky AM, Martinvalet D, Lieberman J.
Cell (2014), Volume: 157, Issue: 6, Pages: 1309-23. (PDF)

Sequencing of Captive Target Transcripts Identifies the Network of Regulated Genes and Functions of Primate-Specific miR-522.
Shen Mynn Tan, Rory Kirchner, Jingmin Jin, Oliver Hofmann, Larry McReynolds, Winston Hide, and Judy Lieberman.
Cell Press (2014). (PDF)

Characterization of Dual PTEN and p53-Targeting MicroRNAs Identifies MicroRNA-638/Dnm2 as a Two-Hit Oncogenic Locus.
Yvonne Tay, Shen Mynn Tan, Florian A. Karreth, Judy Lieberman, and Pier Paolo Pandolfi.
Cell Press (2014). (PDF)



2013

Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach.
Lee MN, Roy M, Ong S-E, Mertins P, V A-C, Li W, Dotiwala F, Sen J, Doench JG, Orzalli MH, Kramnik I, Knipe DM, Lieberman J, Carr SA, and Hacohen N.
Nature Immunology (2013), Volume: 17, Pages: 179-185. (PDF)

Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity.

Tuli A, Thiery J, James AM, Michelet X, Sharma M, Garg S, Sanborn KB, Orange JS, Lieberman J, Brenner MB.
Mol Biol Cell (2013), Volume: 24, Issue: 23, Pages: 3721-35. (PDF)

Micromanaging Hepatitis C Virus.
Lieberman J and Sarnow P.
The New England Journal of Medicine (2013). (PDF)

Efficient and specific gene knockdown by small interfering RNAs produced in bacteria.
Huang L, Jin J, Deighan P, Kiner E, McReynolds L, and Lieberman J.
Nature Biotechnology (2013). (PDF)

Live or let die: posttranscriptional gene regulation in cell stress and cell death.
Thomas MP and Lieberman J.
Immunological Reviews (2013), Volume: 253, Pages: 237-252. (PDF)

Durable Knockdown and Protection from HIV Transmission in Humanized Mice Treated With Gel-formulated CD4 Aptamer-siRNA Chimeras.
Wheeler LA, Vrbanac V, Trifonova R, Brehm MA, Gilboa-Geffen A, Tanno S, Greiner DL, Luster AD, Tager AM and Lieberman J.
Molecular Therapy (2013). (PDF)

A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cells.
Fabio Petrocca, Gabriel Altschuler, Shen Mynn Tan, Marc L. Mendillo, Haoheng Yan, D. Joseph Jerry, Andrew L. Kung, Winston Hide, Tan A. Ince, Judy Lieberman.
Cancer Cell (2013), Volume: 24, Issue: 2, Pages: 182-196. (PDF)

Production of highly potent recombinant siRNAs in Escherichia coli.
Huang L, Lieberman J.
Nature Protocols (2013), Volume: 8, Issue: 12, Pages: 2325-2336. (PDF)
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