Research

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Recent Wu Lab Publications

2016

Structural Basis and Functional Role of Intramembrance Trimerization of the Fas/CD95 Death Receptor.
Fu Q, Fu TM, Cruz AC, Sengupta P, Thomas SK, Wang S, Siegel RM, Wu H, Chou JJ. (2016) Molecular Cell. 61(4):602-13. PMC4761300.


Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism.

Lu A, Li Y, Schmidt FI, Yin Q, Chen S, Fu TM, Tong AB, Ploegh HL, Mao Y, Wu H. (2016) Nature structural molecular biology. 23(5):416-25. PMC4856535.

Data publication with the structural biology data grid supports live analysis.
Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Christopher Fromme J, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P. (2016) Nature communications. 7:10882. PMC4786681.

A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly. 
Schmidt FI, Lu A, Chen JW, Ruan J, Tang C, Wu H, Ploegh HL. The Journal of experimental medicine. 2016; 213(5):771-90. PubMed [journal] PMID: 27069117, PMCID: PMC4854733

The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules. 
Wu H, Fuxreiter M. Cell. 2016; 165(5):1055-66. PMC4878688

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. 
Liu X, Zhang Z, Ruan J, Pan Y, Magupalli VG, Wu H, Lieberman J. Nature. 2016; 535(7610):153-8. PMID: 27383986


2015

Molecular mechanism of V(D)J recombination captured by structures of RAG1-RAG2 synaptic complexes.
Ru H, Chambers MG, Fu T, Tong AB, Liao M, Wu H. (2015).  Cell. 163:1138-52 (PDF)

The inflammasome adaptor ASC induces procaspase-8 death effector domain filaments.
Vajjhala P, Lu A, Brown D, Pang S, Sagulenko V, Sester D, Cridland S, Hill J, Schroder K, Stow J, Wu H, Stacey K. (2015). J Biol Chem. 290:29217-30 (PDF)

Cryo-EM structure of the activated NAIP2/NLRC4 Inflammasome reveals nucleated polymerization.
Zhang L, Shuobing C, Jianbin R, Wu J, Tong AB, Yin Q, Li Y, David L, Lu A, Wang WL, Marks C, Ouyang Q, Zhang X, Mao Y, Wu H. (2015). Science. 350:404-9 (PDF)

What’s your favorite crystal structure? Wu H, Yokoyama S, Lugar K, Doudna J, Wilson I, Xu RM.  (2015). Cell. 159:967-968 (PDF)

Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2.
Lu A, Li Y, Qian Y, Ruan J, Yu X, Egelman E, Wu H. (2015). Cell Discovery. published online (PDF)

The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIP3 and protects cells from necroptosis.
Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, Prodhomme T, Duong B, Whang MI, Advincula R, Agelidis A, Barrera J, Wu H, Burlingame A, Malynn BA, Zamvil SS, Ma A. (2015).  Nature Immunology. 16:618-627 (PDF)

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer.
Wei S, Kozono S, Kats L, Nechama M, Li W, Guarnerio J, Luo M, You MH, Yao Y, Kondo A, Hu H, Bozkurt G, Moerke NJ, Cao S, Reschke M, Chen CH, Rego EM, Lo-Coco F, Cantley LC, Lee TH, Wu H, Zhang Y, Pandolfi PP, Zhou XZ, Lu KP. (2015).  Nat Med.21:457-466 (PDF)

The hierarchical structural architecture of inflammasomes, supramolecular inflammatory machines.
Hauenstein A, Zhang L, Wu H. (2015).  Curr Opin Struct Biol. 31:75-83 (PDF)

Structural Biology of Innate Immunity 
Yin Q, Fu TM, Li J, Wu H. 
Annu. Rev. Immunol. (2015). published online. (PDF)

2014

Li L, Yin Q, Kuss P, Maliga Z, Millán JL, Wu H, Mitchison T. 
Nat Chem Biol. (2014) 10:1043-8. (PDF)

Jang TH, Zheng C, Li J, Richards C, Hsiao YS, Walz T, Wu H, Park HH. 
Biochemistry. (2014). 53:5424-31. (PDF)

Kagan JC, Magupalli V, Wu H. 
Nature Rev Immunol. (2014). 12:821-6. (PDF)

Ferrao R, Zhou H, Shan Y, Liu Q, Li Q, Shaw DE, Li X, Wu H. 
IRAK4 Mol Cell.  (2014). 6:891-903. (PDF)

Ru H, Zhang P, Wu H. 
Mol Cell. (2014). 2:208-9. (PDF)

Lu A, Magupalli VG, Ruan J, Yin Q, Atianand MK, Vos MR, Schröder GF, Fitzgerald KA, Wu H, Egelman E.

Cell (2014), Volume: 156, Issue: 6, Pages: 1193-1206. (PDF)


Ibrutinib Resistance in Chronic Lymphocytic Leukemia. 


Furman RR, Cheng S, Lu P, Setty M, Perez AR, Guo A, Racchumi J, Xu G, Wu H, Ma J, Steggerda SM, Coleman M, Leslie C, Wang YL. 
N Engl J Med. (2014). 24:2352-4. (PDF)


Lu A, Kabaleeswaran V, Fu T, Magupalli VG, Wu H.
J Mol Biol. (2014). (PDF)


2013

Lu TT, Onizawa M, Hammer GE, Turer EE, Yin Q, Damko E, Agelidis A, Shifrin N, Advincula R, Barrera J, Malynn BA, Wu H, Ma A.
Immunity (2013), Volume: 38, Pages: 1-10. (PDF)

Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly. 
Qiao Q, Yang C, Zheng C, Fontan L, David L, Yu X, Bracken C, Rosen M, Melnick A, Egelman E, Wu H. 
Mol Cell. (2013). 51:766-779. (PDF)

Anticancer Flavonoids Are Mouse-Selective STING Agonists.
Kim S, Li L, Maliga Z, Yin Q, Wu H, Mitchison T. 
ACS Chemical Biology. (2013).  8:1396-1401. (PDF)

Napteschnig J, Wu H.
Annual Reviews in Biophysics (2013), Volume: 42, Pages: 19.1-19.26. (PDF)

Wu H.
Cell (2013), Volume: 153, Issue: 2, Pages: 287-292. (PDF)

Qian Yin, David P. Sester, Yuan Tian, Yu-Shan Hsiao, Alvin Lu, Jasmyn A. Cridlan, Vitaliya Sagulenko, Sara J. Thygesen, Divaker Choubey, Veit Hornung, Thomas Walz, Katryn J. Stacey, and Hao Wu.
Cell Reports. (2013), Volume: 4, Issue: 2, Pages: 327-39. (PDF)

Lee JH, Yi L, Schweitzer K, Borgmann M, Naumann M, Wu H.
Proceedings of the National Academy of Sciences (2013), Volume: 110, Issue: 29, Pages: 11845-50. (PDF)

Li J, Yin Q, Wu H.
Advanced Immunology (2013), Volume: 119, Pages: 135-53. (PDF)

Yang C, David L, Qiao Q, Damko E, Wu H.
Cytokine Growth Factor Rev. (2013). (PDF)
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