Research

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2016

Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation mechanisms of the Death-Inducing Signaling Complex.
Fu TM, Li Y, Li Z, Vajjhala PR, Cruz AC, Srivastava DB, DiMaio F, Penczek PA, Siegel RM, Stacey KJ, Egelman EH, Wu H (2016). Mol Cell. 64(2):236-250

A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton.
Erin Janssen, Mira Tohme, Mona Hedayat, Marion Leick, Sudha Kumari, Narayanaswamy Ramesh, Michel J. Massaad, Sumana Ullas, Veronica Azcutia, Christopher C. Goodnow, Katrina L. Randall, Qi Qiao, Hao Wu, Waleed Al-Herz, Dianne Cox, John Hartwig, Darrell J. Irvine, Francis W. Luscinskas, and Raif S. Geha (2016). The Journal of Clinical Investigation. 126(10)3837-3851​

An endogenous caspase-11 ligand elicits interleukin-1release from living dendritic cells. 
Zanoni I, Tan Y, Di Gioia M, Broggi A, Ruan J, Shi J, Donado CA, Shao F, Wu H, Springstead JR, Kagan JC (2016). Science. 352:1232-6

Structural Basis and Functional Role of Intramembrance Trimerization of the Fas/CD95 Death Receptor.
Fu Q, Fu TM, Cruz AC, Sengupta P, Thomas SK, Wang S, Siegel RM, Wu H, Chou JJ. (2016) Molecular Cell. 61(4):602-13. PMC4761300.

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism.
Lu A, Li Y, Schmidt FI, Yin Q, Chen S, Fu TM, Tong AB, Ploegh HL, Mao Y, Wu H. (2016) Nature structural molecular biology. 23(5):416-25. PMC4856535.

Data publication with the structural biology data grid supports live analysis.
Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Christopher Fromme J, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P. (2016) Nature communications. 7:10882. PMC4786681.

A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly. 
Schmidt FI, Lu A, Chen JW, Ruan J, Tang C, Wu H, Ploegh HL. The Journal of experimental medicine. 2016; 213(5):771-90. PubMed [journal] PMID: 27069117, PMCID: PMC4854733

The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules. 
Wu H, Fuxreiter M. Cell. 2016; 165(5):1055-66. PMC4878688

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. 
Liu X, Zhang Z, Ruan J, Pan Y, Magupalli VG, Wu H, Lieberman J. Nature. 2016; 535(7610):153-8. PMID: 27383986

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