Research

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Recent Rossi Lab Publications

2016

Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin. Paulchaudhuri R, Saez B, Hoggatt J, Schajnovitz A, Sykes DB, Tate TA, Czechowicz A, Kfoury Y, Ruchika F, Rossi DJ, Verdine GL, Mansour MK, Scadden DT. Nat Biotechnol. 2016 Jun 6. [Epub ahead of print]. PMCID in process.

Glycoengineering of E-selectin ligands by intracellular versus extracellular fucosylation differentially affects osteotropism of human mesenchymal stem cells. Dykstra B, Lee J, Mortensen L, Yu H, Wu Z, Rossi DJ, Lin C, Sackstein R. Stem Cells. In press. [PMCID in process.]

Mitotic history reveals distinct stem cell populations and their contributions to hematopoiesis. Säwén P, Lang S, Mandal P, Rossi DJ, Soneji S, Bryder D. Cell Reports. Epub 2016 Mar 17.

DNA Damage and Aging around the Clock. Gutierrez-Martinez P, Rossi DJ, Beerman I. Trends in Molecular Medicine. In press. [PMCID in process].


2015

Two new routes to make blood: Hematopoietic specification from pluripotent cell lines versus reprogramming of somatic cells.  Singbrant S, van Galen P, Lucas D, Challen G, Rossi DJ, Daley GQ. Exp Hematol. 2015 Sep;43(9):756-9. Review. 

Progress and obstacles towards generating hematopoietic stem cells from pluripotent stem cells.  Lee J, Dykstra B, Sackstein R, Rossi DJ. Curr Opin Hematol. 2015 Jul;22(4):317-23.  (PDF)

Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and Disease.  Beerman I, Rossi DJ. Cell Stem Cell. 2015 Jun 4;16(6):613-25.  Review. (PDF)

Transcription factor-mediated reprogramming toward hematopoietic stem cells.  Ebina W, Rossi DJ. EMBO J. 2015 Mar 12;34(6):694-709. Review. (PDF)

The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal in mice.  Stewart MH, Albert M, Sroczynska P, Cruickshank VA, Guo Y, Rossi DJ, Helin K, Enver T. Blood. 2015 Mar 26;125(13):2075-8. (PDF)


2014

Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors.
Riddell J, Gazit R, Garrison BS, Guo G, Saadatpour A, Mandal PK, Ebina W, Volchkov P, Yuan GC, Orkin SH, Rossi DJ.
Cell (2014), Volume: 157, Issue: 3, Pages: 549-564. (PDF)

Mandal PK, Ferreira LM, Collins R, Meissner TB, Boutwell CL, Friesen M, Vrbanac V, Garrison BS, Stortchevoi A,
Bryder D, Musunuru K, Brand H, Tager AM, Allen TM, Talkowski ME, Rossi DJ, Cowan CA.
Cell Stem Cell (2014), Volume: 15, Issue: 5, Pages 643-652. (PDF)


Gazit R, Mandal PK, Ebina W, Ben-Zvi A, Nombela-Arrieta C, Silberstein LE, Rossi DJ.
The Journal of Experimental Medicine (2014), Volume: 211, Issue: 7, Pages: 1315-1331. (PDF)


Growth hormone receptor signaling is dispensable for HSC function and aging.
Stewart MH, Gutierrez-Martinez P, Beerman I, Garrison B, Gallagher EJ, LeRoith D, Rossi DJ.
Blood (2014), Volume: 124, Issue: 20, Pages: 3076-3080. (PDF)


Garrison BS, Rossi DJ.
J Clin Invest. (2014), Volume: 124, Issue: 7, Pages: 2846-2848. (PDF)


Beerman I, Seita J, Inlay MA, Weissman IL, Rossi DJ.
Cell Stem Cell (2014), Volume: 15, Issue: 1, Pages: 37-50. (PDF)


Santos MA, Faryabi RB, Ergen AV, Day AM, Malhowski A, Canela A, Onozawa M, Lee JE, Callen E, Gutierrez-Martinez P, Chen HT, Wong N, Finkel N, Deshpande A, Sharrow S, Rossi DJ, Ito K, Ge K, Aplan PD, Armstrong SA, Nussenzweig A.
Nature (2014). (PDF)



2013

Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging
Beerman I, Bock C, Garrison B, Smith Z, Gu H, Meissner A, and Rossi DJ.
Cell Stem Cell (2013), Volume: 12, Issue: 4, Pages: 413-425. (PDF)


Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction.
Zangi L, Lui KO, von Gise A, Ma Q, Ebina W, Ptaszek LM, Später D, Xu H, Tabebordbar M, Gorbatov R, Sena B, Nahrendorf M, Briscoe DM, Li RA, Wagers AJ, Rossi DJ, Pu WT, Chien KR.
Nature Biotechnology (2013), Volume: 31, Issue: 10, Pages: 898-907. (PDF)


Human iPSC-based modeling of late-onset disease via progerin-induced aging.
Miller JD, Ganat YM, Kishinevsky S, Bowman RL, Liu B, Tu EY, Mandal PK, Vera E, Shim JW, Kriks S, Taldone T, Fusaki N, Tomishima MJ, Krainc D, Milner TA, Rossi DJ, Studer L.
Cell Stem Cell (2013), Volume: 13, Issue: 6, Pages: 691-705. (PDF)


Transcriptiome analysis identifies regulators of hematopoietic stem and progenitor cells.
Gazit R, Garrison BS, Rao TN, Shay T, Costello J, Ericson J, Kim F, Collins JJ, Regev A, Wagers AJ, Rossi DJ.
Stem Cell Reports (2013), Volume: 1, Issue: 3, Pages: 266-80. 


Reprogramming human fibroblasts to plurpotency using modified mRNA.
Mandal PK, Rossi DJ.
Nat Protoc (2013), Volume: 8, Issue: 3, Pages: 568-82. 

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