Research

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2014

A systematic analysis of recombination activity and genotype-phenotype correlation in human recombination-activating gene 1 deficiency.     
Lee YN, Frugoni F, Dobbs K, Walter JE, Giliani S, Gennery AR, Al-Herz W, Haddad E, LeDeist F, Bleesing JH, Henderson LA, Pai S-Y, Nelson RP, El-Ghoneimy DH, El-Feky RA, Reda SM, Hossny E, Soler-Palacin P, Fuleihan RL, Patel NC, Massaad MJ, Geha RS, Puck JM, Palma P, Cancrini C, Chen K, Vihinen M, Alt FW, Notarangelo LD   J. Allergy & Clinical Immunology (2014), Volume: 133,  Pages: 1099-1108 (PDF)

Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes.
Macdonald LE, Karow M, Stevens S, Auerbach W, Poueymirou WT, Yasenchak J, Frendewey D, Valenzuela DM, Giallourakis CC, Alt FW, Yancopoulos G D, Murphy AJ Proc. Natl. Acad. Sci. USA (2014), Volume 111, Pages: 5147-52  (PDF)

Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability.   
Meng F-L, Du Z, Federation A, Hu J, Wang Q, Kieffer-Kwon KR, Meyers RM, Amor C, Wasserman CR, Neuberg D, Casellas R, Nussenzweig MC, Bradner JE, Liu XS,  Alt FW  Cell (2014), Volume: 159, PagesL 1538-48 (PDF)

IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances
Gostissa M, Schwer B, Chang A, Dong J, Meyers RM, Marecki GT, Choi VW, Chiarle R, Zarrin AA, Alt FW.
Proc Natl Acad Sci U S A. (2014), Volume: 111, Issue: 7, Pages: 2644-9 (PDF)

Kumar Vipul, Alt Frederick W, Oksenych Valentyn.
DNA Repair (2014), Volume: 16, Pages: 11-22 (PDF)

Hu J, Tepsuporn S, Meyers RM, Gostissa M, Alt FW.
PNAS (2014), Volume: 111, Issue: 28, Pages: 10269-74 (PDF)

Tepsuporn S, Hu J, Gostissa M, Alt FW

Cancer Immunol Res. (2014), Volume: 2, Issue: 9, Pages: 857-66 (PDF)

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