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Shi Laboratory - Lab Members

Chief Research Assistant

AB, Harvard College
PhD, University of California, San Francisco
Dr. Jambhekar has studied cell division and noncoding functions for RNA, both in a variety of contexts. She is working on projects focused on the roles of RNA in epigenetically-regulated processes, including cell proliferation and differentiation. 

Instructor in Pediatrics

MD, University of Pavia, Italy
Dr. Spadafora’s main research focus is to (1) study which epigenetic mechanisms drive differentiation in the cells and/or help to change the state of pluripotency; and (2) identify which epigenetic mechanisms are used by cells to modify their gene expressions in order to cope with significant changes in the environment. My long-term goal is to be able to apply these findings to the study of newborn and infant disease.

Post-Doctoral Fellows

BS, Cornell University
PhD, University of Washington
Dr. Anastas is studying how mutations in chromatin-associated factors affect heterochromatin organization in pediatric cancer.

BS, Chemical Engineering, The University of Texas at Austin
PhD, Molecular Carcinogenesis, MD Anderson Cancer Center
Dr. Badeaux is interested in understanding the epigenetic processes driving cellular memory and plasticity. This knowledge will contribute to our understanding of cellular fate changes (differentiation, trans-differentiation, reprogramming) and biological windows of epigenetic plasticity during human development.

BA, Cornell University
PhD, Princeton University
Dr. Blanco is currently studying epigenetic control of cellular differentiation in myeloid lineage cancers  such as AML.  He is also interested in DNA damage and repair in tumorigenesis, with a current focus on mechanisms of DNA dealkylation in varying chromatin contexts.

Hao Chen, PhD

BS, National Base of Biology, Wuhan University, China 
PhD, Molecular Biology & Disease Proteomics, IBS, Fudan University, China
Dr. Chen is interested in how environmental signals translated into epigenetic codes and the regulatory mechanisms towards the pivotal epigenetic players involved in epigenetic profiles establishment and maintenance.

BS, Biotechnology, Zhejiang Normal University, China
PhD, Computational Cancer Epigenomics, German Cancer Research Center and Heidelberg University, Germany
Dr. Gu's research is focused on long range epigenetic regulations in cancer, transgenerational epigenetic inheritance in mammals, and developing tools for the integration of epigenomic and genomic data.

Chih-Hung Hsu, PhD

BS, Chinese Culture University, Taiwan
PhD, Tsing Hua University, Taiwan
Dr. Hsu is working on discovering novel histone modifications and investigating their biological functions.

MD, Medical School Hannover, Germany
PhD, MRC Centre for Regenerative Medicine, University of Edinburgh, UK
Dr. Karwacki-Neisius is studying X linked intellectual disability. She will use iPS cells containing mutations in the histone demethylase KDM5C together with isogenic control cell lines to define mechanisms underlying intellectual disability.

Benoit Laurent, PhD

BS, Poitiers University, France
MSc, Paris Diderot University, France 
PhD, Paris Descartes University, France
Alternative splicing (AS) contributes to the proteomic diversity. In the brain, it emerges as a potent and pervasive mechanism that plays a crucial role in the regulation of synaptic maturation, maintenance or activity. Benoit is interested in shedding light on how AS regulates the brain development and functions, and how its dysfunctions impact human health.

BS, Martin Luther University Halle-Wittenberg, Germany
PhD, Max-Planck-Institute of Immunobiology, Freiburg, Germany
Dr. Liefke investigates the role of the novel PRC2 interacting protein C17orf96. His main interest is to better understand the chromatin regulatory role of C17orf96 that is dependent and independent of PRC2. Further, he studies the potential implication of this protein in stem cell biology, embryogenesis and cancer.

Jernej Murn, PhD
BS, University of Ljubljana, Slovenia
PhD, University of Ljubljana, Slovenia and Laboratory for Functional Genomics, CEA, France
Dr. Murn focuses on transcriptional and post-transcriptional control of gene expression by RNA-binding proteins in neurons and stem cells. His recent work uncovered an RNA-based molecular program that specifies the early morphology of neurons through a metazoan-specific zinc finger protein, Unkempt (Murn et al, Genes & Dev, 2015). Dr. Murn is also interested in understanding the principles of neuronal communication; his aim is to engineer circuits of stem cell-derived neurons where some of the basic cognitive processes could be mimicked.

BS, Molecular Biology and Genetics at Middle East Technical University, Turkey
PhD, Biochemistry and Molecular Genetics, University of Virginia
Dr. Sendinc is interested in identifying mechanisms by which epigenetic information is inherited over the generations in C. elegans.

Yang Xiang, PhD

BS, Nanjing Agricultural University, China
PhD, Institute of Biochemistry & Cell Biology, Shanghai Institutes for Biological Sciences, China
Dr. Xiang is interested in the characterization of chromatin-associated molecules and their function in disease.

Lab Manager - Research Technologist

BS, Biology, Boston College

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