Research

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2016

Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin.
Paulchaudhuri R, Saez B, Hoggatt J, Schajnovitz A, Sykes DB, Tate TA, Czechowicz A, Kfoury Y, Ruchika F, Rossi DJ, Verdine GL, Mansour MK, Scadden DT.
Nat Biotechnol. 2016 Jun 6. [Epub ahead of print].

Glycoengineering of E-selectin ligands by intracellular versus extracellular fucosylation differentially affects osteotropism of human mesenchymal stem cells. 
Dykstra B, Lee J, Mortensen L, Yu H, Wu Z, Rossi DJ, Lin C, Sackstein R. 
Stem Cells. In press.

Mitotic history reveals distinct stem cell populations and their contributions to hematopoiesis
Säwén P, Lang S, Mandal P, Rossi DJ, Soneji S, Bryder D. 
Cell Reports. Epub 2016 Mar 17.

DNA Damage and Aging around the Clock. 
Gutierrez-Martinez P, Rossi DJ, Beerman I. 
Trends in Molecular Medicine. In press.

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.
Inoue S, Li WY, Tseng A, Beerman I, Elia AJ, Bendall SC, Lemonnier F, Kron KJ, Cescon DW, Hao Z, Lind EF, Takayama N, Planello AC, Shen SY, Shih AH, Larsen DM, Li Q, Snow BE, Wakeham A, Haight J, Gorrini C, Bassi C, Thu KL, Murakami K, Elford AR, Ueda T, Straley K, Yen KE, Melino G, Cimmino L, Aifantis I, Levine RL, De Carvalho DD, Lupien M, Rossi DJ, Nolan GP, Cairns RA, Mak TW.
Cancer Cell. 2016 Aug 8;30(2):337-48. 

Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease.
Burberry A, Suzuki N, Wang JY, Moccia R, Mordes DA, Stewart MH, Suzuki-Uematsu S, Ghosh S, Singh A, Merkle FT, Koszka K, Li QZ, Zon L, Rossi DJ, Trowbridge JJ, Notarangelo LD, Eggan K.
Sci Transl Med. 2016 Jul 13;8(347):347ra93. 

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