Research

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Shane Cronin PhD

Research Fellow

Background and Research Interests
I received my BA (Hons.) in Human Genetics from Trinity College Dublin, Ireland and my PhD in Molecular Biology and Genetics from the University of Vienna, Austria. I have also researched at The Scripps Research Institute, San Diego, the University of Pittsburgh and the Institute of Molecular Biotechnology in Vienna. I am interested in identifying novel genes and pathways involved in the initiation and maintenance of chronic pain as well as the role the immune system plays in affecting the nociceptive circuit and vice versa.

Publications

  • Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Pospisilik JA, Schramek D, Schnidar H, Cronin SJ, Nehme NT, Zhang X, Knauf C, Cani PD, Aumayr K, Todoric J, Bayer M, Haschemi A, Puviindran V, Tar K, Orthofer M, Neely GG, Dietzl G, Manoukian A, Funovics M, Prager G, Wagner O, Ferrandon D, Aberger F, Hui CC, Esterbauer H, Penninger JM. Cell. 2010 Jan 8;140(1):148-60.PMID: 20074523 [PubMed - indexed for MEDLINE]Related citations
  • Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection.Cronin SJ, Nehme NT, Limmer S, Liegeois S, Pospisilik JA, Schramek D, Leibbrandt A, Simoes Rde M, Gruber S, Puc U, Ebersberger I, Zoranovic T, Neely GG, von Haeseler A, Ferrandon D, Penninger JM.Science. 2009 Jul 17;325(5938):340-3. Epub 2009 Jun 11.PMID: 19520911 [PubMed - indexed for MEDLINE]Related citations
  • From T-cell activation signals to signaling control of anti-cancer immunity. Cronin SJ, Penninger JM.Immunol Rev. 2007 Dec;220:151-68. Review.PMID: 17979845 [PubMed - indexed for MEDLINE]Related citations
  • The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers.Zhang L, Anglesio MS, O'Sullivan M, Zhang F, Yang G, Sarao R, Mai PN, Cronin S, Hara H, Melnyk N, Li L, Wada T, Liu PP, Farrar J, Arceci RJ, Sorensen PH, Penninger JM. Nat Med. 2007 Sep;13(9):1060-9. Epub 2007 Aug 12.PMID: 17694067 [PubMed - indexed for MEDLINE] Related citations
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