Research

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2016

Long neural genes harbor recurrent DNA break clusters in neural stem/progenitor cells.
Wei P-C, Chang AN, Kao J, Du Z, Meyers RM, Alt FW, Schwer B. Cell (2016) Feb 11;164(4):644-55.
(PDF)

Sequential activation and distinct functions for distal and proximal modules within the IgH 3' regulatory region.
Garot A, Marquet M, Saintamand A, Bender S, Le Noir S, Rouaud P, Carrion C, Oruc Z, Bébin A-G, Moreau J, Lebrigand K, Denizot Y, Alt FW, Cogné M, Pinaud E. Proc Natl Acad Sci U S A. (2016) 113(6):1618-23. (PDF)

Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells. 
Schwer B, Wei P-C, Chang AN, Kao J, Du Z, Meyers RM, Alt FW. Proc. Natl. Acad. Sci. USA  (2016) 113(8):2258-63. (PDF)

Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing.
Hu J, Meyers RM, Dong J, Panchakshari RA, Alt FW, Frock RL. Nat Protoc. (2016) 11(5):853-71. (PDF)

NEHJ and other repair factors in V(D)J recombination.
Kumar V, Alt FW. In: Ratcliffe MJH. Editor in Chief, Encyclopedia of Immunobiology, Vol. 2, Oxford: Academic Press, pp. 107–14. (PDF)

An Ectopic CTCF Binding Element Inhibits Tcrd Rearrangement by Limiting Contact between Vδ and Dδ Gene Segments.
Chen L, Zhao L, Alt FW, Krangel MS.
J Immunol (2016), Volume: 197, Issue: 8, Pages: 3188-3197

Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires
Tian M, Cheng C, Chen X, Duan H, Cheng HL, Dao M, Sheng Z, Kimble M, Wang L, Lin S, Schmidt SD, Du Z, Joyce MG, Chen Y, DeKosky BJ, Chen Y, Normandin E, Cantor E, Chen RE, Doria-Rose NA, Zhang Y, Shi W, Kong WP, Choe M, Henry AR, Laboune F, Georgiev IS, Huang PY, Jain S, McGuire AT, Georgeson E, Menis S, Douek DC, Schief WR, Stamatatos L, Kwong PD, Shapiro L, Haynes BF, Mascola JR, Alt FW
Cell (2016), Volume: 166, Issue: 6, Pages: 1471-1484

PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1-arrested progenitor B-cell line.
Kumar V, Alt FW, Frock RL.
Proc Natl Acad Sci U S A (2016), Volume: 113, Issue: 38, Pages: 10619-24

Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development.
Zhao L, Frock RL, Du Z, Hu J, Chen L, Krangel MS, Alt FW.
J Exp Med (2016), Volume: 213, Issue: 9, Pages: 1921-36

Highly sensitive and unbiased approach for elucidating antibody repertoires.
Lin SG, Ba Z, Du Z, Zhang Y, Hu J, Alt FW.
Proc Natl Acad Sci U S A (2016), Volume: 113, Issue: 28, Pages: 7846-51

Pillars Article: A Functional T3 Molecule Associated with a Novel Heterodimer on the Surface of Immature Human Thymocytes. Nature. 1986. 322: 179-181.
Bank I, DePinho RA, Brenner MB, Cassimeris J, Alt FW, Chess L.
J Immunol (2016), Volume: 196, Issue: 9, Pages: 3514-6

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