Research

LIke ThisLIke ThisLIke This

Shi Laboratory - Lab Members

Instructor in Pediatrics - Research Lab Chief

AB, Harvard College
PhD, University of California, San Francisco
Dr. Jambhekar has studied cell division and noncoding functions for RNA, both in a variety of contexts. She is working on projects focused on the roles of RNA in epigenetically-regulated processes, including cell proliferation and differentiation. 


Post-Doctoral Fellows

BS, Cornell University
PhD, University of Washington

Dr. Anastas is studying how mutations in chromatin-associated factors affect heterochromatin organization in pediatric cancer.

 

BS, Chemical Engineering, The University of Texas at Austin
PhD, Molecular Carcinogenesis, MD Anderson Cancer Center
Dr. Badeaux is interested in understanding the epigenetic processes driving cellular memory and plasticity. This knowledge will contribute to our understanding of cellular fate changes (differentiation, trans-differentiation, reprogramming) and biological windows of epigenetic plasticity during human development.


BA, Cornell University
PhD, Princeton University

Dr. Blanco is currently studying epigenetic control of cellular differentiation in myeloid lineage cancers  such as AML.  He is also interested in DNA damage and repair in tumorigenesis, with a current focus on mechanisms of DNA dealkylation in varying chromatin contexts.

 

Hao Chen, PhD

BS, National Base of Biology, Wuhan University, China 
PhD, Molecular Biology & Disease Proteomics, IBS, Fudan University, China

Dr. Chen is interested in how environmental signals translated into epigenetic codes and the regulatory mechanisms towards the pivotal epigenetic players involved in epigenetic profiles establishment and maintenance.

 

BS, Biotechnology, Zhejiang Normal University, China
PhD, Computational Cancer Epigenomics, German Cancer Research Center and Heidelberg University, Germany

Dr. Gu's research is focused on long range epigenetic regulations in cancer, transgenerational epigenetic inheritance in mammals, and developing tools for the integration of epigenomic and genomic data.

 

Chih-Hung Hsu, PhD

BS, Chinese Culture University, Taiwan
PhD, Tsing Hua University, Taiwan

Dr. Hsu is working on discovering novel histone modifications and investigating their biological functions.

 


MD, Medical School Hannover, Germany
PhD, MRC Centre for Regenerative Medicine, University of Edinburgh, UK

Dr. Karwacki-Neisius is studying X linked intellectual disability. She will use iPS cells containing mutations in the histone demethylase KDM5C together with isogenic control cell lines to define mechanisms underlying intellectual disability.

 

Benoit Laurent, PhD

BS, Poitiers University, France
MSc, Paris Diderot University, France 
PhD, Paris Descartes University, France
Alternative splicing (AS) contributes to the proteomic diversity. In the brain, it emerges as a potent and pervasive mechanism that plays a crucial role in the regulation of synaptic maturation, maintenance or activity. Benoit is interested in shedding light on how AS regulates the brain development and functions, and how its dysfunctions impact human health.

BS, Martin Luther University Halle-Wittenberg, Germany
PhD, Max-Planck-Institute of Immunobiology, Freiburg, Germany
Dr. Liefke investigates the role of the novel PRC2 interacting protein C17orf96. His main interest is to better understand the chromatin regulatory role of C17orf96 that is dependent and independent of PRC2. Further, he studies the potential implication of this protein in stem cell biology, embryogenesis and cancer.


Jernej Murn, PhD
BS, University of Ljubljana, Slovenia
PhD, Laboratory for Functional Genomics, CEA, France, and University of Ljubljana, Slovenia

RNA-binding proteins (RBPs) control essentially all aspects of gene expression and are commonly compromised in devastating human diseases ranging from neurodegeneration to cancer. Dr. Murn investigates the mechanistic bases of RBPs in regulating cell homeostasis in health and disease. His particular focus is on the chromatin-dependent roles of RBPs and their associated non-coding RNAs.

BS, Molecular Biology and Genetics at Middle East Technical University, Turkey
PhD, Biochemistry and Molecular Genetics, University of Virginia

Dr. Sendinc is interested in identifying mechanisms by which epigenetic information is inherited over the generations in C. elegans.


Wanqiang Sheng, PhD                                                                                                                                                                                BS, Ocean University of China                                                                                                                                                                     PhD, National University of Singapore                                                                                                                                                         Dr. Sheng is currently studying RNA modifications and relevant responses to various cellular stress.

Visiting Researchers

Jiekai Chen, PhD                                                                                                                                                                                          BS, Sun Yat-sen University, China                                                                                                                                                             PhD, Chinese Academy of Sciences, Guangzhou Institutes of Biomedicine and Health (GIBH), China                                                     Dr. Chen is interested in revealing epigenetic principles in cell fate determination. Currently he is focusing on the following aspects: 1) Epigenetic regulation in somatic reprogramming and functional cell differentiation/transdifferentiation; 2) Crosstalk between signaling transduction and histone/DNA modification. His long-term goal is to understand the role that epigenetic regulation plays in complexity evolution of metazoa and the brain.  

Ricardo Petroni, PhD                                                                                                                                                                                BS, Pharmacy, FMU University, Brazil                                                                                                                                                       PhD, University of Sao Paulo, Medical School, Brazil                                                                                                                           Dr. Petroni is currently studying epigenetic factors that control acute myeloid leukemia (AML) cell differentiation.

Lab Manager

William Jacobus                                                                                                                                                                                           BS, Biology, Boston College

LIke ThisLIke ThisLIke This
Close