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Recent Wagner Lab Publications


Erpenbeck L, Demers M, Zsengeller Z, Gallant M, Cifuni S, Stillman IE, Karumanchi SA, Wagner DD  

JASN.2016, 27(1): 120-31. (PDF)

Peptidylarginine deiminase 4 promotes age-related organ fibrosis.
Martinod K, Witsch T, Erpenbeck L, Savchenko A, Hayashi H, Cherpokova D, Gallant M, Mauler M, Cifuni SM, Wagner DD.
J. Exp. Med. In press.
PAD4 deficiency decreases inflammation and susceptibility to pregnancy loss in a mouse model. 
Erpenbeck L, Chowdhury C, Zsengelle ZK, Gallant M, Burke SD, Cifuni S, Hahn S, Wagner DD, Karumanchi A.
Biology of Reproduction. Volume: 95 (6), Pages:0, 1-11. In press.

Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice.

Shaw MA, Kombrinck KW, McElhinney KE, Sweet DR, Flick MJ, Palumbo JS, Cheng M, Esmon NL, Esmon CT, Brill A, Wagner DD, Degen JL, Mullins ES.
Blood. Volume: 128 (5), Pages: 721-31 

Priming of neutrophils toward NETosis promotes tumor growth. 
Demers M, Wong SL, Martinod K, Gallant M, Cabral JE, Wang Y, Wagner DD. 
Oncoimmunology. Volume: 5 (5) 

Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease
Pillai PS, Molony RD, Martinod K, Dong H, Pang IK, Tal MC, Solis AG, Bielecki P, Mohanty S, Trentalange M, Homer RJ, Flavell RA, Wagner DD, Montgomery RR, Shaw AC, Staeheli P, Iwasaki A. 
Science. Volume: 352(6284), Pages: 463-6 

OC-16 - Neutrophil extracellular traps and tissue factor-bearing microvesicles: a liaison dangereuse causing overt DIC in cancer patients? 
Hell L, Thaler J, Martinod K, Ay C, Posch F, Wagner DD, Pabinger I. 
Thromb Res. 

NETosis promotes cancer-associated arterial microthrombosis presenting as ischemic stroke with troponin elevation.  
Thålin C, Demers M, Blomgren B, Wong SL, von Arbin M, von Heijne A, Laska AC, Wallén H, Wagner DD, Aspberg S.  
Thromb Res. Volume: 139, Pages: 56-64.

Neutrophil elastase-deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis. 

Martinod K, Witsch T, Farley K, Gallant M, Remold-O'Donnell E, Wagner DD.  
J Thromb Haemost. Volume: 14(3), Pages:551-8 


Neutrophil elastase-deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis.
Martinod K, Witsch T, Farley K, Gallant M, Remold-O'Donnell E, Wagner DD. 
J Thromb Haemost. 2015 Dec 29. (PDF)

Flow cytometric assay for direct quantification of neutrophil extracellular traps in blood samples.
Gavillet M, Martinod K, Renella R, Harris C, Shapiro NI, Wagner DD, Williams DA. 
Am J Hematol. 2015 Dec;90(12):1155-8 (PDF)

PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock
Martinod K, Fuchs Ta, Zitomersky NL, Wong SL, Demers M, Gallant M Wang Y, Wagner DD
Blood (2015)

 Mar 19;125(12):1948-56


Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation
Lewis HD, Liddle J, Coote JE, Atkinson SJ, Barker MD, Bax BD, Bicker KL, Bingham RP, Campbell M, Chen YH, Chung C, Craggs PD, Davis RP, Eberhard D, Joberty G, Lind KE, Locke K, Maller C, Martinod K, Patten C, Polyakova O, Rise CE, Rüdiger M, Sheppard RJ, Slade DJ, Thomas P, Thorpe J, Yao G, Drewes G, Wagner DD, Thompson PR, Prinjha RK, David M. Wilson DM
Nature Chemical Biology (2015), Volume: 11, Issue: 3, Pages: 189-9 (PDF)

Dietary Omega-3 Alpha-Linolenic Acid does not prevent venous thrombosis in mice
Reiner MF, Martinod K, Stivala S, Camici GC, Luscher TF, Wagner DD, Beer JH
Thrombosis and haemostasis. (2015), Volume: 113, Issue: 1, Pages: 177-84 (PDF)

Etulain J, Martinod K, Wong SL, Cifuni SM, Schattner M, Wagner DD.
Blood. 2015 Jul 9;126(2):242-6. Epub 2015 May 15. (PDF)

Thomas GM, Brill A, Mezouar L, Crescence L, Gallant M, Dubois C, Wagner DD., 
JTH 2015 Jul;13(7):1310-9. (PDF)

Wong SL, Demers M, Martinod K, Gallant M, Wang Y, Goldfine AB, Kahn CR, Wagner DD. 
Nat Med. 2015, 21(7): 815-9 (PDF)


Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease
Chen G, Zhang D, Fuchs TA, Manwani D, Wagner DD, Frenette PS
Blood (2014), Volume: 123, Issue: 24, Pages: 3818-27

Neutrophil extracellular traps form predominantly during the organizing stage of human venous thromboembolism development
Savchenko AS, Martinod K, Seidman MA, Wong SL, Borissoff JI, Piazza G, Libby P, Goldhaber SZ, Mitchell RN, Wagner DD
J Thromb Haemost (2014), Volume: 12, Issue: 6, Pages: 860-70

NETosis: a new factor in tumor progression and cancer-associated thrombosis.
Demers M, Wagner DD
Semin Thromb Hemost (2014), Volume: 40, Issue: 3, Pages: 277-283

VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice.
Savchenko AS, Borissoff JI, Martinod K, De Meyer SF, Gallant M, Erpenbeck L, Brill A, Wang Y, Wagner DD.
Blood (2014), Volume: 123, Issue: 1, Pages: 141-148

Thrombosis: Tangled up in NETs.
Martinod K, Wagner DD
Blood (2014), Volume: 123, Issue: 18, Pages: 2768-2776


Lack of tryptophan hydroxylase-1 in mice results in gait abnormalities.
Suidan GL, Duerschmied D, Dillon GM, Vanderhorst V, Hampton TG, Wong SL, Voorhees JR, Wagner DD.
PLoS One (2013), Volume: 8, Issue: 3, Pages: e59032

Isoflurane inhibits neutrophil recruitment in the cutaneous Arthus reaction model.
Carbo C, Yuki K, Demers M, Wagner DD, Shimaoka M.
J Anesth (2013), Volume: 27, Issue: 2, Pages: 261-268

Plasma DNA is elevated in patients with deep vein thrombosis.
Diaz JA, Fuchs TA, Jackson TO, Hovinga JA, Lämmle B, Henke PK, Myers DD Jr, Wagner DD, Wakefield TW; for the Michigan Research Venous Group
J Vasc Surg (2013), Volume: 1, Issue: 4, Pages: doi: 10.1016/j.jvsv.2012.12.002.

Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice.
Duerschmied D, Suidan GL, Demers M, Herr N, Carbo C, Brill A, Cifuni SM, Mauler M, Cicko S, Bader M, Idzko M, Bode C, Wagner DD.
Blood (2013), Volume: 121, Issue: 6, Pages: 1008-15

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice.
Martinod K, Demers M, Fuchs TA, Wong SL, Brill A, Gallant M, Hu J, Wang Y, Wagner DD.
Proc Natl Acad Sci U S A (2013), Volume: 110, Issue: 21, Pages: 8674-9

Elevated levels of circulating DNA and chromatin are independently associated with severe coronary atherosclerosis and a prothrombotic state.
Borissoff JI, Joosen IA, Versteylen MO, Brill A, Fuchs TA, Savchenko AS, Gallant M, Martinod K, Ten Cate H, Hofstra L, Crijns HJ, Wagner DD, Kietselaer BL.
Arterioscler Thromb Vasc Biol (2013), Volume: 33, Issue: 8, Pages: 2032-2040

Hypoxia, such as encountered at high altitude, promotes deep vein thrombosis in mice.
Brill A, Suidan GL, Wagner DD.
J Thromb Haemost (2013), Volume: 11, Issue: 9, Pages: 1773-5

Endothelial von Willebrand factor promotes blood-brain barrier flexibility and provides protection from hypoxia and seizures in mice.
Suidan GL, Brill A, De Meyer SF, Voorhees JR, Cifuni SM, Cabral JE, Wagner DD.
Arterioscler Thromb Vasc Biol (2013), Volume: 33, Issue: 9, Pages: 2112-20

Neutrophils release extracellular DNA traps during storage of red blood cell units.
Fuchs TA, Alvarez JJ, Martinod K, Bhandari AA, Kaufman RM, Wagner DD.
Transfusion (2013), Volume: 53, Issue: 12, Pages: 3210-6


Neutrophil extracellular traps promote deep vein thrombosis in mice
Brill A, Fuchs TA, Savchenko AS, Thomas GM, Martinod K, De Meyer SF, Bhandari AA, Wagner DD. 
J Thromb Haemost. 2012;10(1):136-144. PMCID: 3319651.

Extrahepatic high-density lipoprotein receptor SR-BI and apoA-I protect against deep vein thrombosis in mice 
Brill A, Yesilaltay A, De Meyer SF, Kisucka J, Fuchs TA, Kocher O, Krieger M, Wagner DD.
Arterioscler Thromb Vasc Biol. 2012;32(8):1841-1847. PMCID: 3495568.

Endocytosis of soluble immune complexes leads to their clearance by FcgammaRIIIB but induces neutrophil extracellular traps via FcgammaRIIA in vivo.
Chen K, Nishi H, Travers R, Tsuboi N, Martinod K, Wagner DD, Stan R, Croce K, Mayadas TN. 
Blood. 2012;120(22):4421-4431. PMCID: 3507149.

ADAMTS13 exerts a thrombolytic effect in microcirculation.
Crescente M, Thomas GM, Demers M, Voorhees JR, Wong SL, Ho-Tin-Noe B, Wagner DD.
Thromb Haemost. 2012;108(3):527-532.

Protective anti-inflammatory effect of ADAMTS13 on myocardial ischemia/reperfusion injury in mice.
De Meyer SF, Savchenko AS, Haas MS, Schatzberg D, Carroll MC, Schiviz A, Dietrich B, Rottensteiner H, Scheiflinger F, Wagner DD. 
Blood. 2012;120(26):5217-5223. PMCID: 3537313.

von Willebrand factor: an emerging target in stroke therapy 
De Meyer SF, Stoll G, Wagner DD, Kleinschnitz C.
Stroke. 2012;43(2):599-606.

Extracellular chromatin is an important mediator of ischemic stroke in mice.
De Meyer SF, Suidan GL, Fuchs TA, Monestier M, Wagner DD. 
Arterioscler Thromb Vasc Biol. 2012;32(8):1884-1891. PMCID: 3494463.

Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis.
Demers M, Krause DS, Schatzberg D, Martinod K, Voorhees JR, Fuchs TA, Scadden DT, Wagner DD. 
Proc Natl Acad Sci U S A. 2012;109(32):13076-13081. PMCID: 3420209.

Targeting platelet function to improve drug delivery.
Demers M, Wagner DD. 
Oncoimmunology. 2012;1(1):100-102. PMCID: 3376975.

Neutrophil extracellular trap (NET) impact on deep vein thrombosis. 
Fuchs TA, Brill A, Wagner DD. 
Arterioscler Thromb Vasc Biol. 2012;32(8):1777-1783. PMCID: 3495595.

Circulating DNA and myeloperoxidase indicate disease activity in patients with thrombotic microangiopathies 
Fuchs TA, Kremer Hovinga JA, Schatzberg D, Wagner DD, Lammle B. 
Blood. 2012;120(6):1157-1164. PMCID: 3418712.

Desialylation accelerates platelet clearance after refrigeration and initiates GPIbalpha metalloproteinase-mediated cleavage in mice.
Jansen AJ, Josefsson EC, Rumjantseva V, Liu QP, Falet H, Bergmeier W, Cifuni SM, Sackstein R, von Andrian UH, Wagner DD, Hartwig JH, Hoffmeister KM. 
Blood. 2012;119(5):1263-1273. PMCID: 3277358.

Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels.
Korin N, Kanapathipillai M, Matthews BD, Crescente M, Brill A, Mammoto T, Ghosh K, Jurek S, Bencherif SA, Bhatta D, Coskun AU, Feldman CL, Wagner DD, Ingber DE. 
Science. 2012;337(6095):738-742.

ARC15105 is a potent antagonist of von Willebrand factor mediated platelet activation and adhesion. 
Siller-Matula JM, Merhi Y, Tanguay JF, Duerschmied D, Wagner DD, McGinness KE, Pendergrast PS, Chung JK, Tian X, Schaub RG, Jilma B. 
Arterioscler Thromb Vasc Biol. 2012;32(4):902-909.

Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice.
Thomas GM, Carbo C, Curtis BR, Martinod K, Mazo IB, Schatzberg D, Cifuni SM, Fuchs TA, von Andrian UH, Hartwig JH, Aster RH, Wagner DD. 
Blood. 2012;119(26):6335-6343. PMCID: 3383196.

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo.
von Bruhl ML, Stark K, Steinhart A, Chandraratne S, Konrad I, Lorenz M, Khandoga A, Tirniceriu A, Coletti R, Kollnberger M, Byrne RA, Laitinen I, Walch A, Brill A, Pfeiler S, Manukyan D, Braun S, Lange P, Riegger J, Ware J, Eckart A, Haidari S, Rudelius M, Schulz C, Echtler K, Brinkmann V, Schwaiger M, Preissner KT, Wagner DD, Mackman N, Engelmann B, Massberg S.
J Exp Med. 2012;209(4):819-835. PMCID: 3328366.


von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models. 
Brill A, Fuchs TA, Chauhan AK, Yang JJ, De Meyer SF, Kollnberger M, Wakefield TW, Lammle B, Massberg S, Wagner DD.
Blood. 2011;117(4):1400-1407. PMCID: 3056477.

Platelet glycoprotein Ibalpha is an important mediator of ischemic stroke in mice.
De Meyer SF, Schwarz T, Schatzberg D, Wagner DD. 
Exp Transl Stroke Med. 2011;3:9. PMCID: 3180255.

Increased efficacy of breast cancer chemotherapy in thrombocytopenic mice.
Demers M, Ho-Tin-Noe B, Schatzberg D, Yang JJ, Wagner DD. 
Cancer Res. 2011;71(5):1540-1549. PMCID: 3078642.

The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A 
Flick MJ, Chauhan AK, Frederick M, Talmage KE, Kombrinck KW, Miller W, Mullins ES, Palumbo JS, Zheng X, Esmon NL, Esmon CT, Thornton S, Becker A, Pelc LA, Di Cera E, Wagner DD, Degen JL.. 
Blood. 2011;117(23):6326-6337. PMCID: 3122951.

Histones induce rapid and profound thrombocytopenia in mice.
Fuchs TA, Bhandari AA, Wagner DD. 
Blood. 2011;118(13):3708-3714. PMCID: 3186342.

How platelets safeguard vascular integrity.
Ho-Tin-Noe B, Demers M, Wagner DD. 
J Thromb Haemost. 2011;9 Suppl 1:56-65. PMCID: 3229170.

Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rolling.
Stadtmann A, Brinkhaus L, Mueller H, Rossaint J, Bolomini-Vittori M, Bergmeier W, Van Aken H, Wagner DD, Laudanna C, Ley K, Zarbock A. 
Eur J Immunol. 2011;41(7):2074-2085. PMCID: 3124568.


The lack of ADAM17 activity during embryonic development causes hemorrhage and impairs vessel formation.
Canault M, Certel K, Schatzberg D, Wagner DD, Hynes RO.
PLoS One. 2010;5(10):e13433. PMCID: 2955552.

p38 mitogen-activated protein kinase activation during platelet storage: consequences for platelet recovery and hemostatic function in vivo.
Canault M, Duerschmied D, Brill A, Stefanini L, Schatzberg D, Cifuni SM, Bergmeier W, Wagner DD.
Blood. 2010;115(9):1835-1842. PMCID: 2832811.

Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis.
Carbo C, Duerschmied D, Goerge T, Hattori H, Sakai J, Cifuni SM, White GC, 2nd, Chrzanowska-Wodnicka M, Luo HR, Wagner DD.
J Leukoc Biol. 2010;88(2):313-319. PMCID: 2908939.

A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function.
Falet H, Pollitt AY, Begonja AJ, Weber SE, Duerschmied D, Wagner DD, Watson SP, Hartwig JH.
J Exp Med. 2010;207(9):1967-1979. PMCID: 2931168.

Extracellular DNA traps promote thrombosis.
Fuchs TA, Brill A, Duerschmied D, Schatzberg D, Monestier M, Myers DD, Jr., Wrobleski SK, Wakefield TW, Hartwig JH, Wagner DD.
Proc Natl Acad Sci U S A. 2010;107(36):15880-15885. PMCID: 2936604.


The distal carboxyl-terminal domains of ADAMTS13 are required for regulation of in vivo thrombus formation.
Banno F, Chauhan AK, Kokame K, Yang J, Miyata S, Wagner DD, Miyata T.
Blood. 2009;113(21):5323-5329. PMCID: 2686194.

Differential stimulation of monocytic cells results in distinct populations of microparticles.
Bernimoulin M, Waters EK, Foy M, Steele BM, Sullivan M, Falet H, Walsh MT, Barteneva N, Geng JG, Hartwig JH, Maguire PB, Wagner DD.
J Thromb Haemost. 2009;7(6):1019-1028. PMCID: 3242443.

Oxidative stress activates ADAM17/TACE and induces its target receptor shedding in platelets in a p38-dependent fashion.
Brill A, Chauhan AK, Canault M, Walsh MT, Bergmeier W, Wagner DD.
Cardiovasc Res. 2009;84(1):137-144. PMCID: 2741344.

Inhibition of von Willebrand factor-mediated platelet activation and thrombosis by the anti-von Willebrand factor A1-domain aptamer ARC1779.
Diener JL, Daniel Lagasse HA, Duerschmied D, Merhi Y, Tanguay JF, Hutabarat R, Gilbert J, Wagner DD, Schaub R.
J Thromb Haemost. 2009;7(7):1155-1162.

Serotonin stimulates platelet receptor shedding by tumor necrosis factor-alpha-converting enzyme (ADAM17).
Duerschmied D, Canault M, Lievens D, Brill A, Cifuni SM, Bader M, Wagner DD.
J Thromb Haemost. 2009;7(7):1163-1171. PMCID: 3244876.

Structure, biology and genetics of von Willebrand factor.
Ginsburg D, Wagner DD. In: Hoffman R, Benz EJ, Shattil SJ, Furie B, Silberstein LE, McGlave P, Heslop H, editors.
Hematology: Basic Principles and Practices. 5th ed. New York: Churchill Livingstone; 2009.

Innate immune cells induce hemorrhage in tumors during thrombocytopenia.
Ho-Tin-Noe B, Carbo C, Demers M, Cifuni SM, Goerge T, Wagner DD.
Am J Pathol. 2009;175(4):1699-1708. PMCID: 2751565.

Platelets: guardians of tumor vasculature. 
Ho-Tin-Noe B, Goerge T, Wagner DD. 
Cancer Res. 2009;69(14):5623-5626.

Elevated levels of soluble P-selectin in mice alter blood-brain barrier function, exacerbate stroke, and promote atherosclerosis.
Kisucka J, Chauhan AK, Zhao BQ, Patten IS, Yesilaltay A, Krieger M, Wagner DD.
Blood. 2009;113(23):6015-6022. PMCID: 2700332.

Inhibition of VEGF or TGF-{beta} signaling activates endothelium and increases leukocyte rolling.
Walshe TE, Dole VS, Maharaj AS, Patten IS, Wagner DD, D'Amore PA.
Arterioscler Thromb Vasc Biol. 2009;29(8):1185-1192. PMCID: 2775449.

von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke.
Zhao BQ, Chauhan AK, Canault M, Patten IS, Yang JJ, Dockal M, Scheiflinger F, Wagner DD.
Blood. 2009;114(15):3329-3334. PMCID: 2759655


Glycoprotein Ibalpha and von Willebrand factor in primary platelet adhesion and thrombus formation: lessons from mutant mice.
Bergmeier W, Chauhan AK, Wagner DD.
Thromb Haemost. 2008;99(2):264-270.

ADAMTS13: a new link between thrombosis and inflammation.
Chauhan AK, Kisucka J, Brill A, Walsh MT, Scheiflinger F, Wagner DD.
J Exp Med. 2008;205(9):2065-2074. PMCID: 2526201.

Prothrombotic effects of fibronectin isoforms containing the EDA domain.
Chauhan AK, Kisucka J, Cozzi MR, Walsh MT, Moretti FA, Battiston M, Mazzucato M, De Marco L, Baralle FE, Wagner DD, Muro AF.
Arterioscler Thromb Vasc Biol. 2008;28(2):296-301.

The combined roles of ADAMTS13 and VWF in murine models of TTP, endotoxemia, and thrombosis.
Chauhan AK, Walsh MT, Zhu G, Ginsburg D, Wagner DD, Motto DG.
Blood. 2008;111(7):3452-3457. PMCID: 2275014.

CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets.
Cifuni SM, Wagner DD, Bergmeier W.
Blood. 2008;112(5):1696-1703. PMCID: 2518880.

Thrombocytopenia and platelet abnormalities in high-density lipoprotein receptor-deficient mice.
Dole VS, Matuskova J, Vasile E, Yesilaltay A, Bergmeier W, Bernimoulin M, Wagner DD, Krieger M.
Arterioscler Thromb Vasc Biol. 2008;28(6):1111-1116. PMCID: 2683374.

Inflammation induces hemorrhage in thrombocytopenia.
Goerge T, Ho-Tin-Noe B, Carbo C, Benarafa C, Remold-O'Donnell E, Zhao BQ, Cifuni SM, Wagner DD. 
Blood. 2008;111(10):4958-4964. PMCID: 2384127.

Platelet granule secretion continuously prevents intratumor hemorrhage.
Ho-Tin-Noe B, Goerge T, Cifuni SM, Duerschmied D, Wagner DD.
Cancer Res. 2008;68(16):6851-6858. PMCID: 2547489.

Peroxiredoxin1 prevents excessive endothelial activation and early atherosclerosis.
Kisucka J, Chauhan AK, Patten IS, Yesilaltay A, Neumann C, Van Etten RA, Krieger M, Wagner DD.
Circ Res. 2008;103(6):598-605.

The effect of C1 inhibitor on intestinal ischemia and reperfusion injury.
Lu F, Chauhan AK, Fernandes SM, Walsh MT, Wagner DD, Davis AE, 3rd.
Am J Physiol Gastrointest Liver Physiol. 2008;295(5):G1042-1049.

von-Willebrand factor influences blood brain barrier permeability and brain inflammation in experimental allergic encephalomyelitis.
Noubade R, del Rio R, McElvany B, Zachary JF, Millward JM, Wagner DD, Offner H, Blankenhorn EP, Teuscher C.
Am J Pathol. 2008;173(3):892-900. PMCID: 2526288.

The vessel wall and its interactions.
Wagner DD, Frenette PS.
Blood. 2008;111(11):5271-5281. PMCID: 2396724.


In vitro function and phagocytosis of galactosylated platelet concentrates after long-term refrigeration.
Babic AM, Josefsson EC, Bergmeier W, Wagner DD, Kaufman RM, Silberstein LE, Stossel TP, Hartwig JH, Hoffmeister KM. 
Transfusion. 2007;47(3):442-451.

Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III.
Bergmeier W, Goerge T, Wang HW, Crittenden JR, Baldwin AC, Cifuni SM, Housman DE, Graybiel AM, Wagner DD. 
J Clin Invest. 2007;117(6):1699-1707. PMCID: 1865026.

Formation of platelet strings and microthrombi in the presence of ADAMTS-13 inhibitor does not require P-selectin or beta3 integrin.
Chauhan AK, Goerge T, Schneider SW, Wagner DD.
J Thromb Haemost. 2007;5(3):583-589.

von Willebrand factor and factor VIII are independently required to form stable occlusive thrombi in injured veins.
Chauhan AK, Kisucka J, Lamb CB, Bergmeier W, Wagner DD.
Blood. 2007;109(6):2424-2429. PMCID: 1852205.

Platelet adhesion receptors and their ligands in mouse models of thrombosis.
Denis CV, Wagner DD.
Arterioscler Thromb Vasc Biol. 2007;27(4):728-739.

PSGL-1 regulates platelet P-selectin-mediated endothelial activation and shedding of P-selectin from activated platelets.
Dole VS, Bergmeier W, Patten IS, Hirahashi J, Mayadas TN, Wagner DD.
Thromb Haemost. 2007;98(4):806-812.

Platelet adhesion receptors do not modulate infarct volume after a photochemically induced stroke in mice.
Frederix K, Chauhan AK, Kisucka J, Zhao BQ, Hoff EI, Spronk HM, Ten Cate H, Wagner DD.
Brain Res. 2007;1185:239-245. PMCID: 2692282.

ApoE deficiency leads to a progressive age-dependent blood-brain barrier leakage.
Hafezi-Moghadam A, Thomas KL, Wagner DD.
Am J Physiol Cell Physiol. 2007;292(4):C1256-1262.

Dynamic visualization of thrombopoiesis within bone marrow.
Junt T, Schulze H, Chen Z, Massberg S, Goerge T, Krueger A, Wagner DD, Graf T, Italiano JE, Jr., Shivdasani RA, von Andrian UH.
Science. 2007;317(5845):1767-1770.

Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury.
Zhu L, Bergmeier W, Wu J, Jiang H, Stalker TJ, Cieslak M, Fan R, Boumsell L, Kumanogoh A, Kikutani H, Tamagnone L, Wagner DD, Milla ME, Brass LF. 
Proc Natl Acad Sci U S A. 2007;104(5):1621-1626. PMCID: 1785259.


The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis.
Bergmeier W, Piffath CL, Goerge T, Cifuni SM, Ruggeri ZM, Ware J, Wagner DD.
Proc Natl Acad Sci U S A. 2006;103(45):16900-16905. PMCID: 1636551.

Inflammation. In: Michelson A, editor. Platelets.
Bergmeier W, Wagner D.
2nd ed. San Diego: Elsevier-Academic Press; 2006.

Systemic antithrombotic effects of ADAMTS13.
Chauhan AK, Motto DG, Lamb CB, Bergmeier W, Dockal M, Plaimauer B, Scheiflinger F, Ginsburg D, Wagner DD.
J Exp Med. 2006;203(3):767-776. PMCID: 2118248.

Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy.
Hirahashi J, Mekala D, Van Ziffle J, Xiao L, Saffaripour S, Wagner DD, Shapiro SD, Lowell C, Mayadas TN.
Immunity. 2006;25(2):271-283.

Elevated levels of homocysteine compromise blood-brain barrier integrity in mice.
Kamath AF, Chauhan AK, Kisucka J, Dole VS, Loscalzo J, Handy DE, Wagner DD.
Blood. 2006;107(2):591-593. PMCID: 1895614.

Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage.
Kisucka J, Butterfield CE, Duda DG, Eichenberger SC, Saffaripour S, Ware J, Ruggeri ZM, Jain RK, Folkman J, Wagner DD.
Proc Natl Acad Sci U S A. 2006;103(4):855-860. PMCID: 1348013.

Decreased plasma fibronectin leads to delayed thrombus growth in injured arterioles.
Matuskova J, Chauhan AK, Cambien B, Astrof S, Dole VS, Piffath CL, Hynes RO, Wagner DD.
Arterioscler Thromb Vasc Biol. 2006;26(6):1391-1396.

The A2B adenosine receptor protects against inflammation and excessive vascular adhesion.
Yang D, Zhang Y, Nguyen HG, Koupenova M, Chauhan AK, Makitalo M, Jones MR, St Hilaire C, Seldin DC, Toselli P, Lamperti E, Schreiber BM, Gavras H, Wagner DD, Ravid K.
J Clin Invest. 2006;116(7):1913-1923. PMCID: 1483170.

Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo.
Yang H, Reheman A, Chen P, Zhu G, Hynes RO, Freedman J, Wagner DD, Ni H.
J Thromb Haemost. 2006;4(10):2230-2237.


Aspirin induces platelet receptor shedding via ADAM17 (TACE)
Aktas B, Pozgajova M, Bergmeier W, Sunnarborg S, Offermanns S, Lee D, Wagner DD, Nieswandt B..
J Biol Chem. 2005;280(48):39716-39722.

A direct role for C1 inhibitor in regulation of leukocyte adhesion.
Cai S, Dole VS, Bergmeier W, Scafidi J, Feng H, Wagner DD, Davis AE,
3rd. J Immunol. 2005;174(10):6462-6466.

Activated platelets induce Weibel-Palade-body secretion and leukocyte rolling in vivo: role of P-selectin.
Dole VS, Bergmeier W, Mitchell HA, Eichenberger SC, Wagner DD.
Blood. 2005;106(7):2334-2339. PMCID: 1895274.

Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice. 
Motto DG, Chauhan AK, Zhu G, Homeister J, Lamb CB, Desch KC, Zhang W, Tsai HM, Wagner DD, Ginsburg D. 
J Clin Invest. 2005;115(10):2752-2761. PMCID: 1240119.

The P-selectin, tissue factor, coagulation triad.
Polgar J, Matuskova J, Wagner DD.
J Thromb Haemost. 2005;3(8):1590-1596.

New links between inflammation and thrombosis.
Wagner DD.
Arterioscler Thromb Vasc Biol. 2005;25(7):1321-1324.

Elevated soluble ICAM-1 levels induce immune deficiency and increase adiposity in mice.
Wang HW, Babic AM, Mitchell HA, Liu K, Wagner DD.
Faseb J. 2005;19(8):1018-1020.

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