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Program in Cellular and Molecular Medicine (PCMM)

The Program in Cellular and Molecular Medicine (PCMM), previously known as the Immune Disease Institute (IDI), is a research program at Boston Children's Hospital (BCH) recognized worldwide for its discoveries that increase the body's ability to fight disease and to heal.

The breakthroughs of PCMM scientists are greatly increasing our understanding of the influence of immune defense and inflammation on medical discovery, healthcare, and disease management.

PCMM officially joined seven other interdisciplinary programs at Boston Children's Hospital in October 2012 with the goal of increasing collaborations and scientific synergies.

Our investigators are academically affiliated with Harvard Medical School.

PCMM Announcements

Denisa Wagner Received William Harvey Medal from William Harvey Institute, London, UK 

Fred Alt Received William Silen Lifetime Achievement in Mentoring Award from Harvard Medical School


PCMM Research News


October 25, 2016

Modulation of Scramblase: a novel paradigm to fight chronic infection and cancer

In a study published in The Journal of Experimental Medicine, the Winau lab identified a new pathway involving scramblase TMEM16F that preserves efficient T cell responses to control viral infection. These findings provide a novel target for therapy against chronic diseases such as cancer, as well as HIV and hepatitis B virus infections.

September 8, 2016 

Keeping up  with HIV mutations: Building a nimble vaccine test system             

Group led by PCCM director Frederick Alt, PhD, developed a technology to greatly speed up HIV development. Described in the September 8 issue of Cell, the group’s method generates mouse models with built-in human immune systems. The model recapitulates what the human immune system does, only much more rapidly, enabling researchers to continuously test and tweak potential HIV vaccines.

 Other News

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