Research

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2016

Phenotypic lentivirus screens to identify functional single domain antibodies.
Schmidt FI, Hanke L, Morin B, Brewer R, Brusic V, Whelan SP, Ploegh HL.
Nat Microbiol (2016), Volume: 1, Issue: 8

Posttranscriptional Regulation of Glycoprotein Quality Control in the Endoplasmic Reticulum Is Controlled by the E2 Ub-Conjugating Enzyme UBC6e.
Hagiwara M, Ling J, Koenig PA, Ploegh HL.
Mol. Cell (2016), Volume: 63, Issue: 5

Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83.
von Rohrscheidt J, Petrozziello E, Nedjic J, Federle C, Krzyzak L, Ploegh HL, Ishido S, Steinkasserer A, Klein L
J. Exp. Med. (2016), Volume: 9, Issue: 213

Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia.
Demircioglu FE, Sosa BA, Ingram J, Ploegh HL, Schwartz TU.
Elife (2016), Issue: 5

Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose.
Chahal JS, Khan OF, Cooper CL, McPartlan JS, Tsosie JK, Tilley LD, Sidik SM, Lourido S, Langer R, Bavari S, Ploegh HL, Anderson DG
Proc. Natl. Acad. Sci. U.S.A. (2016), Volume: 29, Issue: 113

Transnuclear CD8 T cells specific for the immunodominant epitope Gra6 lower acute-phase Toxoplasma gondii burden.
Sanecka A, Yoshida N, Dougan SK, Jackson J, Shastri N, Ploegh H, Blanchard N, Frickel EM
Immunology (2016), Volume: 3, Issue: 149

Recent advances in sortase-catalyzed ligation methodology.
Antos JM, Truttmann MC, Ploegh HL.
Curr. Opin. Struct. Biol. (2016), Issue: 38

Longitudinal multiparameter assay of lymphocyte interactions from onset by microfluidic cell pairing and culture.
Dura B, Servos MM, Barry RM, Ploegh HL, Dougan SK, Voldman J.
Proc. Natl. Acad. Sci. U.S.A. (2016), Volume: 26, Issue: 113

The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones.
Truttmann MC, Cruz VE, Guo X, Engert C, Schwartz TU, Ploegh HL.
PLoS Genet. (2016), Volume: 5, Issue: 12

Durable antitumor responses to CD47 blockade require adaptive immune stimulation.
Sockolosky JT, Dougan M, Ingram JR, Ho CC, Kauke MJ, Almo SC, Ploegh HL, Garcia KC.
Proc. Natl. Acad. Sci. U.S.A. (2016), Volume: 19, Issue: 113

A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly.
Schmidt FI, Lu A, Chen JW, Ruan J, Tang C, Wu H, Ploegh HL.
J. Exp. Med. (2016), Volume: 5, Issue: 213

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism.
Lu A, Li Y, Schmidt FI, Yin Q, Chen S, Fu TM, Tong AB, Ploegh HL, Mao Y, Wu H.
Nat. Struct. Mol. Biol. (2016), Volume: 5, Issue: 23

Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.
Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS.
Nature (2016), Volume: 536, Issue: 7616

Crystal structure of a substrate-engaged SecY protein-translocation channel.
Li L, Park E, Ling J, Ingram J, Ploegh H, Rapoport TA.
Nature (2016), Volume: 531, Issue: 7594

Corrigendum: Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining.
Maruyama T, Dougan SK, Truttmann MC, Bilate AM, Ingram JR, Ploegh HL.
Nat. Biotechnol. (2016), Volume: 2, Issue: 34

Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling.
Jahan AS, Lestra M, Swee LK, Fan Y, Lamers MM, Tafesse FG, Theile CS, Spooner E, Bruzzone R, Ploegh HL, Sanyal S.
roc. Natl. Acad. Sci. U.S.A. (2016), Volume: 6, Issue: 113

Enzyme-Mediated Modification of Single-Domain Antibodies for Imaging Modalities with Different Characteristics.
Rashidian M, Wang L, Edens JG, Jacobsen JT, Hossain I, Wang Q, Victora GD, Vasdev N, Ploegh H, Liang SH.
Angew. Chem. Int. Ed. Engl. (2016), Volume: 2, Issue: 55

The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment.
Hanke L, Knockenhauer KE, Brewer RC, van Diest E, Schmidt FI, Schwartz TU, Ploegh HL.
MBio (2016), Volume: 7, Issue: 6

Generation of Immunity against Pathogens via Single-Domain Antibody-Antigen Constructs.
Duarte JN, Cragnolini JJ, Swee LK, Bilate AM, Bader J, Ingram JR, Rashidfarrokhi A, Fang T, Schiepers A, Hanke L, Ploegh HL.
J Immunol. (2016), Volume: 197, Issue: 12, Pages: 4838-4847

Rapid capture and labeling of cells on single domain antibodies-functionalized flow cell.
Chen GY, Li Z, Duarte JN, Esteban A, Cheloha RW, Theile CS, Fink GR, Ploegh HL.
Biosens Bioelectron. (2016), Volume: 89, Issue: Pt 2, Pages: 789-794


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